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MicroRNA-126 inhibits the proliferation of lung cancer cell line A549

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 239-242页

作者： Xun Yang Bei-Bei Chen Ming-Hua Zhang xin-rong wang Respiratory Department Central Hospital of Wuhan

Objective:To study the role of microRNA-126 in the development of lung ***:The biological function of microRNA-126 was delected using EdU assay and CCK-8 assay:the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot ***:In A549 cell line,overexpression of microRNA-126 inhibils the prolileralion rate:VEGF is the target gene of microRNA-126:microRNA-126 exerts its function via regulating VEGF protein ***:microRNA-126 inhibits the proliferation in A549 cell line.

关键词： microRNA-126 Proliferation VEGF

Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 249-252页

作者： Cheng-De wang xin-rong wang Chao-Yang wang Yi-Jun Tang Ming-Wen Hao Department of Thoracie Surgery Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University Department of Reproductive Medicine.Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University

Objective:To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung ***:A total of 297 patients from July 2009 to May 2013 were chosen as *** gene mutation were detected with fluorescence quantitative *** of EGFR gene mutation with clinical and pathological features was analyzed,and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was ***:In 297 patients.136(45.79%) showed EGFR gene *** gene mutation had no significant relevance with ***,smoking history,family history of cancer and clinical stage(P>0.05);there was significant relevance between EGFR gene mutation and blood type,pathologic types,differentiation and diameter of cancer(P<0.05).The difference between prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was statistical significance(P<0.05).Conclusions:EGFR gene mutation has significant relevance with pathological features,the prognosis of EGFRmutant-paticnts is better than that of EGFR- wide type-patients.

关键词： Epidermal growth factor receptor Non-small-cell lung carcinoma Fluorescence quantitative PCR Pathological features Prognosis

Efficient construction of calcium fluoride nanoaggregates for enhanced water vapor adsorption

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Particuology 2024年第6期89卷 191-197页

作者： Dan-Lei Yang Jing Cao rong-Kun Liu Jie-xin wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing100029China Petrochemical Research Institute PetroChinaBeijing102206China

Calcium fluoride(CaF_(2))is an ideal adsorbent for the dehydration of gaseous hydrogen fluoride(HF)containing water *** this work,a novel CaF_(2)absorbent,spherical CaF_(2)nanoaggregates(NAs)with a closely packed structure,was proposed and efficiently fabricated by spray drying *** the building blocks of CaF_(2)NAs,the CaF_(2)nanoparticles(NPs)were prepared by the addition of excess calcium ions(Ca^(2+))or fluorine ions(F−)in the *** results indicated that the CaF_(2)NPs synthesized by excess Ca^(2+)and the corresponding NAs exhibited much better water vapor adsorption properties than their counterparts by excess F−,owing to higher zeta *** importantly,whether excess Ca^(2+)or F^(−),CaF_(2)NAs had further enhanced water vapor adsorption capacity compared to primary CaF_(2)NPs,possibly owing to their unique nano-micro secondary structures and higher surface *** work has great potential in the development of high-performance absorbents for separating moisture from corrosive gas HF.

关键词： CaF_(2)nanoaggregates Water vapor adsorption Spray drying

Surface iodine and pyrenyl-graphdiyne co-modified Bi catalysts for highly efficient CO_(2) electroreduction in acidic electrolyte

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Nano Research 2024年第4期17卷 2381-2387页

作者： Min Zhang Juan wang xin rong Xiu-Li Lu Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

CO_(2) electroreduction to formic acid/formate would contribute to alleviating the energy and climate *** work reports a Bi-based catalyst derived from the in-situ electroreduction of Bi_(2)O_(2)CO_(3) modified with iodine and pyrenyl-graphdiyne(PGDY)on the surface for efficient electroreduction of CO_(2) in acidic electrolyte,with a high partial current density of 98.71 mA·cm^(-2) and high Faradaic efficiency(FE)>90%over the potential range from^(-1).2 to-1.5 V *** hydrogen electrode(RHE),as well as the long-term operational stability over 240 h without degradation in H-type *** results and density function theory calculations show that the synergistic effect of surface iodine and PGDY is responsible for this active and extremely stable process of CO_(2) electroreduction via lowering the energy barriers for formation of*OCHO intermediate,suppressing the competitive HER by enhancing the concentration of both K+and CO_(2) at reaction interface,as well as preventing the dissolution and re-deposition of active Bi atoms on surface during catalytic *** work provides new insight into designing highly active and stable electrocatalysts for CO_(2) reduction.

关键词： CO_(2) reduction electrocatalysis Bi-based catalysts acidic electrolyte

Three-dimensional conjugated macrocycle with large polyaromatic blocks constructed by post-π-extension

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Science China Chemistry 2020年第11期63卷 1626-1631页

作者： Shun-He Liu Hao Hou Ze-Ying Deng xin-rong wang Chun Tang Yang-Yang Ju Liu-Bin Feng Yuan-Zhi Tan State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Generally,the conjugated homo-macrocycles(CHMs)are synthesized by covalently linking the repeating ***,large subunits are often difficult to conjugate together due to severe ***,large polyaromatic blocks can not only incorporate its appealing electronic and optical properties into CHMs but also distort the CHMs from planar to three-dimensional(3D)molecular *** we synthesized the 3D CHM composed of large polyaromatic units by post-π-***,cyclo-m-phenylenes,as the cyclic precursor,wereπ-extended by C-C coupling and then subjected to dehydrocyclization,affording cyclo-1,3-dibenzo[e,l]pyrenylenes(CMDP).The structures of CMDPs were unambiguously characterized by single crystal X-ray diffraction,showing a congested and strained 3D conformation,which was also confirmed by theoretical *** with the monomer,CMDPs showed redshifted absorption and emission,as well as a ten-fold enhancement in photoluminescence quantum yield,which could be attributed to their 3D conformation.

关键词： macrocycle 7r-extension polyaromatic photoluminescence

Micro-sized nanoaggregates:Spray-drying-assisted fabrication and applications

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Particuology 2024年第2期85卷 22-48页

作者： Dan-Lei Yang rong-Kun Liu Yan Wei Qian Sun Jie-xin wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning530004China

The applications of nanoparticles suffer from their extremely small size and intrinsic trend of *** nanoparticles to form micro-sized nanoaggregates(MNAs)with increased size,ordered structure,as well as controllable size,shape,and morphology is a crucial step in various fields of science and technology to maintain the unique characteristics of nanoparticles while obtaining greatly enhanced or new performance at the *** structure of MNAs prominently affects their functionality,which is determined by the arrangement of nanoparticles and the interaction between primary *** methods have been proposed to prepare the MNAs,in which spray-drying technology stands out considering the feasibility,scalability for industry,cost,and *** assembly of nanoparticles through spray-drying under tunable process parameters yields diverse physical properties and structural arrangements of nanoparticles of the MNAs,they therefore exhibit enormous potential in a wide range of application *** review presents the construction and applications of spray-dried *** factors that influence the size,morphology,and structure of the MNAs are discussed in *** addition,the outstanding application performance resulting from the tightly packed nanoparticles in regular-shaped MNAs obtained by the spray-drying process is illustrated.

关键词： Spray-drying Micro-sized nanoaggregates Applications

Effect of PDGF-Rb antagonist imatinib on endometrial injury repairing in mouse model

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 553-557页

作者： xin-rong wang Cheng-De wang Xue-Mei Liu Hong-Chu Bao Qing-Lan Qu Cui-Fang Hao Department of Reproductive Medicine Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College Department of Thoracic Surgery Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College

Objective: To study the effects of PDGF-Rb antagonists imatinib on endometrial injury repairing in the mouse model. Methods: The cultured MSCs cells from male mice were marked with Brd U in vitro, and then transplanted to the female mice which suffered from radiation injury through tail vein, PDGF-Rb antagonists imatinib was injected through abdominal cavity. Four groups were arranged, which were radiation transplantation group, normal control group, imatinib intervention group and radiation control group. Brd U incorporation, SRY expression and MVD status were detected in uterus of mice. Results: SRY gene was negative expressed in normal control group and radiation control group. SRY gene presented positive in radiation transplantation group and imatinib intervention group; Brd U incorporation showed negative in radiation control group and normal control group which died in the early stage in mice; the incorporation of Brd U was higher in radiation transplantation group compared with imatinib intervention group; CD34 was positive on the uterus of all the four groups,which showed highest in radiation control group and lowest in radiation control group; The MVD in imatinib intervention group was lower than radiation control group; the difference of MVD was significantly compared with normal control group(P<0.05). Conclusions: PDGF-Rb antagonists imatinib could inhibit the repairing function of MSCs in the endometrial lesions in mice.

关键词： PDGF-Rb Endometrium Imatinib mesylate BrdU MVD

Upcycling of Poly(butylene adipate-co-terephthalate)into Dual Covalent Adaptable Networks through Chain Breaking-Crosslinking Strategy

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Chinese Journal of Polymer Science 2024年第10期42卷 1505-1513,I0011页

作者： Bin-Bo wang rong Huang xin wang Tao Jiang Yi wang Shuai Du Fa-Lin Li Jin Zhu Song-Qi Ma Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Divisions of Polymers and CompositesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(butylene adipate-co-terephthalate)(PBAT),a widely studied biodegradable material,has not effectively addressed the problem of plastic *** into consideration the cost-effectiveness,upcycling PBAT should take precedence over direct composting *** present work adopts a chain breaking-crosslinking strategy,upcycling PBAT into dual covalent adaptable networks(CANs).During the chainbreaking stage,the ammonolysis between PBAT and polyethyleneimine(PEI)established the primary crosslinked ***,styrene maleic anhydride copolymer(SMA)reacted with the hydroxyl group,culminating in the formation of dual covalent adaptable *** contrast to PBAT,the PBAT-dual-CANs exhibited a notable Young's modulus of 239 MPa,alongside an inherent resistance to creep and *** to catalysis from neighboring carboxyl group and excess hydroxyl groups,the PBAT-dual-CANs exhibited fast stress ***,they could be recycled through extrusion and hot-press reprocessing,while retaining their *** straightforward strategy offers a solution for dealing with plastic waste.

关键词： Poly(butylene adipate-co-terephthalate) Dynamic crosslinked networks Chain breaking-crosslinking strategy Upcycle Recycle

Hierarchical crystalline-amorphous nanocomposites with high strength and large deformability enabled by elemental diffusion

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Journal of Materials Science & Technology 2024年第4期171卷 150-161页

作者： Liqiang wang Heyi wang xin Zhou Huangliu Fu James Utama Surjadi Shuo Qu Xu Song rong Fan Yang Lu Department of Mechanical Engineering City University of Hong KongHong KongChina Nano-Manufacturing Laboratory(NML) Shenzhen Research Institute of City University of Hong KongShenzhen 518057China Chengdu Research Institute City University of Hong KongChengdu 610200China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina Department of Mechanical Engineering The University of Hong KongHong KongChina

Amorphous/nanocrystalline dual-phase structures have recently emerged as an effective way for over-coming the strength-ductility trade-offand breaking the limitation of the reverse Hall-Petch ***,we proposed a new strategy to develop a hierarchical and interconnected amorphous-crystalline nanocomposite arising from the nanoscale elemental interdiffusion and oxygen adsorption behavior dur-ing thermal treatment *** nanocomposite consisted of a three-dimensional(3D)hierarchical network structure where the crystalline phase(Cr-Co-Ni-Al)was embedded into the Al-O-based amor-phous phase network with critical feature sizes encompassing three orders of magnitude(from microm-eter to nanometer scale).It can achieve ultrahigh compression yield strength of-3.6 GPa with large homogeneous deformation of over 50%*** massive interstitial atoms induced lattice distortion and hierarchical amorphous phase boundary contributed to the strength *** situ Uniaxial compression inside a transmission electron microscope(TEM)revealed that the exceptional deformability of the nanocomposites resulted from the homogenous plastic flow of nano-sized amorphous phase and the plastic co-deformation behavior restricted by the nano-architected dual-phase *** proposed dual-phase synthesis approach can outperform conventional nanolaminates design strategies in terms of the mechanical properties achievable while providing a pathway to easily tune the microstructure of these nanolaminates.

关键词： Nanolaminates Dual-phase nanocomposites In situ transmission electron microscopy Multi-component alloy