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Pyogenic liver abscesses associated with nonmetastatic colorectal cancers: An increasing problem in Eastern Asia

World Journal of Gastroenterology 2012年第23期18卷 2948-2955页

作者： Kai Qu Chang Liu zhi-xin wang Feng Tian Ji-Chao Wei Ming-Hui Tai Lei Zhou Fan-Di Meng Rui-Tao wang xin-Sen Xu Department of Hepatobiliary Surgery First AfTfiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To elaborate the clinicopathologic features of colorectal cancer-related pyogenic liver abscess (PLA). METHODS: Reported cases of colorectal cancer-related PLAs were collected from the literature published up to October 2011 and evaluated for their clinicopathologic features. Data of collected cases included demographics, clinical presentation, microbial findings and treatment. Categorical variables were compared by 2 analysis and continuous variables were evaluated using Student's t test. RESULTS: A total 96 cases of colorectal cancer-related PLA were collected from the previous literature. Most patients (60%) were male and 40% cases occurred in the age group of 61-70 years. Apart from some special types of PLA, there were significant differences in the microbiological spectrum between Eastern Asia and non-Eastern Asian countries, which implied different risk factors and courses of the disease. Gram negative bacteria especially Klebsiella pneumoniae (K. pneu- moniae ) PLA was predominant in Eastern Asia (80.0%) in contrast to non-Eastern Asian countries (P < 0.01). Meanwhile, most of the Eastern Asian patients exhibited smaller size of liver abscess and atypical presentation. Sigmoid colon and rectum (72.73%) were the main sites of tumor in Eastern Asian patients, whereas tumor sites were uneven among most of the non-Easter Asian PLA patients. CONCLUSION:K. pneumoniae PLA was strongly associated with colorectal cancer, especially those occurring in sigmoid colon and rectum, in elderly Eastern Asian male patients.

关键词： Colorectal cancer Pyogenic liver abscess Etiology Microbiology Treatment

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Consideration on immunotherapy of liver metastases of malignant tumors

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2374-2381页

作者： Chuang Jiang zhi-Hong Zhang Jia-xin Li Division of Liver Surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article“Analysis of the impact of immuno-therapy efficacy and safety in patients with gastric cancer and liver metastasis”by Liu et al that was published in the recent issue of the World Journal of Gastroin-testinal *** has prompted us to think and summarize some thoughts on immunotherapy for malignant tumor liver *** plays a crucial role in the treatment of malignant tumors;however,the presence of liver metastases in advanced tumors may impact its *** patients with liver metastases can still benefit from immunotherapy,multiple clinical studies have indicated that,compared to other sites of metastasis,liver metastases may diminish the effectiveness of *** efficacy of immune checkpoint inhibitors in patients with liver metastases often fails to reach the ideal level,primarily due to the liver metastases exploiting the host's peripheral immune to-lerance mechanisms to promote systemic CD8(+)T cell exhaustion,resulting in a systemic immune-tolerant *** article aims to summarize the reasons for the decreased efficacy of immunotherapy following liver metastasis in various malignant tumors and propose potential clinical strategies for manage-ment.

关键词： Liver metastasis Immunotherapy Immune tolerance Cancer Treatment

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Target Controllability of Multi-Layer Networks With High-Dimensional Nodes

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1999-2010页

作者： Lifu wang Zhaofei Li Ge Guo zhi Kong School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004China

This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and *** influence of inter-layer couplings on the target controllability of multi-layer networks is *** is found that even if there exists a layer which is not target controllable,the entire multi-layer network can still be target controllable due to the inter-layer *** the multi-layer networks with general structure,a necessary and sufficient condition for target controllability is given by establishing the relationship between uncontrollable subspace and output *** the derived condition,it can be found that the system may be target controllable even if it is not state *** this basis,two corollaries are derived,which clarify the relationship between target controllability,state controllability and output *** the multi-layer networks where the inter-layer couplings are directed chains and directed stars,sufficient conditions for target controllability of networked systems are given,*** conditions are easier to verify than the classic criterion.

