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Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 202-208页

作者： Huiyan Shi Chenzhi Hou Liqiang Gu Zhe Wei hang xing Meiyu Zhang Shixiao Wang Longshan Zhao Kaishun Bi Xiaohui Chen School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Material Medica Shenyang Pharmaceutical UniversityShenyang 110016China

The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat *** and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with *** analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for *** parameters were all within the acceptance *** validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/*** suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine *** method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.

关键词： Methotrexate Piperazine ferulate Pharmacokinetic parameters HPLC-MS

Association between chromosomal aberration of COX8C and tethered spinal cord syndrome:array-based comparative genomic hybridization analysis

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Neural Regeneration Research 2016年第8期11卷 1333-1338页

作者： Qiu-jiong Zhao Shao-cong Bai Cheng Cheng Ben-zhang Tao Le-kai Wang Shuang Liang Ling Yin xing-yi hang Ai-jia Shang Department of Neurosurgery Chinese PLA General Hospital Beijing China iGeneTech Biotechnology Co. Ltd. Beijing China Department of Neurology Chinese PLA General Hospital Beijing China

Copy number variations have been found in patients with neural tube *** this study,we performed genome-wide screening using high-resolution array-based comparative genomic hybridization in three children with tethered spinal cord syndrome and two healthy *** eight copy number variations,four were *** non-polymorphic copy number variations were associated with Angelman and Prader-Willi syndromes,and *** function enrichment analysis revealed that COX8 C,a gene associated with metabolic disorders of the nervous system,was located in the copy number variation region of Patient *** results indicate that array-based comparative genomic hybridization can be used to diagnose tethered spinal cord *** results may help determine the pathogenesis of tethered spinal cord syndrome and prevent occurrence of this disease.

关键词： nerve regeneration neural tube defects tethered spinal cord syndrome comparative genomic hybridization COX8C gene function enrichment analysis database of genomic variants database of DECIPHER copy number variations neural regeneration

Fluorinated Surfactants and Fluorinated Polymer Materials(Ⅰ): General Review

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China Detergent & Cosmetics 2019年第1期4卷 52-62页

作者： Xiao Jinxin xing hang Dou Zengpei Xiao Zibing Beijing FLUOBON Surfactant Institute

Fluorinated surfactants and fluorinated functional materials were introduced. Their fundamental concept, classification and structure, major physicochemical properties, industrial production methods, as well as applications in industrial and high technological fields were summarized. Their current environmental problems and the countermeasures in this field were also briefed.

关键词： fluorinated surfactant fluorinated functional materials fluoropolymer PFOS POPs

基于三角单元外心下的幂率格式在丁坝绕流中的应用

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水科学进展 2007年第3期18卷 362-367页

作者：邢领航华祖林河海大学水文水资源与水利工程科学国家重点实验室环境科学与工程学院浅水湖泊综合治理与资源开发教育部重点试验室江苏南京210098

针对在非结构网格水流数值计算,将各变量储存在三角单元外心进行离散,从而避免了由于非结构网格的非正交性而使用各种校正方法所带来的校正误差。采用Rhie-Chow的动量插值思想推导出基于SIMPLE意义下的水位校正方程,并详细给出了水位校... 详细信息

针对在非结构网格水流数值计算,将各变量储存在三角单元外心进行离散,从而避免了由于非结构网格的非正交性而使用各种校正方法所带来的校正误差。采用Rhie-Chow的动量插值思想推导出基于SIMPLE意义下的水位校正方程,并详细给出了水位校正方程的离散形式。动量方程采用数值性能优良的幂率格式。计算结果成功地模拟出丁坝上、下游涡的特征量及流场情况,与水槽试验的资料吻合良好。

关键词：非结构网格有限体积法 SIMPLE算法三角单元外心丁坝绕流

Fluorinated Surfactants and Fluorinated Polymer Materials(Ⅲ): Personal Opinion on the Problems of PFOS

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China Detergent & Cosmetics 2019年第3期4卷 54-62页

作者： xing hang Dou Zengpei Xiao Zibing Xiao Jinxin Beijing FLUOBON Surfactant Institute

As surfactant researchers, we have discussed the current problems of PFOS in China from our personal standpoint. The difficulties in both elimination and investigation on PFOS are analyzed. The production, application, biodegradation and regulation for some other important fluorinated alkylated substances are also briefly introduced. Finally, the objective and tasks for surfactant researchers are pointed out.

关键词： fluorinated surfactant fluoropolymer PFOS POPs PFOA

Fluorinated Surfactants and Fluorinated Polymer Materials(Ⅳ): Strategy for Solving PFOS Problems

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China Detergent & Cosmetics 2019年第4期4卷 69-76页

作者： xing hang Dou Zengpei Xiao Zibing Xiao Jinxin Beijing FLUOBON Surfactant Institute

Fluorinated alkyl substances are irreplaceable in many fields because of the special properties of fluorocarbon *** efforts have been made to solve the historic problems of *** this paper,several strategies were discussed,including the possibilities in the methods of degradation,separation,recycling use,and reducing the using *** most reliable one is to obtain replacement products of *** kinds of replacement products were introduced and their feasibility of application was also discussed.

