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Two polyoxovanadoborates with over 100 nuclei assembled from a {V_(14)Co_(12)B_(72)} cluster

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Science China Chemistry 2024年第8期67卷 2578-2585页

作者： Shuang-Xue Wu Yu-Jiao Dong Yang Yang Chao Qin Chun-Yi Sun Wei guan xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130013China Key Laboratory of Advanced Materials of Tropical Island Resources Hainan UniversityHaikou 570228China

Combining theoretical prediction and experimental exploration, the first sandwich-type polyoxovanadoborate(POVB) with an odd number of nuclei, [V_(11)B_(26)O_(73)(OH)_(10)]^(8-)(1), was discovered under hydrothermal conditions. Density-functional theory(DFT)gives a rationalization for the existence of this structure and the structural feature is consistent with the {V_NB_(2N+X)}(X = 2, 4, 6, 8)general formula. Excitingly, when Co and 1,10-phenanthroline(phen) are introduced into the synthesis of vanadoborates system,a 100-nuclei [Co_6(phen)_(10)(H_(2)O)_8][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·28H_(2)O(2) and a 102-nuclei [Co_6(phen)_(14)(H_(2)O)_(4)][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·23H_(2)O(3) with the same core structure of [V_(14)Co_(12)B_(72)]^(12-)are obtained. The vase-shaped [V_(14)Co_(12)B_(72)] polyanion is a multilayered sandwich-type structure containing seven distinct structural layers and is the largest known POVB. Furthermore, 2demonstrates exceptional thermal and chemical stability and serves as an efficient and stable catalyst for the photoreduction of carbon dioxide.

关键词： boronate metallic materials polyoxovanadoborates density functional theory photocatalysis CO_(2)reduction

New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2862-2864页

作者： Shi-Hao guan Wen-Jing Hu xin-Yu Wang Yue-Xia Gu De-Hua Zhou Department of Plastic Surgery Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Gastrointestinal Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and *** data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune ***,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关键词： Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research

Impact of COVID-19 Interventions on Respiratory and Intestinal Infectious Disease Notifications-Jiangsu Province,China,2020–2023

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China CDC weekly 2024年第41期6卷 1059-1064,I0003页

作者： Ziying Chen xin Liu Jinxing guan Yingying Shi Wendong Liu Zhihang Peng Jianli Hu School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Acute Infectious Diseases Control and Prevention Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Jiangsu Province Engineering Research Center of Health Emergency Nanjing CityJiangsu ProvinceChina.

Introduction:Many measures implemented to control the coronavirus disease 2019(COVID-19)pandemic have reshaped the epidemic patterns of other infectious *** study estimated the impact of the COVID-19 pandemic on respiratory and intestinal infectious diseases and potential changes following ***:The optimal intervention and counterfactual models were selected from the seasonal autoregressive integrated moving average(SARIMA),neural network autoregression(NNAR),and hybrid models based on the minimum mean absolute percentage error(MAPE)in the test *** relative change rate between the actual notification rate and that predicted by the optimal model was calculated for the entire COVID-19 epidemic prevention period and the“reopening”***:Compared with the predicted notification rate based on the counterfactual model,the total relative change rates for the 9 infectious diseases were−44.24%,respiratory infections(−55.41%),and intestinal infections(−26.59%)during 2020–*** with the predicted notification rate based on the intervention model,the total relative change rates were+247.98%,respiratory infections(+389.59%),and intestinal infections(+50.46%)in *** them,the relative increases in influenza(+499.98%)and hand-foot-mouth disease(HFMD)(+70.97%)were ***:Measures taken in Jiangsu Province in response to COVID-19 effectively constrained the spread of respiratory and intestinal infectious *** and HFMD rebounded significantly after the lifting of COVID-19 intervention restrictions.

关键词： Impact lifting prevention

Nucleophiles promotes the decomposition of electrophilic functional groups of tetracycline in ZVI/H_(2)O_(2) system: Efficiency and mechanism

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Chinese Chemical Letters 2024年第10期35卷 414-420页

作者： xin Li Wanting Fu Ruiqing guan Yue Yuan Qinmei Zhong Gang Yao Sheng-Tao Yang Liandong Jing Song Bai Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission School of Chemistry and EnvironmentSouthwest Minzu UniversityChengdu 610041China Key Laboratory of General Chemistry of the National Ethnic Affairs Commission School of Chemistry and EnvironmentSouthwest Minzu University.Chengdu 610041China Institute of Environmental Engineering RWTH Aachen UniversityAachen 52062Germany

When zero-valent iron(ZVI)is prepared and applied under neutral conditions,it is easy to form oxides or hydroxides on its surface,which hinders the electron release of *** this end,a nucleophile was introduced into the ZVI system to inhibit the precipitation of iron ions,improve the conductivity of the solution,and promote the removal efficiency of electrophilic functional groups in organic *** this study,the addition of nucleophiles such as ethylenediamine,methylamine and dimethylamine to the ZVI/H_(2)O_(2)system resulted in an enhanced removal efficiency of tetracycline(TC)under neutral condition,while electrophiles such as EDTA-2Na and oxalic acid dihydrate impeded the removal of *** results demonstrated that the presence of nucleophiles could effectively promote the release of iron ions and increase the proportion of ferrous in both aqueous solution and solid surface of *** and theoretical calculation results revealed that the electrophilic functional group was eliminated in the TC molecule,and the toxicity of the treated solution was reduced ***,this work provides a selection of the conditions and pollutants applicable to ZVI under neutral pH conditions.

关键词： ZVI Nucleophiles Tetracycline Electrophilicfunctionalgroup Electronic transfer

Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2685-2697页

作者： Fangyan Gao Yueyao Wu Runtian Wang Yuhui Yao Yiqiu Liu Lingling Fan Jingtong Xu Jian Zhang xin Han Xiaoxiang guan Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjing 210023China Department of Oncology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210023China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211166China

Targeting androgen receptor(AR)has shown great therapeutic potential in triple-negative breast cancer(TNBC),yet its efficacy remains ***,we aimed to identify promising targeted agents that synergize with enzalutamide,a second-generation AR inhibitor,in *** using a strategy for screening drug combinations based on the Sensitivity Index(SI),we found that MK-8776,a selective checkpoint kinase1(CHK1)inhibitor,showed favorable synergism with enzalutamide in AR-positive *** combination of enzalutamide and MK-8776 was found to exert more significant anti-tumor effects in TNBC than the single application of enzalutamide or MK-8776,***,a nanoparticle-based on hyaluronic acid(HA)-modified hollow-manganese dioxide(HMnO_(2)),named HMnE&M@H,was established to encapsulate and deliver enzalutamide and *** HA-modified nanosystem managed targeted activation via pH/glutathione ***&M@H repressed tumor growth more obviously than the simple addition of enzalutamide and MK-8776 without a ***,our study elucidated the synergy of enzalutamide and MK-8776 in TNBC and developed a novel tumor-targeted nano drug delivery system HMnE&M@H,providing a potential therapeutic approach for the treatment of TNBC.

关键词： Triple-negative breast cancer Androgen receptor Checkpoint kinase 1 Enzalutamide MK-8776 Synergy HMnO_(2) Nanodrug delivery system

Climate warming is likely to weaken the performance of two-phase closed thermosyphon on the Qinghai-Tibet Plateau

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Advances in Climate Change Research 2024年第1期15卷 90-100页

作者： guan-Li JIANG Zi-Teng FU xin-Yu MEN Hong-Ting ZHAO Si-Ru GAO Yong-Zhi LI Qing-Bai WU State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Beiluhe Observation and Research Station on Frozen Soil Engineering and Environment in the Qinghai-Tibet Plateau Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Muli Field Scientific Observation and Research Station for Gas Hydrate China Geological SurveyBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China School of Civil Engineering and Architecture Jiaxing Nanhu UniversityJiaxing 314001China

Over the years,numerous geotechnical approaches have been implemented to mitigate the adverse effects of climate warming on various infrastructures in the permafrost region of the Qinghai-Tibet Plateau(QTP),such as the Qinghai-Tibet Highway and Railway,and achieved the expected engineering ***,little attention has been given to whether the performance of these geotechnical approaches has changed during the ongoing process of climate *** investigate the performance variation of one of these geotechnical approaches,which is two-phase closed thermosyphon(TPCT),during sustained climate warming,we conducted a statistical analysis of soil temperature monitoring data in 2003-2020 from eight regular embankments and six TPCT embankments in our permafrost monitoring *** results indicate that TPCT undeniably has a cooling effect on the permafrost beneath embankments,even rapidly eliminated previously formed taliks beneath ***,further analysis reveals that the performance of TPCT has been weakening during sustained climate warming,which has confirmed by the re-forming of the taliks beneath embankment where they had been previously *** on the current understanding,we attributed the weakening of thermosyphon performance to a significant reduction in the air temperature freezing index caused by ongoing climate *** this study,we aimed to draw attention to the evolving performance of geotechnical approaches in permafrost regions amid climate warming,prompting necessary engineering innovations to address this situation and ensure the sustainable development of the permafrost region on the QTP.

关键词： Two-phase closed thermosyphon Climate warming Supra-permafrost talik Permafrost degradation Qinghai-Tibet Highway

Regulating interfacial chemistry and kinetic behaviors of F/Mo co-doping Ni-rich layered oxide cathode for long-cycling lithium-ion batteries over-20°C-60°C

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Journal of Energy Chemistry 2024年第7期94卷 449-457页

作者： Siqi guan Lin Tao Pei Tang Ruopian Fang Huize Wu Nan Piao Huicong Yang guangjian Hu xin Geng Lixiang Li Baigang An Feng Li Institute of Energy Materials and Electrochemistry Research University of Science and Technology LiaoningAnshan 114051LiaoningChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina Shenyang King Power Tech.Co. Ltd.Shenyang 110016LiaoningChina School of Chemical Engineering The University of New South WalesSydney 2052NSWAustralia

Ni-rich layered oxide cathodes have shown promise for high-energy lithium-ion batteries(LIBs)but are usually limited to mild environments because of their rapid performance degradation under extreme temperature conditions(below0°C and above 50 °C).Here,we report the design of F/Mo co-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(FMNCM)cathode for high-performance LIBs from-20 to 60°C.F^(-) doping with high electronegativity into the cathode surface is found to enhance the stability of surface lattice structure and protect the interface from side reactions with the electrolyte by generating a LiF-rich surface ***,the Mo^(6+) doping suppresses phase transition,which blocks Li^(+)/Ni^(2+) mixing,and stabilizes lithium-ion diffusion ***,the FMNCM cathode demonstrates excellent cycling stability at a high cutoff voltage of 4.4 V,even at 60°C,maintaining 90.6%capacity retention at 3 C after 150 ***,at temperatures as low as-20°C,it retains 77.1%of its room temperature capacity,achieving an impressive 97.5%capacity retention after 500 *** stable operation under wide temperatures has been further validated in practical Ah-level *** study sheds light on both fundamental mechanisms and practical implications for the design of advanced cathode materials for wide-temperature LIBs,presenting a promising path towards high-energy and long-cycling LIBs with temperatureadaptability.

关键词： Anion-cation co-doping Wide temperature operation Ni-richlayered cathode Phase transition Surface/interface

Impacts of high temperature,relative air humidity,and vapor pressure deficit on the seed set of contrasting maize genotypes during flowering

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Journal of Integrative Agriculture 2024年第9期23卷 2955-2969页

作者： xin Dong Baole Li Zhenzhen Yan Ling guan Shoubing Huang Shujun Li Zhiyun Qi Ling Tang Honglin Tian Zhongjun Fu Hua Yang Chongqing Academy of Agricultural Sciences Chongqing 401329China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Heat stress is a major constraint to current and future maize production at the global *** and female reproductive organs both play major roles in increasing seed set under heat stress at flowering,but their relative contributions to seed set are *** this study,a 2-year field experiment including three sowing dates in each year and 20 inbred lines was *** set,kernel number per ear,and grain yield were all reduced by more than 80%in the third sowing dates compared to the first sowing *** viability,silk emergence ratio,and anthesis-silking interval were the key determinants of seed set under heat stress;and their correlation coefficients were 0.89^(***),0.65^(***),and-0.72^(***),*** pressure deficit(VPD)and relative air humidity(RH)both had significant correlations with pollen viability and the silk emergence *** RH can alleviate the impacts of heat on maize seed set by maintaining high pollen viability and a high silk emergence *** a warming climate from 2020 to 2050,VPD will decrease due to the increased *** on their pollen viability and silk emergence ratios,the 20 genotypes fell into four different *** group with high pollen viability and a high silk emergence ratio performed better under heat stress,and their performance can be further improved by combining the improved flowering pattern traits.

关键词： maize pollen viability silk emergence heat stress relative humidity

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling guan xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution