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Relationship between the Plasma Fibulin-1 Levels,Pulse Wave Velocity,and Vascular Age in Asymptomatic Hyperuricemia

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Current Medical Science 2021年第1期41卷 94-99页

作者： Yu SANG Kai-min MAO Yi HUANG Xiao-fen WU xing-fen WANG Lei RUAN Cun-tai ZHANG Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pulmonary and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Geriatrics Beijing Aerospace General HospitalBeijing 100076China

Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity(baPWV)in patients with asymptomatic hyperuricemia(AHU).In total,66 patients with AHU and 66 gender-and age-matched healthy individuals were *** plasma fibulin-1 levels were measured by *** with AHU presented significantly higher vascular age[median(interquartile range):54(22)vs.48(14)years,P=0.01]and baPWV[mean±SD:1373±223 vs.1291±177 cm/s,P=0.02]than the healthy subjects;however,no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects[median(interquartile range):4018(3838)vs.3099(3405)ng/mL,P=0.31].A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU(r=0.29,P=0.02);and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age(r=0.22,P=0.08).However,these associations were rendered insignificant after adjustments for potential *** healthy subjects,no correlation was observed between fibulin-1 levels and CVD *** study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU,but the relationship is not robust.

关键词： fibulin-1 cardiovascular risk vascular age brachial-ankle pulse wave velocity asymptomatic hyperuricemia

Autophagy Enhances the Aggressiveness of Human Colorectal Cancer Cells and Their Ability to Adapt to Apoptotic Stimulus

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Clinical oncology and cancer researeh 2012年第2期9卷 105-110页

作者： Hai-yang Zheng Xiao-yang Zhang xing-fen Wang Bao-cun Sun Department of Pathology The Second Hospital of Tianiin Medical University Department of Pathology Tianjin Medical University Cancer Institute and Hospital

Objective To investigate LC3B-Ⅱand active caspase-3 expression in human colorectal cancer to elucidate the role of autophagy and to explore the relationship of autophagy with apoptosis in human colorectal cancer. Methods LC3B expression was detected by immunohistochemistry in 53 human colorectal cancer tissues and 20 normal colon *** protein levels of LC3B-Ⅱand active caspase-3 were also determined by Western blot analysis in 23 human colorectal cancer tissues and 10 normal colon tissues. Results LC3B was expressed both in cancer cells and normal epithelial ***3B expression in the peripheral area of cancer tissues was correlated with several clinicopathological factors,including tumor differentiation(P=0.002),growth pattern of the tumor margin (P=0.028),pN(P=0.002),pStage(P=0.032),as well as vessel and nerve plexus invasion(P=0.002).The protein level of LC3B-Ⅱin cancer tissue was significantly higher than in normal tissue(P=0.038),but the expression of active forms of procaspase-3 in cancer tissue was lower(P=0.041).There was a statistically significant positive correlation between the expression levels of LC3B-Ⅱand the active forms of procaspase-3(r=0.537,P=0.008). Conclusions Autophagy has a prosurvival role in human colorectal *** enhances the aggressiveness of colorectal cancer cells and their ability to adapt to apoptotic stimulus.

关键词： autophagy apoptosis colorectal neoplasms LC3B caspase-3

Navigating the complex landscape of crawling-type gastric adenocarcinomas:Insights and implications for clinical practice

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World Journal of Gastrointestinal Oncology 2024年第11期16卷 4309-4314页

作者： Hai-Bo Yu Ke-feng Jia xing-fen Wang Bao-Yu Li Qi Xin Laboratory The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Radiology Tianjin Third Central HospitalTianjin 300170China Department of Pathology The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Gastrointestinal Surgery The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Pathology The Third Central Hospital of TianjinTianjin 300170China

In this editorial,we comment on an article by Xu et *** article describes a case of crawling-type gastric adenocarcinoma(CRA)distinguished by its rare occurrence and diagnostic *** reviewed the detailed case-report findings showcasing clinical,pathological,and molecular characteristics of CRA that shed light on its elusive nature and challenges for early detection and *** case underscored the significance of advanced diagnostic tools such as endoscopic submucosal *** was placed on the molecular peculiarities of CRA,including the higher mutation rates of genes such as TP53 and RHOA and the notable absence of HER2 amplification,differentiating it from more conventional forms of gastric *** this editorial,we advocate for a multidisciplinary approach to effectively manage this rare subtype and highlight the necessity for precision in both diagnostic and therapeutic ***,a heightened awareness urging the adoption of advanced diagnostic techniques and collaborative approaches is necessary among clinicians and *** aim to contribute to the ongoing discourse in gastrointestinal oncology,emphasizing the importance of recognizing and addressing the complexities associated with rare cancer subtypes such as CRA.

关键词： Crawling-type gastric adenocarcinoma Diagnosis Pathology Endoscopy Treatment

Anti-proliferation and radiosensitization effects of chitooligosaccharides on human lung cancer line Hep G2

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Asian Pacific Journal of Tropical Medicine 2015年第9期8卷 742-746页

作者： Fu-Shi Han Bo-Han Cui Xiao-Fang You Yan-fen xing Xi-Wen Sun Medical Imaging Division Pulmonary Hospital Affiliated to Tongji University

Objective: To observe the anti-proliferation and radiosensitization effect of chitooligosaccharides(COS) on human lung cancer cell line Hep G2. Methods: CCK-8 assay was employed to obtain the inhibition ratio of COS on Hep G2 cells at 24 h after treatment. The clonogenic assay was used to analyze the cell viability of RAY group and RAY+COS group with X-ray of 0, 1, 2, 4, 6 and 8 Gy, and the cell survival curve was used to analyze the sensitization ratio of COS. Flow cytometry was employed to detect cell cycle and apoptosis rate in control group, RAY group and RAY+COS group after 24 h treatment. Results: COS inhibited the proliferation of Hep G2 cells, and the inhibition rate positively correlated with the concentration of COS. The cell viability decreased with increasing exposure dose in RAY group and RAY+COS group. The cell viabilities of RAY+COS group were lower than those of RAY group at the dose of 4, 6 and 8 Gy(P<0.05), and the sensitization ratio of COS was 1.19. There were higher percentage at G2/M phase and apoptosis rate, and lower percentage at S phase in RAY+COS group versus the other two groups(P<0.01). Conclusions: COS can inhibit the proliferation of Hep G2 cells, and enhance the radiosensitization of Hep G2 cells, induce apoptosis and G2/M phase arrest.

关键词： Chitooligosaccharides Lung cancer Radiotherapy Radiosensitization Cell cycle Apoptosis

Somatic Embryogenesis and Plant Regeneration from Two Recalcitrant Genotypes of Gossypium hirsutum L.

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Agricultural Sciences in China 2006年第5期5卷 323-329页

作者： WANG Yan-xia WANG xing-fen MA Zhi-ying ZHANG Gui-yin HAN Gai-ying Hebei Agricultural University/Key Laboratory of Crop Germplasm Resources of Hebei Baoding 071001 P.R. China

An improved protocol has been developed for somatic embryogenesis and plant regeneration of recalcitrant cotton cultivars. High callus frequencies and embryogenic tissue were developed in MSB medium supplemented with gradient concentrations of KT and 2,4-D, their concentration decreasing from 0.1 to 0.01 mg·L^-1. Somatic embryos were successfully incubated in 1/2 macronutrient MSB suspension supplemented with 0.5 g· L^-1 glutamine and 0.5 g·L^-1 asparagine. Decrease in macronutrient concentration of MSB significantly alleviated browning and was beneficial to suspension cells. Transformation of somatic embryos into plants was induced in MSB medium supplemented with 3% sucrose, 0.5 g·L^-1 glutamine, 0.5 g·L^-1 asparagine, and 6.0 g·L^-1 agar. The effect of sucrose as carbohydrate was better than that of glucose for plant germination. Using this protocol, regenerated plantlets from the CCRI521 and Zhongzhi86-6 reached to as much as 19.6 and 18.5% somatic embryos, respectively.

关键词： Gossypium hirsutum L. recalcitrant genotypes plant regeneration somatic embryogenesis effect of macronutrients suspension culture

日军遗华化学武器诉讼案及其前景析——兼论日本的战后责任问题

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河北法学 2007年第3期25卷 60-64,83页

作者：邢爱芬北京师范大学法学院北京100875

近年来,日军遗华化学武器致人伤亡事件不断发生,从1996年起中国受害者就开始在日本法院提起民间索赔诉讼,但迄今无一最终胜诉。民间赔偿不同于战争赔偿,中国受害者的民间索赔诉讼属日本未尽的战后责任问题,这不仅涉及受害者利益,而且关... 详细信息

近年来,日军遗华化学武器致人伤亡事件不断发生,从1996年起中国受害者就开始在日本法院提起民间索赔诉讼,但迄今无一最终胜诉。民间赔偿不同于战争赔偿,中国受害者的民间索赔诉讼属日本未尽的战后责任问题,这不仅涉及受害者利益,而且关乎中日关系。2006年4月3日中国民间对日索赔联合会在北京成立,开启了中国民间对日索赔的国内诉讼程序。另一方面,中国政府也应从各方面给受害者的索赔诉讼提供支持,包括尝试国际求偿。但这一问题的解决最终还有赖于日本正确看待其侵略历史,彻底履行战争责任。

关键词：日军遗华化学武器诉讼案战后责任民间赔偿

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履行《联合国反腐败公约》的国内立法研究

河南大学学报（社会科学版） 2011年第1期51卷 61-66页

作者：邢爱芬北京师范大学法学院北京100875

《联合国反腐败公约》是缔约国建立和完善反腐败犯罪立法的重要依据和参考。"公约"的基本刑事思想及对缔约国的要求主要是以预防为主,更加高效有力地打击腐败犯罪。2009年3月通过的《刑法修正案(七)》以及2010年8月递交全国人大常委会... 详细信息

《联合国反腐败公约》是缔约国建立和完善反腐败犯罪立法的重要依据和参考。"公约"的基本刑事思想及对缔约国的要求主要是以预防为主,更加高效有力地打击腐败犯罪。2009年3月通过的《刑法修正案(七)》以及2010年8月递交全国人大常委会的《刑法修正案(八)草案》是我国履行"公约"的积极成果。目前,我国的刑事立法距"公约"的要求仍有差距,主要是缺乏反腐败犯罪的专门立法以及在反腐败犯罪的定罪体系、法定刑、特别程序等方面存在不足,这也是我国进一步改革反腐败犯罪立法的发展方向和具体内容。

关键词：《联合国反腐败公约》腐败犯罪国内立法

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防治生物入侵的国际法原则与实施机制

生态经济 2006年第12期22卷 26-30,35页

作者：邢爱芬北京师范大学北京100875

生物入侵已成为仅次于栖息地退化的全球生物多样性的第二大威胁。在国际自然保护联盟(IUCN)公布的全球100种最具威胁的外来生物中,我国已发现50多种,成为遭受外来生物侵害最严重的国家之一。加强国际合作是防治生物入侵的良方,相关国际... 详细信息

生物入侵已成为仅次于栖息地退化的全球生物多样性的第二大威胁。在国际自然保护联盟(IUCN)公布的全球100种最具威胁的外来生物中,我国已发现50多种,成为遭受外来生物侵害最严重的国家之一。加强国际合作是防治生物入侵的良方,相关国际法规定是各国相互协作解决该问题的基础,也是各国制定生物入侵国内法的参考。防治生物入侵的国际法核心原则是风险与损害预防原则,环境影响评价和风险评估制度等是该原则得以实现的机制保障。

关键词：生物入侵国际法风险与损害预防

Prediction of Ocular Irritancy of 26 Chemicals and 26 Cosmetic Products with Isolated Rabbit Eye (IRE) Test

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Biomedical and Environmental Sciences 2012年第3期25卷 359-366页

作者： GUO Xiang YANG xing fen YANG Ying HANS Raabe CAI Jing Heng XUE Jin Yu TAN Xiao Hua XIE Xiao Ping XIONG Xi Kun HUANG Jun Ming Guangdong Provincial Center for Disease Control China National Institute for Occupational Health and Prevention Guangzhou 510300Guangdongand Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China Institute for in vitro Science Gaithersburg MD 20878MarylandUSA Faculty of Mathematics and Computational Science Sun Yat-sen UniversityGuangzhou 510275GuangdongChina

Objective This study aims to establish and evaluate the methodology of isolated rabbit eye （IRE） test. Methods IRE test was performed according to modifications of the in vitro toxicology （INVITTOX） Protocol No.85： Rabbit enucleated eye test by European Centre for the Validation of Alternative Methods （ECVAM）, and then 26 chemicals and 26 cosmetic products were tested in both in vitro IRE and in vivo Draize tests. A statistical analysis was conducted to determine the relevance of the IRE test to the data generated in the Draize test. Results IRE test was established successfully in our laboratory. It was shown that ranking correlation and class concordance were fairly well between the IRE test and the Draize test for 26 reference chemicals （Fisher＇s Exact Test X2=51.314, P〈0.001; McNemar P=0.261; Gamma=0.960, P〈0.001; Kappa=0.843, P〈0.001） and 26 cosmetic products （Fisher＇s Exact Test X^2=15.522, P〈0.O01; McNemar P=0.311; Gamma=0.967, P〈0.001; Kappa=0.611, P〈0.O01）. Conclusion IRE test was established successfully for in vitro testing of eye irritation as an alternative to Draize test.

关键词： Isolated rabbit eye IRE Eye irritation Alternative testing Draize test