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Chinese Chemical Letters 2024年第11期35卷 512-516页

作者： Le Zhang Hui-Yu Xie xin Li Li-ying sun ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi'an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi'an 710127China

Conventionally,organic radicals adhere to the Aufbau principle,the energy level of the singly occupied molecular orbital(SOMO)is not below the highest occupied molecular orbital(HOMO),but somewhat abnormal phenomena have appeared *** this study,we introduce a novel strategy by incorporating unique NHC-Au-X units into a tris(2,4,6-trichlorophenyl)methyl(TTM)system to create metal-involved open-shell complexes,denoted as TTM-NHC-Au-X(X=I,Br,or Cl).Density-functional theory calculations were used to predict an inversion in the energy of the SOMO and highest doubly occupied molecular orbital(HOMO)of TTM-NHC-Au-I,which is supported by experimental *** radicals TTM-NHC-Au-X demonstrated distinct properties with different coordinated *** radical behaviors have been investigated by EPR,UV-vis spectroscopy and cyclic voltammetry,additional structural information provided by structurally comparing related the precursor complexes given by X-ray ***-NHC-Au-I with SOMO-HOMO conversion(SHC)features a highly thermal decomposition temperature up to 305℃.Furthermore,the photostability of TTM-NHC-Au-I was found to be 75and 23 times greater than that of TTM-NHC-Au-Br and TTM-NHC-Au-Cl,*** findings provide valuable insights into the structural and electronic design principles governing the occurrence of SOMO-HOMO conversion in open-shell systems.

关键词： SOMO-HOMO conversion N-heterocyclic carbenes Aufbau and non-Aufbau Electronic structure Halogen atoms Radical

Multi-Objective Optimal Feedback Controls for Under-Actuated Dynamical System

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Journal of Shanghai Jiaotong university(Science) 2020年第5期25卷 545-552页

作者： QIN Zhichang xin ying sun Jianqiao School of Transportation and Vehicle Engineering Shandong University of TechnologyZibo 255000ShandongChina School of Mechanical Engineering Tianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control Tianjin University of TechnologyTianjin 300384China School of Engineering University of California MercedCA 95343USA

This paper presents a study of optimal control design for a single-inverted pendulum(SIP)system with the multi-objective particle swarm optimization(MOPSO)*** proportional derivative(PD)control algorithm is utilized to control the *** the SIP system is nonlinear and the output(the pendulum angle)cannot be directly controlled(it is under-actuated),the PD control gains are not tuned with classical *** this work,the MOPSO method is used to obtain the best PD *** use of multi-objective optimization algorithm allows the control design of the system without the need of linearization,which is not provided by using classical *** multi-objective optimal control design of the nonlinear system involves four design parameters(PD gains)and six objective functions(time-domain performance indices).The HausdorfF distances of consecutive Pareto sets,obtained in the MOPSO iterations,are computed to check the convergence of the MOPSO *** MOPSO algorithm finds the Pareto set and the Pareto front *** simulations and experiments of the rotary inverted pendulum system are done to verify this design *** and experimental results show that the multi-objective optimal controls offer a wide range of choices including the ones that have comparable performances to the linear quadratic regulator(LQR)control.

关键词： multi-objective optimal control under-actuated system particle swarm optimization(PSO) rotary inverted pendulum

鬼臼毒素固体脂质纳米粒对非小细胞肺癌A549细胞增殖和迁移的影响

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药物流行病学杂志 2023年第6期32卷 648-654页

作者：王云柯青唐之俭周磊孙颖新梁爱凤复旦大学附属中山医院青浦分院呼吸与危重症科上海201700 复旦大学附属中山医院青浦分院检验科上海201700

目的研究鬼臼毒素固体脂质纳米粒(PPT-SLNs)对非小细胞肺癌A549细胞增殖和迁移的影响。方法采用低温乳化凝固法制备PPT-SLNs,透射电镜观察纳米粒的形态,粒径分析仪测定其粒径和电位,HPLC法测定PPT-SLNs的包封率,透析法评估PPT-SLNs体外... 详细信息

