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Clinical and preclinical treatment of urologic diseases with phosphodiesterase isoenzymes 5 inhibitors： an update

Asian Journal of Andrology 2016年第5期18卷 723-731页

作者： Wen-Hao zhang xin-hua zhang Department of Urology Zhongnan Hospital of Wuhan University Wuhan City 430071 Hubei Province P.R. China.

Phosphodiesterase isoenzymes 5 inhibitors （PDE5-1s） are the first-line therapy for erectile dysfunction （ED）. The constant discoveries of nitric oxide （NO）/cyclic guanosine monophosphate （cGMP） cell-signaling pathway for smooth muscle （SM） control in other urogenital tracts （UGTs） make PDE5-1s promising pharmacologic agents against other benign urological diseases. This article reviews the literature and contains some previously unpublished data about characterizations and activities of PDE5 and its inhibitors in treating urological disorders. Scientific discoveries have improved our understanding of cell-signaling pathway in NO/cGMP-mediated SM relaxation in UGTs. Moreover, the clinical applications of PDE5-1s have been widely recognized. On-demand PDE5-1s are efficacious for most cases of ED, while daily-dosing and combination with testosterone are recommended for refractory cases. Soluble guanylate cyclase （sGC） stimulators also have promising role in the management of severe ED conditions. PDE5-1s are also the first rehabilitation strategy for postoperation or postradiotherapy ED for prostate cancer patients. PDE5-1s, especially combined with （z-adrenoceptor antagonists, are very effective for benign prostatic hyperplasia （BPH） except on maximum urinary flow rate （Qmax） with tadalafil recently proved for BPH with/without ED. Furthermore, PDE5-1s are currently under various phases of clinical or preclinical researches with promising potential for other urinary and genital illnesses, such as priapism, premature ejaculation, urinary tract calculi, overactive bladder, Peyronie＇s disease, and female sexual dysfunction. Inhibition of PDE5 is expected to be an effective strategy in treating benign urological diseases. However, further clinical studies and basic researches investigating mechanisms of PDE5-1s in disorders of UGTs are required.

关键词： benign prostatic hyperplasia erectile dysfunction overactive bladder phosphodiesterase isoenzymes 5 inhibitor priapism smooth muscle

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Euclidean distance harmonic method for establishing theoretical MAPK/Erk signaling pathway in treated breast cancer line MCF-7

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 80-84页

作者： zhang Hong-xin LU Ying-hua zhang Jin-ling School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Hierarchical clustering algorithms, such as Pearson＇s correlation, Euclidean distance, Euclidean distance harmonic, Spearman rank correlation, Kendall＇s tau, and City-block distance, were used to find the best way to establish theoretical MAPK/Erk signaling pathway on the basis of breast cancer line MCF-7 gene expressions. The algorithm constructs a hierarchy from top to bottom on the basis of a self-organizing tree. It dynamically finds the number of clusters at each level. It was found that only Euclidean distance harmonic is fit for the analysis of the cascade composed from a RAF1 （c-Raf）, a MKNK1, a MAPKK （MEK1/2） to MAPK （Erk） in breast cancer line MCF-7. The result is consistent with the biological experimental MAP/Erk signaling pathway, and the theoretical MAPK/Erk signaling pathway on breast cancer line MCF-7 is set up.

关键词： hierarchical clustering signaling pathway,Euclidean distance harmonic

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Ultrasound-guided,direct suprainguinal injection for fascia iliaca block for total hip arthroplasty:A retrospective study

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World Journal of Clinical Cases 2021年第15期9卷 3567-3575页

作者： Ya-Li Wang Yun-Qing Liu hua Ni xin-Lei zhang Li Ding Fei Tong Hong-Ye Chen xin-hua zhang Ming-Jian Kong Department of Anesthesiology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Rehabilitation Department The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Peripheral regional block combined with general anesthesia might be a preferable anesthetic regimen for elderly patients undergoing total hip *** To investigate whether ultrasound-guided,direct suprainguinal injection for fascia iliaca block accelerated recovery after general anesthesia and relieved postoperative pain after total hip *** Patients who underwent total hip arthroplasty under general anesthesia in 2015 or 2019 at The Second Affiliated Hospital of Xuzhou Medical University were retrospectively *** patients were grouped based on whether preoperative suprainguinal fascia iliaca block was performed or *** time to tracheal extubation and time spent in the post-anesthesia care unit(PACU),intraoperative remifentanil dosage,fentanyl consumption in the PACU,postoperative cumulative fentanyl consumption within 48 h after operation,visual analogue scale at rest and during movement on the first and second days after surgery,and adverse reactions were *** Thirty-one elderly patients who underwent total hip arthroplasty were included in the study(block group,n=16;no-block group,n=15).The visual analog scale scores at rest and during movement on the first and second days were significantly lower in the block group than in the no-block group(all P<0.05).Compared with the no-block group,the intraoperative remifentanil dosage was lower,the time to tracheal extubation and the time spent in the PACU were shorter in the block group(all P<0.01).Fentanyl consumption in the PACU and postoperative cumulative fentanyl consumption in 48 h after operation were lower in the block group(all P<0.01).The incidence of dizziness was higher in the no-block group than in the block group(P=0.037).CONCLUSION Ultrasound-guided,direct suprainguinal injection for fascia iliaca block led to faster recovery after general anesthesia and early postoperative pain relief in elderly patients undergoing total hip arthroplasty.

