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Current Zoology 2013年第2期59卷 271-277页

作者： xin LU Xianhai zeng Bo DU Department of Zoology College of Life Sciences Wtthan University Wuhan 430072 China

Theory predicts that because males are more variable in reproductive success than females, a mother should produce more sons to maximize fitness return from the sex allocation if she is of high-quality （the female quality hypothesis） or mates with a high-quality male （the male quality hypothesis）. While most previous studies have looked at each hypothesis, we tested both of them simultaneously in the white-rumped snowfinch Montifringilla taczanowskii, a socially monogamous, sexually monomorphic passerine where body size is a potential indicator of individual quality in intrasexual competition and territory de- fense. Brood sex ratios at the population level did not deviate from random expectation. Among individual broods, the proportion of sons did not depend on body size of either male or female parent, but on interaction of this trait of both parents. Further analy- ：~es revealed that brood sex ratios were independent of body size of male or female parents when their mates were smaller, but positively related with body size of male or female parents when their mates were larger. These results suggest that mechanisms underlying the two hypotheses may act jointly on offspring sex allocation. The mechanisms are expected to evolve through size-assortative mating which is often reached by sexual selection [Current Zoology 59 （2）： 271-277, 2013].

关键词： Brood sex ratio Parental quality Size-assortative mating White-rumped snowfinch

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高原铁路某特长隧道独头掘进通风技术分析

山西建筑 2025年第1期51卷 150-153页

作者：梁星刘明杨琨曾强中铁隧道局集团一处有限公司重庆404100

文章面向高原铁路特长隧道,开展通风技术研究,提出一种基于避车洞通风技术、人行通道通风技术的蓄风房通风策略。基于高原铁路特长隧道通风案例,研究了蓄风房技术。文中研究成果供我国高原铁路特长隧道建设单位、运营单位加以参考、借鉴... 详细信息

文章面向高原铁路特长隧道,开展通风技术研究,提出一种基于避车洞通风技术、人行通道通风技术的蓄风房通风策略。基于高原铁路特长隧道通风案例,研究了蓄风房技术。文中研究成果供我国高原铁路特长隧道建设单位、运营单位加以参考、借鉴,以保证特长隧道通风性能,满足相关制度、规范对高原铁路特长隧道的环境要求,并实现铁路通风的节能效果。

关键词：高原铁路特长隧道蓄风房避车洞

The Superlinear Convergence Analysis of a Nonmonotone BFGS Algorithm on Convex Objective Functions

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Acta Mathematica Sinica,English Series 2008年第1期24卷 35-42页

作者： Gong Lin YUAN zeng xin WEI School of Science East China University of Science and Technology Shanghai 200237 P. R. China College of Mathematics and Information Science Guangxi University Nanning 530004 P. R. China

We prove the superlinear convergence of a nonmonotone BFGS algorithm on convex objective functions under suitable conditions.

关键词： BFGS method superlinear convergence nonmonotone linesearch

Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy

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Nano Research 2022年第1期15卷 716-727页

作者： Meijiao Zhao Qin zeng Xipeng Li Da xing Tao Zhang MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Tumor oxygen spatial heterogeneity is a critical challenge for the photodynamic inhibition of solid *** of an intelligent nanoagent to initiate optimal therapeutics according to the localized oxygen levels is an effective ***,we report an activatable nanoagent(BDP-Oxide nanoparticles(NPs))to enable the oxygen auto-adaptive photodynamic/photothermal complementaly *** the nanoagent accumulated in the tumor region,the low extracellular pH could trigger the disassociation of the nanoagent to release the phototheranostic agent,BDP-Oxide,which will subsequently afford the fluorescence imaging-guided photodynamic oxidation after it gets into the outer oxygen-rich *** with the penetration deepening in the solid tumor,furthermore,BDP-Oxide could be reduced into BDP by the cytochrome P450(CYP450)enzymes activated in the low oxygen tension regions of inner hypoxic tumors,which will switch on the photothermal and photoacoustic ***,the BDP-Oxide NPs-enabled photodynamic/photothermal complementary therapy significantly suppressed the solid tumor growth(inhibition rate of 94.8%).This work proposes an intelligent platform to address the oxygen partial pressure for the optimization of cancer phototherapeutics.

关键词： boron dipyrromethene(BODIPY) complementary therapy self-adaptive spatial heterogeneity of oxygen

Continuous high-temperature rapid nanomanufacturing of electrocatalysts

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Nano Research 2025年第1期18卷 225-235页

作者： Xiaoyang Wang Ziyi Luo Baihua Cui Ziqi Fu Yanchang Liu Weidi Liu Jia Ding Jianrong zeng Yanan ChenWenbin Hu School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt.LuciaBrisbane 4072Australia Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

Encapsulating metal nanoparticles in carbon shells(Metal@C)to enhance catalytic activity and stability has been certified ***,most existing methods for preparing Metal@C are complex,time-consuming,and lack of *** this study,a novel method that couples the high-temperature shock(HTS)with ultrasonic spray pyrolysis is reported,which can realize facile and scalable production of various Metal@C through the pyrolysis of glucose and metal chloride *** proposed HTS ultrasonic spray pyrolysis offers several advantages,including compact size,short reaction time(~120 ms),and uniform *** the Ni@C-40 nanocomposite as an example,the ultrasmall Ni nanoparticles(~10 nm)with thin carbon protective shells(~2 nm)are uniformly dispersed in the carbon matrix and applied for oxygen evolution reaction(OER)in alkaline *** Ni@C-40 optimized by tuning the thickness of carbon shell exhibits significantly enhanced OER activity with low overpotential of 242 mV at 10 mA·cm^(-2) and stability,which is attributed to the optimized interactions between Ni nanoparticles and carbon *** method also shows promise for continuous pyrolysis synthesis of various extreme materials at ultra-high temperatures using alternative electric heating materials.

关键词： ultrasonic spray pyrolysis high-temperature shock carbon shell oxygen evolution reaction Metal@C nanocomposite

Chemical constituents,biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver

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Food Science and Human Wellness 2019年第2期8卷 177-188页

作者： Yi-Fan xing Dong He Yi Wang Wen zeng Chong Zhang Yuan Lu Nan Su Yan-Hua Kong xin-Hui xing Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringRoom 601Yingshi BuildingBeijing 100084China Centre for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Animal Disease Control and Prevention Centre South Section of Hangu RoadLingbao CityHenan 472500China

Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development ***,the comprehensive utilization rate of *** *** still very low,only bark has been used as medicine and other parts of Eucommia ulmoides *** be fully utilized,even the leaves have been well utilized in food products in Japan in the past *** order to improve the comprehensive utilization efficiency of *** Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of *** *** findings suggest that other parts of *** *** replace the bark of *** *** some extent besides of their respective *** unique and extensive physiological functions between different parts of *** *** that the comprehensive utilization of *** *** a wide space to develop,which is also an effective way to protect *** *** and improve its the utilization rate.

关键词： Eucommia ulmoides Oliver Comprehensive utilization Chemical constituents Biological functions Pharmacological effects

Light-responsive charge-reversal nanovector for high-efficiency in vivo CRISPR/Cas9 gene editing with controllable location and time

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Nano Research 2020年第9期13卷 2399-2406页

作者： Yunxia Wu Judun Zheng Qin zeng Tao Zhang Da xing MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Controllably and efficaciously localized CRISPR/Cas9 plasmids transfection plays an essential role in genetic editing associated with various key human *** employed near-infrared(NIR)light-responsive CRISPR/Cas9 plasmids delivery via a charge-reversal nanovector to achieve highly efficient and site-specific gene *** nanovector with abundant positive charges was fabricated on the basis of an ultraviolet-sensitive conjugated polyelectrolyte coated on an upconversion nanomaterial(UCNP-UVP-P),which can convert into negative charges upon 980 nm light *** the as-prepared nanovector,we demonstrated the plasmids could be efficiency transfected into tumor cells(~63%±4%)in a time-contolled manner,and that functional CRISPR/Cas9 proteins could be successfully expressed in a selected NIR-irradiated ***,this strategy was successfully applied to the delivery of CRISPR/Cas9 gene to tumor cells in vivo,inducing high efficiency editing of the target gene PLK-1 under ***,this precisely controlled gene regulation strategy has the potential to serve as a new paradigm for gene engineering in complex biological systems.

关键词： light-responsive charge-reversal CRISPR/Cas9 gene editing

Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi zeng Chunyan Wang Li Yang Cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

Effect of CD4^+CD25^+ regulatory T cells in the development of anterior chamber-associated immune deviation

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 19-25页

作者： Shu-xing Ji, Pei-zeng Yang Department of Ophthalmology Daping Hospital Third Military Medical University Chongqing 400042 China Uveitis Study Center Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China National Ophthalmic Research Laboratory Guangzhou 510060 Guangdong Province China

AIM: To investigate whether CD4(+)CD25(+) regulatory T (Treg) cells play a role in the development of anterior chamber-associated immune deviation (ACAID). METHODS: The dynamic changes in the frequency of CD4(+)D25(+) T cells, CD4(+)D25(+) FoxP3(+) T cells and CD4(+)CD25(+) PD-1(+) T cells from spleens of mice with ACAID were analyzed by flow cytometry. Foxp3 mRNA expression in purified CD4(+)CD25(+) T cells was analyzed using real-time PCR. The suppressive effect of purified CD4(+)CD25(+) T cells on the proliferation of CD4(+)CD25(-) T cells was evaluated by [H-3] thymidine incorporation. A blocking experiment was performed to further address the role of CD4(+)CD25(+) T cells in ACAID. The expression of IL-10 in purified CD4(+)CD25(+) T cells was evaluated by ELISA. RESULTS: Increased frequencies of CD4(+)CD25(+) T cells, CD4(+)CD25(+) Foxp3(+) T cells and CD4(+)CD25(+) PD-1(+) T cells were observed in ACAID. The CD4(+)CD25(+) T cells from mice with ACAID showed enhanced suppressive effect on the proliferation of CD4(+)CD25(-) T cells. Treatment of BALB/c mice with anti-CD25 antibody after injection of OVA into the anterior chamber significantly inhibited the induction of ACAID. Furthermore, purified CD4(+)CD25(+) T cells from ACAID mice secreted IL-10. CONCLUSION: Our results demonstrate that Treg cells are induced in the mice undergoing ACAID. These Treg cells may play a role in the development of ACAID.

关键词： CD4+CD25+ regulatory T cells Foxp3 ACAID IL-10 PD-1

Characteristics of LiCoO2, LiMn2O4 and LiNi0.45Co0.1Mn0.45O2 as cathodes of lithium ion batteries

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Journal of Central South University of Technology 2005年第Z1期12卷 44-49页

作者： GUO Hua-jun LI xin-hai ZHANG xin-ming zeng Su-ming WANG Zhi-xing PENG Wen-jie School of Metallurgical Science and Engineering Central South University Changsha 410083 China School of Metallurgical Science and Engineering Central South University Changsha 410083 China School of Materials Science and Engineering Central South University Changsha 410083 China School of Materials Science and Engineering Central South University Changsha 410083 China School of Metallurgical Science and Engineering Central South University Changsha 410083 China School of Metallurgical Science and Engineering Central South University Changsha 410083 China

LiNi0. 45 Co0. 10 Mn0. 4sO2 was synthesized from Li2CO3 and a triple oxide of nickel, cobalt and manganese at 950 ℃ in air. The structures and characteristics of LiNi0. 45 Co0.10 Mn0. 45 O2, LiCoO2 and LiMn2 O4 were investigated by XRD, SEM and electrochemical measurements. The results show that LiNi0.4s Co0.10 Mn0. 45 O2 has a layered structure with hexagonal lattice. The commercial LicoO2 has sphere-like appearance and smooth surfaces, while the LiMn2 O4 and LiNi0.45 Co0. 10 Mn0. 45 O2 consist of cornered and uneven particles. LiNi0. 45 Co0.10 Mn0. 45 O2 has a large disLiMn2 O4 and LiCoO2, respectively. LiCoO2 and LiMn2 O4 have higher discharge voltage and better rate-capability than LiNi0. 45Co0.10 Mn0. 45 O2. All the three cathodes have excellent cycling performance with capacity retention of above 89.3 % at the 250th cycle. Batteries with LiMn2 O4 or LiNi0.45 Co0.10 Mn0. 45 O2 cathodes show better safety performance under abusive conditions than those with LiCoO2 cathodes.

关键词： lithium ion batteries cathode LiCoO2 LiMn2O4 LiNi0. 45 Co0. 10 Mn0. 45 O2