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Impact of Polymer Matrix on Polymer Mechanochromism from Excited State Intramolecular Proton Transfer

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Chinese Journal of Chemistry 2024年第6期42卷 611-616页

作者： Yu Wu xin Cheng huan hu Shui hu Zhimin Ma Zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing State Key Laboratory of Organic-Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing100029 China Center of Advanced Elastomer Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029 China College of Engineering Peking UniversityBeijing100871 China

Mechanochromic polymers based on non-covalent changes have attracted much attention ***,we report the impact of inter/intramolecular hydrogen bonds on polymer mechanochromism from the excited state intramolecular proton transfer (ESIPT) ***-NH2-OH and PhMz=2A are designed and obtained by simple and high-yield synthesis,and are connected into polyurethane and poly(methyl acrylate-co-2-ethylhexyl acrylate),*** the initial state,the PhMz-NH2-OH@PU sample shows blue fluorescence from the excited enol form (E*) excitons,owing to intermolecular hydrogen bonds that interrupt the ESIPT reactions but the PhMz=2A@PMA-2-EA sample expresses cyan fluorescence belonging to the excited keto form (K*) emission,implying that the intramolecular hydrogen bonds ***,under stretching,external force can tune the emission of the PhMz=2A@PMA-2-EA sample from K* to E* *** external force can putatively still promote a bond rotation,ESIPT reactions remain equivalently interrupted in both the relaxed and stressed states in a hydrogen-bond donating *** calculation confirms the force-induced increase in dihedral angle for the transition of ESIPT-on/***,PhMz-NH2-OH@PU and PhMz=2A@PMA-2-EA showed disparate initial ESIPT states and further different responses/sensitivity to *** study reports a novel and efficient strategy for enriching mechanochromic investigation and extending the applications of ESIPT reactions.

关键词： Polymer mechanochromism Excited state intramolecular proton transfer Hydrogen bonding Supramolecular chemistry Elastomers

Laminar Flame Instability of n-Hexane,n-Octane,and n-Decane in Spherical Expanding Flames

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Journal of Thermal Science 2024年第3期33卷 1189-1199页

作者： YIN Geyuan hu Erjiang LI Xiaotian LV xin huANG Zuohua State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China United Automotive Electronic Systems Co. LtdShanghai201206China Chongqing Changan Automobile Co. Ltd.Chongqing401120China

This paper focuses on the laminar flame instability of three high molecular weight n-alkanes,namely n-hexane,n-octane,and *** experiment was carried out in a constant volume combustion bomb to get the flame *** critical radius under different conditions was extracted using the image processing *** with the existing critical Peclet number theory,the dominant factors of flame instability under current conditions for three n-alkanes can be figured ***,the average cell size(equivalent cell radius,R_(cell))was extracted to provide quantitative analysis of the flame cellular structure,based on the method developed in this *** theoretical R_(cell)were also calculated and compared with the experimental results to validate the proposed method.

关键词： cellular instability equivalent cell radius critical Peclet number spherical flame

维普期刊数据库

Advances and clinical applications of immune checkpoint inhibitors in hematological malignancies

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Cancer Communications 2024年第9期44卷 1071-1097页

作者： Wenyue Sun Shunfeng hu xin Wang Department of Hematology Shandong Provincial HospitalShandong UniversityJinanShandongP.R.China Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongP.R.China Taishan Scholars Program of Shandong Province JinanShandongP.R.China Branch of National Clinical Research Center for Hematologic Diseases JinanShandongP.R.China National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuP.R.China

