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Slime mould imitates transport networks in China

International Journal of Intelligent Computing and Cybernetics 2013年第3期6卷 232-251页

作者： Andrew Adamatzky xin-She Yang yu-xin zhao Unconventional Computing Centre University of the West of EnglandBristolUK Mathematics and Scientific Computing National Physical LaboratoryTeddingtonUK Middlesex University LondonUK School of Automation Harbin Engineering UniversityHarbinChina

Purpose-The purpose of this paper is to study the slime mould Physarum polycephalum as an ideal biological substrate for transport *** presented with several sources of nutrients the slime mould propagates colonises the sources and spans them with a network of protoplasmic tubes allegedly optimised for transfer of nutrients and *** formation of slime mould’s protoplasmic network resembles development of man-made transport ***,it sounds reasonable to compare the protoplasmic network with an established network of vehicular transport links to uncover potential(dis-)similarities between slime mould grown and man-made networks and shed more light onto general principle guiding growing biological and socio-engineering ***/methodology/approach-The paper proceeds by representing major urban areas of China by oat flakes,inoculating the slime mould in Beijing,waiting till the slime mould colonises all urban areas,or colonises some and cease further propagation,and analysing the protoplasmic networks formed and comparing with man-made motorway network and planar proximity ***-Laboratory experiments found that *** provides a very good match for the Chinese motorway ***,both the Chinese motorway network and the slime mould protoplasmic networks have minimum spanning trees and other proximity graphs as their *** experiments also identified the urban areas unlikely to be spanned by the protoplasmic networks,which may reflect hot-spots in existing challenges of modernising the ***/value-The paper demonstrated the strong component of transport system built by slime mould of *** on major urban areas of China consisting of one chain of four nodes and one planar graph with three leaves and eight cycles;the planar graph resides on the urban areas in the south-east part of China.

关键词： Transport networks Unconventional computing Slime mould Bio-inspired computing Bio-cybernetics Adaptive control Intelligent transportation

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Friedberg-Lee neutrino model with μ–τ reflection symmetry

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Communications in Theoretical Physics 2022年第5期74卷 70-74页

作者： Hui-Chao Bao xin-yu zhao Zhen-hua zhao Department of Physics Liaoning Normal UniversityDalian 116029 China

In this letter,we make an attempt to embed theμ–τreflection symmetry(which predicts maximal atmospherical mixing angle and Dirac CP phase)in the Friedberg-Lee neutrino model(which employs a translational flavor sym... 详细信息

关键词： neutrino masses neutrino mixing Friedberg-Lee symmetry mu-tau reflection symmetry

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Macular Bruch's membrane defects and other myopic lesions in high myopia

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 466-473页

作者： Li-Hui Meng Ming-Zhen yuan xin-yu zhao You-xin Chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China

AIM: To compare the ocular fundus features of highly myopic eyes with and without macular Bruch’s membrane(BM) defects and investigate the associations between macular BM defects and other myopic ***: This retrospective, observational case series included 262 eyes(139 patients) with high myopia(HM) refractive error ≥-6.0 diopters(D) or axial length ≥26.5 mm from March 2019 to December *** patients underwent a comprehensive ophthalmic examination, including sweptsource optical coherence tomography(SS-OCT).The features of macular BM defects and other ocular fundus lesions were examined in OCT ***: Totally 51 eyes(19.5%) were detected with macular BM defects, which were characterized by a lack of BM, retinal pigment epithelium(RPE), and an almost complete loss of photoreceptors or *** with macular BM defects had worse best-corrected visual acuity(BCVA) than those without(P<0.001).Dome-shaped macula(DSM, P=0.042), retinal cysts(P=0.006), choroidal neovascularization(CNV, P<0.001), choroidal defects and abnormality(P=0.003), scleral defects(P=0.015), scleral deformation(P=0.005), posterior staphyloma(P=0.011), and perforating vessels(P<0.001) occurred more frequently in eyes with macular BM *** multivariate analysis, the presence of macular BM defects remained the significant association with presence of DSM(P=0.013), scleral defects(P=0.015), posterior staphyloma(P=0.001), perforating vessels(P<0.001) and CNV(P=0.004).CONCLUSION: Macular BM defects has a prevalence of approximately 20% in HM and it has tight association with other myopic fundus *** might be crucial in the pathogenesis of myopic fundus lesions due to its biomechanical function.A comprehensive understanding of BM’s role is useful for further researches about myopic lesions.

关键词： Bruch’s membrane high myopia swept source optical coherence tomography

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Fundus manifestations and HIV viral loads of AIDS patients before and after HAART

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1438-1443页

作者： yu Di xin-yu zhao Jun-Jie Ye Bing Li Nan Ma Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM: To investigate the fundus manifestations and human immunodeficiency virus(HIV) viral loads of acquired immune deficiency syndrome(AIDS) patients before and after highly active antiretroviral therapy(HAART).METHODS: This retrospective study included 21 AIDS patients(42 eyes) who presented to the Department of Ophthalmology, Peking Union Medical College Hospital, from 2007 to 2011. Among the patients, 16 showed a good response to HAART, 3 presented drug resistance and 2 were pre-HAART. All patients underwent comprehensive ophthalmic examinations. The HIV viral loads and the CD4+ T-cell counts were also ***: The best-corrected visual acuity(BCVA) of 38 eyes(19 patients) was improved, and cytomegalovirus retinitis(CMVR) in 5 eyes(3 patients) regressed after HAART. Furthermore, 16 patients treated with effective HAART had decreased plasma HIV viral loads(<78 copies/mL)and increased CD4+ T-cell counts(343±161 cells/μL, P<0.005), but the HIV viral load in tears was still detected at 2404 copies/mL. The CD4+ T-cell count was lower in the CMVR group than in the non-CMVR group(P=0.022), but the HIV viral load in the tears was not significantly different between the two groups(P=0.439).CONCLUSION: Most patients with AIDS show a good viral response with a decreased HIV viral load and an increased CD4+ T-cell count in plasma after HAART. However, the HIV viral load remain quite high in the tear samples. Based on our results, we suggest that AIDS patients undergo long-term HAART that should not be interrupted.

关键词： acquired immune deficiency syndrome cytomegalovirus retinitis highly active antiretroviral therapy human immunodeficiency virus viral loads tears

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Controlling coffee ring structure on hydrophobic polymer surface by manipulating wettability with O2 plasma

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Chinese Chemical Letters 2017年第1期28卷 1-5页

作者： Li-Ying Cui yu Yan xin-yu zhao Cun-Long yu Ying Ma Bai Yang College of Resources and Environment Jilin Agricultural UniversityChangchun 130118China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China School of Materials Science and Engineering Shenyang Jianzhu University Shenyang 110168China

A simple and novel method is firstly reported for controlling coffee ring structure on polystyrene（PS）film surface by O2 plasma. O2 plasma treatment leads to the wettability change of PS surface from hydrophobic to hydrophilic. For hydrophilic PS surface the coffee ring structure is avoided relying on the motion of contact line（CL） while SiO2 microspheres are left. The motion of the CL is produced based on the viscosity and Marangoni effect with the addition of polymer additives. For hydrophobic PS surface coffee ring structure still persists even with polymer additives because SiO2 microspheres transfer with the motion of the CL at the beginning of droplet evaporation and accumulate at the droplet edge at late stage with the pinning of the CL. As a result, uniform and macroscale SiO2 microspheres deposition without coffee ring structure and SiO2 microspheres deposition with coffee ring structure are controlled by O2 plasma. This method provides a new way to tune coffee ring structure with smart surface and may be potentially useful for a range of application at material deposition and diagnosing diseases.

关键词： Coffee ring SiO2 microspheres deposition Drop evaporation O2 plasma PS surface

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A case of paracentral acute middle maculopathy after small incision lenticule extraction surgery

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 169-171页

作者： Li-Hui Meng xin-yu zhao Wei-Hong yu You-xin Chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Dear Editor,Paracentral acute middle maculopathy(PAMM)is characterized by optical coherence tomography(OCT)finding of a hyper-reflective band spanning the inner nuclear layer(INL),which is primarily due to ischemic hy... 详细信息

关键词： capillary spanning finding

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Intestinal obstruction in pregnancy with reverse rotation of the midgut:A case report

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World Journal of Clinical Cases 2020年第16期8卷 3553-3559页

作者： xin-yu zhao xin Wang Chun-Qiang Li Qi Zhang An-Qi He Gang Liu epartment of General Surgery Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Reverse rotation of the midgut is a rare type of intestinal *** of the right colon or entire midgut,stenosis of the transverse colon and obstruction of the duodenojejunal junction are common complications of reverse *** this study,we report the first case of intestinal obstruction associated with reverse rotation in *** SUMMARY A 31-year-old woman at 362+wk gestation presented to the emergency department with progressive abdominal cramping,nausea and bilious *** ultrasound scanning showed dilatation of the *** tomography scanning revealed features of reverse rotation of the midgut with intestinal *** consultation with the obstetrician,the pregnancy was terminated and exploratory abdominal surgery was ***-operatively,it was found that the mesentery of the colon and small intestine was insufficiently *** right colon and the small intestinal mesentery was twisted,and intestinal necrosis was *** duodenum and duodenojejunal junction were curved in front of the transverse colon,and the transverse colon passed through the tunnel behind the mesenteric *** reverse rotation with volvulus was *** necrotic intestine was resected and small intestine mesenteric reconstruction was *** patient recovered after *** leaving the hospital,the patient and her daughter remained well during an 8-month follow-up *** We report the diagnosis,treatment and etiology of a pregnant patient with intestinal obstruction due to reverse rotation of the *** similar cases,appropriate diagnosis and treatment should be carried out according to the condition of the fetus and pregnant woman.

关键词： Congenital intestinal malrotation Volvulus Reverse rotation of the midgut Intestinal obstruction Pregnancy Case report

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Experimental investigation on upstream-injection interaction with a scramjet cavity flameholder

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Chinese Science Bulletin 2014年第14期59卷 1568-1574页

作者： Ming-Bo Sun Shun-Ping Zhang Yan-Hui zhao yu-xin zhao Jian-Han Liang Science and Technology on Scramjet Laboratory National University of Defense Technology

The study has evaluated the coherent structures and the velocity field of gaseous transverse jet upstream of a scramjet flameholder in a supersonic turbulent *** high spatiotemporal resolution coherent structures of the jet plume/wakes and the cavity shear layer were obtained by utilizing the nanoparticle-based planar laser scattering *** to the no upstream injection case,the cavity shear layer downstream of the jet shows significant mass exchange with *** particle image velocimetry velocity field and the velocity profiles demonstrated that the interaction intensity of the cavity shear layer with the upstream injection is further enhanced as the injection stagnation pressure increases.

关键词：超燃冲压发动机相互作用强度火焰稳定器上游实验激光散射技术横向喷流相干结构

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Impacts of angiotensin II on retinal artery changes in apolipoprotein E deficient mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 16-24页

作者： Li-Hui Meng Shi-yu Cheng He Chen yue-Lin Wang Wen-Fei Zhang Huan Chen xin-yu zhao You-xin Chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Lab of Ocular Fundus Diseases Chinese Academy of Medical SciencesBeijing 100730China

AIM:To investigate the impacts of angiotensin II(Ang II)on retinal artery changes in apolipoprotein E deficient(apoE^(-/-))***:ApoE^(-/-)male mice were infused by minipumps with Ang II at 1000 ng/kg·min(Ang II group)or saline(control group)for *** were underwent ophthalmic fundus examination on day 0,14,and 28 of *** examination,ribonucleic acid(RNA)sequencing and local Ang II measurement of retinas were ***:Ophthalmic fundus examination showed Ang II infusion promoted the formation of retinal arterial aneurysm-like lesions on day *** coherence tomography revealed the ganglion cell and inner plexiform layer(GCIPL)thickness in the control group was significantly thinner than that in Ang II group(P<0.001).Hematoxylin-eosin staining demonstrated diffused swelling of GCIPL layer and its disordered structure in Ang II *** electron microscopy showed Ang II infusion caused aggravation of atherosclerotic lesions,including increased swelling,roughness,disorganization of the retinal vasculature,and vacuoles ***-sequencing and gene ontology enrichment analysis demonstrated that the structure and function of cellular membrane might be disturbed and visual function might be compromised by Ang *** local level of Ang II was higher in Ang II infusion group but did not show significant differences compared to the control group(P=0.086).CONCLUSION:Ang II infusion promotes the formation of retinal arterial aneurysm-like lesions in apoE^(-/-)mice,causing aggravation of atherosclerotic lesions,more severe disorganization of the retinal vasculature and disturbance of the cellular membrane.

关键词： angiotensin II retinal artery aneurysm apoE^(-/-)mice

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Effects of bleed hole size on supersonic boundary layer bleed mass flow rate

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2020年第8期21卷 652-662页

作者： Bao-hu ZHANG yu-xin zhao Jun LIU College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

The bleed hole diameter,depth,and boundary layer thickness are key design parameters of a supersonic bleed *** evolution trend of single-hole bleed flow coefficient with the ratio of boundary layer thickness to bleed hole diameter and the ratio of bleed hole depth to diameter is investigated by numerical simulations under choking and non-choking *** results show that the subsonic leading edge of the circular hole and the subsonic part of the boundary layer are the main factors causing lateral flow of the bleed *** effect of diameter on bleed mass flow rate is due to the viscous effect which reduces the effective *** larger the ratio of displacement thickness to bleed hole diameter,the more obvious the viscous effect *** depth affects bleed flow rate by changing the opening and closing states of the separation *** a certain depth is reached,the development of the boundary layer reduces the effective captured stream tube and thus reduces the bleed mass flow *** main objective of the study is to obtain the physical mechanism of the bleed hole size parameters affecting the bleed mass flow rate,and to provide theoretical guidance for the selection of the size of bleed holes in the design of a porous arrays bleed system in hypersonic inlets.

关键词： Inlet Supersonic bleed Scale effects Choking Bleed mass flow rate Lateral flow

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