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Two polyoxovanadoborates with over 100 nuclei assembled from a {V_(14)Co_(12)B_(72)} cluster

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Science China Chemistry 2024年第8期67卷 2578-2585页

作者： Shuang-Xue Wu Yu-jiao Dong Yang Yang Chao Qin Chun-Yi Sun Wei Guan xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130013China Key Laboratory of Advanced Materials of Tropical Island Resources Hainan UniversityHaikou 570228China

Combining theoretical prediction and experimental exploration, the first sandwich-type polyoxovanadoborate(POVB) with an odd number of nuclei, [V_(11)B_(26)O_(73)(OH)_(10)]^(8-)(1), was discovered under hydrothermal conditions. Density-functional theory(DFT)gives a rationalization for the existence of this structure and the structural feature is consistent with the {V_NB_(2N+X)}(X = 2, 4, 6, 8)general formula. Excitingly, when Co and 1,10-phenanthroline(phen) are introduced into the synthesis of vanadoborates system,a 100-nuclei [Co_6(phen)_(10)(H_(2)O)_8][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·28H_(2)O(2) and a 102-nuclei [Co_6(phen)_(14)(H_(2)O)_(4)][V_(14)Co_(12)B_(72)O_(144)(OH)_(20)]·23H_(2)O(3) with the same core structure of [V_(14)Co_(12)B_(72)]^(12-)are obtained. The vase-shaped [V_(14)Co_(12)B_(72)] polyanion is a multilayered sandwich-type structure containing seven distinct structural layers and is the largest known POVB. Furthermore, 2demonstrates exceptional thermal and chemical stability and serves as an efficient and stable catalyst for the photoreduction of carbon dioxide.

关键词： boronate metallic materials polyoxovanadoborates density functional theory photocatalysis CO_(2)reduction

Construction and validation of a neovascular glaucoma nomogram in patients with diabetic retinopathy after pars plana vitrectomy

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World Journal of Diabetes 2024年第4期15卷 654-663页

作者： Yi Shi Yan-xin Zhang Ming-Fei jiao xin-Jun Ren Bo-Jie Hu Ai-Hua Liu Xiao-Rong Li Surgical Retina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Glaucoma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Ocular Trauma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected *** the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical *** To develop a visual risk profile model to explore factors influencing DR after *** We retrospectively selected 151 patients with DR undergoing *** patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after *** risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction *** After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram *** area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,*** AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,*** A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction *** study can help formulate relevant preventive and treatment measures.

关键词： Diabetic retinopathy Retinopathy Neovascular Glaucoma Risk factors Nomogram

Association between physical activity and risk of gastroesophageal reflux disease:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第5期13卷 687-698页

作者： Chuting Yu Tinglu Wang Ye Gao Yunfei jiao Huishan Jiang Yan Bian Wei Wang Han Lin Lei xin Luowei Wang Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China National Clinical Research Center for Digestive Diseases(Shanghai) Shanghai 200433China

Background:Lifestyle plays an important role in preventing and managing gastroesophageal reflux disease(GERD).In response to the conflicting results in previous studies,we performed a systematic review and meta-analysis to investigate this ***:Relevant studies published until January 2023 were retrieved from 6 databases,and the prevalence of symptomatic gastroesophageal reflux(GER)or GERD was determined from the original studies.A random effects model was employed to meta-analyze the association by computing the pooled relative risk(RR)with 95%confidence intervals(95%CIs).Furthermore,subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity(PA)time and ***:This meta-analysis included 33 studies comprising 242,850 participants.A significant negative association was observed between PA and the prevalence of symptomatic GER(RR=0.74,95%CI:0.66-0.83;p<0.01)or GERD(RR=0.80,95%CI:0.76-0.84;p<0.01),suggesting that engaging in PA might confer a protective benefit against *** analyses consistently indicated the presence of this association across nearly all subgroups,particularly among the older individuals(RR_(<40 years):RR_(≥40 years)=0.85:0.69,p<0.01)and smokers(RR_(smoker):RR_(non-smoker)=0.67:0.82,p=0.03).Furthermore,a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09%lower risk of developing ***:Maintaining high levels of PA decreased the risk of GERD,particularly among older adults and *** the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.

关键词： Physical activity Gastroesophageal reflux disease Prevalence Systematic review

IREla is required for pancreas development

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IREla is required for pancreas development

Mechanical characteristics and reservoir stimulation mechanisms of the Gulong shale oil reservoirs, the northern Songliao Basin

2012全国发育生物学大会

作者： xin-xin Li,jiao-jiao Feng,Chen-Yang Yin,Li Yuan~* Department of Biochemistry and Molecular Biology,Nanjing Medical University,Nanjing,210029

Inositol requiring enzyme-1(IRE1) is highly conserved from yeast to *** the endoplasmic reticulum(ER) stress,IRE1 activates X-box-binding protein 1(XBP1) by unconventional splicing of XBP1 mRNA,which activates unfolded protein reponse(UPR) to restore thehomeostasis of the *** mice,IRE1αplays an essential role in extraembryonic ***,itsprecise action during development is yet *** this study,The complete open reading frame of xIRE1αwas amplified and compared with the amino acid sequence of mice and human IRE1αand Xenopus IRE1β.Then the gain and loss of function analyses were used to investigate the function of Xenopus IRE1α(xIRE1α).The results showed that xIRE1αis much closer to human IRE1αcompared with their sequence *** gain and loss of xIRE1αfunction had no significant effect on germ layer formation,but xIRE1αis sufficient for cytoplasmic splicing of xXBP1 and knockdown of xIRE1αcould rescue the TM induced developmental defects and apoptosis at tail bud stages of *** tadpole stages of development,knockdown of xIRE1αled to a gut-coiling defect,and pancreas hypoplasia or even *** knockdown of xXBP1,the downstream gene of xIRE1α,showed the similar phenotype. Conclusions:Our data indicate that IRE1αis not required for germ layer formation,but for pancreas development.

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Petroleum Science 2024年第3期21卷 2023-2036页

作者： Si-Wei Meng Jia-Ping Tao Tian-jiao Li Dong-Xu Li Su-Ling Wang Liu Yang xin Liu Li-Hao Liang He Liu PetroChina Research Institute of Petroleum Exploration Development Beijing100083China National Key Laboratory of Continental Shale Oil Daqing 163002HeilongjiangChina Dalian University of Technology Dalian116024LiaoningChina PetroChina Daqing Oilfield Co.Ltd. Daqing163002HeilongjiangChina Northeast Petroleum University Daqing163002HeilongjiangChina China University of Mining and Technology(Beijing) Beijing100083China

Shale oil of the Qingshankou Formation of the Gulong Sag,the northern Songliao Basin,represents the first attempt at large-scale development of pure-shale-type shale oil in *** integrating the multiscale refined reservoir characterization with macro-micro-scale mechanical testing,it is clarified that the Gulong shale is characterized by high clay mineral content,high rock plasticity,highly-developed bedding,and prominent mechanical anisotropy.A three-dimensional(3D)fracture propagation model of hydraulic fracturing was built for the Gulong shale,which fully captures the hydraulic fracture distribution pattern affected by the high bedding density,in-situ stress,and fracturing treatment *** research showed that due to influences of bedding,hydraulic fracturing in the Gulong shale forms a complex fracture morphology featuring the main fracture with multiple perpendicular branches that have different lengths(like the outdoor directional TV antenna);however,the vertical propagation of fractures is inhibited,and the fracture height is commonly less than 10 *** limited stimulated reservoir volume(SRV)is the main problem facing the fracturing stimulation of the Gulong shale *** density has vital effects on fracture morphology,so case-specific fracturing designs shall be developed for shale intervals with different bedding development *** reservoirs with welldeveloped bedding,it is suggested to properly increase the perforation cluster spacing and raise the volume and proportions of viscous fluids of the pad,so as to effectively promote vertical fracture propagation and improve reservoir stimulation *** study integrates multi-scale fine reservoir characterization and macro-micro-scale mechanical testing,as well as the construction and numerical simulation of hydraulic fracturing models for high-density layered shale reservoirs,providing a new approach and methodological framework for the fracturing research of high-density layer

关键词： Shale oil Hydraulic fracturing High bedding density Fracture propagation model

基于正交试验的工艺参数对门内板成形性的影响

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塑性工程学报 2020年第12期27卷 73-81页

作者：焦欣吴越武黄河科技学院工学部河南郑州450006

针对车门内板成形过程中出现的局部开裂问题,通过综合应用试验法和Auto Form有限元仿真技术,基于正交试验法实现快速定位影响车门内板成形缺陷的主要工艺参数;分析了主要工艺参数对车门内板成形性的影响规律,以此为依据对车门内板冲压... 详细信息

针对车门内板成形过程中出现的局部开裂问题,通过综合应用试验法和Auto Form有限元仿真技术,基于正交试验法实现快速定位影响车门内板成形缺陷的主要工艺参数;分析了主要工艺参数对车门内板成形性的影响规律,以此为依据对车门内板冲压工艺参数进行调整,现场开展零件试制,获取零件应变情况。结果表明,影响车门内板危险区最大减薄率的主要因素为摩擦系数和压边力;随着摩擦系数和压边力的增大,破裂风险处的减薄率提高;当压边力控制在900~1100 k N范围内,摩擦系数控制在0.09~0.12时,成形结果较好;经过对车门内板进行冲压工艺参数调整,未出现开裂情况,原来开裂区域的安全裕度均大于10%,符合生产要求。

关键词：车门内板工艺参数成形性正交试验成形极限图

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应用模糊分析法汽车覆盖件加工过程参数优化

机械设计与制造 2023年第2期384卷 112-116页

作者：焦欣李鑫黄河科技学院工学部河南郑州450006

汽车车身覆盖件用冷轧钢板的成形性能与材料内部结构、力学性能等指标密切相关,当工艺技术参数相关稳定时,成形结果很大程度决定于自身的性能。根据汽车覆盖件的特点和使用要求,对钢板成形性能指标进行分析,采用模糊层次分析法来求取各... 详细信息

汽车车身覆盖件用冷轧钢板的成形性能与材料内部结构、力学性能等指标密切相关,当工艺技术参数相关稳定时,成形结果很大程度决定于自身的性能。根据汽车覆盖件的特点和使用要求,对钢板成形性能指标进行分析,采用模糊层次分析法来求取各评价指标值的权重,并且使用模糊综合评价获得材料的成形性能决策参数,作为汽车用钢新产品开发和性能评价的基本依据。利用DYNAFORM建立冲压仿真模型,对覆盖件加工过程进行仿真分析,获取合理的试验工艺参数。在此基础上,基于网格应变分析技术,进行胀形试验,对选取的汽车覆盖件冲压时工艺参数进行验证。结果可知:参数优化结果表明,当板料与凸模、压边圈、凹模的摩擦系数设置为0.025、0.125、0.125,压边力为120kN时,材料的成形结果较为理想;试验测试与仿真分析结果误差控制在3%以内,且临界区域保持一致,表明分析方法和结果的可靠性,为此类设计研究提供参考。

关键词：车身覆盖件加工工艺冲压模型成形评价

Co-Design and Trust in Social Network’s Websites

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Social Networking 2016年第3期5卷 93-99页

作者： Jyh-Jeng Wu Shu-Hua Chien Khash-Orgil Gansukh xin-jiao Yang Department of Business Management National United University Taiwan Department of Insurance and Finance National Taichung University of Science and Technology Taiwan

This research is focused on internet shoppers co-design, individual tendency of trust, trust belief, and purchase intention. An online questionnaire was set out in survey form on Google Docs in or-der to collect data. The survey was conducted of participants in Mongolia. 236 usable responses were obtained from Mongolian potential customers in order to examine constructs. The findings suggest that co-design and individual tendency of trust have significant positive effect on the trust levels throughout intention to purchase.

关键词： Co-Design Trust Purchase Intention

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun GU jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of EndMT(P0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway