检索结果-南通市图书馆

Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report

引用

World Journal of Gastrointestinal Oncology 2024年第2期16卷 563-570页

作者： Yu-Qing Cheng Geng-Fang Wang Xiao-Li Zhou Min Lin xin-wen zhang Qin Huang Department of Pathology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Gastroenterology Center The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215United States

BACKGROUND Early adenocarcinoma mixed with a neuroendocrine carcinoma(NEC)component arising in the gastroesophageal junctional(GEJ)region is rare and even rarer in young ***,we report such a case in a 29-year-old Chinese *** SUMMARY This patient presented to our hospital with a 3-mo history of dysphagia and *** endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line,without Barrett’s esophagus or involvement of the gastric *** nodule was completely resected by endoscopic submu-cosal dissection(ESD).Pathological examination confirmed diagnosis of intra-mucosal adenocarcinoma mixed with an NEC component,measuring 1.5 ***,both adenocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%;NEC was positive for synaptophysin and ***-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene,a common gastric cancer driver gene,in addition to pathogenic somatic mutations in P53 and CHEK2 *** patient was alive without evidence of the disease 36 mo after *** Early adenocarcinoma with an NEC component arising in the distal esophageal side of the GEJ region showed evidence of gastric origin.

关键词： Adenocarcinoma Neuroendocrine carcinoma Gastroesophageal junction Next generation sequencing Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theoretical Study of Haloacetonitrile Anions： CH2XCN^- （X=F, Cl）

引用

Chinese Journal of Chemical Physics 2008年第3期21卷 255-262页

作者： xin-wen zhang Mei Li Shan-xi Tian Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technologyof China Hefei 230025 China Department of Chemical Physics University of Science and Technology of China Hefei 230026China

Haloacetonitrile anions CH2XCN- （X=F, Cl） were studied by HF-SCF, Becke3-LYP, and MP2 methods together with the Dunning＇s basis set aug-cc-PVTZ. The vertical electron attachments to the neutral are endothermic. The geometrically optimized CH2FCN^- is mainly a valence-bounded anion and CH2FCN→CH2CN＋F^- is a nonadiabatic dissociation. This theoretical study in good agreement with the experimental results shows that the Becke3-LYP method is reasonable in describing the electronic structures of anions and dissociative attachment dynamics, while significant differences between MP2 and Becke3-LYP results are shown for the dissociation potential curves of CH2ClCN→CH2CN＋Cl^-.

关键词： Haloacetonitrile Electron attachment Dissociation dynamics Electron correlation effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Minimum Time Overtaking Problem of Vehicle Handling Inverse Dynamics Based on Two Kinds of Safe Distances

引用

Chinese Journal of Mechanical Engineering 2018年第6期31卷 207-216页

作者： You-Qun Zhao xing-Long zhang wen-xin zhang Fen Lin College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics

Overtaking accidents caused by improper operations performed by a driver occur frequently. However, most stud?ies on overtaking safety have neglected research into driver control input. A novel method is proposed to obtain the driver control input during the overtaking process. Meanwhile, to improve the safety of overtaking, two types of safe distances, and the time of the overtaking are considered. Path constraints are established when considering the two types of safe distances. An optimal control model is established to solve the minimum time maneuver under multiple constraints. Using the Gauss pseudospectral method, the optimal control problem is converted into a nonlinear pro?gramming problem, which is then solved through sequential quadratic programming(SQP). In addition, the e ective?ness of the proposed method is verified based on the results of a Carsim simulation. The simulation results show that by adopting an inverse dynamics method to solve the manipulation problem of the vehicle’s minimum overtaking time, the manipulation capability of a vehicle in completing an overtaking safely within the minimum time can be obtained. This method can provide a reference for research into the active safety of manned and unmanned vehicles.

