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Tungsten 2025年第1期7卷 183-194页

作者： xin-Ran Sun Hao-Ming Yuan Guo-Da Zhang chao Wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

Presepsin as a novel sepsis biomarker

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World Journal of Emergency Medicine 2014年第1期5卷 16-19页

作者： Qi Zou Wei Wen xin-chao Zhang Emergency Medicine Department Beijing Hospital

BACKGROUND: In 2004, a new biomarker sCD14-subtypes(presepsin) was found and its value was shown in the diagnosis and evaluation of sepsis. This article is a brief overview of the new *** SOURCES: A literature search using multiple databases was performed for articles, especially meta-analyses, systematic reviews, and randomized controlled ***: Compared with other markers, presepsin seems to have a better sensitivity and specificity in the diagnosis of sepsis. Presepsin as a biom1 arker is not only suitable for the early diagnosis of sepsis, but also for the assessment of its severity and ***: Presepsin has a higher sensitivity and specificity in the diagnosis of sepsis as a new biomarker, and is a predictor for the prognosis of sepsis. More importantly, preseptin seems to play a crucial role as a supplemental method in the early diagnosis of sepsis. Since there is no multicenter study on the relationship between presepsin and sepsis, further studies on the clinical values of presepsin are needed.

关键词： Presepsin Sepsis Diagnosis

Effects of TAT-SOD at Acupoints on Essential Hypertension by Monitoring Meridians Electrical Potential

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Chinese Journal of Integrative Medicine 2020年第9期26卷 694-700页

作者： GUO Jing-ke XU Jin-sen CHEN Tian-bao XU Ming-ming LIU Shu-tao ZHANG chao-xin KE Li-jing ZHOU Jian-wu WANG Qiang RAO Ping-fan Shanghai Institutes for Biological Sciences Chinese Academy of Sciences/Zhejiang Gongshang University Joint Centre for Food and Nutrition ResearchZhejiang Gongshang UniversityHangzhou(310035)China Acupuncture College Fujian University of Traditional Chinese MedicineFuzhou(350003)China Natural Drug Discovery Group School of PharmacyQueen's UniversityBelfast(BT97BL)UK College of Oceanology and Food Science Quanzhou Normal UniversityQuanzhouFujian(362000)China College of Biological Science and Technology Fuzhou UniversityFuzhou(350108)China Guangzhou Halcyon Technology Ltd. Guangzhou(510630)China Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijing(100193)China

Objectives:To investigate the effect on essential hypertension of the topical application of TAT-Cu,Zn-superoxide dismutase(TAT-SOD)at left acupoint Zusanli(ST 36),and to observe whether the change of electrical potential difference(EPD)can be related to the change of blood ***:Sixteen patients with essential hypertension and 16 healthy subjects were included in the *** between the left acupoints of Yanglingquan(GB 34)and Qiuxu(GB 40)was firstly screened out for the EPD *** intracellular superoxide quenching enzyme,TAT-SOD,was topically applied to the acupoint ST 36 within an area of 1 cm^2 once a day,and the influence on EPD was *** dosage applied to TAT-SOD group(n=8)was 0.2 mL of 3000 U/mL TAT-SOD cream prepared by adding purified TAT-SOD to a vehicle cream,while placebo group(n=8)used the vehicle cream *** left acupoints of Yanglingquan(GB 34)and Qiuxu(GB 40)were selected for EPD measurement after comparing EPD readings between 5 acupoints on each of all 12 ***:EPDs between the left acupoints of GB 34 and GB 40 for 16 patients of essential hypertension and 16 healthy subjects were 44.9±6.4 and 5.6±0.9 mV,*** application of TAT-SOD for 15 days at ST 36 of essential hypertension patients significantly decreased systolic blood pressure(SBP)and diastolic blood pressure(DBP)of 179.6 and 81.5 mm Hg to 153.1 and 74.1 mm Hg,*** to the change in blood pressure,EPD between the left acupoints of GB 34 and GB 40 also declined from 44.4 to 22.8 mV with the same *** change was observed with SBP,DBP and EPD between the left acupoints of GB 34 and GB 40 with the daily application of the placebo ***:Enzymatic scavenging of the intracellular superoxide at ST 36 proved to be effective in decreasing SBP and *** results reconfirm the involvement of superoxide anions and its transportation along the meridians,and demonstrate that EPD between acupoints may be an indi

关键词： TAT-SOD reactive oxygen species electrical potential essential hypertension acupoints

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen xin Zhang Lingcong chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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新古典偏左:政府在经济发展中的作用

首都经济贸易大学学报 2014年第5期16卷 5-14页

作者：辛超中国社会科学院研究生院北京102488

政府与市场具有内在联系,现实中既存在市场失灵和政府失灵,还存在二者共同失灵,因此一方面不能忽视政府在经济发展中的作用,另一方面政府应以市场参与者身份和模拟市场运行的方式在技术与发展等多个方面发挥作用。落后国家在发展过程中... 详细信息

政府与市场具有内在联系,现实中既存在市场失灵和政府失灵,还存在二者共同失灵,因此一方面不能忽视政府在经济发展中的作用,另一方面政府应以市场参与者身份和模拟市场运行的方式在技术与发展等多个方面发挥作用。落后国家在发展过程中,需要政府进行发展诊断、发展环境多样性识别、经济系统化建设等工作。由于多样化的技术进步依赖于产业多样化,因此需要重视产业多样化发展和密切融入国际产业体系。

