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Paraneoplastic leukemoid reaction in a patient with sarcomatoid hepatocellular carcinoma: A case report

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World Journal of Clinical Cases 2019年第11期7卷 1330-1336页

作者： bo Hu xin-Ting Sang Xiao-bo Yang Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Sarcomatoid hepatocellular carcinoma (SHC) combined with paraneoplastic leukemoid reaction (PLR), which is associated with a poor prognosis, is rarely seen in the clinic. here, we report the case of a patient in the above situation. CASE SUMMARY A 75-year-old female patient with a past medical history of hypertension and cerebral infarction paid a hospital visit as a result of right upper quadrant abdominal pain and anorexia for two months. Laboratory examination revealed a white blood cell (WBC) count of 43790/μL, which was then increased up to 77050/μL. In addition, the results of bone marrow examination suggested a leukemoid reaction. Computed tomography (CT) revealed a focal hepatic mass, which was confirmed through pathological examination to be an SHC postoperatively. In addition, the WBC count had fallen to a normal level before she left the hospital. However, the patient died two and a half months after the second hospital admission. CONCLUSION This is a rare case of SHC combined with PLR, both of which have an extremely poor prognosis.

关键词： Paraneoplastic leukemoid reaction White blood cells bone marrow examination Sarcomatoid hepatocellular carcinoma Poor prognosis Case report

Eco-friendly aqueous foam stabilized by cellulose microfibers with great salt tolerance and high temperature resistance

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Petroleum Science 2023年第4期20卷 2499-2511页

作者： Li-Li Yang Xian-bo he Yi-Xiu Cheng Guan-Cheng Jiang Ze-Yu Liu Shi-bo Wang Shi-xin Qiu Jian-Hua Wang Wei-Guo Tian MOE Key Laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and EngineeringChina University of Petroleum(Beijing)Changping DistrictBeijing102249China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of Chemistry Chinese Academy of Sciences(CAS)Haidian DistrictBeijing100190China MOE Key CNPC Drilling Research Institute Changping DistrictBeijing102206China

A low-cost eco-friendly aqueous foam,especially the robust foam with great tolerance to high salinity and high temperature,is in great demand in the oil industry,e.g.,oil and gas well or geothermal well ***,an ultra-stable aqueous foam was developed using the biodegradable cellulose microfiber(CMF)as a foam *** foam stabilized by CMF shows excellent tolerance to the high concentration of NaCl(6.0 wt%)and CaCl_(2)(0.25 wt%)and the related drainage half-life times(T_(0.5))reach 1750 and 2340 s *** contrast,the foams without CMF are completely drained(T_(0.5)=0 s)when NaCl concentration is greater than 6.0 wt%or CaCl_(2) concentration is greater than 0.20 wt%.Notably,T0.5 of the foams stabilized by CMF at these saline concentrations still can maintain above 1000 s even after aging at 120℃ for 16 h,exhibiting an outstanding foam-stabilizing performance at high *** results suggest that the salt and high-temperature tolerance of CMF in foam stabilization is attributed to the electrically uncharged surfaces,the formation of a gel-like structure and the excellent thermal *** work not only provides a promising candidate of aqueous foam stabilizer to deal with high temperature and high salinity but also presents a natural-based solution for an environmentally friendly drilling industry in the future.

关键词： Aqueous foam Foam stabilizer Cellulose microfiber Salt tolerance Sustainable

Multiple genotyping based on multiplex PCR and microarray

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Chinese Chemical Letters 2016年第11期27卷 1661-1665页

作者： Xian-bo Mou Zeeshan Ali bo Li Tao-Tao Li Huan Yi Hong-Ming Dong Nong-Yue he Yan Deng xin Zeng State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology Hunan University of Technology Zhuzhou 412007 China Nanjing Maternity and Child health Care Hospital Nanjing 210029 China

The genetic variability has obtained more and more attention in the process of diagnosis and treatment of tumors. herein, we have described a multiple genotyping method based on magnetic enrichment- multiplex PCR （MEM-PCR） and microarray technology. Monodisperse magnetic beads were fabricated and modified with streptavidin. Four loci on two genes （M235T and A-6G loci on AGT gene, A1298C and C677T loci on MTHFR gene） were selected to study single nucleotide polymorphisms （SNP）. Target sequences of these SNP loci were amplified using Cy3-1abeled primers through multiplex PCR in one tube after the templates were enriched and purified by functional magnetic beads （MB）. Four pairs of NH2- labeled probes, corresponding to each locus, were fixed on CHO-modified glass slide by covalent binding. Hybridization between target sequences and probes was performed under suitable conditions. The spotting locations on microarray and the ratio of fluorescence intensity, produced by different loci, were used to distinguish the SNP genotypes. Finally, three of gastric cancer samples were collected and genotvping analysis for these four SNP loci was carried out successfully simultaneously by this method.

关键词： Magnetic beads Multiplex PCR Microarray Multiple genotyping Gastric cancer

The Double Self—Dual Gravity with Cosmological Term and Constraints Under the Double Constant Conformal Transformation

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Communications in Theoretical Physics 2002年第6期37卷 663-666页

作者： WUYa－bo GUOYong－xin DepartmentofPhysics LiaoningNormalUniversityDalian116029China DepartmentofPhysics LiaoningUniversityShenyang110036China

The double constraint equations in the self-dual gravitational theory containing the cosmological term are derived in gravity. Furthermore, in order to deeply study the Lorentzian and Euclidean reality conditions for this theory, the relations between constraints are discussed by introducing the double constant conformal transformation and the double complex function method.

关键词： self-dual gravity constraint equations conformal transformations reality conditions

C-jun N-terminal Kinase-mediated Signaling Is Essential for Staphylococcus Aureus-induced U937 Apoptosis

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Chinese Medical Sciences Journal 2009年第1期24卷 26-29页

作者： Jia-he Wang bo Yu Hui-yan Niu Hui Li Yi Zhang xin Wang Ping he Department of Geriatrics Shengjing HospitalChina Medical University Shenyang 110004 China Department of Neurosurgery Shengjing HospitalChina Medical University Shenyang 110004 China

Objective To investigate the effect of SP600125, a specific c-jun N-terminal protein kinase (JNK) inhibitor, on Staphylococcus aureus (S. aureus)-induced U937 cell death and the underlying mechanism. Methods The human monocytic U937 cells were treated with S. aureus at different time with or without SP600125. Cell apoptosis was analyzed by flow cytometry. JNK, Bax, and caspase-3 activities were detected by Western blotting. Results S. aureus induced apoptosis in cultured U937 cells in a time-dependent manner. Expression of Bax and phospho-JNK significantly increased in S. aureus-treated U937 cells, and the level of activated caspase-3 also increased in a time-dependent manner. Inhibition of JNK with SP600125 significantly inhibited S. aureus-induced apoptosis in U937 cells. Conclusions S. aureus can induce apoptosis in U937 cells by phosphorylation of JNK and activation of Bax and caspase-3. SP600125 protects U937 cells from apoptosis induced by S. aureus via inhibiting the activity of JNK.

关键词： cell apoptosis U937 cells Staphylococcus aureus JNK signaling pathway SP600125

From macro to microarchitecture: reviews and trends of SRAM-based compute-in-memory circuits

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Science China(Information Sciences) 2023年第10期66卷 42-60页

作者： Zhaoyang ZHANG Jinwu CheN Xi CheN An GUO bo WANG Tianzhu XIONG Yuyao KONG xingyu PU Shengnan he xin SI Jun YANG National Application Specific Integrated Circuit Center Southeast University

The rapid growth of CMOS logic circuits has surpassed the advancements in memory access,leading to significant “memory wall” bottlenecks, particularly in artificial intelligence applications. To address this challenge, compute-in-memory(CIM) has emerged as a promising approach to enhance the performance,area efficiency, and energy efficiency of computing systems. By enabling memory cells to perform parallel computations, CIM improves data reuse and minimizes data movement between the memory and the processor. This study conducts a comprehensive review of various domains of SRAM-based CIM macros and their associated computing paradigms. Additionally, it presents a survey of recent SRAM-CIM macros, with a specific focus on the key challenges and design tradeoffs involved. Furthermore, this research identifies potential future trends in SRAM-CIM macro-level design, including hybrid computing, precision enhancement, and operator reconfiguration. These trends aim to resolve the tradeoff between computational accuracy, energy efficiency, and support for diverse operators within the SRAM-CIM framework. At the microarchitecture level, two possible solutions for tradeoffs are proposed: chiplet integration and sparsity optimization. Finally,research perspectives are proposed for future development.

关键词： artificial intelligence (AI) compute-in-memory (CIM) static random access memory (SRAM)

Brain injury in combination with tacrolimus promotes the regeneration of injured peripheral nerves

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Neural Regeneration Research 2017年第6期12卷 987-994页

作者： xin-ze he Jian-jun Ma Hao-qi Wang Tie-min Hu bo Sun Yun-feng Gao Shi-bo Liu Wei Wang Pei Wang Department of Hand and Foot Surgery Affiliated Hospital of Chengde Medical College Binzhou Central Hospital Postgraduate School Chengde Medical College Department of Neurosurgery Affiliated Hospital of Chengde Medical College Department of Hand and Foot Surgery the First Hospital of Qinhuangdao

