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New sustainable polymers with on-demand depolymerization property

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Science China Chemistry 2024年第9期67卷 2803-2841页

作者： Yangyang Sun Zesheng An Yanshan Gao Rongrong Hu Ye Liu Hua Lu Xiao-Bing Lu Xuan Pang Anjun Qin Yong Shen Youhua Tao Yu-Zhong Wang Junpeng Wang Gang Wu Guang-Peng Wu Tie-Qi Xu xing-Hong zhang Yuetao zhang Zhenbiao zhang Jian-Bo Zhu Miao Hong Zhibo Li State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China State Key Laboratory Base of Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsDalian University of TechnologyDalian 116024China Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)College of ChemistryState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610064China School of Polymer Science and Polymer Engineering the University of AkronAkronOH 44325USA MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

To combat the crisis of today's synthetic polymers arising from unsustainable production and disposal,it is essential for the synthetic polymer community to reshape the current polymer industry with sustainable *** an emerging class of sustainable polymers,the development of chemically depolymerizable polymers(CDPs),which can undergo closed-loop depolymerization/repolymerization cycles to reproduce virgin polymers without the loss of properties from recovered monomers,offers an ideal solution to preserve finite natural resources,provides a feasible solution to the end-of-life issue of polymer waste,and thereby establishes a circular materials ***,two grand key challenges have been encountered in the establishment of practically useful CDPs:how to balance polymerization and depolymerization ability and how to unify conflicted depolymerizability and physical ***,this critical review article presents our vision for summarizing feasible strategies to overcome the above two significant challenges and the design principles for constructing an ideal CDP by highlighting selected major progress made in this rapidly expanding field.

关键词： chemically depolymerizable polymers sustainable polymers depolymerization monomer recovery degradation plastics

深刻把握习近平总书记关于党的建设的重要思想的原创性贡献——“第十届执政党建设理论与实践论坛”综述

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马克思主义研究 2024年第7期 152-154页

作者：张幸中国社会科学院大学马克思主义学院

为深入学习宣传贯彻党的二十大精神,推进习近平总书记关于党的建设的重要思想的研究阐释,2024年6月16日,由中国社会科学院马克思主义研究院、华东师范大学、中国科学院大学联合主办的“第十届执政党建设理论与实践论坛”在华东师范大学... 详细信息

为深入学习宣传贯彻党的二十大精神,推进习近平总书记关于党的建设的重要思想的研究阐释,2024年6月16日,由中国社会科学院马克思主义研究院、华东师范大学、中国科学院大学联合主办的“第十届执政党建设理论与实践论坛”在华东师范大学隆重举行。论坛的主题为“习近平总书记关于党的建设的重要思想的原创性贡献”。

关键词：党的建设中国社会科学院学习宣传贯彻华东师范大学深刻把握原创性贡献习近平总书记论坛

Temperature-gradient method for gaining insights into the luminescence origin and formation mechanism of carbon dots

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Science China Materials 2024年第10期67卷 3096-3105页

作者： Yan-Ting Yang Yue-xing zhang You Cheng Xin-Ru Xu Jing Han Zi-Xin Chen Hang-xing Wang College of Chemistry and Chemical Engineering Key Laboratory for the Synthesis and Application of Organic Functional Molecules(MOE)Hubei UniversityWuhan 430062China Shandong Universities Engineering Research Center of Integrated Circuits Functional Materials and Expanded Applications Dezhou UniversityDezhou 253023China

Carbon dots(CDs)are a fascinating new class of fluorescent nanomaterials,yet the understanding of the fluorescent origin of CDs still lags well behind their *** key challenges for unveiling the fluorescent mechanism of CDs relate to the insufficient basis for structural *** work presents a temperature-gradient route to control the bottom-up approach of CDs,enabling the precise structural characterization of intermediates and the establishment of definite structure-property relationships,akin to the domino reaction synthesis of complex natural products from small organic *** the binary components citric acid and meta-dimethylaminophenol generated CDs as a case study,their emissive mechanism,particularly the unique excitation-dependent fluorescence behavior,is reasonably explained and supported by structural evaluation through retrosynthetic *** formation process of CDs is investigated using a combination of spectroscopic,thermal,and theoretical calculation techniques,demonstrating the significant potential of the temperature-gradient route in the exploration structure-property relationships and guiding the rational design of advanced CD applications.

关键词： carbon dots temperature gradient domino effect fluorescent origin solid-state emission

Cytokine release syndrome triggered by programmed death 1 blockade(sintilimab)therapy in a psoriasis patient:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3555-3560页

作者： Ming-Hui Zhou Min-Feng Ye Zhen-xing zhang Feng Tao Yu zhang Department of Gastrointestinal Surgery Shaoxing People’s HospitalShaoxing 312000Zhejiang ProvinceChina School of Medicine Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina

BACKGROUND In recent years,immune checkpoint inhibitors(ICIs)have demonstrated remarkable efficacy across diverse ***,in patients with advanced gastric cancer,the use of programmed death 1(PD-1)blockade has significantly prolonged overall survival,marking a pivotal advancement comparable to the impact of Herceptin over the past two *** the therapeutic benefits of ICIs are evident,the increasing use of immunotherapy has led to an increase in immune-related adverse *** SUMMARY This article presents the case of a patient with advanced gastric cancer and chronic plaque *** sintilimab therapy,the patient developed severe rashes accompanied by cytokine release syndrome(CRS).Fortunately,effective management was achieved through the administration of glucocorticoid,tocilizumab,and acitretin,which resulted in favorable *** Glucocorticoid and tocilizumab therapy was effective in managing CRS after PD-1 blockade therapy for gastric cancer in a patient with chronic plaque psoriasis.

关键词： Cytokine release syndrome Programmed death 1 blockade Sintilimab Psoriasis Gastric cancer Case report

碱预处理耦合三元DES体系对提高桉木组分分离效率的研究

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中国造纸 2024年第5期43卷 18-27页

作者：张兴武书彬华南理工大学制浆造纸工程国家重点实验室广东广州510640 华南理工大学轻工与食品国家级实验教学示范中心广东广州510640

本研究探索了一种氢氧化钾预处理耦合三元低共熔溶剂(DES)两段处理法,并用于分离桉木组分。首先采用单因素和Box-Behnken法优化了碱预处理分离桉木半纤维素的工艺条件,然后探究了碱预处理耦合三元DES两段处理桉木的微观形貌、比表面积... 详细信息

本研究探索了一种氢氧化钾预处理耦合三元低共熔溶剂(DES)两段处理法,并用于分离桉木组分。首先采用单因素和Box-Behnken法优化了碱预处理分离桉木半纤维素的工艺条件,然后探究了碱预处理耦合三元DES两段处理桉木的微观形貌、比表面积、结晶度等。结果表明,优化后的氢氧化钾处理工艺条件为:处理温度76℃、处理时间5 h、氢氧化钾质量分数15%,此时半纤维素去除率可达(77.1±0.2)%。经碱预处理耦合三元DES(固液比1∶20(g∶mL)、反应时间30 min、反应温度90℃)两段处理后,桉木中纤维素、半纤维素和木质素形成的致密结构被打破,半纤维素去除率达83.3%,木质素去除率达96.5%,纤维素保留率达91.0%,比表面积和相对结晶度分别达0.9015 m^(2)/g和89.7%,显著提升了后续溶剂或生物酶的接触表面积。

关键词：低共熔溶剂组分分离半纤维素木质素响应面法

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Elongated antiferromagnetic skyrmion in two-dimensional RuF_(4)

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Science China Materials 2024年第10期67卷 3282-3287页

作者： Mu Lan Rong Wang Shihao Wei Lezhong Li Wenning Ren xing zhang Xi zhang Gang Xiang College of Optoelectronic Engineering Chengdu University of Information TechnologyChengdu 610225China Hangzhou Innovation Center Zhejiang UniversityHangzhou 311200China College of Physics Sichuan UniversityChengdu 610064China

Two-dimensional(2D)antiferromagnetic(AFM)skyrmions are free from stray magnetic field and skyrmion Hall effect,and can be driven by a small current density up to a high speed,desirable for low-power spintronic ***,most 2D AFM skyrmions are realized in complex heterostructured materials,which impedes the dense integration of spintronic ***,we propose that 2D AFM skyrmions can be achieved in ruthenium tetrafluoride(RuF_(4))monolayer using hybrid functional theory combined with atomistic spin dynamics *** study indicates that 2D RuF_(4)is dynamically stable and its nondegenerate vibration modes in optical branches are either Raman or infrared ***,2D RuF_(4)acts as an indirect bandgap semiconductor with an out-of-plane AFM ***,the presence of a weak Dzyaloshinskii-Moriya interaction in 2D RuF_(4)leads to a spin spiral ground state at low temperatures,enabling the formation of AFM skyrmions with possible length modulation by an external magnetic *** results give insight into 2D RuF_(4)and may provide an intriguing platform for 2D AFM skyrmion-based spintronic applications.

关键词： two-dimensional antiferromagnetic skyrmion density functional theory spin dynamics magnetic field modulation

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu xing zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

Broadband bidirectional Brillouin–Raman random fiber laser with ultra-narrow linewidth

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Chinese Physics B 2024年第2期33卷 371-376页

作者：杨茜李阳邹辉梅杰徐恩明张祖兴 Advanced Photonic Technology Laboratory College of Electronic and Optical Engineering&College of MicroelectronicsNanjing University of Posts and TelecommunicationsNanjing 210023China

We present a Brillouin–Raman random fiber laser(BRRFL)with full-open linear cavity structure to generate broadband Brillouin frequency comb(BFC)with double Brillouin-frequency-shift *** incorporation of a regeneration portion consisting of an erbium-doped fiber and a single-mode fiber enables the generation of broadband *** dynamics of broadband BFC generation changing with the pump power(EDF and Raman)and Brillouin pump(BP)wavelength are investigated in detail,*** suitable conditions,the bidirectional BRRFL proposed can produce a flatamplitude BFC with 40.7-nm bandwidth ranging from 1531 nm to 1571.7 nm,and built-in 242-order Brillouin Stokes lines(BSLs)with double Brillouin-frequency-shift ***,the linewidth of single BSL is experimentally measured to be about 2.5 *** broadband bidirectional narrow-linewidth BRRFL has great potential applications in optical communication,optical sensing,spectral measurement,and so on.

关键词： random laser fiber laser stimulated Brillouin scattering(SBS) stimulated Raman scattering(SRS)

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie xing zhang Xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen Department of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China Department of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China Department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology Maoming People’s HospitalMaoming 525000China Department of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academy of Sciences Ion Medical Technology Co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed ***:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November *** underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatment due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival