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Comparison of fundus fluorescein angiography and fundus photography grading criteria for early diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 261-267页

作者： xin-yue li Shu Wang li Dong Hong Zhang Eye Hospital the First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Eye Department Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China

AIM:To compare the assessment outcomes of the characteristics of mild to moderate non-proliferative diabetic retinopathy(NPDR) established by fundus photography and fundus fluorescein angiography(FFA).METHODS:The fundus photos and FFA results of 260 patients with diabetes mellitus were *** retinopathy(DR) severity was graded based on the international classification *** microaneurysms,hemorrhages,and intraretinal microvascular abnormalities(IRMA) in FFA images of patients with mild to moderate NPDR were *** differences between the fundus photos and the FFA results were summarized,analyzed,and ***:The counting of intraretinal hemorrhages identified by FFA revealed that only 9 eyes(1.9%) had more than 20 intraretinal hemorrhages in all four quadrants;15 eyes(3.1%) had more than 20 intraretinal hemorrhages in three quadrants;26 eyes(5.4%) had over 20 intraretinal hemorrhages in two quadrants;and 37 eyes(7.7%) had more than 20 intraretinal hemorrhages in only one ***,the number of IRMAs appeared ≥4 in 17 eyes,3 in 35 eyes,2 in 69 eyes,and 1 in 93 ***:FFA has higher detection accuracy of retinal angiopathy than fundus *** grading results are helpful for timely detection and proper treatment of lesions easily missed by fundus photography.

关键词： diabetic retinopathy fundus fluorescein angiography grading criteria

Surgical treatment of Pitt-Hopkins syndrome associated with strabismus and early-onset myopia:Two case reports

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World Journal of Clinical Cases 2022年第34期10卷 12734-12741页

作者： Ying Huang yue Di Xiao-Xiao Zhang xin-yue li Wang-Yi Fang Tong Qiao Department of Ophthalmology Shanghai Children's HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200062China

BACKGROUND Pitt-Hopkins syndrome(PTHS;MIM#610954)is a rare genetic neurological *** and strabismus have been reported in approximately 50%of PTHS *** studies have reported details about the required surgery for PTHS with strabismus and early-onset ***,we retrospectively reviewed the surgical management of two patients with PTHS combined with strabismus and/or early-onset *** SUMMARY A 5-year-old girl presented with congenital esotropia and left eye myopia,and the second girl was a 5-year-old girl who presented with intermittent *** testing performed on both patients showed a mutation in transcription factor 4,which is a diagnostic marker of *** first girl underwent bilateral medial rectus recession combined with posterior scleral reinforcement(PSR)in the left eye and the second patient underwent bilateral lateral rectus recession strabismus *** made key innovations in surgical timing and strategy,and the results were *** combination of strabismus and PSR surgery is an innovative strategy for patients with both strabismus and early-onset *** Early treatment of strabismus and myopia positively influence motor development and should be included in rehabilitation programs for patients with PTHS.

关键词： Pitt-Hopkins syndrome Transcription factor 4 Strabismus Myopia Surgery Case report

Astrophysical 22Mg(p,γ)23Al reaction rates from asymptotic normalization coefficient of 23Ne→22Ne+n

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Chinese Physics C 2020年第7期44卷 80-86页

作者： xin-yue li Bing Guo Zhi-Hong li Wei-Ping liu China Institute of Atomic Energy Beijing 102413China

The radionuclide 22Na generates the emission of a characteristic 1.275 MeVγ-*** is a potential astronomical observable,whose occurrence is suspected in classical *** 22Mg(p,γ)23Al reaction is relevant to the nucleosynthesis of 22Na in Ne-rich *** this study,employing the adiabatic distorted wave approximation and continuum discretized coupled channel methods,the squared neutron asymptotic normalization coefficients(ANCs)231 for the virtual decay of Ne→22Ne+n were extracted,and determined as(0.483±0.060)fm-1 and(9.7±2.3)fm-1 for the ground state and the first excited state from the experimental angular distributions of 22Ne(d,p)23Ne populating the ground state and the first excited state of 23Ne,***,the squared proton ANC of *** obtained as Cd5/22(23Al)(2.65±0.33)×103 fm-1 according to the charge symmetry of the strong *** astrophysical S-factors and reaction rates for the direct capture contribution in 22Mg(p,γ)23Al were also ***,the proton width of the first excited state of 23Al was derived to be(57±14)eV from the neutron ANC of its mirror state in 23Ne and used to compute the contribution from the first resonance of *** result demonstrates that the direct capture dominates the 22Mg(p,γ)23Al reaction at most temperatures of astrophysical relevance for 0.33