关键词： High-dimensional nodes inter-layer couplings multi-layer networks target controllability

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Managing immune checkpoint inhibitor-associated gastritis: Insights and strategies

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World Journal of Gastroenterology 2024年第24期30卷 3120-3122页

作者： Li-Li Yu zhi-Lin He xin-Lai Qian Department of Pathology The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Department of Basic Medical Sciences Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina

Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various ***-related adverse events(irAEs)are defined as adverse effects resulting from ICI *** irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the discontinuation of ICIs.

关键词： Immunotherapy Immune checkpoint inhibitor Immune checkpoint inhibitor-related gastritis Immune-related adverse events Autoimmune responses

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Threshold Selection and Resource Allocation for Quantized Identification

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Journal of Systems Science & Complexity 2024年第1期37卷 204-229页

作者： wang Ying LI xin ZHAO Yanlong ZHANG Ji-Feng Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

This paper is concerned with the optimal threshold selection and resource allocation problems of quantized identification, whose aims are improving identification efficiency under limited resources. Firstly, the first-order asymptotically optimal quantized identification theory is extended to the weak persistent excitation condition. Secondly, the characteristics of time and space complexities are established based on the Cramér-Rao lower bound of quantized systems. On these basis, the optimal selection methods of fixed thresholds and adaptive thresholds are established under aperiodic signals, which answer how to achieve the best efficiency of quantized identification under the same time and space complexity. In addition, based on the principle of maximizing the identification efficiency under a given resource, the optimal resource allocation methods of quantized identification are given for the cases of fixed thresholds and adaptive thresholds, respectively, which show how to balance time and space complexity to realize the best identification efficiency of quantized identification.

关键词： Quantized output resource allocation system identification threshold selection.

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Wind-sand flow simulation and radius optimization of highway embankment under different vertical curve radius

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Journal of Mountain Science 2024年第8期21卷 2533-2546页

作者： LI Liangying LI Qi wang Xu xin Guowei wang Zhenqiang School of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

It is of great practical value to explore the correlation between the vertical curve radius of desert highway and the increase of sand accumulation in local lines,and to select the appropriate vertical curve radius for reducing the risk of sand *** this study,three-dimensional models of desert highway embankments with different vertical curve radii were constructed,and Fluent software was used to simulate the wind-sand flow field and sand accumulation distribution of vertical curve *** results show that:(1)Along the direction of the road,the concave and the convex vertical curve embankments have the effect of collecting and diverging the wind-sand flow,*** the radius of the concave vertical curve is 3000 m,5000 m,8000 m,10000 m and 20000 m,the wind velocity in the middle of the vertical curve is 31.76%,22.58%,10.78%,10.53%and 10.44%,higher than that at both *** the radius of the convex vertical curve is 6500 m,8000 m,10000 m,20000 m and 30000 m,the wind velocity at both ends of the vertical curve is 14.06%,9.99%,6.14%,3.22%and 2.41%,higher than that in the *** diversion effect also decreases with the increase of the radius.(2)The conductivity of the concave and convex vertical curve embankments with different radii is greater than 1,which is the sediment transport *** conductivity increases with the increase of radius and gradually tends to be *** the radius of the concave and convex vertical curves reaches 8000 m and 20000 m respectively,the phenomenon of sand accumulation is no longer *** the same radius condition,the concave vertical curve embankment is more prone to sand accumulation than the convex one.(3)Considering the strength of the collection and diversion of the vertical curve embankment with different radii,and the sand accumulation of the vertical curve embankment in the desert section of Wuma Expressway,the radius of the concave vertical curve is not less than 8000 m,and the r

关键词： Highway engineering Vertical curve Numerical simulation Embankment wind-sand flow Radius optimization

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Carrying Capacity and Coupling Coordination of Water and Land Resources Systems in Arid and Semi-arid Areas: A Case Study of Yulin City, China

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Chinese Geographical Science 2024年第5期34卷 931-950页

作者： ZHANG Qianxi CAO zhi wang Yongsheng HUANG Yijia Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Quantitatively assessing the carrying capacity of water and land resources systems in arid and semi-arid areas is crucial for achieving the 2030 Sustainable Development *** this work,taking Yulin City in China as a case study and employing the Criteria Importance Through Intercriteria Correlation(CRITIC)method,a modified model of coupling degree was developed to evaluate the car-rying capacity of water and land resources systems endowment and utilization,as well as their coupling coordination degree from 2013 to *** findings indicate that the water and land resources of Yulin are diminishing due to declines in agriculture,higher industrial water use,and wetland ***,reallocating domestic water for ecological sustainability and reducing sloping farmland can mitigate this trend of ***,as the coupling coordination between water and land resources system endowment in Yulin continuously improved,the coupling coordination between water and land resources system utilization first decreased and then in-creased with 2016 as the turning ***,the carrying capacity of water and land resources systems,the coupling coordination degree between water and land resources system endowment,and the coupling coordination degree between water and land resources system utilization in Yulin exhibited the same pattern of being higher in the six northern counties than in the six southern *** the water resources endowment is vital for the highly efficient use of water and land resources.

关键词： water and land resources systems carrying capacity coupling coordination human-earth system sustainable development Yulin City,China

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Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： zhi-Zeng Si Yue-Yue wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

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Rapid prediction of damaged ship roll motion responses in beam waves based on stacking algorithm

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Journal of Hydrodynamics 2024年第2期36卷 394-405页

作者： xin-ran Liu Ting-qiu Li Zi-ping wang School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan430063China

Accurate modeling for highly non-linear coupling of a damaged ship with liquid sloshing in waves is still of considerable interest within the computational fluid dynamics(CFD)and AI *** paper describes a data-driven Stacking algorithm for fast prediction of roll motion response amplitudes in beam waves by constructing a hydrodynamics model of a damaged ship based on the dynamic overlapping grid CFD *** general idea is to optimize various parameters varying with four types of classical base models like multi-layer perception,support vector regression,random forest,and hist gradient boosting *** offers several attractive properties in terms of accuracy and efficiency by choosing the standard DTMB 5415 model with double damaged compartments for *** is clearly demonstrated that the predicted response amplitude operator(RAO)in the regular beam waves agrees well with the experimental data available,which verifies the accuracy of the established damaged ship hydrodynamics *** high-quality CFD samples,therefore,implementation of the designed Stacking algorithm with its optimal combination can predict the damaged ship roll motion amplitudes effectively and accurately(e.g.,the coefficient of determination 0.9926,the average absolute error 0.0955 and CPU 3s),by comparison of four types of typical base models and their various ***,the established Stacking algorithm provides one potential that can break through problems involving the time-consuming and low efficiency for large-scale lengthy CFD simulations.

关键词： Ship motion damaged ship computational fluid dynamics(CFD) machine learning stacking algorithm

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Visible Light-Induced[3+2]Annulation Reaction of Alkenes with Vinyl Azides:Direct Synthesis of Functionalized Pyrroles

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Chinese Journal of Chemistry 2024年第2期42卷 151-156页

作者： Ming Yang xin-Yu wang Jie wang Yu-Long Zhao Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis Faculty of ChemistryNortheast Normal UniversityChangchunJilin 130024China

A photocatalytic[3+2]annulation of alkenes with vinyl azides was developed under irradiation by visible light in the presence of organic dye *** substrate scope and high functional group tolerance were demonstrated by more than 50 *** reaction provides a novel and efficient method for the synthesis of polyfunctionalized pyrroles under very mild metal-free conditions without other additives.

关键词： Photocatalysis Vinyl azides Alkenes Pyrroles Annulation Radical reactions

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