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Targeting the chromatin structural changes of antitumor immunity

Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian li Deng-xing Lun Ningning Gong Gang Meng xin-ying Du He Wang Xiangxiang Bao xin-yang li Ji-wu Song Kewei Hu Lala li Si-ying li Wenbo liu Wanping Zhu Yunlong Zhang Jikai li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu lin liu Hongguang Zhu Yuyun Wu Bin liu Weifang People's Hospital WeifangShandong261000China School of life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

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抗冻型丝蛋白胶黏剂的设计与制备

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高分子学报 2024年第11期55卷 1463-1475页

作者：李欣阳陈旎杨公雯邵正中聚合物分子工程国家重点实验室、复旦大学先进材料实验室高分子科学系上海200433

为应对传统化学黏合剂因环境污染和潜在健康风险所带来的挑战,本研究在成功制备一款天然桑蚕丝蛋白和单宁酸复合胶黏剂的同时,很好地解决了传统黏合剂在低温环境下无法工作或性能不佳等问题.通过在丝蛋白中引入与其有强相互作用的单宁酸... 详细信息

为应对传统化学黏合剂因环境污染和潜在健康风险所带来的挑战,本研究在成功制备一款天然桑蚕丝蛋白和单宁酸复合胶黏剂的同时,很好地解决了传统黏合剂在低温环境下无法工作或性能不佳等问题.通过在丝蛋白中引入与其有强相互作用的单宁酸,抑制了丝蛋白由无规卷曲构象向β-折叠构象的转变,进而保障了此复合胶黏剂的强黏附力.在优化丝蛋白与单宁酸复合物配比的基础上,选用乙二醇和水二元溶剂体系,不仅有效提升了此生物基胶黏剂溶解性能和对各种基体黏结的普适性,并且显著降低了其冻结点,赋予了其相应的抗冻性能.实验结果证实,此生物基胶黏剂在从-20℃到室温范围内均展现出超越传统商用化学黏合剂和其他生物基黏合剂的黏附能力.因此,所研发的抗冻型丝蛋白生物基胶黏剂,以其环保性、生物降解性及在低温条件下出色的黏结性能,在包装、生物医疗及环境保护等领域中具有很好的应用前景.

关键词：丝蛋白单宁酸抗冻生物基胶黏剂环境友好

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IgG4相关性疾病2023年度进展

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中华临床免疫和变态反应杂志 2024年第1期18卷 41-44页

作者：杨欣莉张文中国医学科学院、北京协和医学院、北京协和医院风湿免疫科风湿免疫病学教育部重点实验室国家皮肤与免疫疾病临床医学研究中心北京100730

IgG4相关性疾病(IgG4-RD)是一种由免疫介导的可致多器官受累的慢性炎症伴纤维化疾病,2023年IgG4-RD的研究取得了诸多进展,主要涵盖流行病学、动物模型及发病机制、诊断标准验证、临床表现和分型和治疗等多方面内容。本文将介绍上述领域... 详细信息

IgG4相关性疾病(IgG4-RD)是一种由免疫介导的可致多器官受累的慢性炎症伴纤维化疾病,2023年IgG4-RD的研究取得了诸多进展,主要涵盖流行病学、动物模型及发病机制、诊断标准验证、临床表现和分型和治疗等多方面内容。本文将介绍上述领域的代表性成果。

关键词： IgG4相关性疾病单细胞测序生物标志物诊断治疗预后

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High-Impact Bug Report Identification with Imbalanced Learning Strategies

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Journal of Computer Science & Technology 2017年第1期32卷 181-198页

作者： xin-li yang David Lo xin Xia Qiao Huang Jian-ling Sun College of Computer Science and Technology Zhejiang University Hangzhou 310027 China School of Information Systems Singapore Management University Singapore Singapore

In practice, some bugs have more impact than others and thus deserve more immediate attention. Due to tight schedule and limited human resources, developers may not have enough time to inspect all bugs. Thus, they often concentrate on bugs that are highly impactful. In the literature, high-impact bugs are used to refer to the bugs which appear at unexpected time or locations and bring more unexpected effects （i.e., surprise bugs）, or break pre-existing functionalities and destroy the user experience （i.e., breakage bugs）. Unfortunately, identifying high-impact bugs from thousands of bug reports in a bug tracking system is not an easy feat. Thus, an automated technique that can identify high-impact bug reports can help developers to be aware of them early, rectify them quickly, and minimize the damages they cause. Considering that only a small proportion of bugs are high-impact bugs, the identification of high-impact bug reports is a difficult task. In this paper, we propose an approach to identify high-impact bug reports by leveraging imbalanced learning strategies. We investigate the effectiveness of various variants, each of which combines one particular imbalanced learning strategy and one particular classification algorithm. In particular, we choose four widely used strategies for dealing with imbalanced data and four state-of-the-art text classification algorithms to conduct experiments on four datasets from four different open source projects. We mainly perform an analytical study on two types of high-impact bugs, i.e., surprise bugs and breakage bugs. The results show that different variants have different performances, and the best performing variants SMOTE （synthetic minority over-sampling technique）＋ KNN （K-nearest neighbours） for surprise bug identification and RUS （random under-sampling）＋ NB （naive Bayes） for breakage bug identification outperform the Fl-scores of the two state-of-the-art approaches by Thung et al. and Garcia and Shihab.

关键词： high-impact bug imbalanced learning bug report identification

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What Security Questions Do Developers Ask？ A Large-Scale Study of Stack Overflow Posts

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Journal of Computer Science & Technology 2016年第5期31卷 910-924页

作者： xin-li yang David Lo xin Xia Zhi-Yuan Wan Jian-ling Sun College of Computer Science and Technology Zhejiang University Hangzhou 310027 China School of Information Systems Singapore Management University Singapore Singapore

Security has always been a popular and critical topic. With the rapid development of information technology, it is always attracting people＇s attention. However, since security has a long history, it covers a wide range of topics which change a lot, from classic cryptography to recently popular mobile security. There is a need to investigate security-related topics and trends, which can be a guide for security researchers, security educators and security practitioners. To address the above-mentioned need, in this paper, we conduct a large-scale study on security-related questions on Stack Overflow. Stack Overflow is a popular on-line question and answer site for software developers to communicate, collaborate, and share information with one another. There are many different topics among the numerous questions posted on Stack Overflow and security-related questions occupy a large proportion and have an important and significant position. We first use two heuristics to extract from the dataset the questions that are related to security based on the tags of the posts. And then we use an advanced topic model, Latent Diriehlet Allocation （LDA） tuned using Genetic Algorithm （GA）, to cluster different security-related questions based on their texts. After obtaining the different topics of security-related questions, we use their metadata to make various analyses. We summarize all the topics into five main categories, and investigate the popularity and difficulty of different topics as well. Based on the results of our study, we conclude several implications for researchers, educators and practitioners.

关键词： security Stack Overflow empirical study topic model

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A new chain-like heteropolytungstate formed by Keggin cluster units:Synthesis and structure of[H2bpy]3[SiMnW(11)O(39)].1.25H2O

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Chinese Chemical Letters 2007年第1期18卷 81-84页

作者： Jing xin Meng Ying Ma xin xin Xu yang Guang li En Bo Wang Key Laboratory of Polyoxometalate Science of Ministry of Education Department of Chemistry Northeast Normal University Ren Min Street No.5268 Changchun Jilin 130024 PR China

A new heteropolytungstate, [H2bpy]3[SiMnW11O39]· 1.25H2O （1）, has been prepared under mild hydrothermal conditions and structurally characterized by single crystal X-ray diffraction. It is the first characterized compound containing ID zigzag chain of transition metal substituted Keggin heteropolytungstate, which is connected through a common oxygen atom. The elemental analysis and IR of it are also described.

关键词： Heteropolytungstate Keggin clusters Zigzag chain

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Data Driven Vibration Control:A Review

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1898-1917页

作者： Weiyi yang Shuai li xin Luo Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714 Chongqing School University of Chinese Academy of SciencesChongqing 400714China Faculty of Information Technology and Electrical Engineering University of OuluOulu 90570 VTT-Technology Research Center of Finland Oulu 90570Finlan College of Computer and Information Science Southwest UniversityChongqing 400715China

With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests from both the industrial and academic *** shaping(IS),as a simple and effective feedforward method,is greatly demanded in DDVC *** convolves the desired input command with impulse sequence without requiring parametric dynamics and the closed-loop system structure,thereby suppressing the residual vibration *** on a thorough investigation into the state-of-the-art DDVC methods,this survey has made the following efforts:1)Introducing the IS theory and typical input shapers;2)Categorizing recent progress of DDVC methods;3)Summarizing commonly adopted metrics for DDVC;and 4)Discussing the engineering applications and future trends of *** doing so,this study provides a systematic and comprehensive overview of existing DDVC methods from designing to optimizing perspectives,aiming at promoting future research regarding this emerging and vital issue.