关键词： fluorocarbon surfactant POPs PFOA bioaccumulation toxicity sustainability regulation

Fluorinated Surfactants and Fluorinated Polymer Materials(Ⅱ):Environmental and Safety Issues

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China Detergent & Cosmetics 2019年第2期4卷 66-79页

作者： xing hang Dou Zengpei Xiao Zibing Xiao Jinxin Beijing FLUOBON Surfactant Institute

The environmental and safety issues of perfluorooctane sulfonyl fluoride/perfluorooctane sulfonic acid/ perfluorooctane sulfonates (PFOS) were introduced in detail by summarizing several published reviews, including their production, occurrence and emission in environment, exposure and intake to human being, supervision and emission reduction, long-distance transport, bioaccumulation and excretion, degradation and toxicity. Opinion with respect to safety issues of PFOS was also proposed in view of surfactant working field in order to upgrade their application value. The overreaction in the current state for the fear of “fluorine” was concerned. For fire-fighting foams, the issue of “safety” needs to be critically weighed.

关键词： fluorocarbon surfactant fluoropolymer PFOS POPs PFOA

Effects of Hydroxyl Groups in Organic Ammonium Counterions on the Properties of Fluorinated Surfactants

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China Detergent & Cosmetics 2017年第4期2卷 57-65页

作者： Zhang Tiantian Zhou Hongyu Wu Bowan Xiao Jinxin xing hang Longdong University-Fluobon Surfactant Engineering Technology Center College of Chemistry and Chemical EngineeringLongdong University Beijing FLUOBON Surfactant Institute

The surface tension, foaming and viscosity for C7F15COO^-N^＋H（C2H4OH）χ（C2Hs）3-x and C8F17SO3- N^＋H（C2H4OH）χ（C2H5）3-χ （x = 0, 1, 2, 3） were measured to systematically study the effects of hydroxyl groups in organic ammonium counterions on the properties of perfluorooctanoates and perfluorooctanesulfonates. The results showed that the critical micelle concentration （cmc） and the surface tension at cmc （γcmc） were both increased with the increase of number of hydroxyl groups （χ） in the two series. The perfluorooctanesulfonate had smaller cmc but higher γ=cmc than perfluorooctanoate with the same counterion. The minimum molecular area of surface adsorption （Amin） of C8F17zSO3^-N^＋H（C2H4OH）χ（C2H5）3-χ were 0.64, 0.57, 0.63 and 0.72 nm^2 while the Amin values of C7F15COO^-N^＋H（C2H4OH）χ（C2H5）3-χ were 0.61, 0.62, 0.61 and 0.71 nm^2 when χ = 0, 1, 2 and 3, respectively. For the investigated systems of surfactants, the results of foam expansion ratio agreed with those of surface activity, while the 25% drainage time were consistent with the results of viscosity.

关键词： counter-ion organic ammonium ion fluorocarbon surfactant foam surface activity micellization

Temperature-gradient method for gaining insights into the luminescence origin and formation mechanism of carbon dots

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Science China Materials 2024年第10期67卷 3096-3105页

作者： Yan-Ting Yang Yue-xing Zhang You Cheng Xin-Ru Xu Jing Han Zi-Xin Chen hang-xing Wang College of Chemistry and Chemical Engineering Key Laboratory for the Synthesis and Application of Organic Functional Molecules(MOE)Hubei UniversityWuhan 430062China Shandong Universities Engineering Research Center of Integrated Circuits Functional Materials and Expanded Applications Dezhou UniversityDezhou 253023China

Carbon dots(CDs)are a fascinating new class of fluorescent nanomaterials,yet the understanding of the fluorescent origin of CDs still lags well behind their *** key challenges for unveiling the fluorescent mechanism of CDs relate to the insufficient basis for structural *** work presents a temperature-gradient route to control the bottom-up approach of CDs,enabling the precise structural characterization of intermediates and the establishment of definite structure-property relationships,akin to the domino reaction synthesis of complex natural products from small organic *** the binary components citric acid and meta-dimethylaminophenol generated CDs as a case study,their emissive mechanism,particularly the unique excitation-dependent fluorescence behavior,is reasonably explained and supported by structural evaluation through retrosynthetic *** formation process of CDs is investigated using a combination of spectroscopic,thermal,and theoretical calculation techniques,demonstrating the significant potential of the temperature-gradient route in the exploration structure-property relationships and guiding the rational design of advanced CD applications.

关键词： carbon dots temperature gradient domino effect fluorescent origin solid-state emission