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Causal effect of education on type 2 diabetes:A network Mendelian randomization study

World Journal of Diabetes 2021年第3期12卷 261-277页

作者： Li-Zhen liao Zhi-Chong Chen wei-Dong Li Xiao-Dong Zhuang xin-Xue liao Department ofHealth Guangdong Pharmaceutical UniversityGuangzhou 510275Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina Department of Cardiology The Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Cardiology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND The causality between education and type 2 diabetes(T2DM)remains *** To identify the causality between education and T2DM and the potential metabolic risk factors[coronary heart disease(CHD),total cholesterol,lowdensity lipoprotein,triglycerides(TG),body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),fasting insulin,fasting glucose,and glycated hemoglobin]from summarized genome-wide association study(GWAS)data used a network Mendelian randomization(MR).METHODS Two-sample MR and network MR were performed to obtain the causality between education-T2DM,education-mediator,and *** statistics from the Social Science Genetic Association Consortium(discovery data)and Neale Lab consortium(replication data)were used for education and DIAGRAMplusMetabochip for *** The odds ratio for T2DM was 0.392(95%CI:0.263-0.583)per standard deviation increase(3.6 years)in education by the inverse variance weighted method,without heterogeneity or horizontal *** was genetically associated with CHD,TG,BMI,WC,and WHR in the discovery phase,yet only the results for CHD,BMI,and WC were replicated in the replication ***,BMI was genetically associated with *** Short education was found to be associated with an increased T2DM *** might serve as a potential mediator between them.

关键词： Mendelian randomization Education Type 2 diabetes mellitus Genome-wide association study Coronary heart disease Body mass index

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Waveform Design for MIMO Radar with One-Bit DACs via Block-Sparse Semidefinite Relaxation

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Journal of Beijing Institute of Technology 2021年第4期30卷 323-339页

作者： Tong wei Bin liao the Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgL-1855Luxembourg the Guangdong Key Laboratory of Intelligent Information Processing Shenzhen UniversityShenzhen 518060China

Multiple-input multiple-output(MIMO)systems which deploy one-bit DACs are at-tractive in many fields,such as wireless communications and *** this paper,the problem of transmit waveform design in MIMO radar system with one-bit DACs is *** appropri-ately designing the transmitted QPSK signal waveforms,the majority of radiated energy can be fo-cused into the mainlobe region(s)by minimizing the integrated sidelobe to mainlobe ratio(ISMR)of beampattern,such that the intensity of backscattered signals from targets can be ***,the resulting optimization problem which consists of constrained fractional quadratic problem(CFQP)is *** tackle this problem,a block-sparse semidefinite relaxation meth-od is first utilized to reformulate the CFQP into a reduced convex semidefinite programming(SDP).Further,a customized interior point algorithm(IPA)is developed to solve the small-scale ***,the desirable one-bit transmit waveform sequence can be properly synthesized by us-ing Gaussian randomization *** simulation results demonstrate that the proposed method offer better performance than the state-of-the-art algorithms.

关键词： MIMO radar beampattern synthesis one-bit quantization waveform design

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Experimental model of Fusarium solani keratitis in rats

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 371-376页

作者： Jiang-Li Zhu, xin liao People's Hospital Affiliated to Tongji University School of Medicine Shanghai 200072 China People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200011 China Department of Ophthalmology Shanghai East Hospital Affiliated to Tongji University School of Medicine Shanghai 200120 China

AIM: To establish a repeatable rat model of Fusarium solani keratitis (F. solani keratitis) that mimicked fungal keratitis in humans. METHODS: Wistar rats' corneas were scratched on the superficial stroma after scraping the unilateral corneal epithelia. Then, the corneal surface was inoculated with different inoculum dose of E solanispore suspension. Doses ranged from 10(6) to 10(9) colony-forming unit per milliliter (CFU/mL). The treated corneas were covered by contact lenses that were made of Parafilm M membrane. Negative controls were inoculated with sterile phosphate-buffered saline (PBS). For statistical analysis, corneas were evaluated daily on a 12-point scale to check the state of corneal inflammation. Furthermore, the pathological characteristics of this model were investigated. RESULTS: The rat model of F solani keratitis was established by the combination methods of corneal trauma and parafilm-made contact lens and inoculation of fungus spore suspension. 10(6) and 10(7)CFU/mL of F solani induced mild corneal infection, while 10(8)CFU/mL of F solani was sufficient to induce moderate infection that was consistent with human keratomycosis. Dose of 10(9)CFU/mL of E solani was excessive and led to perforated corneas. CONCLUSION: The rat model of E solani keratitis, established by the combinational methods of corneal trauma, parafilm-made contact lens and the appropriate dose of inoculum, that imitates the developing processes of F solani keratitis in human beings and provides a repeatable method of creating a rat model.

关键词： fungal keratitis Fusarium solani corneal trauma contact lens rat

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Normal Mode Analysis on Three Different Structures of a Duplex DNA d(CGCGAATTCGCG)

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Chemical Research in Chinese Universities 1998年第3期14卷 67-71页

作者： LIN Dong-hai liao xin-li Department of Chemistry The Research Laboratory of SEDC of Analytical Science for Material and Life ChemistryXiamen UniversityXiamen361005

Normal mode analysis in dihedral angle space was carried out on two X ray crystal structures and one model structure responded to the same sequence of duplex DNA: d(CGCGAATTCGCG). Comparing these results indicates that it is reliable and meaningful to carry out normal mode analysis on model structures. The reliability is greater except for the ends of helix.

