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The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice

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Journal of Environmental Sciences 2025年第5期151卷 54-67页

作者： Xiang Zuo Minghe Sun Huijuan Bai Shuhui Zhang Jialu Luan Qian Yu Zhenhua Fu Qili zhao Mingzhu Sun xin zhao Xizeng Feng College of Life Science State Key Laboratory of Medicinal Chemical BiologyThe Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071China Institute of Robotics&Automatic Information System College of Artificial IntelligenceNankai UniversityTianjin 300071China

17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly ***,17-TB acts as a hormone with properties similar to testosterone,and the consequences of juvenile exposure on adult social behavior remain *** A(BPA)acts as an estrogen-like hormone,compared to ***-week-old male Balb/c mice were exposed orally to 17-TB(100μg/(kg·day))and BPA(4 mg/(kg·day))for 28 *** of social interactions and a three-chamber test showed that 17-TB increased virility in male mice,intensified both male and female sexual behavior,and attracted and accepted female *** also increased social dominance through tube tests inmalemice and markedly activated the c-Fos^(+)immune response in themedial prefrontal cortex(mPFC)and basal amygdala(BLA).ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone(GnRH),growth hormone(GH),estradiol(E2),and luteinizing hormone(LH)levels,as well as testicular lesions and androgen receptor(ARβ)and estrogen receptor(ERα)*** transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic *** findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice,possibly through modulation of the hypothalamic-pituitary-gonadal *** study provides insights relevant to human reproductive health and neuro-social behavioral research,and the potential risk of environmental disturbances should not be overlooked.

关键词： 17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) Sex hormones Social dominance Sexual behavior

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Different Impacts of Aerosols on Cloud Development over Land and Ocean Regions in East China

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第4期42卷 731-743页

作者： zhao, xin zhao, Chuanfeng Chi, Yulei Yang, Jie Sun, Yue Yang, Yikun Fan, Hao Beijing Normal Univ Fac Geog Sci Beijing 100875 Peoples R China Peking Univ Sch Phys Dept Atmosphere & Ocean Sci Lab Climate & Ocean Atmosphere Studies Beijing 100871 Peoples R China Beijing Normal Univ Sch Syst Sci Beijing 100875 Peoples R China

The impact of aerosols on clouds, which remains one of the largest aspects of uncertainty in current weather forecasting and climate change research, can be influenced by various factors, such as the underlying surface type, cloud type, cloud phase, and aerosol type. To explore the impact of different underlying surfaces on the effect of aerosols on cloud development, this study focused on the Yangtze River Delta (YRD) and its offshore regions (YRD sea) for a comparative analysis based on multi-source satellite data, while also considering the variations in cloud type and cloud phase. The results show lower cloud-top height and depth of single-layer clouds over the ocean than land, and higher liquid cloud in spring over the ocean. Aerosols are found to enhance the cumulus cloud depth through microphysical effects, which is particularly evident over the ocean. Aerosols are also found to decrease the cloud droplet effective radius in the ocean region and during the mature stage of cloud development in the land region, while opposite results are found during the early stage of cloud development in the land region. The quantitative results indicate that the indirect effect is positive (0.05) in the land region at relatively high cloud water path, which is smaller than that in the ocean region (0.11). The findings deepen our understanding of the influence aerosols on cloud development and the mechanisms involved, which could then be applied to improve the ability to simulate cloud-associated weather processes.

关键词： cloud depth cloud effective radius aerosol land ocean

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Different Impacts of Aerosols on Cloud Development over Land and Ocean Regions in East China

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Advances in Atmospheric Sciences 2025年第04期 731-743页

作者： xin zhao Chuanfeng zhao Yulei CHI Jie YANG Yue SUN Yikun YANG Hao FAN Faculty of Geographical Science Beijing Normal University Laboratory for Climate and Ocean–Atmosphere Studies Department of Atmosphere and Oceanic SciencesSchool of Physics Peking University School of Systems Science Beijing Normal University

The impact of aerosols on clouds, which remains one of the largest aspects of uncertainty in current weather forecasting and climate change research, can be influenced by various factors, such as the underlying surface type, cloud type, cloud phase, and aerosol type. To explore the impact of different underlying surfaces on the effect of aerosols on cloud development, this study focused on the Yangtze River Delta(YRD) and its offshore regions(YRD sea) for a comparative analysis based on multi-source satellite data, while also considering the variations in cloud type and cloud phase. The results show lower cloud-top height and depth of single-layer clouds over the ocean than land, and higher liquid cloud in spring over the ocean. Aerosols are found to enhance the cumulus cloud depth through microphysical effects,which is particularly evident over the ocean. Aerosols are also found to decrease the cloud droplet effective radius in the ocean region and during the mature stage of cloud development in the land region, while opposite results are found during the early stage of cloud development in the land region. The quantitative results indicate that the indirect effect is positive(0.05) in the land region at relatively high cloud water path, which is smaller than that in the ocean region(0.11). The findings deepen our understanding of the influence aerosols on cloud development and the mechanisms involved, which could then be applied to improve the ability to simulate cloud-associated weather processes.

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不同类型学业压力对不同年级高中生执行功能子成分的影响

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心理学报 2025年第1期57卷 18-35页

作者：马超汪彦云付军军赵鑫甘肃省行为与心理健康重点实验室西北师范大学心理学院兰州730070

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交... 详细信息

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交压力对各执行功能成分的负向预测作用逐渐减弱。相比之下,自我压力对高中生的干扰抑制、反应抑制和注意转换能力均显示出了正向预测作用,并随年级的升高而增强。这表明,不同类型学业压力对各执行功能成分的预测作用存在差异,并将随高中生年级的升高而发生变化。本研究所产生的结论对于教育工作者有效制定高中生学业压力应对策略具有重要的启示意义。

关键词：执行功能学业压力高中生结构方程模型

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桃树主要种植环节机械化技术应用

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中国农机装备 2025年第3期 77-80页

作者：赵鑫山东省潍坊市临朐县东城街道办事处潍坊262619

近年来,临朐县着力打造“特色”产业集群,采用“合作社+农户”模式,提升桃树种植机械化水平,扩大种植规模,并与市级企业合作实现定点供应,保障果农权益。发展机械装备是桃树产业现代化的关键,需依据栽培环节完善机械化技术应用方案,推... 详细信息

近年来,临朐县着力打造“特色”产业集群,采用“合作社+农户”模式,提升桃树种植机械化水平,扩大种植规模,并与市级企业合作实现定点供应,保障果农权益。发展机械装备是桃树产业现代化的关键,需依据栽培环节完善机械化技术应用方案,推动全程机械化。结合实际,探讨了桃树种植环节机械化技术的应用,提出了桃树种植机械化发展策略,以供桃树种植者参考。

关键词：桃树规模化发展机械化技术应用

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WRRB轮轨滚动行为模拟试验台轮轨高频动态模拟特性初探

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铁道学报 2025年第1期47卷 54-62页

作者：罗易飞赵鑫温泽峰黄双超周志军西南交通大学轨道交通运载系统全国重点实验室四川成都610031

为研究WRRB轮轨滚动行为模拟试验台的高频动态模拟特性,利用Ansys/LS-DYNA建立试验轮轨和我国服役轮轨的瞬态滚动接触有限元模型。模型充分考虑轨下离散支承和系统结构高频振动,集成基于罚函数的“面-面接触算法”、轨面不平顺模型、T... 详细信息

为研究WRRB轮轨滚动行为模拟试验台的高频动态模拟特性,利用Ansys/LS-DYNA建立试验轮轨和我国服役轮轨的瞬态滚动接触有限元模型。模型充分考虑轨下离散支承和系统结构高频振动,集成基于罚函数的“面-面接触算法”、轨面不平顺模型、Tγ磨耗模型。对比二者在平顺条件和典型高频激励(轨面单个凹坑和波磨)下的轮轨力、接触应力、钢轨磨耗深度,结果表明,试验轮轨在比例载荷作用下能定量模拟服役轮轨的滚动接触行为,但由于轮轨截面几何、悬挂结构、驱动方式等因素的影响,二者存在以下差异:试验轮轨在零横移时也具有约0.12倍静轮重的横向力,法向接触应力偏低,切向接触应力和钢轨磨耗量偏高;轨面短波不平顺激励下的动态轮轨力偏低,车轮滚出凹坑后轮轨力衰减得更快,波磨引起的轮轨“拍”振不明显,但钢轨磨耗深度平均值和峰-谷值均偏高,有利于实物试验时加速轨面不平顺演变。利用该试验台模拟直线或大半径曲线运行工况时应注意以上差异,并考虑加装车轮悬挂与侧滚装置。

关键词：缩尺车轮-环轨有限元法短波不平顺瞬态滚动接触相似性

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Research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China(Life Sciences) 2025年第2期68卷 354-380页

作者： Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-xin zhao Guo-Long Bu Xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Viral Immunobiology Institute of Experimental ImmunologyUniversity of ZürichZürich 8092Switzerland Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalBoston MA 02115USA Department of Microbiology Harvard Medical SchoolBoston MA 02115USA Harvard Program in Virology Boston MA 02115USA Broad Institute of Harvard and MIT Cambridge MA 02142USA

Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human *** we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex *** this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

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Readout electronics for the gamma detector of the HIRFL-CSR external target facility

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Nuclear Science and Techniques 2025年第2期36卷 71-81页

作者： Xian-Qin Li Hai-Bo Yang Xiao-Meng Ma Chao-Jie Zou Tao Liu Xian-Cai Zhou Duo Yan Yang-Zhou Su Shu-Wen Tang Shi-Tao Wang Yu-Hong Yu Zhi-Yu Sun Cheng-xin zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China School of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China

The Cooling Storage Ring of the Heavy Ion Research Facility in Lanzhou(HIRFL-CSR)was constructed to study nuclear physics,atomic physics,interdisciplinary science,and related *** External Target Facility(ETF)is located in the main ring of the *** gamma detector of the ETF is built to measure emitted gamma rays with energies below 5 MeV in the center-of-mass frame and is planned to measure light fragments with energies up to 300 *** readout electronics for the gamma detector were designed and *** readout electronics consist of thirty-two front-end cards,thirty-two readout control units(RCUs),one common readout unit,one synchronization&clock unit,and one sub-trigger *** using the real-time peak-detection algorithm implemented in the RCU,the data volume can be significantly *** addition,trigger logic selection algorithms are implemented to improve the selection of useful events and reduce the data *** test results show that the integral nonlinearity of the readout electronics is less than 1%,and the energy resolution for measuring the 60 Co source is better than 5.5%.This study discusses the design and performance of the readout electronics.

关键词： HIRFL-CSR Gamma detector External target facility Readout electronics Readout control unit Common readout unit Peak-detection algorithm

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瑞马唑仑对患儿口腔日间手术苏醒期躁动的影响

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临床麻醉学杂志 2025年第01期41卷 51-55页

作者：赵鑫吴征元张雪赵保建南京大学医学院附属口腔医院南京市口腔医院麻醉科南京大学口腔医学研究所

目的探讨瑞马唑仑对患儿口腔日间手术苏醒期躁动的影响。方法选择全麻下行龋齿治疗的患儿62例，男33例，女29例，年龄3～6岁，BMI 12～23 kg/m2,ASAⅠ或Ⅱ级。将患儿随机分为两组：瑞马唑仑组和丙泊酚组，每组31例。瑞马唑仑组麻醉诱... 详细信息

目的探讨瑞马唑仑对患儿口腔日间手术苏醒期躁动的影响。方法选择全麻下行龋齿治疗的患儿62例，男33例，女29例，年龄3～6岁，BMI 12～23 kg/m2,ASAⅠ或Ⅱ级。将患儿随机分为两组：瑞马唑仑组和丙泊酚组，每组31例。瑞马唑仑组麻醉诱导时静脉推注瑞马唑仑0.3 mg/kg,麻醉维持时泵注瑞马唑仑1 mg·kg-1·h-1;丙泊酚组麻醉诱导时静脉推注丙泊酚2 mg/kg,麻醉维持时泵注丙泊酚6 mg·kg-1·h-1。记录拔管即刻、拔管后30 min及拔管后2 h患儿苏醒期躁动（PAED）评分、Ramsay镇静评分和患儿行为学（FLACC）疼痛评分。记录麻醉时间、手术时间、术中输液量、出血量、苏醒时间及阿芬太尼总量。记录恶心呕吐、低氧血症、喉痉挛、嗜睡、苏醒期躁动等不良事件的发生情况。结果与丙泊酚组比较，瑞马唑仑组拔管后30 min PAED评分明显降低（P<0.05）,Ramsay镇静评分明显升高（P<0.05）,苏醒期躁动发生率明显降低（P<0.05）。两组恶心呕吐、低氧血症、喉痉挛及嗜睡不良事件发生率差异无统计学意义。结论与丙泊酚比较，采用瑞马唑仑可降低口腔日间手术患儿苏醒期躁动发生率，且不增加围术期不良事件。

关键词：丙泊酚瑞马唑仑苏醒期躁动日间手术

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五味子甲素改善氧化应激引起的内皮功能障碍

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中国药理学通报 2025年第1期41卷 122-130页

作者：侯惠民张文文赵卫萍赵鑫朴贤美寒地心血管疾病国家重点实验室哈尔滨医科大学药学院药理学教研室黑龙江省生物医药工程重点实验室—省部共建国家重点实验室培育基地心血管药物研究教育部重点实验室黑龙江哈尔滨150086

目的探究五味子甲素(schizandrin A,SchA)对氧化应激引起内皮功能障碍的拮抗作用及其作用机制。方法选用人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)作为研究对象,采用MTT实验检测SchA对HUVECs活力的影响;通过流... 详细信息

目的探究五味子甲素(schizandrin A,SchA)对氧化应激引起内皮功能障碍的拮抗作用及其作用机制。方法选用人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)作为研究对象,采用MTT实验检测SchA对HUVECs活力的影响;通过流式细胞技术检测细胞中ROS的含量;试剂盒检测HUVECs中MDA、CAT的含量以及细胞上清液中NO、ET-1的含量;Western blot实验检测细胞中SOD1、p-eNOS/eNOS蛋白以及Nrf2/Keap1/HO-1通路蛋白的表达情况;免疫荧光实验检测细胞Nrf2的入核情况。结果SchA通过激活Nrf2/Keap1/HO-1信号通路逆转LPS或缺氧诱导的HUVECs内ROS和MDA含量的升高及SOD1和CAT含量的下降;SchA逆转LPS诱导的HUVECs中p-eNOS和eNOS蛋白表达的降低及逆转细胞培养液中NO含量的下降和ET-1含量的升高;Nrf2抑制剂ML385逆转SchA对氧化应激及内皮功能障碍的拮抗作用。结论SchA拮抗LPS及缺氧诱导的氧化应激,SchA通过上调Nrf2/Keap1/HO-1信号通路改善氧化应激引起的内皮功能障碍。

关键词： SchA 氧化应激内皮功能障碍 Nrf2/Keap1/HO-1信号通路 HUVECs LPS

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