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Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

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World Journal of Psychiatry 2024年第2期14卷 276-286页

作者： xin-Lin Huang Ju gao Yong-Ming Wang Feng Zhu Jing Qin qian-Nan Yao Xiao-Bin Zhang Hong-Yan Sun Imaging and Nuclear Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina School of Biology&Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Radiology Shanghai Anting HospitalShanghai 20000China Department of Radiology The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health *** surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of *** studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is *** researchers even mistakenly regard the signals generated by the WM as noise *** fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal *** alterations in WM signals and their relationship with disease severity in adolescents with MDD remain *** To explore potential abnormalities in WM functional signals in adolescents with *** This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide *** addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image *** DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC *** component analysis(ICA)was also used to evaluate the WM functional ***’s correlation was performed to assess the relationship between statistical test results and clinical *** Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel corre

关键词： White matter Regional homogeneity The fractional amplitude of low-frequency fluctuations Independent component analysis Adolescents Major depression disorders

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Dynamic Analysis of a 10 MW Floating Offshore Wind Turbine Considering the Tower and Platform Flexibility

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Journal of Ocean University of China 2024年第2期23卷 358-370页

作者： gao Shan ZHANG Lixian SHI Wei WANG Wenhua WANG Bin LI xin Key Laboratory of Far-Shore Wind Power Technology of Zhejiang Province Hangzhou 311122China State Key Laboratory of Coastal and Offshore Engineering Deepwater Engineering Research CenterDalian University of TechnologyDalian 116024China Powerchina Huadong Engineering Corporation Limited Hangzhou 311122China Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315000China

Recently,semisubmersible floating offshore wind turbine technologies have received considerable *** the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic *** dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed *** simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is *** effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are *** results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind *** the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid ***,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and ***,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.

关键词： floating offshore wind turbine TripleSpar semisubmersible platform rigidity and flexibility platform coupled simulation

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Generation and characterization of customized Laguerre–Gaussian beams with arbitrary profiles

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Frontiers of physics 2024年第4期19卷 235-241页

作者： Chengyuan Wang Yun Chen Jinwen Wang xin Yang Hong gao Fuli Li Ministry of Education Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Shaanxi Province Key Laboratory of Quantum Information and Quantum Optoelectronic DevicesSchool of PhysicsXi’an Jiaotong UniversityXi’an 710049China Department of Physics Huzhou UniversityHuzhou 313000China

We experimentally demonstrate the generation of customized Laguerre–Gaussian(LG)beams whose intensity maxima are localized around any desired *** principle is to act with appropriate algebraic functions on the angular spectra of LG *** characterize the propagation properties of these beams and compare them with non-diffraction caustic beams possessing the same intensity *** results manifest that the customized-LG beams can maintain their profiles during propagation and suffer less energy loss than the non-diffraction caustic beams,and hence are able to propagate a longer ***,the customized-LG beam exhibits self-healing ability when parts of their bodies are *** new structure beam has potential applications in areas such as optical communication,soliton routing and steering,and optical tweezing.

关键词： light manipulation wave propagation invariant optical fields

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Engineering g-C_(3)N_(4)based materials for advanced photocatalysis:Recent advances

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Green Energy & Environment 2024年第2期9卷 166-197页

作者： xin-Lian Song Lei Chen Li-Jiao gao Jin-Tao Ren Zhong-Yong Yuan National Institute for Advanced Materials School of Materials Science and EngineeringSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

Photocatalysis driven by abundant yet intermittent solar energy has considerable potential in renewable energy generation and environmental *** outstanding electronic structure and physicochemical properties of graphitic carbon nitride(g-C_(3)N_(4)),together with unique metal-free characteristic,make them ideal candidates for advanced photocatalysts *** review summarizes the up-to-date advances on g-C_(3)N_(4)based photocatalysts from ingenious-design strategies and diversified photocatalytic ***,the advantages,fabrication methods and limitations of each design strategy are systemically *** order to deeply comprehend the inner connection of theory–structure–performance upon g-C_(3)N_(4)based photocatalysts,structure/composition designs,corresponding photocatalytic activities and reaction mechanisms are jointly discussed,associated with introducing their photocatalytic applications toward water splitting,carbon dioxide/nitrogen reduction and pollutants degradation,***,the current challenges and future perspectives for g-C_(3)N_(4)based materials for photocatalysis are briefly *** design strategies and limitations are also instructive for constructing g-C_(3)N_(4) based materials in other energy and environment-related applications.

关键词： Graphitic carbon nitride g-C_(3)N_(4) Design strategies Photocatalysis Photocatalysts Reaction mechanism

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Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish(Danio rerio)

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Journal of Environmental Sciences 2024年第8期142卷 193-203页

作者： Fucong Zhang Chen Tang Yue Zhu qian Wang xin Huang Chunyan Yang Chengyong He Zhenghong Zuo Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems School of Life SciencesXiamen UniversityXiamen 361102China

Neburon is a phenylurea herbicide that is widely used worldwide,but its toxicity is poorly *** our previous study,we found that neburon has strong aryl hydrocarbon receptor(AhR)agonist activity,but whether it causes reproductive toxicity is not *** the present study,zebrafish were conducted as a model organism to evaluate whether environmental concentrations of neburon(0.1,1 and 10μg/L)induce reproductive disorder in *** exposure to neburon for 150 days from embryo to adult,that the average spawning egg number in high concentration group was 106.40,which was significantly lower than 193.00in control *** result was mainly due to the abnormal male reproductive behavior caused by abnormal transcription of genes associated with reproductive behavior in the brain,such as *** proportions of spermatozoa in the medium and high concentration groups were 82.40%and 83.84%,respectively,which were significantly lower than 89.45%in control *** result was mainly caused by hormonal disturbances and an increased proportion of apoptotic *** hormonal disruption was due to the significant changes in the transcription levels of key genes in the hypothalamus-pituitary-gonadal axis following neburon *** treatment also significantly activated the AhR signaling pathway,causing oxidative stress damage and eventually leading to a significant increase in apoptosis in the exposed ***,these data filled the currently more vacant profile of neburon toxicity and might provide information to assess the ecotoxicity of neburon on male reproduction at environmentally relevant concentrations.

关键词： Zebrafish Neburon Male reproductive toxicity HPG axis AhR agonist

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The potential impact of increased whole grain consumption among Chinese adults on reducing healthcare costs and carbon footprint

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Journal of Integrative Agriculture 2024年第8期23卷 2842-2852页

作者： xin Zhang Jingjing Wang Fuli Tan Haixiu gao Shenggen Fan Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China

Excessive consumption of refined grains harms human health and ecosystem *** grains,as a healthy and sustainable alternative to refined grains,can benefit individual health by providing dietary fiber,B vitamins,and bioactive ***,they aid in improving the environment due to their higher extraction rate and lower carbon emission during the processing ***,few studies have attempted to evaluate the economic and social benefits of increasing the amount of whole grain in grain *** paper estimates the potential savings in healthcare costs and reduced food carbon footprints(CFs)that could result from a shift toward whole grain consumption following the Chinese Dietary Guidelines(CDG).We investigate hypothetical scenarios where a certain proportion(5–100%)of Chinese adults could increase their whole grain intakes as proposed by CDG to meet the average shortfall of 30.2 *** that case,the healthcare costs for associated diseases(e.g.,type2 diabetes mellitus(T2DM),cardiovascular disease(CVD),and colorectal cancer(CRC))are expected to reduce by a substantial amount,from USD 2.82 to 56.37 billion;the carbon emission levels are also projected to decrease by0.24–5.72 million *** study provides compelling evidence that advocating for the transition towards greater consumption of whole grain products could benefit individual health,the environment,and society,by reducing both healthcare costs and carbon emissions.