关键词： Normal mode analysis Duplex DNA Atomic fluctuation Molecular dynamics

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Discrete micropayment protocol based on master-slave payword chain

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 58-60,84页

作者： FAN Li-min liao Jian-xin State Key Laboratory of Net Studying and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China

Using the idea of Payword, the new concept of master-slave payword chain （MSPC） is proposed in this article. MSPC consists of one master payword chain and one slave payword chain. On the basis of MSPC, a new micropayment protocol called discrete micropayment protocol （DMP）, is presented in this article. DMP consists of three sub-protocols： registration, payment, and settlement. Both part fairness and non-unit-wise payment can be provided by DMP.

关键词： payword micropayment fairness unit-wise payment

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Distributional expansion of maximum from logarithmic general error distribution

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Applied Mathematics(A Journal of Chinese Universities) 2016年第2期31卷 157-164页

作者： YANG Geng liao xin PENG Zuo-xiang School of Mathematics and Statistics Southwest University Business School University of Shanghai for Science and Technology

Logarithmic general error distribution is an extension of lognormal distribution. In this paper, with optimal norming constants the higher-order expansion of distribution of partial maximum of logarithmic general erro... 详细信息

关键词： Extreme value distribution Higher-order expansion Logarithmic general error distribution,Maximum

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Greatly enhanced electro-optic modulation efficiency in titanium in-diffusion PIN-PMN-PT waveguide

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Journal of Advanced Ceramics 2023年第7期12卷 1454-1462页

作者： Qingyuan Hu Yuebin Zhang Huimin liao xin Liu Pengfei Li Yali Feng Lei An Yongyong Zhuang Zhuo Xu Xiaoyong wei Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an 710049China

Electro-optic modulators,which convert electrical signals onto the transmission light,are key devices in electro-optic modulating *** efficiency is one of the most important parameters of an electro-optic modulator,which directly determines the footprint and power consumption of the ***,modulation efficiency strongly depends on the electro-optic response of the *** Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PIN-PMN-PT)single crystal with giant electro-optic coefficient(λ_(c))and high transparency indicates the potential to achieve greatly enhanced modulation *** this study,a prototype PIN-PMN-PT phase modulator was fabricated based on a titanium(Ti)in-diffusion waveguide,which is reported for the first *** influences of titanium in-diffusion on the composition and domain structure of the PIN-PMN-PT single crystal were studied by transmission electron microscopy(TEM)and piezoelectric force microscopy(PFM),***,a half-wave voltage(V_(π))of 2.3 V was obtained using a device with 6-mm-long(L)***,the electro-optic modulation efficiency(V_(π)L)was calculated as 1.38 V-cm,which was approximately one order of magnitude lower than that of commercial lithium niobate(LiNbO_(3),LN)phase *** enhanced modulation efficiency indicates more compact device and lower power consumption,which is of great significance for electro-optic modulation systems used in micro-fiber gyroscope,integrated photonic devices,etc.

关键词： Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PIN-PMN-PT)single crystal titanium(Ti)in-diffusion waveguide electro-optic modulator

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Optical scattering imaging with sub-nanometer precision based on position-ultra-sensitive giant Lamb shift

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 96-105页

作者： Zeyang liao Yu-wei Lu wei Li Xue-Hua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The Lamb shift of a quantum emitter in close proximity to a plasmonic nanostructure can be three or more orders of magnitude larger than that in the free space and is ultra-sensitive to the emitter position and *** demonstrate that this large Lamb shift can be sensitively observed from the scattering or absorption spectrum dip shift of the coupled system when the plasmonic nanoparticle or tip scans the *** these observations,we propose a scanning optical scattering imaging method based on the plasmonic-enhanced Lamb shift with achieves sub-nanometer *** method is based on the scattering or absorption spectrum of the plasmon-emitter coupling system,which is free of the fluorescence quenching problem and easier to implement in a plasmon-emitter coupling *** addition,our scheme works even if the quantum emitter is slightly below the dielectric surface,which can bring about broader applications,such as detecting atoms and molecules or quantum dots above or under a surface.

关键词： Lamb shift plasmon optical scattering imaging

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang liao Mengru Cai Dongge Yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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Auto-normalization algorithm for robotic precision drilling system in aircraft component assembly

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Chinese Journal of Aeronautics 2013年第2期26卷 495-500页

作者： Tian wei Zhou weixue Zhou wei liao Wenhe Zeng Yuanfan College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

A novel approach is proposed to detect the normal vector to product surface in real time for the robotic precision drilling system in aircraft component assembly, and the auto-normalization algorithm is presented based on the detection system. Firstly, the deviation between the normal vector and the spindle axis is measured by the four laser displacement sensors installed at the head of the multi-function end effector. Then, the robot target attitude is inversely solved according to the auto-normalization algorithm. Finally, adjust the robot to the target attitude via pitch and yaw rotations about the tool center point and the spindle axis is corrected in line with the normal vector simultaneously. To test and verify the auto-normalization algorithm, an experimental platform is established in which the laser tracker is introduced for accurate measurement. The results show that the deviations between the corrected spindle axis and the normal vector are all reduced to less than 0.5°, with the mean value 0.32°. It is demonstrated the detection method and the autonormalization algorithm are feasible and reliable.

关键词： Aircraft assembly Auto-normalization Industrial robots Normal vector detection Robotic precision drilling

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