关键词： Data driven vibration control(DDVC) data science designing method feedforward control industrial robot input shaping optimizing method residual vibration

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Repair tolerance assessment for aircraft composite structures using Bayesian updating

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Chinese Journal of Aeronautics 2024年第6期37卷 360-391页

作者： xin li Hongfu ZUO Bin yang School of Automotive and Rail Transit Nanjing Institute of TechnologyNanjing 211167China Civil Aviation Key Laboratory of Aircraft Health Monitoring and Intelligent Maintenance College of Civil AviationNanjing University of Aeronautics and AstronauticsNanjing 211106China

Detection and repair of composite damage is crucial to ensure the safety and reliability of aircraft structures.A novel approach to quantitatively evaluate the repair tolerance of composite structures in civil aircraft based on Bayesian updating is *** method incorporates historical damage inspection data to determine the prior distribution of damage size,which is then updated with newly collected damage size data using Bayesian *** Carlo simulation is employed to investigate the probability of failure and estimate maintenance costs,considering various factors such as the frequency and timing of damage events,damage detection,structural strength,gust loads,and maintenance expenses throughout the lifecycle of composite *** and economic factors are considered to establish a lower threshold for repairs and an upper threshold for maintenance based on the occurrence of accidental impact *** of the effectiveness and feasibility of a quantitative assessment method for repair tolerance is conducted using damage statistics data from civil aircraft routes utilizing the structural skin panels of composite outer *** results demonstrate that the method proposed in conjunction with extensive simulations and full utilization of field damage inspection data can effectively simulate unexpected impact damage situations that may occur during civil aircraft service and evaluate the reliability and economic feasibility of the repair of *** research findings hold significant theoretical and practical value for the preparation of documents for continued airworthiness of composite structures,including structural repair manuals and maintenance programs.

关键词： Composite structures Repair tolerance Maintenance Bayesian updating Probability of failure

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Evolution and function of residual solvent in polymer-li_2B_(12)H_(12) composite solid electrolyte

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Rare Metals 2024年第8期43卷 3748-3757页

作者： Xiang-yang Ye Ke-Pan Bao Sai-Nan Luo xin li Tai-Qiang Chen Shui-xin Xia Tao Yuan Yue-Peng Pang Shi-You Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Department of Materials Science and Engineering National University of SingaporeSingapore 119077Singapore

Composite solid electrolytes(CSEs) containing polymer matrices and inorganic fillers hold promise for the next generation of solid-state ***,the role of residual solvents in CSEs remains *** study investigated the evolution and function of the residual solvent in a polymer-li_2B_(12)H_(12) CSE.A partial reaction occurred between li_2B_(12)H_(12) and solvent N,N-dimethylformamide(DMF),which produced dimethylaminomethanol(DMAM) in the *** functional theory calculations have revealed that DMA M forms stronger hydrogen bonds with polyvinylidene fluoride chains than DMF,which can have a plasticizing effect on the polymer matrix,leading to lower crystallinity and quicker segment ***,this CSE exhibited improved li-ion conducting properties,enabling the stable cycling of li‖liFePO_(4) solid-state *** study provided insights into the role of residual solvents in CSEs.

关键词： Composite solid electrolyte Residual solvent lithium borohydride Plasticizing effect

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Engineering catalytic defects via molecular imprinting for high energy li-S pouch cells

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National Science Review 2024年第7期11卷 239-251页

作者： Yufei Zhao Chuannan Geng li Wang Yun Cao Haotian yang linkai Peng xin Jiang Yong Guo Xiaolin Ye Wei Lv Quan-Hong yang Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon Materials Tsinghua Shenzhen International Graduate School Tsinghua University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy StorageSchool of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University

Heterogeneous catalysis promises to accelerate sulfur-involved conversion reactions in lithium-sulfur batteries. Solid-state li2S dissociation remains as the rate-limiting step because of the weakly matched solid-solid electrocatalysis interfaces. We propose an electrochemically molecular-imprinting strategy to have a metal sulfide（MS） catalyst with imprinted defects in positions from which the pre-implanted li2S has been electrochemically removed. Such tailor-made defects enable the catalyst to bind exclusively to li atoms in li2S reactant and elongate the li–S bond, thus decreasing the reaction energy barrier during charging. The imprinted Ni3S2catalyst shows the best activity due to the highest defect concentration among the MS catalysts examined. The li2S oxidation potential is substantially reduced to 2.34 V from 2.96 V for the counterpart free of imprinted vacancies, and an Ah-level pouch cell is realized with excellent cycling performance. With a lean electrolyte/sulfur ratio of 1.80 μL mgS–1, the cell achieves a benchmarkedly high energy density beyond 500 Wh kg–1.

关键词： lithium-sulfur battery catalysts defects energy density metal sulfide

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