关键词： Suprainguinal fascia iliaca block Elderly patients Total hip arthroplasty General anesthesia recovery Postoperative pain

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Association of polymorphisms of A260G and A386G in DAZL gene with male infertility： a meta-analysis and systemic review

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Asian Journal of Andrology 2016年第1期18卷 96-101页

作者： Ping Chen Xiao Wang Chang Xu He Xiao Wen-Hao zhang xing-huan Wang xin-hua zhang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China

To investigate the association of single nucleotide polymorphism 260 and 386 （SNP260 and SNP386） gene with male infertility, an electronic search was performed to identify case-control studies evaluating the relationship of SNP260 or SNP386 of deleted in azoospermia-like （DAZL） and male infertility. Review Manager 5 was used to process the meta-analysis and other statistical analysis. A total of 139 records were retrieved, of which 13 case-control studies with total 2715 patients and 1835 normozoospermic men were included. SNP260 was found not to play a functional role in male oligo/azoospermia either for Caucasians or for Asians. But for SNP386, models of allele （A/G）, dominant （AA/AG ＋ GG）, co-dominant （AA/AG） and super-dominant （AA ＋ GG/AG） had a strong correlation to spermatogenic failure with related odds ratio being 0.15 （95% confidence interval [95% CI] 0.07 to 0.34, P〈 0.00001）, 0.16 （95% CI 0.07 to 0.35, P〈 0.00001）, 0.15 （95% CI 0.06 to 0.33, P〈 0.00001） and 0.15 （95% CI 0.06 to 0.33, P 〈 0.00001）, respectively. Moreover, this correlation was only found in the Chinese Han population （decreasing around 85% risk of oligo/azoospermia infertility） and not found in India, Japan, and Caucasian countries. Our analysis demonstrated that SNP260 of DAZL did not contribute to oligo/azoospermia while SNP386 was correlated to male infertility. However, this correlation was only found in China with a country-specific and ethnicity-specific manner.

关键词： deleted in azoospermia-like male infertility meta-analysis polymorphism single nucleotide polymorphisms

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Parameter identification and global sensitivity analysis of xin'anjiang model using meta-modeling approach

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Water Science and Engineering 2013年第1期6卷 1-17页

作者： Xiao-meng SONG Fan-zhe KONG Che-sheng ZHAN Ji-wei HAN xin-hua zhang Hydrology and Water Resources Department Nanjing Hydraulic Research Institute School of Resource and Earth Science China University of Mining and Technology Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

Parameter identification, model calibration, and uncertainty quantification are important steps in the model-building process, and are necessary for obtaining credible results and valuable information. Sensitivity analysis of hydrological model is a key step in model uncertainty quantification, which can identify the dominant parameters, reduce the model calibration uncertainty, and enhance the model optimization efficiency. There are, however, some shortcomings in classical approaches, including the long duration of time and high computation cost required to quantitatively assess the sensitivity of a multiple-parameter hydrological model. For this reason, a two-step statistical evaluation framework using global techniques is presented. It is based on （1） a screening method （Morris） for qualitative ranking of parameters, and （2） a variance-based method integrated with a meta-model for quantitative sensitivity analysis, i.e., the Sobol method integrated with the response surface model （RSMSobol）. First, the Morris screening method was used to qualitatively identify the parameters＇ sensitivity, and then ten parameters were selected to quantify the sensitivity indices. Subsequently, the RSMSobol method was used to quantify the sensitivity, i.e., the first-order and total sensitivity indices based on the response surface model （RSM） were calculated. The RSMSobol method can not only quantify the sensitivity, but also reduce the computational cost, with good accuracy compared to the classical approaches. This approach will be effective and reliable in the global sensitivity analysis of a complex large-scale distributed hydrological model.

关键词： xin'anjiang model," global sensitivity analysis parameter identification meta-modeling approach," response surface model

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Systematic review and meta-analysis on phosphodiesterase 5 inhibitors and α-adrenoceptor antagonists used alone or combined for treatment of LUTS due to BPH

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Asian Journal of Andrology 2015年第6期17卷 1022-1032,I0012页

作者： xing-huan Wang Xiao Wang Ming-Jun Shi Sheng Li Tao Liu xin-hua zhang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China.

The aim of this systematic review is to determine the comparative effectiveness and safety of phosphodiesterase 5 inhibitors （PDE5-1s） and （x-blockers used alone or combined for the treatment of lower urinary tract symptoms （LUTS） due to benign prostatic hyperplasia （BPH）. An electronic search of PubMed, Cochrane Library and Embase up to January 2014 was performed to identify randomized controlled trials comparing the efficacy and safety of PDE5-Is and （x-blockers for treatment of lower urinary tract symptoms due to benign prostatic hyperplasia, which assessed IPSS score, maximum flow rate, postvoided residual urine, quality of life and Erectile Function （IIEF） score as outcomes. Data were analyzed by fixed or random effect models using Cochrane Collaboration review manager software. A total of 12 studies were included, Our novel data demonstrated that there was a trend that （x-blockers were more efficacious than PDE5-Is on decreasing IPSS score and increasing maximum flow rate. （x-blockers were significantly more effective than PDE5-Is on reduction of postvoided residual urine with a mean difference of 3.67 （95% CI 1.56 to 5.77, P = 0.0006） and PDE5-Is showed greater effect than （x-blockers on increasing IIEF score with a mean difference of 9.82 （95% CI 3.80 to 15.85, P = 0.001）. In conclusion, our novel data demonstrated that PDE5-Is plus ABs ranked the highest on the improvement of LUTS/BPH. PDE5-Is monotherapy was also effective in this kind of disorder except less reduction of PVR than ABs, In addition, both combined- or mono-therapy were safe.

关键词： benign prostatic hyperplasia lower urinary tract symptoms meta-analysis phosphodiesterase 5 inhibitors -adrenoceptorantagonists

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Sample-data Decentralized Reliable H∞ Hyperbolic Control for Uncertain Fuzzy Large-scale Systems with Time-varying Delay

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自动化学报 2009年第12期35卷 1534-1540页

作者： LIU xin-Rui zhang hua-Guang Key Laboratory of Integrated Automation for the Process Industry. Ministry of Education School of Information Science and Engineering Northeastern University Shenyang 110004 P. R. China

这份报纸学习样品数据的问题为有变化时间的延期的不明确的连续时间的模糊大规模系统的可靠 H 夸张控制。第一，模糊夸张模型( FHM )被用来为某些复杂大规模系统建立模型，然后根据 Lyapunov 指导方法和大规模系统的分散的控制理论，线... 详细信息

这份报纸学习样品数据的问题为有变化时间的延期的不明确的连续时间的模糊大规模系统的可靠 H 夸张控制。第一，模糊夸张模型( FHM )被用来为某些复杂大规模系统建立模型，然后根据 Lyapunov 指导方法和大规模系统的分散的控制理论，线性 matrixine 质量( LMI )基于条件 arederived toguarantee H 性能不仅当所有控制部件正在操作很好时，而且面对一些可能的致动器失败。而且，致动器的精确失败参数没被要求，并且要求仅仅是失败参数的更低、上面的界限。条件依赖于时间延期的上面的界限，并且不依赖于变化时间的延期的衍生物。因此，获得的结果是不太保守的。最后，二个例子被提供说明设计过程和它的有效性。

关键词：模糊双曲模型线性矩阵不等式分散控制理论执行器

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Microbial Activity in a Temperate Forest Soil as Affected by Elevated Atmospheric CO_2

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Pedosphere 2010年第4期20卷 427-435页

作者： ZHENG Jun-Qiang HAN Shi-Jie ZHOU Yu-Mei REN Fei-Rong xin Li-hua zhang Yan Forestry Center Institute of Applied Ecology Chinese Academy of Sciences 72 Wenhua Road Shenyang 110016 （China）

Microorganisms play a key role in the response of soil ecosystems to the rising atmospheric carbon dioxide （CO2） as they mineralize organic matter and drive nutrient cycling. To assess the effects of elevated CO2 on soil microbial C and N immobilization and on soil enzyme activities, in years 8 （2006） and 9 （2007） of an open-top chamber experiment that begun in spring of 1999, soil was sampled in summer, and microbial biomass and enzyme activity related to the carbon （C）, nitrogen （N） and phosphorus （P） cycling were measured. Although no effects on microbial biomass C were detected, changes in microbial biomass N and metabolic activity involving C, N and P were observed under elevated CO2. Invertase and .dehydrogenase activities were significantly enhanced by different degrees of elevated CO2. Nitrifying enzyme activity was significantly （P 〈 0.01） increased in the August 2006 samples that received the elevated COs treatment, as compared to the samples that received the ambient treatment. Denitrifying enzyme activity was significantly （P 〈 0.04） decreased by elevated COs treatments in the August 2006 and June 2007 （P 〈 0.09） samples, β-N-acetylglucosaminidase activity was increased under elevated CO2 by 7% and 25% in June and August 2006, respectively, compared to those under ambient CO2. The results of June 2006 samples showed that acid phosphatase activity was significantly enhanced under elevated CO2. Overall, these results suggested that elevated CO2 might cause changes in the belowground C, N and P cycling in temperate forest soils.

关键词： CO2 enrichment microbial biomass soil carbon cycling soil nitrogen cycling

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Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis

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Asian Journal of Andrology 2001年第1期3卷 75-77页

作者： xin-hua zhang Gui-Qin SUN Yu YANG Tai-He zhang Department of Pathology, General Hospital of Nanjing Command, PLA, Nanjing 210002, China Department of Pathology General Hospital of Nanjing Command China

Aim: To determine the immunoreactive pattern of human papillomavirus (HPV) antigen and p53 protein in condylo-mata acuminatum (CA) and squamous cell carcinoma (SCC) of penis. Methods: Immunohistochemistry for HPVand p53 were performed in 40 specimens of formalin fixed, paraffin embedded tissues using a polyclonal (rabbit) anti-body against HPV and a monoclonal (mouse) antibody against human p53 protein. Twenty one cases of CA and nine-teen cases of SCC were examined. Results: HPV antigen was detected in all 21 CA and 2 penile SCC. p53 proteinoverexpression was observed in 12 of 19 (63%) SCC in which 6 cases were strong positive. Five of 21 CA (24%)showed low-grade p53 protein overexpression. Conclusion; CA is related to HPV infection and some cases showp53 protein low-grade overexpression. In contrast, p53 protein overexpression is common in penile SCC, which is sel-dom related to HPV infection. (Asian J Androl 2001 Mar; 3: 75-77)

关键词： condylomata acuminata penile diseases carcinoma HPV protein p53

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miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation

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Neural Regeneration Research 2022年第2期17卷 401-408页

作者： Wen Li Shan-Shan Wang Bo-Quan Shan Jian-Bing Qin He-Yan Zhao Mei-Ling Tian Hui He Xiang Cheng xin-hua zhang Guo-hua Jin Department of Human Anatomy Institute of NeurobiologyNantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NantongJiangsu ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

The regulation of adult neural stem cells(NSCs) is critical for lifelong neurogenesis. MicroRNAs(miRNAs) are a type of small, endogenous RNAs that regulate gene expression post-transcriptionally and influence signaling networks responsible for several cellular processes. In this study, mi R-103-3 p was transfected into neural stem cells derived from embryonic hippocampal neural stem cells. The results showed that mi R-103-3 p suppressed neural stem cell proliferation and differentiation, and promoted apoptosis. In addition, mi R-103-3 p negatively regulated Nud E neurodevelopment protein 1-like 1(Ndel1) expression by binding to the 3′ untranslated region of Ndel1. Transduction of neural stem cells with a lentiviral vector overexpressing Ndel1 significantly increased cell proliferation and differentiation, decreased neural stem cell apoptosis, and decreased protein expression levels of Wnt3 a, β-catenin, phosphor-GSK-3β, LEF1, c-myc, c-Jun, and cyclin D1, all members of the Wnt/β-catenin signaling pathway. These findings suggest that Ndel1 is a novel mi R-103-3 p target and that mi R-103-3 p acts by suppressing neural stem cell proliferation and promoting apoptosis and differentiation. This study was approved by the Animal Ethics Committee of Nantong University, China(approval No. 20200826-003) on August 26, 2020.

关键词： apoptosis canonical Wnt pathway differentiation MiR-103-3p Ndel1 neural stem cells neurogenesis proliferation

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