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Misdiagnosis of an elevated lesion in the esophagus:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9828-9833页

作者： xing-Bin ma Huai-Yuan ma xing-Fang Jia Fei-Fei Wen Cheng-Xia Liu Department of Gastroenterology and Hepatology Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Pathology Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND Esophageal carcinosarcoma(ECS) is a rare biphasic tumor and a type of esophageal malignancy,which presents as protruding or elevated *** patients are often not hospitalized until they have severe *** is easily misdiagnosed as a benign tumor due to its atypical characteristics under *** the popularization of endoscopic treatment,these patients are often referred to endoscopic treatment,such as endoscopic submucosal dissection(ESD).However,there is a lack of consensus on the endoscopic features and therapies for ***,we report a case of ECS and discuss the value of endoscopic diagnosis and therapeutic *** SUMmaRY A 63-year-old man was admitted to the hospital with *** the endoscopic examination,an elevated lesion was found with an erosive and hyperemic surface covered with white pseudomembranous *** ultrasonography(EUS),biopsies,and enhanced thoracic computed tomography were performed,suggesting that it was a benign lesion and located within the submucosal *** lesion was diagnosed as a fibrovascular polyp with a Paris classification of *** patient was then referred to ESD ***,the post-ESD pathological and immunohistochemical study showed that this lesion was ECS with a vertical positive margin(T1b stage),indicating that we made a misdiagnosis and achieved a noncurative *** to the potential tumor residue,additional open surgery was performed at the patient’s *** the postoperative pathological study,no tumor remnants or metastases were *** patient was followed for 1 year and had no *** ECS can be misdiagnosed at the initial *** can help to identify the tumor *** with T1b stage ECS cannot be routinely referred to ESD treatment due to the high risk of metastasis and recurrence rate.

关键词： Esophageal carcinosarcoma Misdiagnosis Endoscopic ultrasonography Endoscopic submucosal dissection T1 stage Case report

Impacts of warming on root biomass allocation in alpine steppe on the north Tibetan Plateau

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Journal of Mountain Science 2017年第8期14卷 1615-1623页

作者： ma xing-xing YAN Yan HONG Jiang-tao LU Xu-yang WANG Xiao-dan Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of Sciences University of Chinese Academy of Sciences

Biomass is an important component of global carbon cycling and is vulnerable to climate change. Previous studies have mainly focused on the responses of aboveground biomass and phenology to warming, while studies of root architecture and of root biomass allocation between coarse and fine roots have been scarcely reported in grassland ecosystems. We conducted an open-top-chamber warming experiment to investigate the effect of potential warming on root biomass and root allocation in alpine steppe on the north Tibetan Plateau. The results showed that Stipa purpurea had significantly higher total root length, root surface area and tips than Carex moocroftii. However,there were no differences in total root volume, mean diameter and forks for the two species. Warming significantly increased total root biomass(27.60%), root biomass at 0–10 cm depth(27.84%) and coarse root biomass(diameter > 0.20 mm, 57.68%) in the growing season(August). However, warming had no significant influence on root biomass in the non-growing season(April). Root biomass showed clear seasonalvariations: total root biomass, root biomass at 0–10 cm depth and coarse root biomass significantly increased in the growing season. The increase in total root biomass was due to the enhancement of root biomass at 0–10 cm depth, to which the increase of coarse root biomass made a great contribution. This research is of significance for understanding biomass allocation, carbon cycling and biological adaptability in alpine grassland ecosystems under future climate change.

关键词： Coarse root Fine root Root architecture Warming Climate change Open-top chambers

Gallium-based liquid metal micro/nanoparticles for photothermal cancer therapy

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Journal of materials Science & Technology 2023年第11期142卷 22-33页

作者： Mingming Fu Yifeng Shen Hao Zhou Xiaojia Liu Wenjun Chen xing ma School of materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Sauvage Laboratory for Smart materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China

Gallium-based liquid metals have attracted significant interest in the biomedical field due to their unique properties such as low viscosity,good fluidity,high thermal/electrical conductivity,and good ***,photothermal therapy has made great development in the field of antitumor with its advantages of low adverse effects,high specificity,and repeatable *** photothermal capability possessed by gallium-based liquid metals makes them show unparalleled advantages in photothermal *** metal-based photothermal therapy has progressed in recent years and can perform a vital role in accurate and noninvasive antitumor ***,a review of the major preparation methods of liquid metal micro/nanoparticles,the mechanism of liquid metal photothermal conversion,and discussions on the factors affecting the photothermal properties of liquid metals are *** biological applications of liquid metal photothermal therapy in synergy with other therapies are discussed,as well as the current challenges and opportunities for the clinical translation of liquid metals in biomedical applications.

关键词： Gallium-based materials Photothermal conversion principle Photothermal therapy Synergistic therapy

Liquid Metal-Based Epidermal Flexible Sensor for Wireless Breath Monitoring and Diagnosis Enabled by Highly Sensitive SnS2 Nanosheets

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Research 2021年第1期2021卷 1319-1331页

作者： Yifan Huang Fan Yang Sanhu Liu Rongguo Wang Jinhong Guo xing ma National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150086China Sauvage Laboratory for Smart materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen STRONG Advanced materials Research Institute Co. Ltd.China School of Communication and Information Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Bay Laboratory No.9 Duxue RoadShenzhen 518055China

Real-time wireless respiratory monitoring and biomarker analysis provide an attractive vision for noninvasive telemedicine such as the timely prevention of respiratory arrest or for early diagnoses of chronic ***,wearable respiratory sensors are in high demand as they meet the requirement of portability in digital healthcare ***,high-performance sensing material plays a crucial role for the precise sensing of specific markers in exhaled air,which represents a complex and rather humid ***,we present a liquid metal-based flexible electrode coupled with SnS_(2)nanomaterials as a wearable gas-sensing device,with added Bluetooth capabilities for remote respiratory monitoring and *** flexible epidermal device exhibits superior skin compatibility and high responsiveness(1092%/ppm),ultralow detection limits(1.32 ppb),and a good selectivity of NO gas at ppb-level *** advantage of the fast recovery kinetics of SnS_(2)responding to H_(2)O molecules,it is possible to accurately distinguish between different respiratory patterns based on the amount of water vapor in the exhaled ***,based on the different redox types of H_(2)O and NO molecules,the electric signal is reversed once the exhaled NO concentration exceeds a certain threshold that may indicate the onset of conditions like asthma,thus providing an early warning system for potential lung ***,by integrating the wearable device into a wireless cloud-based multichannel interface,we provide a proof-of-concept that our device could be used for the simultaneous remote monitoring of several patients with respiratory diseases,a crucial field in future digital healthcare management.

关键词： Highly reversed integrating

TOAST: Automated Testing of Object Transformers in Dynamic Software Updates

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Journal of Computer Science & Technology 2022年第1期37卷 50-66页

作者： Ze-Lin Zhao Di Huang Xiao-xing ma State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Dynamic software update(DSU)patches programs on the *** often involves the critical task of object transformation that converts live objects of the old-version program to their semantically consistent counterparts under the new-version *** task is accomplished by invoking an object transformer on each stale ***,a defective transformer failing to maintain consistency would cause errors or even crash the *** propose TOAST(Test Object trAnSformaTion),an automated approach to detecting potential inconsistency caused by object *** first analyzes an update to identify multiple target methods and then adopts a fuzzer with specially designed inconsistency guidance to randomly generate object states to drive two versions of a target *** creates two corresponding execution traces and a pair of old and new *** finally performs object transformation to create a transformed object and detects inconsistency between it and the corresponding new object produced from scratch by the new ***,TOAST checks behavior inconsistency by comparing the return variables and exceptions of the two *** evaluation on 130 updates with default transformers shows that TOAST is promising:it got 96.0%precision and 85.7%recall in state inconsistency detection,and 81.4%precision and 94.6%recall in behavior inconsistency *** inconsistency guidance improved the fuzzing efficiency by 14.1%for state inconsistency detection and 40.5%for behavior inconsistency detection.

关键词： object state transformer inconsistency detection dynamic software update(DSU) fuzzing testing

Fundamentals and applications of enzyme powered micro/nano-motors

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Bioactive materials 2021年第6期6卷 1727-1749页

作者： Hao Yuan Xiaoxia Liu Liying Wang xing ma Flexible Printed Electronic Technology Center and School of materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen518055China Shenzhen Bay Laboratory No.9 Duxue RoadShenzhen518055China Key Laboratory of Microsystems and Microstructures manufacturing Harbin Institute of TechnologyHarbinHeilongjiang150001China

Micro/nanomotors(MNMs)are miniaturized machines that can convert many kinds of energy into mechanical *** the past decades,a variety of driving mechanisms have been developed,which have greatly extended the application scenarios of *** exist in natural organisms which can convert chemical energy into mechanical *** is an innovative attempt to utilize enzymes as biocatalyst providing driving force for *** fuels for enzymatic reactions are biofriendly as compared to traditional counterparts,which makes enzyme-powered micro/nanomotors(EMNMs)of great value in biomedical field for their nature of *** now,EMNMs with various shapes can be propelled by catalase,urease and many ***,they can be endowed with multiple functionalities to accomplish on-demand ***,combined with the development process of EMNMs,we are committed to present a comprehensive understanding of EMNMs,including their types,propelling principles,and potential *** this review,we will introduce single enzyme that can be used as motor,enzyme powered molecule motors and other micro/*** fundamental mechanism of energy conversion process of EMNMs and crucial factors that affect their movement behavior will be *** current progress of proof-of-concept applications of EMNMs will also be elaborated in *** last,we will summarize and prospect the opportunities and challenges that EMNMs will face in their future development.

