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An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations:A case study of Tibetan medicine Tiebangchui

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Journal of Pharmaceutical Analysis 2024年第4期14卷 615-618页

作者： Yue Liu Mengjia Li xing fu Yi Zhang Ce Tang State Key Laboratory of Southwestern Chinese Medicine Resources School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620010China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

The dried roots of Aconitum pendulum Busch are the major source of a commonly used Tibetan medicine,namely Tiebangchui(TBC)(Fig.S1).However,raw TBC contains a large amount of high toxic diester-diterpenoid alkaloids(DDAs),and the improper use would cause arrhythmia,irreversible cardiovascular damages,and even death.“Paozhi”,an appropriate processing method,is the essential prerequisite for the safe clinical application of ***-decocting and sand-frying are commonly used processing methods for toxicity attenuation and efficacy preservation for TBC.

关键词： dried irreversible roots

Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： xing fu Yexin Hu Ping Hu Hui Li Shuguang Xu Liangfang Zhu Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

Invariance pressures for uncertain control systems

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Acta Mathematica Sinica,English Series 2024年

作者： xing fu ZHONG Yu HUANG School of Mathematics and Statistics Guangdong University of Foreign Studies School of Science Sun Yat-sen University

We provide three types of invariance pressure for uncertain control systems, namely, invariance pressure, strong invariance pressure, and invariance feedback pressure. The first two respectively extend the corresponding pressures for deterministic control systems proposed by Colonius, Cossich,and Santana (2018) and by Nie, Wang, and Huang (2022); and the third generalizes invariance feedback entropy of uncertain control systems presented by Tomar, Rungger, and Zamani (2020), by adding potentials on the control range. Then we prove that (1) an explicit formula for invariance pressure of a controlled invariant set with respect to a potential by the logarithm of the spectral radius of the admissible weighted matrix determined by this potential under some suitable conditions;(2) an explicit formula for pressure of invariant quasi-partitions by maximum mean weight over all irreducible periodic sequences;(3) the invariance feedback pressure of a controlled invariant set is equal to the pressure of an atom partition under some technical assumptions;(4) lower and upper bounds for pressure of invariant quasi-partitions w.r.t. a potential by the logarithm of the spectral radius of the weighted adjacency matrix determined by this potential;(5) a variational principle for strong invariance pressure.

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Acetylene/argon mixture plasma to build ultrathin carbon bridge of CF_(x)/C/MnO_(2) for high-rate lithium primary battery

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Rare Metals 2024年第6期43卷 2574-2584页

作者： Da-Wei Zou xing-Guang fu Gao-Bang Chen Yi-Fan Liu Bao-Shan Wu Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 31300lChina

Forming an ultrathin conducting layer on a fluorinated carbon(CFx)surface for reducing severe electrochemical polarization in lithium/fluorinated carbon primary batteries(Li/CF_(x))remains a considerable challenge for achieving batteries with excellent rate ***,CFxwas modified by using acetylene/argon mixture plasma combined with MnO_(2)*** CF_(x)/C/MnO_(2)composite effectively reduced the voltage hysteresis and improved the electrochemical performance of Li/CF_(x).The excellent rate performance of CF_(x)/C/MnO_(2)was due to the high electrochemical activity provided by the atomicscale conductive carbon layer and ultrafine MnO_(2)*** with pristine CF_(x),the charge transfer resistance of the optimized CF_(x)/C/MnO_(2)decreased from 218.5 to 48.2Ω,the discharge rate increased from 2C to 10C,and the power density increased from 3.11 to 13.44 kW·g^(-1),The intrinsic reason for the enhanced rate performance was attributed to the fact that the ultrathin carbon layer acted as a conductive bridge to reduce the voltage hysteresis at the initial stage of the Li/CF_(x)discharge,and the high electrochemical activity of the ultrafine MnO_(2)particles provided a faster lithium-ion diffusion rate.

关键词： C_(2)H_(2)/Ar plasma Fluorinated carbon Lithium primary battery MnO_(2)

Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia

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当代医学科学（英文） 2024年第4期44卷 799-808页

作者： Tong-yuan LIU xing fu Ying YANG Jia GU Min XIAO Deng-ju LI Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:The metabolic reprogramming of acute myeloid leukemia(AML)cells is a compensatory adaptation to meet energy requirements for rapid *** study aimed to examine the synergistic effects of glutamine deprivation and metformin exposure on AML ***:SKM-1 cells(an AML cell line)were subjected to glutamine deprivation and/or treatment with metformin or bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide(BPTES,a glutaminase inhibitor)or *** viability was detected by Cell Counting Kit-8(CCK-8)assay,and cell apoptosis and reactive oxygen species(ROS)by flow *** blotting was conducted to examine the levels of apoptotic proteins,including cleaved caspase-3 and poly(ADP-ribose)polymerase(PARP).Moreover,the human long noncoding RNA(lncRNA)microarray was used to analyze gene expression after glutamine deprivation,and results were confirmed with quantitative RT-PCR(qRT-PCR).The expression of metallothionein 2A(MT2A)was suppressed using *** growth and apoptosis were further detected by CCK-8 assay and flow cytometry,respectively,in cells with MT2A ***:Glutamine deprivation or treatment with BPTES inhibited cell growth and induced apoptosis in SKM-1 *** lncRNA microarray result showed that the expression of MT family genes was significantly upregulated after glutamine ***2A knockdown increased apoptosis,while proliferation was not affected in SKM-1 *** addition,metformin inhibited cell growth and induced apoptosis in SKM-1 *** glutamine deprivation and metformin enhanced the sensitivity of SKM-1 cells to ***,the combination of glutamine deprivation with metformin exhibited synergistic antileukemia effects on SKM-1 ***:Targeting glutamine metabolism in combination with metformin is a promising new therapeutic strategy for AML.

关键词： acute myeloid leukemia glutamine metallothionein metformin

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Innovation in Orbit

Beijing Review 2024年第42期67卷 24-25页

作者： Xiao Junyong fu xing 不详

By sending seeds on short trips into space,China is developing new crop varieties,contributing to the advancement of agricultural science and bolstering food *** process,known as space breeding,exposes seeds to cosmic... 详细信息

关键词： breeding varieties seeds

大气湍流对空间相干光通信的相干探测性能影响

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物理学报 2024年第10期73卷 203-211页

作者：刘宇韬徐苗付兴虎付广伟燕山大学信息科学与工程学院河北省特种光纤与光纤传感重点实验室秦皇岛066004 自然资源部海洋观测技术重点实验室天津300112

空间相干光通信被认为是突破现有高速空间通信瓶颈的重要手段,但其应用受到大气湍流的极大限制.为此,本文首先基于Huygens-Fresnel原理和低频补偿功率谱反演法,研究了高斯光束经大气湍流传输后振幅和相位的随机分布特性;然后,利用相干... 详细信息

空间相干光通信被认为是突破现有高速空间通信瓶颈的重要手段,但其应用受到大气湍流的极大限制.为此,本文首先基于Huygens-Fresnel原理和低频补偿功率谱反演法,研究了高斯光束经大气湍流传输后振幅和相位的随机分布特性;然后,利用相干混频效率及通信误码率模型,获得大气湍流对空间相干光通信系统性能的影响规律;最后,搭建激光外差探测实验系统,定量研究了大气湍流对空间相干光通信相干探测性能的影响.结果表明:弱湍流条件下,空间相干光通信性能几乎不受大气湍流的影响;中等强度湍流影响下,相干混频效率会随着湍流强度的增大而迅速下降,但通过提高单比特光子数可以有效抑制湍流对通信性能的负面影响;强湍流会显著破坏光束相干性,使得相干混频效率趋近于零,即使提高单比特光子数也无法有效改善通信性能.大气湍流是空间相干光通信发展的重要限制因素,该研究可为空间相干光通信系统性能评估提供有益参考.

关键词：空间相干光通信大气湍流混频效率误码率

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基于深度学习的微纳光纤自动制备系统

物理学报 2024年第10期73卷 212-220页

作者：刘鸿江刘逸飞谷付星上海理工大学光电信息与计算机工程学院上海200093

在微纳光纤拉锥制备过程中,对直径的大范围、高精度和动态实时性测量是实现低损耗传输和色散调控的关键.针对现有传统制备方法直径调控范围小、操作复杂及耗时长等问题,本文基于深度学习神经网络算法实现了微纳光纤自动检测系统.利用计... 详细信息

在微纳光纤拉锥制备过程中,对直径的大范围、高精度和动态实时性测量是实现低损耗传输和色散调控的关键.针对现有传统制备方法直径调控范围小、操作复杂及耗时长等问题,本文基于深度学习神经网络算法实现了微纳光纤自动检测系统.利用计算机视觉中的图像分割方法,通过制作高质量多尺度微纳光纤数据集,使用基于小目标检测改进的YOLOv8-FD算法对微纳光纤直径进行自动检测.在数据集中获得了平均均值精度高达mAP^(IoU=50)=0.975和mAP^(IoU=50_95)=0.765的性能参数.实验结果表明,该系统可实现微纳光纤直径462 nm—125μm范围,误差2.95%以内的测量和自动化制备,并随着光纤直径增长,误差逐渐缩小,且该系统光学成像单个像素分辨率为65.97 nm,平均检测时间为9.6 ms.本文工作适用于对微纳光纤的高精度实时测量和自动精确制备,为低损耗传输和色散可调的微纳光纤器件发展提供新的思路.

关键词：微纳光纤直径测量深度学习图像分割

A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease

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World Journal of Pediatrics 2024年第2期20卷 189-200页

作者： Shu-Na Sun Yan Zhou xing fu Yuan-Zheng Zheng Cao Xie Guo-You Qin Fang Liu Chen Chu Feng Wang Cheng-Long Liu Qing-Tong Zhou De-Hua Yang Di Zhu Ming-Wei Wang Yong-Hao Gui Children's Hospital of fudan University National Children's Medical CenterShanghai 201102China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Accuramed Technology(Shanghai)Ltd. Shanghai 200233China School of Pharmacy Fudan UniversityShanghai 201203China School of Public Health Fudan UniversityShanghai 200032China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 570288China

Kawasaki disease(KD)is a disorder of immune *** prevalence of KD among 100,000 children aged 0-4 years was 71.9-110.0 in China,170.9-194.9 in Korea,and 18.1-21.3 in the USA[1].The most severe complication of KD is coronary artery lesions(CALs),including coronary dilatation and coronary aneurysms,which may even lead to myocardial ischemia,myocardial infarction,and sudden death.

关键词： coronary ischemia differentiated