both brain injury and tacrolimus have been reported to promote the regeneration of injured peripheral nerves. In this study, before transection of rat sciatic nerve, moderate brain contusion was（or was not） induced. After sciatic nerve injury, tacrolimus, an immunosuppressant, was（or was not） intraperitoneally administered. At 4, 8 and 12 weeks after surgery, Masson＇s trichrome, hematoxylin-eosin, and toluidine blue staining results revealed that brain injury or tacrolimus alone or their combination alleviated gastrocnemius muscle atrophy and sciatic nerve fiber impairment on the experimental side, simultaneously improved sciatic nerve function, and increased gastrocnemius muscle wet weight on the experimental side. At 8 and 12 weeks after surgery, brain injury induction and/or tacrolimus treatment increased action potential amplitude in the sciatic nerve trunk. Horseradish peroxidase retrograde tracing revealed that the number of horseradish peroxidase-positive neurons in the anterior horn of the spinal cord was greatly increased. Brain injury in combination with tacrolimus exhibited better effects on repair of injured peripheral nerves than brain injury or tacrolimus alone. This result suggests that brain injury in combination with tacrolimus promotes repair of peripheral nerve injury.

关键词： tacrolimus injured nerves regeneration alone axonal hematoxylin peroxidase tracing Schwann

Energetics and diffusion of point defects in Au/Ag metals:A molecular dynamics study

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Chinese Physics B 2019年第8期28卷 95-104页

作者： Zhi-Yong Liu Bin he xin Qu Li-bo Niu Ru-Song Li Fei Wang Xi’an High Technology Institute

To reveal the potential aging mechanism for self-irradiation in Pu-Ga alloy,we choose Au-Ag alloy as its substitutional material in terms of its mass density and lattice *** a first step for understanding the microscopic behavior of point defects in Au-Ag alloy,we perform a molecular dynamics(MD)simulation on energetics and diffusion of point defects in Au and Ag *** results indicate that the octahedral self-interstitial atom(SIA)is more stable than the tetrahedral *** stability sequence of point defects for he atom in Au/Ag is:substitutional site>octahedral interstitial site>tetrahedral interstitial *** he-V cluster(hen Vm,V denotes vacancy)is the most stable at n=*** the mono-vacancy diffusion,the MD calculation shows that the first nearest neighbour(1 NN)site is the most favorable site on the basis of the nudged elastic band(NEB)calculation,which is in agreement with previous experimental *** are two peaks for the second nearest neighbour(2 NN)and the third nearest neighbour(3 NN)diffusion curve in octahedral interstitial site for he atom,indicating that the 2 NN and 3 NN diffusion for octahedral SIA would undergo an intermediate defect structure similar to the 1 NN *** 3 NN diffusion for the tetrahedral SIA and he atom would undergo an intermediate site in analogy to its initial *** diffusion of point defects,the vacancy,SIA,he atom and he-V cluster may have an analogous effect on the diffusion velocity in Ag.

关键词： interatomic potential radiation damage point defect diffusion barrier

Synthesis of highly active Cu(Ⅰ)-Y(Ⅲ)-Y zeolite and its selective adsorption desulfurization performance in presence of xylene isomers

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Petroleum Science 2021年第1期18卷 295-306页

作者： bo-Long Jiang Nan Jiang You-xin Chang Innovation Institute for Sustainable Maritime Architecture Research and Technology Qingdao University of TechnologyQingdao 266000China Chongqing Changshou Sino French Water Co.Ltd. Chongqing 404100China

A bimetal-exchanged NaY zeolite(Cu(Ⅰ)-Y(Ⅲ)-Y)with a desirable adsorptive desulfurization(ADS)performance was prepared and characterized by means of X-ray diffraction,specific surface area measurements,X-ray fluorescence spectrometer,X-ray photoelectron spectroscopy,thermal gravity analysis and Fourier transform infrared *** effect of Y(Ⅲ)ions on ADS in the presence of the xylenes was *** indicated that the ADS performance of Y(Ⅲ)-Y is higher than that of most reported *** Y(Ⅲ)-based Cu(Ⅰ)-Y(Ⅲ)-Y demonstrated the higher breakthrough loading than those of reported Ce(Ⅲ)/Ce(Ⅳ)-based transition metal Y zeolites,showing that Y(Ⅲ)ions play a promoting role in improving the ADS *** Cu(Ⅰ)-Y(Ⅲ)-Y,a new strong S-M interaction(S stands for sulfur,while M stands for metal)active site was formed,which might be caused by the synergistic effect between Cu(Ⅰ)and Y(Ⅲ).The Cu(Ⅰ)-Y(Ⅲ)-Y,which combined the advantages of Cu(I)-Y and Y(Ⅲ)-Y,is a kind of promising *** breakthrough loading decreased in the order of Cu(Ⅰ)-Y(Ⅲ)-Y>Y(Ⅲ)-Y>Cu(Ⅰ)-Y,and the effect of xylene isomers on the sulfur removal was in the order of ortho-xylene>meta-xylene>para-xylene,which exhibited the same trend with the bond order of xylenes.

关键词： Desulfurization Yttrium Copper Y zeolite Competitive adsorption Xylenes