关键词： classical nova transfer reaction asymptotic normalization coefficient radiative capture

Digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 239-246页

作者： yue Di Zhong-Bao Qiao Hai-Yun Ye xin-yue li Wen-Ting Luo Wang-Yi Fang Tong Qiao Department of Ophthalmology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China

AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python ***:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes *** corresponding photo pixels-actual length ratio was acquired by a proportional *** edge coordinates were identified artificially by ginput *** and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal *** curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric ***,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in *** results were compared between in vivo and in ***:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the *** horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°*** the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical ***:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in *** are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of *** study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.

关键词： ocular morphological parameters guinea pig digital measurement Python

The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants

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Stress Biology 2022年第1期2卷 81-96页

作者： Guang‑yuan xin Lu‑ping li Peng‑tao Wang xin‑yue li Yuan‑ji Han Xiang Zhao State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifengChina

To cope with fluctuating light conditions,terrestrial plants have evolved precise regulation mechanisms to help optimize light capture and increase photosynthetic *** blue light-triggered autophosphorylation,acti-vated phototropin(PHOT1 and PHOT2)photoreceptors function solely or redundantly to regulate diverse responses,including phototropism,chloroplast movement,stomatal opening,and leaf positioning and flattening in *** responses enhance light capture under low-light conditions and avoid photodamage under high-light ***-PHOTOTROPIC HYPOCOTYL 3(NPH3)and ROOT PHOTOTROPISM 2(RPT2)are signal transducers that function in the PHOT1-and PHOT2-mediated ***3 is required for phototropism,leaf expansion and ***2 regulates chloroplast accumulation as well as NPH3-mediated *** PROTEIN FOR CHLOROPLAST MOVE-MENT 1(NCH1)was recently identified as a PHOT1-interacting protein that functions redundantly with RPT2 to medi-ate chloroplast *** PHYTOCHROME KINASE SUBSTRATE(PKS)proteins(PKS1,PKS2,and PKS4)interact with PHOT1 and NPH3 and mediate hypocotyl phototropic *** review summarizes advances in phototropic growth and chloroplast movement induced by *** also focus on how crosstalk in signaling between phototro-pism and chloroplast movement enhances weak light capture,providing a basis for future studies aiming to delineate the mechanism of light-trapping plants to improve light-use efficiency.

关键词： Blue light Chloroplast movement Phototropic growth Phototropin1 Phototropin2

Urgent call for attention to diabetes-associated hospital infections

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World Journal of Diabetes 2024年第8期15卷 1683-1691页

作者： Xue-Lu Yu li-Yun Zhou Xiao Huang xin-yue li Qing-Qing Pan Ming-Ke Wang Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

In this editorial,we discuss the recent article by Zhao et al published in the World Journal of Diabetes,which highlights the importance of recognizing the risk indicators associated with diabetes mellitus(DM).Given the severe implications of healthcare-associated infections(HAIs)in hospitalized individuals-such as heightened mortality rates,prolonged hospitalizations,and increased costs-we focus on elucidating the connection between DM and nosocomial *** patients are susceptible to pathogenic bacterial invasion and subsequent infection,with some already harboring co-infections upon ***,DM is an important risk factor for nosocomial urinary tract infections and surgical site infections,which may indirectly affect the occurrence of nosocomial bloodstream infections,especially in patients with DM with poor glycemic *** evidence regarding the impact of DM on healthcare-associated pneumonias remains inconclusive,attention to this potential association is *** patients with DM should prioritize meticulous blood glucose management,adherence to standard operating procedures,hand hygiene practices,environmental disinfection,and rational use of drugs during *** studies are imperative to explore the main risk factors of HAIs in patients with DM,enabling the development of preventative measures and mitigating the occurrence of HAIs in these patients.

关键词： Diabetes mellitus Healthcare-associated infections Nosocomial urinary tract infections Surgical site infections Nosocomial bloodstream infections

The Development of PCB Enterprise Sewage Monitoring and Management and Controlling Systems

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Journal of Environmental Protection 2012年第8期3卷 782-785页

作者： yue-xin li ling Zhang Si-wei Zhou School of Mathematic and Computer Science Hubei University Wuhan 430062 Zhixing College of Hubei University Wuhan 430062

With the development of science and technology, more and more cities are confronted with the water pollution of various degrees. The article is devoted to the introduction of a secondary sewage monitoring and management system which can automatically check the content of different components in the sewage discharged by enterprises and supply data reports with the help of probes, SBCs, PCs, etc. The article includes five parts. The first part introduces the research background, main research work and innovations of this system. The second part introduces the system architecture and system process. The third presents the fundamental working principles of SBCs and the relevant algorithms of PCs. The fourth expounds the problems and deficiencies which may exist in the algorithms. And the last part consists of summary and prospect, providing the possible solution to the deficiencies and looking forward to the future direction of research.

关键词： Single Board Computer (SBC) PC Data Acquisition Cycle PCB

The large-scale modular BGO detection array(LAMBDA)design and test

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Nuclear Science and Techniques 2024年第11期35卷 228-236页

作者： Yao-De Sheng Lu-Yang Song Jun Su Shi-Lun Jin Fei Lu Yang-Ping Shen Jun-Feng Chen li-Yong Zhang Jian-Jun He xin-yue li Hong-Na liu Feng-Shou Zhang Meng-lin Qiu Shen lin Hao Zhang Luo-Huan Wang Zi-Ming li Yin-Ji Chen xin-Zhi Jiang xin Chen Zhi-lin Shen Feng-Cheng liu Zhi-Wei Qin lin Wang Yi-Tong Huang Xiang li Si-Ze Chen You-Bao Wang Zhi-Hong li Bing Guo Wei-Ping liu Key Laboratory of Beam Technology of Ministry of Education School of Physics and AstronomyBeijing Normal UniversityBeijing 100875China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MoE) Institute of Modern PhysicsFudan University200433 ShanghaiChina School of Mathematics and Physics Handan UniversityHandan 056005China Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Total absorption gamma-ray spectroscopy(TAGS)is a powerful tool for measuring complexγ transitions,which has been effectively applied to the study of reactor decay *** paper presents the design of a new TAGS detector,the large-scale modular BGO detection array(LAMBDA),tailored for measuringβ-decay intensity distributions of fission *** modular design allows the LAMBDA detectors to be assembled in various *** final version of LAMBDA consists of 102 identical 60 mm×60 mm×120 mm BGO crystals and exhibits a high full-energy peak efficiency exceeding 80%at 0.5∼8 MeV based on a Monte Carlo ***,approximately half of the LAMBDA modules have been *** usingγ-ray sources and nuclear reactions demonstrated favorable energy resolution,energy linearity,and efficiency uniformity across the ***-eight modules have been integrated into the prototype *** capability of LAMBDA-I inβ-delayedγ-decay experiments was evaluated by commissioning measurements using the ^(152)Eu source.

关键词： Total absorption gamma-ray spectroscopy Reactor decay heat Beta-decay BGO detector array LAMBDA

Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang li‑Yong Zhang Jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell xin‑yue li Jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang xin‑Zhi Jiang Luo‑Huan Wang Zi‑Ming li Lu‑Yang Song liang‑Ting Sun Qi Wu Jia‑Qing li Bao‑Qun Cui li‑Hua Chen Rui‑Gang Ma Er‑Tao li Gang lian Yao‑De Sheng Zhi‑Hong li Bing Guo Wei‑Ping liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA