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Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang xin-Yang Jin Zheng Lei Xiao-Jiao Liu Yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang Lv-Yuan Shi ding-Yuan Wan xin Fu Lu-Ping Wang Ai-Jia Ma Yi-Song Cheng Jing Yang Min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

High-efficiency gene editing in Anopheles sinensis using ReMOT control

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Insect Science 2024年第1期31卷 307-312页

作者： Xiao-lin Yang Xia Ling Quan Sun Pin-pin Qiu Kai Xiang Jun-feng Hong Shu-lin He Jie Chen xin ding Hai Hu Zheng-bo He Cao Zhou Bin Chen Liang Qiao Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina Xunjian Life Science&Technology Co.Ltd. ChongqingChina State Key Laboratory of Resource Insects Southwest UniversityChongqingChina

Dear editor,Functional genomics studies of mosquito vectors are crucial for understanding their physiological behavior,pathogen transmission,and evolution,and for providing essential molecular targets for genetic control(Severson&Behura,201l;Alphey,2014;Ruzzante et al.,2019;Hong et al.,2022).The main methods involve clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing via embryo microinjection(Criscione et al.,2015;Kistler et al.,2015).

关键词： editor editing injection

A telomere-to-telomere genome assembly of Hongyingzi,a sorghum cultivar used for Chinese Baijiu production

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The Crop Journal 2024年第2期12卷 635-640页

作者： Yanqing ding Yilin Wang Jianxia Xu Feng Jiang Wenzhen Li Qiaoling Zhang Longping Yang Zhenyu Zhao Bin Cheng Ning Cao Xu Gao xin Zhang Guihua Zou Fan Yang Liyi Zhang Guizhou Institute of Upland Crops Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Kweichow Moutai Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Kweichow Moutai Distillery(Group)Hongyingzi Agricultural Technology Development Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Wuhan GrandOmics Biosciences Co. Ltd.Grandomics BiosciencesWuhan 430000HubeiChina Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesZhejiang

Sorghum(Sorghum bicolor(L.)Moench)is a world cereal crop used in China for producing Baijiu,a distilled spirit.We report a telomere-to-telomere genome assembly of the Baijiu cultivar Hongyingzi,HYZ-T2T,using ultralong reads.The 10 chromosome pairs contained 33,462 genes,of which 93%were functionally annotated.The 20 telomeres and 10 centromeric regions on the HYZ-T2T chromosomes were predicted and two consecutive large inversions on chromosome 2 were characterized.A 65-gene reconstruction of the metabolic pathway of tannins,the flavor substances in Baijiu,was performed and may advance the breeding of sorghum cultivars for Baijiu production.

关键词： Sorghum Telomere-to-telomere assembly Hongyingzi(HYZ) Chinese Baijiu-making cultivar

Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu Fu Zheng Hong-Yi Tang Hua-Zhi Li xin-Yu Cui Shuai ding Duo Liu Cui-Ying Li Jiu-Hui Jiang Rui-Li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root resorption.Low-intensity pulsed ultrasound(LIPUS),a noninvasive physical therapy,has been shown to promote bone fracture healing.It is also reported that LIPUS could reduce the duration of orthodontic treatment;however,how LIPUS regulates the bone metabolism during the orthodontic treatment process is still unclear.AIM To investigate the effects of LIPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying mechanisms.METHODS A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue sections.In vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and LIPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red staining.The expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via immunofluorescence.RESULTS The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),decreased.LIPUS could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by force.Mechanically,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by LIPUS.Moreover,the osteogenic differentiation of hBMSCs increased by LIPUS could be attenuated by YAP siRNA treatment.Consistently,LIPUS increased alveolar bone density and decreased vertical bone absorp

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

数字化转型与银行信贷配置——基于银行贷款投向实体经济的视角

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数量经济技术经济研究 2024年第3期41卷 193-216页

作者：丁鑫周晔浙江财经大学金融学院首都经济贸易大学金融学院

在建设数字中国、构建适应现代经济发展的数字金融新格局下,数字化转型能够缓解银企之间信息不对称,精准识别企业信贷需求,成为金融供给侧结构性改革的重要路径。基于成本优化和信息传递视角,本文在微观银行经济学理论框架中引入数字化... 详细信息

在建设数字中国、构建适应现代经济发展的数字金融新格局下,数字化转型能够缓解银企之间信息不对称,精准识别企业信贷需求,成为金融供给侧结构性改革的重要路径。基于成本优化和信息传递视角,本文在微观银行经济学理论框架中引入数字化转型进行理论分析,并采用2010~2021年217家商业银行的面板数据,实证检验银行数字化转型对信贷配置的影响及其内在机理。研究发现,银行数字化转型能够促进信贷供给增加,促使银行信贷由金融业配置到实体行业。作用机制为数字化转型利用信息技术与数据要素增强银行信息甄别能力,缓解银企之间信息不对称性,并通过降低银行经营成本与人力费用,推动信贷配置到实体行业。进一步地,数字化转型具有“顶层设计”的特征,不同转型路径中“创新理念型”对信贷配置的效果最优;相较于“合作式”转型,“自主式”转型方式的信贷配置效果更佳;银行实体网点数量的增加和人力成本的减少有助于数字化转型推动信贷投向实体行业,数字化转型在经济繁荣和信贷上行阶段具有更明显的顺周期性。异质性检验发现,规模较小、盈利较高与贷款质量较低的银行在数字化转型过程中对信贷投向实体行业的边际影响更强。本文的研究为进一步优化金融供求结构,推动商业银行支持实体经济发展提供理论参考。

关键词：数字化转型信贷配置实体经济信贷供给

Chinese herbal medicine Ginkgo biloba L.preparations for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You Min Li Jian-bo Guo xin-bin Song Jing-yi ding Xiao-long Xie An-qi Li Shang-jin Li Xiang-jun Yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba L.preparations(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been published.Objective:This overview aims to assess the quality of related SRs and MAs.Search strategy:Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,2022.Inclusion criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were included.Data extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),respectively.Additionally,descriptive analysis and data synthesis were conducted.Results:Twenty-nine SRs/MAs involving 119 outcomes were included in this review.The overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the ROBIS.According to the PRISMA statement,the reporting items of the included SRs/MAs are relatively complete.The results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low quality.Based on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.Conclusion:GBLPs can be considered a beneficial supplemental therapy for IS.However,because of the low quality of the existing evidence,high-quality RCTs and SRs/MAs are warranted t

关键词： statement synthesis alone

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血管支架预制件的六角形三维虚拟编织

纺织学报 2024年第3期45卷 65-73页

作者：丁彩红顾馨卢晨雨东华大学机械工程学院上海201620

为解决六角形三维编织血管支架的编织工艺复杂、开发周期长的问题,提出了基于MatLab编程的支架三维虚拟编织方法,以快速完成编织工艺开发。首先,基于六角形编织机底盘的结构特点,对底盘单元进行坐标数值化,从而可将支架编织的工艺和工... 详细信息

为解决六角形三维编织血管支架的编织工艺复杂、开发周期长的问题,提出了基于MatLab编程的支架三维虚拟编织方法,以快速完成编织工艺开发。首先,基于六角形编织机底盘的结构特点,对底盘单元进行坐标数值化,从而可将支架编织的工艺和工序转换为不同时刻下携纱器在底盘上的XY平面坐标和运动信息以及纱线在芯棒上的高度坐标z值,并应用数值计算方法进行连接和拟合,建立纱线空间轨迹的数学模型,得到虚拟支架的三维基本形态。然后,将编织支架的三维形态展开为二维形态,分析二维平铺形态下单向支架沿螺旋方向缠绕的特点,应用线性方程组求解纱线的交织点坐标,并通过层内和层间的纱线交织关系判断得到各交织点的交织类型。最后,通过方程修正得到具有六角形编织特征的纱线波动方程,进一步建立了具有纱线立体交织特征的虚拟支架实体化数学模型。经不同编织工艺的支架虚拟仿真实验,将虚拟支架与其实物进行比较发现,虚拟支架均能准确直观地表达实物的几何特征和交织特征。由此验证了虚拟仿真建模的正确性,有利于六角形三维编织工艺的快速开发。

关键词：六角形三维编织血管支架虚拟编织单向管状织物交织判断

Behavior of exciton in direct−indirect band gap Al_(x)Ga_(1−x)As crystal lattice quantum wells

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Journal of Semiconductors 2024年第3期45卷 64-70页

作者： Yong Sun Wei Zhang Shuang Han Ran An xin-Sheng Tang xin-Lei Yu Xiu-Juan Miao xin-Jun Ma Xianglian Pei-Fang Li Cui-Lan Zhao Zhao-Hua ding Jing-Lin Xiao Institute of Condensed Matter Physics Inner Mongolia Minzu UniversityTongliao 028043China College of Physics and Electronic Information Inner Mongolia Minzu UniversityTongliao 028043China

Excitons have significant impacts on the properties of semiconductors.They exhibit significantly different properties when a direct semiconductor turns in to an indirect one by doping.Huybrecht variational method is also found to influence the study of exciton ground state energy and ground state binding energy in Al_(x)Ga_(1−x)As semiconductor spherical quantum dots.The Al_(x)Ga_(1−x)As is considered to be a direct semiconductor at AI concentration below 0.45,and an indirect one at the concentration above 0.45.With regards to the former,the ground state binding energy increases and decreases with AI concentration and eigenfrequency,respectively;however,while the ground state energy increases with AI concentration,it is marginally influenced by eigenfrequency.On the other hand,considering the latter,while the ground state binding energy increases with AI concentration,it decreases with eigenfrequency;nevertheless,the ground state energy increases both with AI concentration and eigenfrequency.Hence,for the better practical performance of the semiconductors,the properties of the excitons are suggested to vary by adjusting AI concentration and eigenfrequency.

关键词： exciton effects aluminum gallium arsenide crystal direct band gap semiconductor indirect band gap semiconductor

基于多目标粒子群优化的污水处理系统自适应评判控制

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工程科学学报 2024年第5期46卷 908-917页

作者：王鼎赵慧玲李鑫北京工业大学信息学部北京100124 计算智能与智能系统北京市重点实验室北京100124 智慧环保北京实验室北京100124 北京人工智能研究院北京100124

考虑到城市污水处理系统存在保证出水水质达标和降低能耗的需要,将其运行过程视为一个多目标优化控制问题.针对此问题,提出一种基于多目标粒子群优化(Multi-objective particle swarm optimization,MOPSO)算法的污水处理系统自适应评判... 详细信息

考虑到城市污水处理系统存在保证出水水质达标和降低能耗的需要,将其运行过程视为一个多目标优化控制问题.针对此问题,提出一种基于多目标粒子群优化(Multi-objective particle swarm optimization,MOPSO)算法的污水处理系统自适应评判控制方案,该方案分为上层优化和底层跟踪控制两部分.首先,污水处理过程存在非线性、多变量、大时变等特点,结合数据驱动思想对入水及出水组分数据进行分析,构建关于出水水质和运行能耗的多目标优化模型.采用径向基函数(Radial basis function,RBF)神经网络进行建模,并与反向传播(Back propagation,BP)神经网络进行了对比.然后,结合MOPSO算法强大的优化能力,采用MOPSO算法对优化目标进行求解,并设计一个决策方式从最优解集中选出偏好解,作为溶解氧与硝态氮浓度的最优设定值.接下来,底层跟踪控制部分采用基于自适应动态规划的辅助控制器对比例–积分–微分算法的控制策略进行补充,弥补了传统控制算法自适应能力差的不足.此外,比例–积分–微分算法也为自适应动态规划算法提供了初始的稳定控制策略,克服了学习算法前期控制效果差的缺陷,保证了污水处理过程的安全性和可靠性.最终,该控制器成功实现了对最优设定值的跟踪控制.将所提算法在污水处理基准仿真平台上进行验证,结果表明所提算法能有效地提高污水处理过程的运行性能,不仅能保证出水水质达标,同时能有效地降低污水处理过程产生的能耗.

关键词：污水处理多目标优化自适应评判跟踪控制神经网络