关键词： whole grains cost analysis public health life cycle assessment(LCA) carbon footprint

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Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway

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Journal of Pharmaceutical Analysis 2024年第6期14卷 914-925页

作者： Guiqin Ye xin Sun Jiuzhou Li Yuanyuan Mai Ruilan gao Jianbin Zhang Cancer Center Department of Medical OncologyKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou310014China Clinical Laboratory Yuhuan City HospitalTaizhouZhejiang317600China Hangzhou Medical College Hangzhou311300China Department of Neurosurgery Binzhou People's HospitalBinzhouShandong256600China Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China

Lung cancer ranks the top of malignancies that cause cancer-related deaths *** leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory *** previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf,but their mechanism of action has still not fully *** synthesized Moracin N(MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic *** and its probe exerted similar growth-inhibitory effect on human lung cancer *** proteomic results showed that MAN targeted the programmed death ligand 1(PD-L1)checkpoint pathway and T cell receptor(TCR)signaling pathway,indicating its immune-regulatory ***-free surface plasmon resonance(SPR)results showed the direct interaction of MAN with PD-L1 *** docking analysis demonstrated that MAN bound to E158 residue of PD-L1 *** downregulated the expression levels of PD-L1 in a time-and dose-dependent manner and disrupted the PD-L1/programmed death 1(PD-1)binding,including other secondary metabolites of mulberry leaves Guangsangon E(GSE)and Chalcomoracin(CMR).Human peripheral blood mononuclear cells(PBMCs)co-cultured with MAN-treated A549 cells,resulting in the increase of CD8^(+)GZMB^(+)T cells and the decrease of CD8^(+)PD-1^(+)T *** suggested that MAN exerts anti-cancer effect through blocking the PD-L1/PD-1 *** vivo,MAN combined with anti-PD-1 antibody significantly inhibited lung cancer development and metastasis,indicating their synergistic *** together,secondary metabolites of mulberry leaves target the PD-L1/PD-1 signaling,enhance T cell-mediated immunity and inhibit the tumorigenesis of lung *** modulatory effect on tumor microenvironment makes them able to enhance the therapeutic efficacy of immune checkpoint inhibitors in lung cancer.

关键词： Moracin N Click chemistry PD-L1 T cell Lung cancer

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Investigation on the vortical structures by the Liutex method in turbulent channels at Re_(τ)=180 with scalloped and triangular riblet control

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Journal of Hydrodynamics 2024年第1期36卷 35-52页

作者： Zhang-dan Yu Shang Jiang Hai-dong Yu Bi-yu Pang xin Dong Yi-qian Wang School of Mathematical Sciences Soochow UniversitySuzhou215006China Beijing Institute of Astronautical System Engineering Beijing100076China

Riblets are a series of small protrusions formed along the flow direction,which have been extensively studied as a passive turbulent drag reduction *** and numerical simulations have shown that well-designed riblets can significantly reduce drag in turbulent flows,making them highly promising and valuable for various *** this study,we focus on a scalloped riblet,which is designed by smoothly connecting two third-order polynomials,and thus the sharpness of the tip and the curvature of the valley can be well *** conduct direct numerical simulations of turbulent channel with smooth plate,scalloped riblet-mounted and triangular riblet-mounted *** in wall units of W^(+)=20 and height-width ratio ofγ=0.5 are selected for both riblet *** with the smooth plate case,the scalloped riblet case achieves an 8.68%drag reduction,while the triangular riblet case achieves a 4.79%drag *** obtained drag reduction rate of the triangular riblet is consistent with previous experiments and simulations,and the results indicate that the scalloped riblet is more effective in reducing drag and deserves further *** compare turbulent statistics of the scalloped riblet case with those of the triangular riblet *** mean velocity profiles of riblets are similar,but both the Reynolds shear stress and second-order statistics of velocity fluctuations and Liutex are significantly reduced in the scalloped riblets controlled turbulent channel,indicating that the scalloped riblet can more effectively suppress the spanwise and wall-normal turbulent intensity near the *** also compare the pre-multiplied spectra of streamwise velocity and streamwise Liutex component for the three cases to investigate the energy distribution and characteristics of Liutex *** Liutex vortex identification method is also utilized to analyze the instantaneous flow field,which provides insights into the flow field and could be bene

关键词： Liutex vector riblet drag reduction tip sharpness turbulent channel scalloped

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Lead-free BiFeO_(3)-BaTiO_(3) based high-Tc ferroelectric ceramics:Antiferroelectric chemical modification leading to high energy storage performance

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Journal of Materiomics 2024年第4期10卷 819-827页

作者： Hongliang Wang Liang Shu Liyu Wei xin Zhang qian Li Jing-Feng Li State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Dielectric capacitors have been widely used in pulsed power devices owing to their ultrahigh power density,fast charge/discharge speed,and excellent ***,developing lead-free dielectric materials with a combination of high recoverable energy storage density and efficiency remains a ***,a high energy storage density of 7.04 J/cm^(3) as well as a high efficiency of 80.5%is realized in the antiferroelectric Ag(Nb_(0.85)Ta_(0.15))O_(3)-modified BiFeO3-BaTiO3 ferroelectric *** achievement is mainly attributed to the combined effect of a high saturation polarization(Pmax),increased breakdown field(Eb),and reduction of the remnant polarization(Pr).The modification of pseudotetragonal BiFeO3 by Ag(Nb_(0.85)Ta_(0.15))O_(3) leads to a high Pmax,and the enhanced relaxor behavior gives rise to a small *** promoted microstructure(such as a dense structure,fine grains,and compact grain boundaries)after modification results in a high breakdown ***,both the recoverable energy density and efficiency exhibit high stability over a broad range of operating frequencies(1–50 Hz)and working temperatures(25–120℃).These results suggest that the(0.67–x)BiFeO_(3)-0.33BaTiO_(3)-xAg(Nb_(0.85)Ta_(0.15))O_(3) ceramics can be highly competitive as a lead-free relaxor for energy storage applications.

关键词： BiFeO_(3) Lead-free ceramics Dielectric capacitors Energy storage

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Research progress of CO_(2) capture and mineralization based on natural minerals

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1208-1227页

作者： Chenguang qian Chunquan Li Peng Huang Jialin Liang xin Zhang Jifa Wang Jianbing Wang Zhiming Sun School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Shanghai Construction Building Material Technology Group Shanghai 200080China

Natural minerals,such as kaolinite,halloysite,montmorillonite,attapulgite,bentonite,sepiolite,forsterite,and wollastonite,have considerable potential for use in CO_(2) capture and mineralization due to their abundant reserves,low cost,excellent mechanical prop-erties,and chemical *** the past decades,various methods,such as those involving heat,acid,alkali,organic amine,amino sil-ane,and ionic liquid,have been employed to enhance the CO_(2) capture performance of natural minerals to attain high specific surface area,a large number of pore structures,and rich active *** research on CO_(2) capture by natural minerals will focus on the full utiliza-tion of the properties of natural minerals,adoption of suitable modification methods,and preparation of composite materials with high specific surface area and rich active *** addition,we provide a summary of the principle and technical route of direct and indirect mineralization of CO_(2) by natural *** process uses minerals with high calcium and magnesium contents,such as forsterite(Mg_(2)SiO_(4)),serpentine[Mg_(3)Si_(2)O(OH)_(4)],and wollastonite(CaSiO_(3)).The research status of indirect mineralization of CO_(2) using hydro-chloric acid,acetic acid,molten salt,and ammonium salt as media is also introduced in *** recovery of additives and high-value-added products during the mineralization process to increase economic benefits is another focus of future research on CO_(2) mineralization by natural minerals.

关键词： natural mineral carbon dioxide capture modification composite material carbon dioxide mineralization

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