关键词： Micro/nano-motors Enzymes Bio-catalytic reactions Active motion Self-propulsion mechanism

USEFUL RELATIVE MOTION DESCRIPTION METHOD FOR PERTURBATIONS ANALYSIS IN SATELLITEFORmaTION FLYING

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Applied mathematics and Mechanics(English Edition) 2005年第11期26卷 1464-1474页

作者：孟鑫李俊峰高云峰 ma xing-rui School of AeroSpace Tsinghua University Beijing 100084 P. R. China 不详

A set of parameters called relative orbital elements were defined to describe the relative motion of the satellites in the formation flying. With the help of these parameters, the effect of the perturbations on the relative orbit trajectory and geometric properties of satellite formation can be easily analyzed. First, the relative orbital elements are derived, and pointed out： if the eccentricity of the leading satellite is a small value, the relative orbit trajectory is determined by the intersection between an elliptic cylinder and a plane in the leading satellite orbit frame reference; and the parameters that describe the elliptic cylinder and the plane can be used to obtain the relative orbit trajectory and the relative orbital elements. Second, by analyzing the effects of gravitational perturbations on the relative orbit using the relative orbital elements,it is found that the propagation of a relative orbit consists of two parts ： one is the drift of the elliptic cylinder; and the other is the rotation of the plane resulted from the rotation of the normal of the plane. Meanwhile, the analytic formulae for the drift and rotation rates of a relative trajectory under gravitational perturbations are presented. Finally, the relative orbit trajectory and the corresponding changes were analyzed with respect to the J2 perturbation.

关键词： satellite formation flying relative orbital element gravitational perturbation drift rate rotation rate

Mesoporous silica as micro/nano-carrier： From passive to active cargo delivery, a mini review

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Journal of materials Science & Technology 2017年第10期33卷 1067-1074页

作者： xing ma Huanhuan Feng Chunyan Liang Xiaojia Liu Fanyu Zeng Yong Wang Sate Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology (Shenzhen) Shenzhen 518055 China Key Laboratory of Micro-systems and Micro-structures manufacturing of Ministry of Education Harbin Institute of Technology Harbin 150001 China

Mesoporous silica has been widely explored for biomedical applications due to its unique structure and good biocompatibility. In particular it exhibits superior properties as micro/nano-carriers in the biomedical field. We explore their potentials in controlled drug/gene co-delivery and photodynamic therapy for cancer treatment both in vitro and in vivo. By incorporating mesoporous silica nanoparticles（MSNP） with two-dimensional nanomaterial, graphene oxide nano-sheet, we utilize MSNP in cellular bio-imaging with squaraine dye. Meanwhile, through delicate combination between mesoporous silica micro/nano carriers with catalytic/bio-catalytic reactions, we manage to achieve self-propelled micro/nano-motors based on mesoporous silica that are capable of transporting cargos in an active manner. Especially, enzyme powered mesoporous silica motors can be powered by physiologically available fuels such as glucose and urea,which are advantageous for future biomedical use. Motion control on both velocity and movement direction provides a powerful tool for targeted drug delivery. Therefore, such mesoporous silica based active carriers pave way to the solution of targeted drug delivery for cancer treatment in future nano-medicine field.

关键词： Mesoporous silica Micro/nano-carrier Drug delivery Self-propulsion Active carrier

Aerobic Enantioselective Epoxidation of Styrene Analogues Induced by (β-Diketone)-iron( Ⅲ ) Complex

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Chinese Chemical Letters 2005年第11期16卷 1467-1470页

作者： Qing Fang CHENG xing You XU Wei xing ma Shu Jie YANG Tian Pa YOU Department of Chemical Technology Huaihai Institute of Technology Lianyungang 222005 Meterials Chemistry Laboratory Nanjing University of Science and Technology Nanjing 210094 Department of Chemistry University of Science and Technology of China Hefei 230026

Tris（d,d-dicampholylmethanato） iron （Ⅲ） complex, Fe（dcm）3, was found to be an excellent catalyst for asymmetric oxygenation of styrene analogues into the corresponding epoxides. Good chemical yields and higher enantioselectivity were obtained with combined use of molecular oxygen and an aldehyde at 30℃, Some factors influencing enantioselectivity were discussed.

关键词： Epoxidation oliefin asymmetric catalysis (β-diketone)-iron (Ⅲ) complex.