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Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu Fu Zheng Hong-Yi Tang Hua-Zhi Li xin-yu cui Shuai Ding Duo Liu cui-Ying Li Jiu-Hui Jiang Rui-Li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root ***-intensity pulsed ultrasound(LIPUS),a noninvasive physical therapy,has been shown to promote bone fracture *** is also reported that LIPUS could reduce the duration of orthodontic treatment;however,how LIPUS regulates the bone metabolism during the orthodontic treatment process is still *** To investigate the effects of LIPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying *** A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue *** vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and LIPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red *** expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via *** The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),*** could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by ***,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by ***,the osteogenic differentiation of hBMSCs increased by LIPUS could be attenuated by YAP siRNA ***,LIPUS increased alveolar

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

A Concise Approach to the Synthesis of Carnosic Acid Type Diterpenes

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Chinese Chemical Letters 2001年第3期12卷 203-204页

作者： yu xin cui Qiang XIAO Peng Fei TU Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100083 Department of Chemistry Lanzhou UniversityLanzhou 730000

10-vinyl-8,11,13-podocatriene 8, which is a modal of Carnosic acid type diterpenes, has been synthesized by an expeditious convergent synthetic approach.

关键词： Carnosic acid synthesis diterpenes cyclization anti-HIV

An Improved Method of Total Synthesis of 2-Methoxypodocarpane-8,11,13-triene

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Chinese Chemical Letters 2001年第3期12卷 197-198页

作者： Qiang XIAO yu xin cui Peng Fei TU Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100083 Department of Chemistry Lanzhou UniversityLanzhou 730000

12-Methoxypodocarpane-8,11,13-triene 1, the key intermediate in the synthesis of some important diterpenes, was synthesized in an efficient way, which has the characteristics of short route simple operation and high y... 详细信息

关键词： Synthesis diterpenes 12-methoxypodocarpane-8 11 13-triene cyclization.

Characterizing some gossypol and gossypolone Schiff's bases by studying their fragmentation patterns with electrospray ionization tandem mass spectra

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Chinese Chemical Letters 2009年第6期20卷 716-719页

作者： Long Zhang xing xin Cao Hai Xia Jiang Biao Jiang yu xin cui State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

To investigate the structural form of gossypol and gossypolone Schiff＇s bases, seven relevant Schiff＇s bases were synthesized and the electrospray ionization-tandem mass spectrometry （ESI-MS/MS） with low-energy collision-induced dissociation was used to analyze their fragmentations. A common fragmentation pathway with the loss of RNH2 from those schiff＇s bases quasi-molecular ions was observed and proposed on the basis of their MS/MS spectra data. This common pathway indicated that those Schiff＇s bases existed mainly as the enamine form not the imine form previously showed in most reports.

关键词： Gossypol Schiff's bases Gossypolone Schiff's bases ESI-MS Enamine form Imine form

Synthesis and preliminary biological evaluation of the derivatives of O^6-benzylguanine as inactivators of O^6-alkylguanine-DNA alkyltransferase

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Chinese Chemical Letters 2008年第7期19卷 801-804页

作者： Lei Zhang Bing Jia Chang Feng Hu Fan Wang yu xin cui The State Key Laboratory of Natural and Biomimetic Drags School of Pharmaceutical Science Peking University Beijing 100083 PR China Medical Isotope Research Center Peking University Beijing 100083 PR China Medical and Healthy Analysis Center Peking University Beijing 100083 PR China

A series of new O6-BG derivatives （14-21,23-30） were synthesized as inactivators of O6-Alkylguanine-DNA alkyltransferase （AGT）, and their ability to inhibit AGT was preliminary evaluated by MTT with O6-BG as the c... 详细信息

关键词： O^6-BG derivatives AGT inactivator

Characteristic fragmentation behavior of the analogs of endomorphin-2 with phenylglycine in position 3 or 4 by ESI-FT tandem mass spectrometry

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Chinese Chemical Letters 2008年第12期19卷 1479-1482页

作者： Chang Feng Hu Chuan Jun Zhu Yan Feng Gao Xuan Shao Rui Wang yu xin cui State Key Laboratory of Natural and Biomimetic Drugs （Peking University） Beijing 100083 China School of Life Science Lanzhou University Lanzhou 730000 China

A series of analogs of endomorphin-2 （EM-2） with phenylglycine （Phg） in position 3 or 4 were synthesized. In electrospray ionization Fourier transform ion cyclotron resonance （ESI-Fr-ICR） MS/MS spectra of these compounds, some b, y, a, and internal ions were observed and slight mass differences between the calculated and observed results are obtained. Their sequences were derived successfully. However, the MS/MS patterns of these analogs with Dphg and Lphg were very similar. It is hard to distinguish them by MS/MS spectra. Moreover, if the third position was substituted by phenylglycine （L or D）, a rearrangement could occur in MS/MS experiment to lose proline residue.

关键词： Endomorphin-2 Opioid peptide analogs Phenylglycine ESI-FT MS

Influence of particulate morphology on microstructure and tribological properties of cold sprayed A380/Al2O3 composite coatings

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Journal of Materials Science & Technology 2020年第9期44卷 9-18页

作者： Xiang Qiu Naeem ul Haq Tariq Lu Qi Jun-Rong Tang xin-yu cui Hao Du Ji-Qiang Wang Tian-Ying Xiong Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Department of Metallurgy and Materials Engineering Pakistan Institute of Engineering and Applied SciencesNiloreIslamabadPakistan

In this study,three kinds of A380/Al2O3 composite coatings were prepared by cold spray(CS)using spherical,irregular and spherical+irregular shaped Al2O3 particulates separately mixed in the original A380 alloy *** influence of Al2O3 particulates’morphology on the microstructural characteristics(*** of Al2O3 content in coatings,coating/matrix interfacial bonding,pore size distribution and morphology etc.)and wear performance of the coatings was investigated by scanning electron microscopy(SEM),X-ray computed tomography(XCT)and 3-D optical *** indicated that the spherical Al2O3 showsobvious tamping effect during deposition *** a result,the interfaceshowedawavy shape while the matrix and particulates were mechanical interlocked with much improved *** addition,the porosity of the coating was minimized and the pores exhibited curved spherical structure with reduced *** irregular Al2O3 particles predominantly displayed the embedding effect together with fragmentation of Al2O3 ***,poor coating/matrix interfacial bonding,high porosity and the formation of angular-shaped pores were resulted in the *** sliding wear tests results revealed that the wear resistance of the coating is directly related with the retained content of Al2O3 in the *** coating containing irregular Al2O3 particulates displayed superior wear performance with its wear rate one seventh of that of the pure A380 alloy *** coating containing both kinds of Al2O3 particulates showed mixed characteristics of above two kinds of Al2O3 composite coatings.

关键词： Cold spray Al2O3 particulates X-ray computed tomography Wear test

Two New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 2000年第2期11卷 139-142页

作者： Xiu Wei YANG Jing ZHAO yu xin cui (National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083) Natl. Lab. Nat. and Biomimetic Drugs Beijing Medical University Beijing 100083 China

Two new triterpenoid saponins, named isoescins IIIa (1) and IIIb (2) were isolated from the seeds of Aesculus chinensis and identified by spectroscopic analysis and chemical hydrolysis. Their structures were established as 21 beta-tigloyl-28-acetylbarringtogenol C-3 beta-O-[beta D-galactopyranosyl( 1-->2)] [beta-D-glucopyranosyl (1-->])1-beta-D-glucopyranosiduronic acid (1) and 21 beta-angeloyl-28-acetylbarringtogenol C-3 beta-O-[beta-D;galactopyranosyl (1-->2)] [beta-D-glucopyranosyl(1 -->4)]-beta-D-glucopyranosiduronic acid (2), which are geometrically isomeric.

关键词： Aesculus chinensis isoescins IIIa and IIIb

Three New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 1999年第12期10卷 0-0,0-0页

作者： Xiu Wei YANG Jing ZHAO yu xin cui(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University,Beding 100083) Natl. Lab. Nat. and Biomimetic Drugs Beijing Medical University Beijing 100083 China

Three new triterpenoid saponins, escins IVg (1), IVh (2) and VIb (3) were isolatedfrom the seeds of Aesculus chinensis along with two known saponins, escin IIIa (4) anddesacylescin I (5). Their structures were elucida... 详细信息

关键词： Aesculus chinensis Hippocastanaceae escins Ⅲ4 IVg IVh and Vib desacylescin I.