检索结果-南通市图书馆

Lactiplantibacillus plantarum AR113 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 2132-2140页

作者： Zhiqiang Xiong Gang Liu Ling Fang Xiuming Li Yongjun Xia Guangqiang Wang xin song Lianzhong ai Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Rehabilitation Huashan HospitalFudan UniversityShanghai 200040China Department of Rehabilitation Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Stroke is one of the leading causes of death and disability ***,information on stroke-related tongue coating microbiome(TCM)is limited,and whether TCM modulation could benefit for stroke prevention and rehabilitation is ***,TCM from stroke patients(SP)was characterized using molecular *** occurrence of stroke resulted in TCM dysbiosis with significantly reduced species richness and *** abundance of Prevotella,Leptotrichia,Actinomyces,Alloprevotella,Haemophilus,and TM7_[G-1]were greatly reduced,but common infection Streptococcus and Pseudomonas were remarkably ***,an antioxidative probiotic Lactiplantibacillus plantarum AR113 was used for TCM intervention in stroke rats with cerebral ischemia/reperfusion(I/R).AR113 partly restored I/R induced change of TCM and gut microbiota with significantly improved neurological deficit,relieved histopathologic change,increased activities of antioxidant enzymes,and decreased contents of oxidative stress ***,the gene expression of antioxidant-related proteins and apoptosis-related factors heme oxygenase-1(HO-1),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),nuclear factor erythroid 2-related factor 2(Nrf2),NAD(P)H:quinone oxidoreductase-1(NQO-1),and Bcl-2 was significantly increased,but cytochrome C,cleaved caspase-3,and Bax were markedly decreased in the brain by AR113 *** results suggested that AR113 could ameliorate cerebral I/R injury through antioxidation and anti-apoptosis pathways,and AR113 intervention of TCM may have the application potential for stroke prevention and control.

关键词： Stroke Cerebral ischemia/reperfusion Tongue coating Lactiplantibacillus plantarum AR113 Probiotic intervention

Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第4期36卷 385-395页

作者： Qing Yang Xiao-Jing Yu Qing Su Qiu-Yue Yi xin-ai song Xiao-Lian Shi Hong-Bao Li Jie Qi Guo-Qing Zhu Yu-Ming Kang Department of Physiology and Pathophysiology Xi'an Jiaotong University School of Basic Medical SciencesKey Laboratory of Environment and Genes Related to Diseases of the Ministry of EducationXi'an Jiaotong UniversityXi’an 710061China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Pharmacology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061China Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of PhysiologyNanjing Medical UniversityNanjing 210029China

Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanism of action of the TLR4 signaling pathway in salt-induced hypertension. Salt-sensitive rats were given a high salt diet for 10 weeks to induce hypertension. This resulted in higher levels of TLR4, activated c-Src, pro-inflammatory cytokines, oxidative stress, and arterial pressure. Infusion of a TLR4 blocker into the hypothalamic paraventricular nucleus (PVN) decreased the activated c-Src, while microinjection of a c-Src inhibitor attenuated the PVN levels of nuclear factor-kappa B, pro-inflammatory cytokines, and oxidative stress. Our findings suggest that a longterm high-salt diet increases TLR4 expression in the PVN and this promotes the activation of c-Src, which upregulates the expression of pro-inflammatory cytokines and results in the overproduction of reactive oxygen ***, inhibiting central c-Src activity may be a new target for treating hypertension.

关键词： Toll-like receptor 4 Cellular Src Inflammatory cytokines Oxidative stress Hypothalamic paraventricular nucleus Salt-induced hypertension

Lactobacillus plantarum AR495 improves stress-induced irritable bowel syndrome in rats by targeting gut microbiota and Mast cell-PAR2-TRPV1 signaling pathway

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun Zhang Guangqiang Wang Zhiqiang Xiong Zhuan Liao Yangyan Qian xin song Li Sui Lianzhong ai Yongjun Xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal *** this study,the effects of Lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were *** results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and *** AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root *** further showed that supplementation with *** AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the *** addition,the microbiota analysis of the colon indicated that *** AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain *** total,*** AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： Lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity Dorsal root ganglia Tryptase Microbiota

No tillage increases soil microarthropod(Acari and Collembola)abundance at the global scale

在线全文

学校读者我要写书评

暂无评论

Soil Ecology Letters 2024年第2期6卷 5-19页

作者： Yulin Liu Lihong song Donghui Wu Zihan ai Qian Xu xin Sun Liang Chang State Key Laboratory of Black Soil Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China University of Chinese Academy of Sciences Beijing100049China College of Agriculture Guizhou UniversityGuiyang550025China Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationFujian Key Laboratory of Watershed EcologyInstitute of Urban EnvironmentChinese Academy of SciencesXiamen361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo315830China

Conservation tillage increases soil microarthropod abundance at the global *** effect of conservative tillage on microarthropods is soil *** positive effect of conservation tillage is particularly evident in nutrient-poor soil *** temperate humid regions,however,this positive effect of conservation tillage is *** effect of conservative tillage on microarthropods varies with fauna group and climate regions.

关键词： no tillage soil microarthropod Acari Collembola meta-analysis

Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 885-897页

作者： Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang xin song Guangqiang Wang Zhiqiang Xiong Yangyang Qian Zhuan Liao Hui Zhang Lianzhong ai School of Health Science and Engineering Shanghai Engineering Research Center of Food MicrobiologyUniversity of Shanghai for Science and TechnologyShanghai 200093China College of Life Sciences Linyi UniversityLinyi 276000China Department of Gastroenterol. Digestive Endoscopy CenterChanghai HospitalShanghai 200082China

Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is *** major purpose of this study was to investigate the mechanism of Lactiplantibacillus plantarun AR113 alleviating oxidative stress injury in the D-galactose induced aging *** result showed that pretreatment with *** AR113 significantly relieving H_(2)O_(2)induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme *** D-galactose induced aging mice,*** AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous glutathione(GSH)synthesis and activating the Nrf2/Keap1 signaling pathway in mice,and increasing the expression of regulated phaseⅡdetoxification enzymes and antioxidant *** analysis shown that gavage of *** AR113 could significantly reduce the expression of G protein-coupled receptor 78(GPR78)and C/EBP homologous protein(CHOP)proteins,and promote the restoration of endoplasmic reticulum(ER)homeostasis,thereby activating cell anti-apoptotic *** results were also confirmed in H_(2)O_(2)-treated HepG2 *** indicated that *** AR113 could inhibit D-galactose-induced liver injury through dual inhibition of ER stress and oxidative *** AR113 have good application potential in anti-aging and alleviating metabolic disorders.

关键词： Lactiplantibacillus plantarun AR113 HepG2 D-galactose Oxidative stress ER stress

Influence of Sub-Cloud Secondary Evaporation Effects on the Stable Isotopes in Precipitation of Urumqi Glacier No.1,Eastern Tianshan

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第1期35卷 177-189页

作者： Mengyuan song Zhongqin Li Feiteng Wang xin Zhang State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesTianshan Glaciological StationChinese Academy of SciencesLanzhou 730000China College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730000China College of Sciences Shihezi UniversityShihezi 832000China

In arid regions,the stable hydrogen and oxygen isotopic composition in raindrops is often modified by sub-cloud secondary evaporation when they descend from cloud base to ground through the unsaturated *** a result of kinetic fractionation,the slope and intercept of the δ^(2)H-δ^(18)O correlation equation *** variation of deuterium excess from cloud base to the ground is often used to quantitatively evaluate the influence of secondary evaporation effect on isotopes in *** on the event-based precipitation samples collected at Urumqi Glacier No.1,eastern Tianshan during four-year observation,the existence and impact of secondary evaporation effects were analyzed by the methods of isotope-evaporation *** high air temperature,small raindrop diameter and precipitation amount,and low relative humidity conditions,the remaining rate of raindrops is small and the change of deuterium excess is large relatively,and the slope and intercept of δ^(2)H-δ^(18)O correlation equation are much lower than those of Global Meteoric Water Line,which mean that the influence secondary evaporation on precipitation *** on the conditions of low air temperature,high relative humidity,heavy rainfall,and large raindrop diameter,the change of deuterium excess is small relatively and the remaining rate of raindrops is large,and the slope and intercept of δ^(2)H-δ^(18)O correlation equation increase,the secondary evaporation is *** isotope-evaporation model described a good linear correlation between changes of deuterium excess and evaporation proportion with the slope of 0.90‰/%,which indicated that an increase of 1%in evaporation may result in a decrease of deuterium excess about 0.90‰.

关键词： stable isotopes meteoric water line deuterium excess sub-cloud secondary evaporation effect precipitation glaciers

Fine-grained grid computing model for Wi-Fi indoor localization in complex environments

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2024年第1期22卷 42-52页

作者： Yan Liang song Chen xin Dong Tu Liu School of Computer Engineering Chengdu Technological UniversityChengdu611730China HAN Networks Corporation Limited Beijing100094China

The fingerprinting-based approach using the wireless local area network(WLAN)is widely used for indoor ***,the construction of the fingerprint database is quite *** when the position of the access point(AP)or wall changes,updating the fingerprint database in real-time is *** appropriate indoor localization approach,which has a low implementation cost,excellent real-time performance,and high localization accuracy and fully considers complex indoor environment factors,is preferred in location-based services(LBSs)*** this paper,we proposed a fine-grained grid computing(FGGC)model to achieve decimeter-level localization *** points(RPs)are generated in the grid by the FGGC ***,the received signal strength(RSS)values at each RP are calculated with the attenuation factors,such as the frequency band,three-dimensional propagation distance,and walls in complex *** a result,the fingerprint database can be established automatically without manual measurement,and the efficiency and cost that the FGGC model takes for the fingerprint database are superior to previous *** proposed indoor localization approach,which estimates the position step by step from the approximate grid location to the fine-grained location,can achieve higher real-time performance and localization accuracy *** mean error of the proposed model is 0.36 m,far lower than that of previous ***,the proposed model is feasible to improve the efficiency and accuracy of Wi-Fi indoor *** also shows high-accuracy performance with a fast running speed even under a large-size *** results indicate that the proposed method can also be suitable for precise marketing,indoor navigation,and emergency rescue.

关键词： Fine-grained grid computing (FGGC) Indoor localization Path loss Random forest Reference points(RPs)

An Aerial Target Recognition Algorithm Based on Self-Attention and LSTM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials and Continua 2024年第1期81卷 1101-1121页

作者： Liang, Futai Chen, xin He, song song, Zihao Lu, Hao Department of Intelligence Early Warning Academy Wuhan 430019 China PLA Troops Nanjing 210000 China Information Technology Room Early Warning Academy Wuhan 430019 China

In the application of aerial target recognition, on the one hand, the recognition error produced by the single measurement of the sensor is relatively large due to the impact of noise. On the other hand, it is difficult to apply machine learning methods to improve the intelligence and recognition effect due to few or no actual measurement samples. aiming at these problems, an aerial target recognition algorithmbased on self-attention and Long Short-TermMemoryNetwork (LSTM) is proposed. LSTMcan effectively extract temporal dependencies. The attention mechanism calculates the weight of each input element and applies the weight to the hidden state of the LSTM, thereby adjusting the LSTM's attention to the input. This combination retains the learning ability of LSTM and introduces the advantages of the attention mechanism, making the model have stronger feature extraction ability and adaptability when processing sequence data. In addition, based on the prior information of the multidimensional characteristics of the target, the three-point estimation method is adopted to simulate an aerial target recognition dataset to train the recognition model. The experimental results show that the proposed algorithm achieves more than 91% recognition accuracy, lower false alarm rate and higher robustness compared with the multi-attribute decision-making (MADM) based on fuzzy numbers. © 2024 The Authors. Published by Tech Science Press.

关键词： Fuzzy rules

Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第6期16卷 708-727页

作者： Lei-Mei Xu xin-xin Yu Ning Zhang Yi-song Chen Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Gynecology Shanghai Key Laboratory of Female Reproductive Endocrine-related DiseasesShanghai 200011China

BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential *** POP,the vaginal walls exhibit abnormal collagen distribution and decreased fibroblast levels and *** intricate etiology of POP and the prohibition of trans-vaginal meshes in pelvic reconstruction surgery present challenges in targeted therapy *** umbilical cord mesenchymal stromal cells(hucMSCs)present limitations,but their exosomes(hucMSC-Exo)are promising therapeutic tools for promoting fibroblast proliferation and extracellular matrix *** inflammation in POP group fibroblasts,stimulated primary fibroblast growth,and elevated collagen I(Col1)production in ***-throughput RNA-seq of fibroblasts treated with hucMSC-Exo and miRNA sequencing of hucMSC-Exo revealed that abundant exosomal miRNAs downregulated matrix metalloproteinase 11(MMP11)*** HucMSC-Exo normalized the growth and function of primary fibroblasts from patients with POP by promoting cell growth and Col1 expression in *** miRNAs in hucMSC-Exo targeted and downregulated MMP11 ***-Exo-based therapy may be ideal for safely and effectively treating POP.

关键词： Pelvic organ prolapse Exosomes Fibroblasts Human umbilical cord mesenchymal stromal cells Extracellular matrix Collagen I