关键词： Handling inverse dynamics Safe distance Overtaking Optimal control Simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Auto-cortex of crystalline lens-induced iris neovascularization

引用

International Journal of Ophthalmology(English edition) 2012年第1期5卷 23-27页

作者： Lin Liu, wen-xin zhang Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010 Guangdong Province China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM:To investigate auto-cortex of crystalline lens induced iris neovascularization (INV). METHODS: Thirty-six eyes of 36 guinea-pigs were included and divided into three groups randomly in this cohort study. Group A: the right lens nucleus was extracted and the remaining cortical lens material was aspirated thoroughly.. Group B: the lens was removed and 30 mu L precipitated lens cortex was injected into the anterior chamber again. Group C: aspirated the lens cortex of the left eyes and inject them into the right anterior chambers about 10 mu L. Clinical changes were followed by slit-lamp examination and photograph. The eye balls were enucleated at the day of 2, 4, 7, 11, 13, 17 after operation. HE was used to detect the pathological changes. ' RESULTS:Group A:INV had not been observed until the end of empirical study. The stromal layer contained thick wall vessels, without expansion. Group B: All eyes developed INV. Postoperative (po) 7 days; the eyes developed intense and extensive INV. The vessels of iris expanded remarkably and neovascularization was observed erupting from it's lateral wall and stretching towards the anterior surface. Poll days, INV regressed gradually after lens cortex had been absorbed. Group C: Po four (4) days, new blood vessels liking red line were presented on the anterior surface of the iris and they were not obvious. CONCLUSION: Anterior chamber inside lens coriaceous can induce iris new blood vessels.

关键词： iris new vessels crystallins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Triphenyl Phosphine Oxide and Carbazole-based Polymer Host Materials for Green Phosphorescent Organic Light-emitting Diodes

引用

Chinese Journal of Polymer Science 2017年第5期35卷 611-622页

作者： Hong-ji Jiang Qing-wei zhang Xu He Xiao-lin zhang xin-wen zhang Key Laboratory of Organic Electronics and Information Displays National Jiangsu Synergetic Innovation Center for Organic Electronics and Information Displays Institute of Advanced Materials Nanjing University of Posts and Telecommunications

Four novel polymers, poly（3,6-9-decyl-carbazole-alt-1,3-benzene）（PB13CZ）, poly（3,6-9-decyl-carbazole-alt- bis（4-phenyl）（phenyl） phosphine oxide）（PTPPO38CZ）, poly（3,6-9-decyl-carbazole-alt-2,4-phenyl（diphenyl） phosphine oxide）（PTPPO13CZ） and poly（3,6-9-decyl-carbazole-alt-bis（3-phenyl）（phenyl） phosphine oxide）（PTTPO27CZ） were synthesized, and their thermal, photophysical properties and device applications were further investigated to correlate the chemical structures with the photoelectric performance of bipolar host materials for phosphorescent organic light emitting diodes. All of them show high thermal stability as revealed by their high glass transition temperatures and thermal decomposition temperatures at 5% weight loss. These polymers have wide band gaps and relatively high triplet energy levels. As a result, the spin coating method was used to prepare the green phosphorescent organic light emitting diodes with polymers PTPPO38CZ, PTPPO13CZ and PTTPO27CZ as the typical host materials. The green device of polymer PTPPO38CZ as host material shows electroluminescent performance with maximum current efficiency of 2.16 cd.A-1, maximum external quantum efficiency of 0.7%, maximum brightness of 1475 cd.m-2 and reduced efficiency roll-off of 7.14% at 600 cd.m-2, which are much better than those of the same devices hosted by polymers PTTPO27CZ and PTPPO13CZ.

关键词： Triphenyl phosphine oxide Phosphorescent organic light-emitting diode Thermal stability Triplet energy levels Polymer host materials Electroluminescent performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

How did high temperature extremes in southern xinjiang,China induce the repaid rise in jujube futures prices in the summer of 2021?

引用

Advances in Climate Change Research 2023年第3期14卷 449-457页

作者： De-Qian LI Shu-Juan HU Jing-Jing zhang Chen-Bin GAO Bing-Qian ZHOU wen-xin zhang Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

In the summer of 2021,southern xinjiang,China,experienced a temporary period of high temperature *** of this weather event,jujube futures prices rose by more than 50%in a short *** clarify the influence mechanism of these two events,we investigated the current status of jujube farming and collected investors’online *** analysed these comments specifically using textual analysis tools,such as co-word *** showed that the concerns of investors about the reduction in jujube production triggered by high temperature extremes were the primary reason for the rapid rise in jujube futures *** in combination with the cultivation density of jujube and their adaptability to the growing environment,a new understanding can be *** is to say,when a crop is excessively densely cultivated in a region and is highly sensitive to a meteorological variable anomaly at a certain growth stage,a less destructive local extreme weather event could induce severe panic among investors regarding production reduction and thus influence the normal changes in futures *** response to the impact mechanisms revealed in this study,we proposed policy recommendations,such as strengthening the degree of crop damage disclosure and designing weather futures derivatives,to address similar situations in the *** study not only fills the gap in the research on the impact paths of high temperature extremes on jujube futures prices but also has a reference value for securing the stability of futures prices of related agricultural products in the future.

关键词： Jujube futures prices High temperature extremes Co-word networks Market hot topics Southern xinjiang

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

引用

Zoological Research 2024年第4期45卷 924-936页

作者： Ruo-wen Guo wen-Jing Xie Biao Yu Chao Song xin-Miao Ji xin-Yu Wang Mei zhang xin zhang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD *** diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic *** this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD *** indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in *** the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory *** examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse *** findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

关键词： lzheimer’s disease Rotating magnetic field Amyloid-β Cognitive function Alzheimer’s disease animal models

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on metal recovery process and kinetics of oxidative leaching from spent LiFePO_(4)Li-batteries

引用

Chinese Journal of Chemical Engineering 2024年第4期68卷 94-102页

作者： Xiaoming zhang wen Xie Xiaolei Zhou wenjie zhang Jiawei wen xin Wang Guoyong Huang Shengming Xu College of New Energy and Materials China University of PetroleumBeijing 102249China State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumBeijing 102249China Beijing Spacecrafts Beijing 100094China Ganfeng Lithium Group Co. Ltd.Xinyu 338000China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Fine Ceramics Tsinghua UniversityBeijing 100084China

A green environmental protection and enhanced leaching process was proposed to recover all elements from spent lithium iron phosphate(LiFePO_(4)) lithium *** order to reduce the influence of Al impurity in the recovery process,NaOH was used to remove *** impurity removal,the spent LiFePO_(4) cathode material was used as raw material under the H_(2)SO_(4) system,and the pressure oxidation leaching process was adopted to achieve the preferential leaching of *** E-pH diagram of the Fe-P-Al-H_(2)O system can determine the stable region of each element in the recovery process of spent LiFePO_(4)*** the optimal conditions(500 r·min^(-1),15 h,363.15 K,0.4 MPa,the liquid-solid ratio was 4:1 ml·g^(-1)and the acid-material ratio was 0.29),the leaching rate of Li was 99.24%,Fe,Al,and Ti were 0.10%,2.07%,and 0.03%,*** Fe and P were precipitated and recovered as FePO_(4)·2H_(2)*** kinetic analysis shows that the process of high-pressure acid leaching of spent LiFePO_(4) materials depends on the surface chemical *** the life cycle assessment(LCA)of the spent LiFePO_(4) whole recovery process,eight midpoint impact categories were selected to assess the impact of recovery *** results can provide basic environmental information on production process for recycling industry.

关键词： Spent LiFePO_(4)Li-batteries Oxidative leaching Kinetic study Life cycle assessment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Large eddy simulation of boundary layer combustion of hydrogen and hydrocarbon fuel films in a modeled scramjet combustor

引用

Chinese Journal of Aeronautics 2024年第7期37卷 109-133页

作者： Jianfei WEI Silong zhang Jingying ZUO xin LI Jiang QIN wen BAO School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China

Supersonic fuel film cooling is a promising way to simultaneously reduce the severe wall heat and friction load of the internal passage in a scramjet engine when operating at hypersonic *** eddy simulations were performed to investigate the cooling and wall friction characteristics of hydrogen and hydrocarbon films under inert and reactive *** results show that the essential difference of the turbulent state in the mixing layer contributes to the totally different behaviors of the cooling and wall friction reduction performances of the two fuel *** turbulent transport processes between the hydrogen film and the mainstream are much weaker as compared to the case of hydrocarbon film,making inert hydrogen rather superior in cooling and friction reduction ***,the increase of wall temperature for hydrogen film under the inert case is mainly driven by the loss of hydrogen with high heat capacity instead of by direct heat ***,the film cooling performance severely deteriorates when the hydrogen film burns due to presence of severe heat release sources near the *** the other hand,combustion of hydrocarbon film in the boundary layer can remarkably improve its originally barely-satisfactory cooling and friction reduction performance to the level comparable to that of hydrogen film,due to the suppression of turbulent transport processes in the mixing layer and presence of heat absorption sources near the ***,the hydrogen film is more advantageous in friction reduction,while the hydrocarbon film is more suitable for cooling.

关键词： Supersonic film cooling Hydrogen Hydrocarbon Boundary layer combustion Large eddy simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immunohistochemical features of carcinoma ex pleomorphic adenoma and pleomorphic adenoma in the lacrimal gland

引用

International Journal of Ophthalmology(English edition) 2019年第8期12卷 1238-1242页

作者： Ping zhang Li-Juan Tang Huan-Huan Gao wen-xin zhang Jian-Xian Lin Hua-Sheng Yang Department of Ocular Pathology State Key Laboratory ofOphthalmologyZhongshan Ophthalmic CenterSun Yat-senUniversityGuangzhou510060Guangdong ProvinceChina Department of Orbital Disease and Oncology State KeyLaboratory of OphthalmologyZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou510060GuangdongProvinceChina

AIM: To investigate C-myc, Ki-67, pan-cytokeratin, and vimentin immunohistochemical features of carcinoma ex pleomorphic adenoma(Ca-ex-PA) and pleomorphic adenoma(PA) in the lacrimal gland in order to find some clues in the differential diagnosis between ***: We reviewed microscopic slides and clinical records of 64 cases of PA and 15 cases of Ca-ex-PA in the lacrimal gland. Immunohistochemical antibodies for C-myc, Ki-67, pan-cytokeratin, and vimentin were ***: Median age of PA was 43.2 y(from 21 to 75). The 35 patients(54.7%) were male and 29 patients(45.3%) were female. For the PAs, the average positivity of C-myc was 4.6%;the average proliferation index of Ki-67 was 3.2%;pan-cytokeratin was positive in ductal cells, and vimentin was positive in myoepithelial cells. Median age of Ca-ex-PA was 54.3 y(from 26 to 76). There were 7 male patients(46.7%) and 8 female patients(53.3%). Among 15 Ca-ex-PAs, there were 6 myoepithelial carcinomas, 4 adenocarcinomas, 3 epithelial-myoepithelial carcinomas, and 2 squamous cell carcinomas. For the Ca-ex-PAs, the average positivity of C-myc was 36.4%;the average proliferation index of Ki-67 was 29.2%;pan-cytokeratin was positive in all cases, and vimentin was positive in myoepithelial ***: PA has a lower positivity of C-myc and Ki-67, while Ca-ex-PA had a higher positivity of these two biomarkers. These four biomarkers as a set could provide valuable clues in the differential diagnosis between Ca-exPA and PA. Our results indicate that the activation of C-myc could play an important role in the pathogenesis of Ca-exPA and PA.

关键词： carcinoma ex pleomorphic adenoma pleomorphic adenoma C-myc immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：