Immune checkpoints are differentially expressed on various immune cells to regulate immune responses in tumor *** cells can activate the immune checkpoint pathway to establish an immunosuppressive tumor microenvironment and inhibit the anti-tumor immune response,which may lead to tumor progression by evading immune *** coinhibitory signaling pathways with immune checkpoint inhibitors(ICIs)could reinvigorate the anti-tumor immune response and promote immune-mediated eradication of tumor *** a milestone in tumor treatment,ICIs have been firstly used in solid tumors and subsequently expanded to hematological malignancies,which are in their ***,immune checkpoints have been investigated as promising biomarkers and therapeutic targets in hematological malignancies,and novel immune checkpoints,such as signal regulatory proteinα(SIRPα)and tumor necrosis factor-alpha-inducible protein 8-like 2(TIPE2),are constantly being *** ICIs have received clinical approval for clinical application in the treatment of hematological malignancies,especially when used in combination with other strategies,including oncolytic viruses(OVs),neoantigen vaccines,bispecific antibodies(bsAb),bio-nanomaterials,tumor vaccines,and cytokine-induced killer(CIK)***,the proportion of individuals with hematological malignancies benefiting from ICIs remains lower than expected due to multiple mechanisms of drug resistance and immune-related adverse events(irAEs).Close monitoring and appropriate intervention are needed to mitigate irAEs while using *** review provided a comprehensive overview of immune checkpoints on different immune cells,the latest advances of ICIs and highlighted the clinical applications of immune checkpoints in hematological malignancies,including biomarkers,targets,combination of ICIs with other therapies,mechanisms of resistance to ICIs,and irAEs,which can provide novel insight into the future

关键词： Immune checkpoint hematological malignancies biomarkers therapeutic targets drug resistance

The regulatory roles and clinical significance of glycolysis in tumor

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Cancer Communications 2024年第7期44卷 761-786页

作者： Qiqi Qiao Shunfeng hu xin Wang Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongP.R.China Department of Hematology Shandong Provincial HospitalShandong UniversityJinanShandongP.R.China Taishan Scholars Program of Shandong Province JinanShandongP.R.China Branch of National Clinical Research Center for Hematologic Diseases JinanShandongP.R.China National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuP.R.China

Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells,among which glycolysis is an important *** research has revealed that the heightened glycolysis levels,the abnormal expression of glycolytic enzymes,and the accumulation of glycolytic products could regulate the growth,proliferation,invasion,and metastasis of tumor cells and provide a favorable microenvironment for tumor development and *** on the distinctive glycolytic characteristics of tumor cells,novel imaging tests have been developed to evaluate tumor proliferation and *** addition,glycolytic enzymes have been found to serve as promising biomarkers in tumor,which could provide assistance in the early diagnosis and prognostic assessment of tumor *** glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment,and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the *** this review,we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.

关键词： glycolysis tumor development biomarkers targeted therapy

All-fluorinated electrolyte for non-flammable batteries with ultra-high specific capacity at 4.7 V

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Green Energy & Environment 2024年第10期9卷 1601-1609页

作者： Zhe Wang zhuo Li Jialong Fu Sheng Zheng Rui Yu Xiaoyan Zhou Guanjie He xin Guo State Key Laboratory of Material Processing and Die&Mould Technology Laboratory of Solid State IonicsSchool of Materials Science and EngineeringHuazhong University of Science and Technology Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College London

Li metal batteries （LMBs） with Li Ni0.8Mn0.1Co0.1O2（NMC811） cathodes could release a specific energy of >500 Wh kg-1by increasing the charge ***,high-nickel cathodes working at high voltages accelerate degradations in bulk and at interfaces,thus significantly degrading the cycling lifespan and decreasing the specific ***,we rationally design an all-fluorinated electrolyte with addictive tri（2,2,2-trifluoroethyl） borate （TFEB）,based on 3,3,3-fluoroethylmethylcarbonate （FEMC） and fluoroethylene carbonate （FEC）,which enables stable cycling of high nickel cathode (Li Ni0.8Co0.1Mn0.1O2,NMC811) under a cut-off voltage of 4.7 V in Li metal *** electrolyte not only shows the fire-extinguishing properties,but also inhibits the transition metal dissolution,the gas production,side reactions on the cathode ***,the NMC811||Li cell demonstrates excellent performance by using limited Li and high-loading cathode,delivering a specific capacity>220 m A h g-1,an average Coulombic efficiency >99.6% and capacity retention >99.7% over 100 cycles.

关键词： Fluorinated electrolyte Li metal batteries Solid electrolyte interphase Cathode electrolyte interphase Coulombic efficiency

Research progress of slippage characteristic and gas film stability enhancement methods on biomimetic hydrophobic surfaces

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Journal of Hydrodynamics 2024年第1期36卷 87-101页

作者： Meng-zhuo Zhang Hai-bao hu Liu-zhen Ren Lu-yao Bao Jun Wen Luo Xie School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China

The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophobic surfaces(HS)and the gas-liquid interface(GLI)of superhydrophobic surfaces(SHS)in recent years,but also introduces some innovative methods that can effectively improve the gas film stability and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,by MD and multibody dissipative particle dynamics(MDPD)method,the slippage behavior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hybrid slip boundary condition model to describe the slippage characteristic on *** addition,we found through experiment that a three-dimensional backflow will appear on the GLI under the interfacial adsorption of surfactants,and the backflow direction will reverse with the change of GLI ***,we put forward the wettability step structure and gas injection method to enhance the stability and drag reduction effect of the gas film on SHS.

关键词： Hydrophobic surface superhydrophobic surface interfacial slip underwater drag reduction

An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

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Petroleum Science 2024年第2期21卷 885-902页

作者： xin Zhang Yun-hu Lu Yan Jin Mian Chen Bo Zhou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum *** deep learning technique has been receiving more interest due to the great potential to deal with pore pressure ***,most of the traditional deep learning models are less efficient to address generalization *** fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic ***,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss *** machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure *** CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining Eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few *** validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization *** adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1D convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

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Determination of the chromosomal position effects for plug-and-play application in the Myxococcus xanthus chassis cells

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Synthetic and Systems Biotechnology 2024年第3期9卷 540-548页

作者： xin-jing Yue Jia-rui Wang Jun-ning Zhao zhuo Pan Yue-zhong Li State Key Laboratory of Microbial Technology Institute of Microbial TechnologyShandong UniversityQingdaoPR China

The chromosomal position effect can significantly affect the transgene expression,which may provide an efficient strategy for the inauguration of alien genes in new hosts,but has been less explored *** bacterium Myxococcus xanthus harbors a large circular high-GC genome,and the position effect in this chassis may result in a thousand-fold expression variation of alien natural *** this study,we conducted transposon insertion at TA sites on the *** genome,and used enrichment and dilution indexes to respectively appraise high and low expression potentials of alien genes at insertion *** enrichment sites are characteristically distributed along the genome,and the dilution sites are overlapped well with the horizontal transfer *** experimentally demonstrated the enrichment sites as high expression integration sites(HEISs),and the dilution sites unsuitable for gene integration *** work highlights that HEISs are the plug-and-play sites for efficient expression of integrated genes.

关键词： Position effect High expression integration sites(HEISs) Myxococcus xanthus Tn-seq

Comment on:Clinical Characteristics,Diagnosis,and Treatments for COVID-19

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Current Medical Science 2024年第3期44卷 667-668页

作者： Ying WEN xin-dan hu Department of Infectious Diseases The First Affiliated Hospital of China Medical UniversityShenyang 110001China

The clinical characteristics of COVID-19 patients have been well summarized by Xie et ***,we should pay attention to another special manifestation of COVID-19,COVID-19-related immune reconstitution inflammatory syndrome(IRIS).SARS-CoV-2,an infectious agent,can alscoause IRIS,similar to Mycobacterium *** the era of the COVID-19 pandemic,increasing cases of COVID-19-related IRIS have been ***,the definition and detailed criteria of COVID-19-related IRIS have not been thoroughly *** should pay attention to 3 essential components in a classical model of IRIS,including a primary disease that causes immunosuppression,a trigger that induces immune reconstitution.

关键词： al. clinical Clinical