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Tetrahedron constellation of gravitational wave observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 86-93页

作者： Hong-Bo jin Cong-feng Qiao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

For the first time,we have introduced the tetrahedron constellation of gravitational wave observatory(TEGO)composed of four identical spacecrafts(S/Cs).The laser telescopes and their pointing structures are mounted on the S/C platform and are evenly distributed at three locations 120 degrees *** structures form automatically a stable mass center for the *** time delay interferometry(TDI)is used to suppress the frequency noise of gravitational wave(GW)*** unequal-arm Michelson TDI configuration and the Sagnac TDI configuration are equally effective at eliminating the laser frequency noise based on the TEGO ***,compared with the configurations of LISA,Taiji,and Tian Qin,the TEGO has more combinations of optical paths in its TDI system sensitive to GW *** six arms of TEGO are simultaneously sensitive to the six polarization modes of *** sensitivity implies that GW modes beyond the predictions of general relativity(GR)can be detected *** instance,a scalar longitudinal mode of GWs,which is not predicted by GR,has been identified as a dominant polarization *** mode is found to be evident in the response amplitudes of the TEGO arms,such as between S/C1 and S/C4,and S/C3 and S/C4,at certain orbital positions.

关键词： gravitational wave detectors and experiments gravitational waves experimental tests of gravitational theories experimental studies of gravity

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Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas

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Chinese Medical Journal 2009年第22期122卷 2763-2769页

作者： LIU Qun LI Ji-guang ZHENG xin-yu jin feng DONG Hui-ting Department of Surgical Oncology the First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China

Background Biomarkers in breast neoplasms provide invaluable information regarding prognosis and help determining the optimal treatment. We have examined the possible correlation between cancer stem cell （CSC）-like markers （CD133, paired box gene 2 protein （PAX2）, epithelial specific antigen （ESA））, and a new membrane estrogen receptor （G-protein coupled receptor 30 （GPR30）） in invasive ductal breast carcinomas with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers. Methods In 74 invasive ductal breast carcinomas, we investigated the protein expression of these molecular markers by immunohistochemistry, and their associations with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers. We studied the interrelationship between the expressions of these proteins. Results CD133, a putative CSC marker, was positively related to tumor size, tumor stage, and lymph node metastasis. PAX2 was negatively correlated with tumor recurrence. ESA, one of the breast CSC markers, was an indicator of tumor recurrence. GPR30 was associated with hormone receptors. Despite the correlation between GPR30 and the nuclear estrogen receptor, the expression was dependent. Positive staining of GPR30 in tumors displayed a significant association with high C-erbB2 expression and a tendency for tumor recurrence. A positive relationship between GPR30 and CD133 existed. Conclusion Detecting the expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas may be of help in more accurately predicting the aggressive properties of breast cancer and determining the optimal treatment.

关键词： breast neoplasms immunohistochemistry tumor markers retrospective study

Differential-geometry-based multi-dimensional joint position-velocity estimation using Crab pulsar profile distortion

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Chinese Journal of Aeronautics 2025年第1期38卷 551-567页

作者： jin LIU Huanzi ZHANG Xiaolin NING xin MA School of Electronic Information Wuhan University of Science and TechnologyWuhan 430081China School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Hefei National Laboratory Hefei 230088China

The traditional orbit determination method based on pulsar profile distortion can determine the six elements of the ***,the estimation accuracies of these methods are limited and the computational load of a six-dimensional search is *** solve this problem,the differential-geometry-based Multi-dimensional Joint Position-Velocity Estimation(MJPVE)using Crab pulsar profile distortion is proposed in this ***,through theoretical analysis,it is found that the pulsar profile distortion caused by the initial state error in some joint positionvelocity directions is very *** other words,the accuracies of estimation in these directions are very ***,the search dimension can be reduced,which in turn greatly reduces the computational ***,we construct the chi-squared function of the pulsar profile with respect to the estimation error in joint position-velocity direction and use differential geometry to find the joint position-velocity directions corresponding to different degrees of ***,we utilize the grid search based on directory folding in these joint position-velocity directions corresponding to large degrees of distortion to obtain the joint position-velocity *** experimental results show that compared with the grouping bi-chi-squared inversion method,MJPVE has high precision and extensive navigation information.

关键词： Joint Position-Velocity Estimation Pulsars Profile Distortion Orbit Determination Differential Geometry

Spatial-temporal distribution and emission of urban scale air pollutants in Hefei based on Mobile-DOAS

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Journal of Environmental Sciences 2025年第5期151卷 238-251页

作者： Zhidong Zhang Pinhua Xie Ang Li Min Qin jin Xu Zhaokun Hu xin Tian feng Hu Yinsheng Lv Jiangyi Zheng Youtao Li School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Chinese Academy of Sciences Beijing 100049China Information Materials and Intelligent Sensing Laboratory of Anhui Province Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China

As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban ***,there has been limited research in recent years on the spatial-temporal distribution and emission of its atmospheric *** address this,this study conducted mobile observations of urban roads using the Mobile-DOAS instrument from June 2021 to May *** monitoring results exhibit a favourable consistent with TROPOMI satellite data and ground monitoring station ***,there were pronounced seasonal variations in air ***,high concentration of HCHO and NO_(2)were closely associated with traffic congestion on roadways,while heightened SO_(2)levels were attributed to winter heating and industrial *** study also revealed that with the implementation of road policies,the average vehicle speed increased by 95.4%,while the NO concentration decreased by 54.4%.In the estimation of urban NO_(x)emission flux,it was observed that in temporal terms,compared with inventory data,the emissions calculated viamobile measurements exhibitedmore distinct seasonal patterns,with the highest emission rate of 349 g/sec in winter and the lowest of 142 g/sec in *** spatial terms,the significant difference in emissions between the inner and outer ring roads also suggests the presence of the city’s primary NO_(x)emission sources in the area between these two *** study offers data support for formulating the next phase of air pollution control measures in urban areas.

关键词： Mobile-DOAS HCHO NO_(2) SO_(2) Spatial-temporal distribution NOx emission

Mechanism of AsperosaponinⅥRelated to EGFR/MMP9/AKT/PI3K Pathway in Treatment of Rheumtoid Arthritis

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Chinese Journal of Integrative Medicine 2025年第2期31卷 131-141页

作者： LUO jin-fang YU Yang LIU Jian-xin School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Sino-Pakistan Center on Traditional Chinese Medicine China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan ProvinceSchool of Pharmaceutical SciencesHunan University of MedicineHuaihua CityHunan Province(418000)China

Objective:To explore the mechanism of action of asperosaponinⅥ(AⅥ)in the treatment of rheumatoid arthritis(RA)and validate it in ex vivo experiments using network pharmacology and molecular docking ***:The predicted targets of AⅥwere obtained from PharmMaper,UniProt and Swiss Target Prediction platforms,the disease targets were collected from Online Mendelian Inheritance in Man,Therapeutic Target Database and Gene Cards databases,the intersection targets of AⅥand RA were obtained from Venny 2.1.0,and the protein-protein interaction(PPI)network was obtained from STRING database,which was analyzed by Cytoscape software and screened to obtain the core *** software was used to analyze PPI network and screen the core *** on the Database for Annotation,Visualization and Integrated Discovery database,Gene Ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed,and Cytoscape software was used to construct the"DiseasePathway-Target-Drug"network,which was finally verified by molecular docking and animal ***:Network pharmacological studies showed that AⅥwas able to modulate 289 targets,with 102 targets for the potential treatment of RA,with the core pathway being the AKT/PI3K signaling pathway,and the core targets being the epidermal growth factor receptor(EGFR)and matrix metalloproteinase 9(MMP9).Molecular docking results showed that AⅥcould produce strong binding with both of the 2 core *** vitro cellular experiments showed that AⅥreduced nitric oxide,prostaglandin E_2,tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1βlevels(P<0.05)and inhibited cyclooxygenase-2,nitric oxide synthase,EGFR,MMP9,phosphorylated phosphoinositide 3-kinase(p-PI3K),and phosphorylated serine-threonine kinase(p-AKT)proteins(P<0.05).The results of in vivo studies showed that AⅥimproved RA score and foot swelling thickness and decreased TNF-α,IL-6,p-PI3K and p-AKT levels in RA rat

关键词： inflammation rheumatoid arthritis network pharmacology asperosaponinⅥ EGFR/MMP9/AKT/PI3K pathway

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 93-104页

作者： Pan Guo Hong-Bo jin Cong-feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of SciencesBeijing 100190China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China The School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China

For space-based gravitational wave(GW)detection,the main noise source for massive black hole binaries(MBHBs)is attributed to approximately 107 double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratioΔD_(L)/D_(L) at the 95%confidence level,is enhanced by factors of∼*** angular resolutions,denoted byΔΩs,are enhanced by a factor of∼*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

Vector meson’s spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 1-16页

作者： jin-Hui Chen Zuo-Tang Liang Yu-Gang Ma xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation(MOE)Shandong UniversityQingdao 266237China INFN-Firenze Sesto Fiorentino FI 50019Italy Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Mechanics and Physics Anhui University of Science and TechnologyHuainan 232001China

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider(RHIC)at Brookhaven National Laboratory(BNL).It provides a unique opportunity to probe the correlation between the po-larized quark and antiquark in the strongly coupled quark-gluon plasma(sQGP)produced in relativistic heavy ion collisions,opening a new window to explore the properties of *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e^(+)e^(−)annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimen-tal advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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航空发动机传感器信号重构的K-ELM方法

航空动力学报 2017年第1期32卷 221-226页

作者：尤成新鲁峰黄金泉南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016 中国航空发动机集团有限公司航空动力控制系统研究所江苏无锡214063 先进航空发动机协同创新中心北京100191

针对航空发动机传感器信号重构,提出了评价核极限学习机(K-ELM)模型性能的一种快速留一交叉验证方法.结果表明:该方法可以避免原始的留一验证方法 N次模型的显式训练,将计算复杂度降低为原来的1/N(N为样本数目).该算法可以快速准确评价... 详细信息

针对航空发动机传感器信号重构,提出了评价核极限学习机(K-ELM)模型性能的一种快速留一交叉验证方法.结果表明:该方法可以避免原始的留一验证方法 N次模型的显式训练,将计算复杂度降低为原来的1/N(N为样本数目).该算法可以快速准确评价核极限学习机的性能,为核极限学习机确定最优的核参数.

关键词：航空发动机传感器信号重构核极限学习机留一交叉验证方法核参数

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-Ying jin feng-Li Sun Wei-Dong jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury