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Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 422-437页

作者： xin LI Yanan HU Yueting wu Zuocheng YANG Yang LIU Hanmin LIU Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China NHC Key Laboratory of Chronobiology(Sichuan University) Chengdu 610041China The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital Sichuan University and School of Life Sciences of Fudan UniversityWest China Institute of Women and Children's HealthWest China Second University HospitalSichuan UniversityChengdu 610041China Sichuan Birth Defects Clinical Research Center West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics the Third Xiangya HospitalCentral South UniversityChangsha 410013China

Viral myocarditis(VMC)is one of the most common acquired heart diseases in children and ***,its pathogenesis is still unclear,and effective treatments are *** study aimed to investigate the regulatory pathway by which exosomes alleviate ferroptosis in cardiomyocytes(CMCs)induced by coxsackievirus B3(CVB3).CVB3 was utilized for inducing the VMC mouse model and cellular *** echocardiography,left ventricular ejection fraction(LVEF),and left ventricular fractional shortening(LVFS)were implemented to assess the cardiac *** CVB3-induced VMC mice,cardiac insufficiency was observed,as well as the altered levels of ferroptosis-related indicators(glutathione) peroxidase 4(GPX4),glutathione(GSH),and malondialdehyde(MDA).However,exosomes derived from human umbilical cord mesenchymal stem cells(hucMSCs-exo)could restore the changes caused by CVB3 ***-7a-5p was enriched in hucMSCs-exo,and the inhibitory ffect of hucMSCs-exoa-ie-pmimo on CVB3-induced ferroptosis was higher than that of hucMSCs-exommie N(NC:negative control).Mothers against decapentaplegic homolog 2(SMAD2)increased in the VMC group,while the expression of zinc-finger protein 36(ZFP36)***-7a-5p was confirmed to interact with SMAD2 messenger RNA(mRNA),and the SMAD2 protein interacted directly with the ZFP36 *** SMAD2 and overexpressing ZFP36 inhibited the expression of ferroptosis-related ***,the levels of GPX4,solute carrier family 7,member 11(SLC7A11),and GSH were lower in the SMAD2 overexpression plasmid(oe-SMAD2)+let-7a-5p mimic group than in the oe-NC+let-7a-5p mimic group,while those of MDA,reactive oxygen species(ROS),and Fe^(2+)*** conclusion,these data showed that ferroptosis could be regulated by mediating SMAD2 ***-let-7a-5p derived from hucMSCs could mediate SMAD2 to promote the expression of ZFP36,which further inhibited the ferroptosis of CMCs to alleviate CVB3-induced VMC.

关键词： Exosome Let-7a-5p Mothers against decapentaplegic homolog 2(SMAD2) Coxsackievirus B3(CVB3) Ferroptosis

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Photoredox-Catalyzed Metal-Free Regio-&Stereoselective C(sp^(2))-H Amination of Enamides with N-Aminopyridium Salts

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Chinese Journal of Chemistry 2024年第18期42卷 2235-2242页

作者： Zheng-bao Qin Kun Ni Li Wang Xiao-Di wu Yu Zhang Kai Zhao Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjingJiangsu211816China college of Chemical Engineering Nanjing Forestry UniversityNanjingJiangsu 210037China

A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp')-H amination of enamides with bench-stable and A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp)-H amination of enamides with bench-stable and easily accessible N-aminopyridium salts is developed,affording synthetically and biologically prominent vicinal 1,2-diamine scaffolds with broad substrate scope and excellent functional group *** transformation proceeded through a radical pathway involving the Giese addition of the relatively electrophilic N-centered sulfonamidyl radical species to nucleophilicβ-olefinic position of enamides followed by the ensuing single electron oxidation andβ-H elimination,delivering geometrically-defined Z-configuredβ-sulfonamidylated *** operational simplicity,environmental friendliness and cost efficiency of this methodology allowed it to pave a new avenue to enrich the arsenal of synthetically crucial functionalized enamides and their related derivatives.

关键词： Enamides Amination Photoredox catalysis Regioselective Stereoselective Metal-free

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Interfacial engineering for high-performance garnet-based solid-state lithium batteries

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SusMat 2024年第1期4卷 72-105页

作者： Lingchen Wang Jiaxin wu Chengshuai bao Zichang You Yan Lu Zhaoyin Wen State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina

Solid-state batteries represent the future of energy storage technology,offering improved safety and energy ***-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO)solidstate electrolytes-based solid-state lithium batteries(SSLBs)stand out for their appealingmaterial properties and chemical ***,their successful deployment depends on conquering interfacial *** review article primarily focuses on the advancement of interfacial engineering for LLZO-based *** commence with a concise introduction to solid-state electrolytes and a discussion of the challenges tied to interfacial properties in LLZO-based *** deeply explore the correlations between structure and properties and the design principles vital for achieving an ideal electrode/electrolyte ***,we delve into the latest advancements and strategies dedicated to overcoming these challenges,with designated sections on cathode and anode interface *** the end,we share our insights into the advancements and opportunities for interface design in realizing the full potential of LLZO-based SSLBs,ultimately contributing to the development of safe and high-performance energy storage solutions.

关键词： anode interfaces cathode interfaces garnet-based electrolytes interfacial modifications solidstate lithium batteries

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How incubation temperature affects hatchling performance in reptiles: an integrative insight based on plasticity in metabolic enzyme

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Current Zoology 2024年第2期70卷 195-203页

作者： Dan-Yang wu xing-Zhi Han Teng Li bao-Jun Sun Xiao-Yan Qin College of Life and Environment Sciences Minzu University of ChinaBeijing 100081China Key Laboratory of Animal Ecology and Conservational Biology Institute of ZoologyChinese Academy of SciencesBeijing 10011China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China College of Resources and Environmental Sciences Nanjing Agricultural UniversityNanjing 210095China

Evaluating the effects of temperature variations on animals plays an important role in understanding the threat of climate *** effects of developmental temperature on offspring performance are critical in evaluating the effects of warming temperatures on the fitness of ovipa-rous species,but the physiological and biochemical basis of this developmental plasticity is largely *** this study,we incubated eggs of the turtle Pelodiscus sinensis at low(24℃),medium(28℃),and high(32℃)temperatures,and evaluated the effects of developmental temperature on offspring fitness,and metabolic enzymes in the neck and limb muscles of *** hatchlings from eggs incubated at the medium temperature showed better fitness-related performance(righting response and swimming capacity)and higher activities of metabolic enzymes(hexokinase,HK;lactate dehydrogenase,LDH)than hatchlings from the eggs incubated at high or low *** addition,the swimming speed and righting response were significantly correlated with the HK activities in limb(swimming speed)and neck(righting response)muscles,suggesting that the developmental plasticity of energy metabolic pathway might play a role in determining the way incubation temperature affects offspring *** the fitness-related performance and the activities of metabolic enzymes,we predict that the P sinensis from high latitude would not face the detrimental effects of climate warming until the average nest temperatures reach 32℃.

关键词： developmental plasticity energetic metabolism enzyme activity hatchling turtle.

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Key technology and application of AB_(2) hydrogen storage alloy in fuel cell hydrogen supply system

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Materials Reports(Energy) 2024年第1期4卷 113-122页

作者： Ming Yao Jianguang Yuan bao Zhang Youhua Yan Shaoxiong Zhou Ying wu School of Energy Power and Machinery Engineering North China Electric Power UniversityNo.2 BeinongluChangping DistrictBeijing 102206China Institute of Energy Power Innovation North China Electric Power UniversityNo.2 BeinongluChangping DistrictBeijing 102206China Jiangsu JITRI Advanced Energy&Materials Research Institute Co. LtdNo.5 ChongyinanluXinbei DistrictChangzhou 213000China

At present,there is limited research on the application of fuel cell power generation system technology using solid hydrogen storage materials,especially in hydrogen-assisted *** the disadvantages of low hydrogen storage capacity and poor kinetics of hydrogen storage materials,our primary focus is to achieve smooth hydrogen ab-/desorption over a wide temperature range to meet the requirements of fuel cells and their integrated power generation *** this paper,the Ti_(0.9)Zr_(0.1)Mn_(1.45)V_(0.4)Fe_(0.15) hydrogen storage alloy was successfully prepared by arc *** maximum hydrogen storage capacity reaches 1.89 wt% at 318 *** alloy has the capability to absorb 90% of hydrogen storage capacity within 50 s at 7 MPa and release 90% of hydrogen within 220 *** Multiphysics 6.0 software was used to simulate the hydrogen ab-/desorption processes of the *** flow rate of cooling water during hydrogen absorption varied in a gradient of(0.02 t x)m s^(-1)(x=0,0.02,0.04,0.06,0.08,0.1,0.12).Cooling water flow rate is positively correlated with the hydrogen absorption rate but negatively correlated with the *** the cooling rate is 0.06 m s^(-1),both simulation and experimentation have shown that the hydrogen storage tank is capable of steady hydrogen desorption for over 6 h at a flow rate of 2 L min^(-1).Based on the above conclusions,we have successfully developed a hydrogen-assisted two-wheeler with a range of 80 km and achieved regional demonstration operations in Changzhou and *** paper highlights the achievements of our team in the technological development of fuel cell power generation systems using solid hydrogen storage materials as hydrogen storage carriers and their application in twowheelers in recent years.

关键词： AB_(2)hydrogen storage alloy Hydrogen storage tanks Simulation Hydrogen-electric coupling system Power-assisted two-wheelers

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Dissolution kinetics and reaction mechanism of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag

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Journal of Iron and Steel Research International 2024年第4期31卷 861-869页

作者： Yao-xin Du Yan-wu Dong Zhou-hua Jiang Ganna Stovpchenko Yu-shuo Li Jun Huang xin-wei Wang Yu-xiao Liu School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Ecological Metallurgy of Multimetallic Mineral Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina E.O.Paton Electric Welding Institute of the National Academy of Science of Ukraine Kiev 03115Ukraine

The dissolution behavior of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag,a basic slag system of electroslag remelting process,was investigated by rotating cylinder method using corundum rods to simulate Al_(2)O_(3) inclusions in *** experimental results show that the dissolution rate of Al_(2)O_(3);rods in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in rotating speed and temperature,and the rate-controlling step is the mass transfer in the *** dissolution rate of Al_(2)O,in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in the ratio of CaO to Al_(2)O_(3),which is due to the increase in dissolution driving force and the decrease in slag *** apparent activation energy of the mass transfer of AlOs in slag C is calculated to be 222.86 kJ mol^(-1).During the dissolution of Al_(2)0,inclusions in the slag,it reacts with F in liquid slag at first,then reacts with CaO to form the intermediate compounds of xCaO-yAl_(2)O_(3) system,and finally dissolves in molten *** dissolution rate of Al_(2)O_(3) inclusions in CaF_(2)-CaO-Al_(2)O_(3) slag for electroslag remelting is positively correlated with the ratio of the dissolution driving force and slag viscosity,and the correlation coeficient is 2.487×10^(-11).

关键词： Inclusion Electroslag remelting Mass transfer:Dissolution rate-Dissolution driving force

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High performance 2T0C DRAM cells based on atomic-layer-deposited InAlZnO FETs

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Science China(Information Sciences) 2024年第9期67卷 344-345页

作者： Wen XIONG Binbin LUO Wei MENG bao ZHU Xiaohan wu Shi-Jin DING School of Microelectronics Fudan University

Recently, the oxide semiconductor-based 2T0C dynamic random-access memory(DRAM) has shown great potential in monolithic three-dimensional(M3D)-integrated memory,owing to some unique advantages of oxide semiconductors,such as high electron mobility, wide band gap, and compatibility with back-end-of-line(BEOL) processes [1, 2].

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Adaptive evolution of scn4aa in Takifugu and Tetraodon

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Aquaculture and Fisheries 2024年第5期9卷 745-752页

作者： Hexing wu Yonglai Hu Jing Wang Xiaoling Gong baolong bao Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of EducationInternational Research Center for Marine Biosciences at Shanghai Ocean UniversityMinistry of Science and TechnologyNational Demonstration Center for Experimental Fisheries Science EducationShanghai Ocean UniversityShanghai201306China

Tetrodotoxin(TTX)is a potent neurotoxin firstly discovered in the ovary of *** genetic basis of voltage-gated sodium channel resistance to TTX has been widely studied,but it remains unclear in the evolution history of voltage-gated sodium channel resistance to TTX in pufferfish with different TTX *** this study,six scn4aa coding sequences of pufferfish were firstly cloned and sequenced,then used to investigate the adaptive evolution of scn4aa associated with TTX concentration and reconstruct ancestral sequences with seven scn4aa of other *** result of CODEML(codon substitution model)program from the PAML(phylogenetic analysis by maximum likelihood)package shows only in the genus of Takifugu,which contains TTX highly in the liver,under positive *** result also indicates that three of four positively selected sites are located in the intracellular regions,which may compensate for normal *** ancestral sequence reconstruction may suggest that the replacements providing weak toxin resistance might have appeared first in scn4aa,then the genus Takifugu evolved stronger resistance to TTX *** results contribute to the explanation of the evolutional history of voltage-gated sodium channel resistance to TTX in pufferfish.

关键词： Tetrodotoxin Voltage-gated sodium channel scn4aa Adaptive evolution Pufferfish

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Orbit and clock products for quad-system satellites with undifferenced ambiguity fixing approach

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Satellite Navigation 2024年第1期5卷 125-139页

作者： Jiaqi wu xingxing Li Yongqiang Yuan Keke Zhang xin Li Jiaqing Lou Yun Xiong School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079China Hubei Luojia Laboratory 129 Luoyu RoadWuhan430079China German Research Centre for Geosciences GFZ Telegrafenberg14473PotsdamGermany Technische Universitat Berlin(TUB) Straße Des 17.Juni10623BerlinGermany

Integer Ambiguity Resolution(IAR)can significantly improve the accuracy of GNSS Precise Orbit Determination(POD).Traditionally,the IAR in POD is achieved at the Double Differenced(DD)*** this contribution,we develop an Un-Differenced(UD)IAR method for Global Positioning System(GPS)+BeiDou Navigation Satellite System(BDS)+Galileo navigation satellite system(Galileo)+Global'naya Navigatsionnaya Sputnikovaya Sistema(GLONASS)quad-system POD by calibrating UD ambiguities in the raw carrier phase and generating the so-called carrier *** on this method,we generate the UD ambiguity-fixed orbit and clock products for the wuhan Innovation Application Center(IAC)of the International GNSS Monitoring and Assessment System(iGMAS).One-year observations in 2020 from 150 stations are employed to investigate performance of orbit and clock ***,the UD Ambiguity Resolution(AR)yields more resolved integer ambiguities than the traditional DD AR,scaling up to 9%,attributable to its avoidance of station baseline *** from the removal of ambiguity parameters,the computational efficiency of parameter estimation undergoes a substantial 70%*** with the float solution,the orbit consistencies of UD AR solution achieve the accuracy of 1.9,5.2,2.8,2.1,and 2.7 cm for GPS,BeiDou-2 Navigation Satellite System(BDS-2),BeiDou-3 Navigation Satellite System(BDS-3),Galileo,and GLONASS satellites respectively,reflecting enhancements of 40%,24%,54%,34%,and 42%.Moreover,the standard deviations of Satellite Laser Ranging(SLR)residuals are spanning 2.5–3.5 cm,underscoring a comparable accuracy to the DD AR solution,with discrepancies below 5%.A notable advantage of UD AR lies in its capability to produce the Integer Recovered Clock(IRC),facilitating Precise Point Positioning(PPP)AR without requiring additional Uncalibrated Phase Delay(UPD)*** assess the performance of quad-system kinematic PPP based on IRC,a network comprising 120 stations is uti

关键词： Multi-GNSS Precise orbit determination Integer recover clock Undifferenced ambiguity resolution iGMAS innovation application center

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Halotolerant Bacillus *** RA coordinates myo-inositol metabolism to confer salt tolerance to tomato

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Journal of Integrative Plant Biology 2024年第9期66卷 1871-1885页

作者： Fenghui wu Zengting Chen Xiaotong Xu xin Xue Yanling Zhang Na Sui Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJinan 250014China Dongying Key Laboratory of Salt Tolerance Mechanism and Application of Halophytes Dongying InstituteShandong Normal UniversityNo.2 Kangyang RoadDongying 257000China

Soil salinity is a worldwide problem threatening crop *** plant growth-promoting rhizobacteria(PGPR)could survive in high salt environment and assist plant adaptation to ***,the genomic and metabolic features,as well as the regulatory mechanisms promoting salt tolerance in plants by these bacteria remain largely *** the current work,a novel halotolerant PGPR strain,namely,Bacillus *** RA can enhance tomato tolerance to salt *** genomic analysis of strain RA with its closely related species indicated a high level of evolutionary plasticity exhibited by strain-specific genes and evolutionary constraints driven by purifying selection,which facilitated its genomic adaptation to salt-affected *** transcriptome further showed that strain RA could tolerate salt stress by balancing energy metabolism via the reprogramming of biosynthetic *** exude a plethora of metabolites that can strongly influence plant *** accumulation of myo-inositol in leaves under salt stress was observed,leading to the promotion of plant growth triggered by Bacillus *** ***,myo-inositol serves as a selective force in the assembly of the phyllosphere microbiome and the recruitment of plant-beneficial *** promotes destabilizing properties in phyllosphere bacterial co-occurrence networks,but not in fungal ***,interdomain interactions between bacteria and fungi were strengthened by myo-inositol in response to salt *** work highlights the genetic adaptation of RA to salt-affected soils and its ability to impact phyllosphere microorganisms through the adjustment of myo-inositol metabolites,thereby imparting enduring resistance against salt stress in tomato.

关键词： myo‐inositol PGPR phyllosphere microorganisms salt stress tomato

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