目的研究鬼臼毒素固体脂质纳米粒(PPT-SLNs)对非小细胞肺癌A549细胞增殖和迁移的影响。方法采用低温乳化凝固法制备PPT-SLNs,透射电镜观察纳米粒的形态,粒径分析仪测定其粒径和电位,HPLC法测定PPT-SLNs的包封率,透析法评估PPT-SLNs体外药物缓释性能,CCK8和细胞划痕实验检测鬼臼毒素(PPT)及PPT-SLNs对A549细胞增殖和迁移能力的影响。结果PPT-SLNs纳米粒基本呈圆球形或椭圆球形,粒径为(44.0±21.6)nm,Zeta电位为(-15.1±3.2)mV,包封率为(85.5±2.6)%;缓释性能测定显示PPT-SLNs在模拟生理条件下(pH 7.4)的稳定性较好,在弱酸性条件下(pH 5.0)水解速度明显加快;PPT-SLNs和PPT对A549细胞增殖的抑制作用呈一定的剂量和时间依赖性,48 h浓度为5μmol·L^(-1)时,PPT-SLNs对细胞增殖的抑制作用显著高于PPT[(69.60±0.62)%vs.(56.61%±4.71)%,P<0.05],在正常肺上皮BEAS-2B细胞中,PPT-SLNs的增殖抑制作用则显著低于PPT[(24.52±3.94)%vs.(35.07±0.47)%,P<0.05];细胞划痕24 h时,PPT-SLNs对A549细胞体外迁移抑制作用明显高于PPT[(17.18±2.10)%vs.(28.31±2.71)%,P<0.01]。结论PPTSLNs可增强对A549细胞增殖和迁移的抑制,且对正常肺上皮细胞的毒性更小。

关键词：鬼臼毒素固体脂质纳米粒肺癌细胞增殖细胞迁移

Sporadic E responds to the 2022 Tonga volcano eruptions recorded by the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 20-28页

作者： YangYi sun Tao Yu Jin Wang Chi Long School of Geophysics and Geomatics China University of Geosciences(Wuhan)Wuhan 430047China School of Physics and Electronic Science Guizhou Normal UniversityGuizhou 550001China

In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances caused by the Tonga volcanic eruptions on January 15,*** most prominent signature was the disappearance of the layer after~10:00 UT over Wuhan and Fuke,which was attributed to the vertical drift caused by the *** occurred intermittently after 13:00 UT following the arrival of the tropospheric Lamb *** examine the causal mechanism for the intermittence,we also included data of horizontal winds in the mesosphere and lower thermosphere region recorded by the meteor radars at Wuhan and Mohe in this *** wind disturbances with periods of~20 hours contributed to the formation of the layer in the nighttime on January 15.

关键词： sporadic E Tonga eruptions neutral wind disturbances

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期 183-194页

作者： xin-Ran sun Hao-Ming Yuan Guo-Da Zhang Chao Wang Shu-Juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

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图联邦学习:问题、方法与挑战

计算机科学 2025年第1期52卷 362-373页

作者：王鑫熊书博孙凌云浙江工业大学计算机科学与技术学院杭州310023 浙江大学计算机科学与技术学院杭州310058

图作为一种高效、灵活、通用的数据结构,在多个学科领域得到了广泛应用。近年来,基于图的深度学习算法不断涌现,并在社交网络、生物信息学、推荐系统等领域取得显著成效。尽管公开的图数据量在增加,但高质量的数据往往分散在不同的数据... 详细信息

图作为一种高效、灵活、通用的数据结构,在多个学科领域得到了广泛应用。近年来,基于图的深度学习算法不断涌现,并在社交网络、生物信息学、推荐系统等领域取得显著成效。尽管公开的图数据量在增加,但高质量的数据往往分散在不同的数据所有者手中。随着社会对数据隐私保护要求的提高,现有的图学习算法面临着许多挑战。图联邦学习作为一种有效的解决方案应运而生。文中系统回顾了图联邦学习领域近五年的研究进展,将该领域的核心问题划分为3个部分,并在结构上进行了垂直整合,在关系上进行了递进阐述,包括:1)原始图数据差异导致的结构异构性;2)图联邦特性导致的模型聚合问题;3)模型整体调优方面的挑战。针对每个问题,详细分析了代表性工作及其优缺点,并总结了图联邦学习领域的典型应用和未来挑战。

关键词：联邦学习图神经网络图联邦学习隐私计算

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-xin Qin xin Tan Xiao-Yan sun Xu-Fang ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy

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Nano Research 2022年第3期15卷 2335-2346页

作者： ying sun Minglong Chen Dan Yang Wanbing Qin Guilan Quan Chuanbin Wu xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China Jieyang Affiliated Hospital Sun Yat-Sen UniversityGuangzhou 522091China Physical Sciences at the Microscale Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Nanomedicine with high specificity has been a promising tool for cancer diagnosis and ***,the successful application of nanoparticle-based superficial cancer therapy is severely hindered by restricted deep tumor tissue accumulation and ***,a self-assembly nanomicelle dissolving microneedle(DMN)patch according to the“nano in micro”strategy was conducted to co-deliver a first-line chemotherapeutic agent paclitaxel(PTX),and a photosensitizer IR780(PTX/IR780-NMs@DMNs)for chemo-photothermal synergetic melanoma *** direct insertion into the tumor site,DMNs created a regular and multipoint three-dimensional drug depot to maximize the tumor *** by the DMN dissolution,the composition of the needle matrixes self-assembled into nanomicelles,which could efficiently penetrate deep tumor *** laser irradiation,the nanomicelles could not only ablate tumor cells directly by photothermal conversion but also trigger PTX release to induce tumor cell *** vivo results showed that compared with intravenous injection,IR780 delivered by PTX/IR780-NMs@DMNs was almost completely accumulated at the tumor *** antitumor results revealed that the PTX/IR780-NMs@DMNs could effectively eliminate tumors with an 88%curable rate without any damage to normal *** work provides a versatile and generalizable framework for designing self-assembly DMN-mediated combination therapy to fight against superficial cancer.

关键词： dissolving microneedle tumor penetration nanomicelle superficial tumor chemo-photothermal therapy

Mechanical effects of needle texture on acupoint tissue

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Journal of Integrative Medicine 2023年第3期21卷 254-267页

作者： Ming-zhu sun xin Wang ying-chen Li Wei Yao Wei Gu Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Department of Aeronautics and AstronauticsFudan UniversityShanghai 200433China Department of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Objective:This study aims to clarify how the stimulation of acupuncture points is achieved by needles with different surface texture during acupuncture;it also seeks to lessen injury at the insertion site and increase the therapeutic efficacy of acupuncture,by simulating the mechanical effects of various needle surface patterns on Zusanli(ST36)without changing the radius of acupuncture ***:Five acupuncture needle models with different surface patterns,including the smooth needle,the lined needle,the ringed needle,the left-hand threaded needle and the right-hand threaded needle,and a layered model of the Zusanli acupoint were used to investigate how to reduce tissue damage and increase stimulation during acupuncture treatment,Puncturing of the skin as well as liftinginserting and twisting needle manipulations were simulated using these models,and the degree of damage and force of stimulation caused by the acupuncture needles with different surface patterns during ***:The smooth needle and the lined needle caused the least tissue damage during insertion,while the left-hand threaded and the right-hand threaded needles caused the most *** ringed needle,the left-hand threaded needle and the right-hand threaded needle stimulated the acupoint tissue more during lifting-inserting manipulations,while the lined needle and the smooth needle produced less *** stimulation of the lined needle on the acupoint tissue was the largest during twisting manipulation,whereas the left-hand threaded needle and the right-hand threaded needle had smaller *** lifting-inserting and twisting manipulations,both the left-hand threaded needle and right-hand threaded needle provided more stimulation,but the torsion direction in which they produced better stimulation was ***:According to the simulation results,the ringed pattern enhances stimulation best in the lifting-inserting manipulation,whereas the lined patter

关键词： Biomechanics Finite elementmethod Acupuncture Needle roughness Mechanical effects