关键词：新古典偏左政府失灵市场失灵发展经济学政策干预

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软包锂电池铝塑膜的耐电解液性能

塑料工业 2024年第10期52卷 131-137页

作者：辛潮合诚技术股份有限公司广东广州510530

为了研究锂电池铝塑膜复合工艺对铝塑膜性能的影响,本文通过测定在不同成分的电解液中浸泡后的热封层/铝箔层剥离力来分析电解液对锂电池铝塑膜的腐蚀机理;以17种不同的复合工艺(即改变预贴合温度、预贴合时间、熟化温度和熟化时间)制... 详细信息

为了研究锂电池铝塑膜复合工艺对铝塑膜性能的影响,本文通过测定在不同成分的电解液中浸泡后的热封层/铝箔层剥离力来分析电解液对锂电池铝塑膜的腐蚀机理;以17种不同的复合工艺(即改变预贴合温度、预贴合时间、熟化温度和熟化时间)制备的锂电池铝塑膜为研究对象,分析复合工艺对锂电池铝塑膜热封层/铝箔层剥离力和耐电解液性能的影响规律。结果表明,电解液对铝塑膜的腐蚀机理为:电解液中的六氟磷酸锂(LiPF6)与水(H2O)反应产生氢氟酸(HF),然后强腐蚀性的HF对热封层/铝箔层的粘接界面进行侵蚀,进而引起热封层与铝箔层的粘接失效;复合工艺会影响铝塑膜热封层/铝箔层的剥离力和其耐电解液性能,复合时预贴合温度越高、预贴合时间越长、熟化温度越高、熟化时间越长,热封层/铝箔层的剥离力越高,耐电解液性能越好,但增大到一定的数值后影响就不存在了。在复合工艺为预贴合温度180℃,预贴合时间15 s,熟化温度190℃,熟化时间40 s下制备的铝塑膜热封层/铝箔层的剥离力最高,耐电解液性能最好;在低于此工艺参数时,预贴合温度/熟化温度越高,预贴合时间/熟化时间越长,热封层/铝箔层剥离力和耐电解液性能越好。

关键词：锂电池铝塑膜剥离力电解液复合工艺

Asymmetric Total Synthesis of a Diastereisomer A of Tuxpanolide

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有机化学 2004年第Z1期24卷 149-页

作者： WANG,Jin-xin ZHANG,chao-xin LI,Ying State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzho 730000 Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzho 730000 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzho 730000

　　α-Alkylidene-β-hydroxy butyrolactones have been attractive and challenging targets for organic synthesis in various laboratories because that not only they are rich in skeletal diversity and stereochemistry complexity but also many of them possess quite intriguing and wide biological activities.[1] A novel class of the phytane-type diterpenoid named Tuxpanolide, bearing α-alkylidene-β-hydroxy-γ-butyrolactone skeleton, was isolated from Perymenium hintonii in Central Mexico by Maldonado and co-wokers in 1998.[2] Now we firstly report the efficient strategy of the stereocontrolled total synthesis of a diastereisomer A of Tuxpanolide.……

关键词： biological activities organic synthesis total synthesis

Asymmetric Synthesis of β, γ-β-Hydroxyl-γ-butyrolactones

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有机化学 2003年第Z1期23卷 461-461页

作者： WANG Jin-xin ZHANG chao-xin LI Ying National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

　　Chiral β-hydroxyl-γ-butyrolactones have attracted substantial interest in recent years due to their presence inmany strongly active natural products having antitumor, fungicidal, anti-inflammatory activity, and their use as important precursors in natural product synthesis. [1] In the course of the total synthesis of the natural product Tuxpano lide ,[2] we found a concise and efficient strategy on the stereocontrolled synthesis of β-hydroxyl-γ-butyrolactonederivatives from cheap and achiral starting material.……

关键词： natural products total synthesis

Robustness with respect to Small Delays for Controllability of Linear Dynamic Systems

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Robustness with respect to Small Delays for Controllability ...

Effect of simplifying bogie regions on aerodynamic performance of high-speed train

第二十三届中国控制会议

作者： Yu xin , Xu chao (Department of Mathematics, ZhejiangUniversity,Hangzhou,310027)

＜正＞ This paper studies the robustness with respect to delays for controllability of linear dynamic systems in Banach space. We prove that the linear dynamic system with a small delay is X -exactly controllable if t... 详细信息

关键词： semigroup Controllability Robustness Delay

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Journal of Central South University 2022年第5期29卷 1717-1734页

作者： ZHANG Jie ADAMU Abdulmalik SU xin-chao GUO Zhan-hao GAO Guang-jun Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075China Joint International Research Laboratory of Key Technology for Rail Traffic Safety Central South UniversityChangsha 410075China National&Local Joint Engineering Research Center of Safety Technology for Rail Vehicle Changsha 410075China

An investigation of the effect of simplifying bogie regions on the aerodynamic performance of a high-speed train was carried out by studying four train models,to explore possible ways to optimise the train underbody structure,improve the underbody aerodynamic performance,and reduce the aerodynamic *** shear stress transport(SST)k-ωturbulence model was used to study the airflow features of the high-speed train with different bogie regions at Re=2.25×10^(6).The calculated aerodynamic drag and surface pressure were compared with the experimental benchmark of wind tunnel *** results show that the SST k-ωmodel presents high accuracy in predicting the flow fields around the train,and the numerical results closely agree with the experimental *** with the train with simplified bogies,the aerodynamic drag of the train with a smooth surface and the train with enclosed bogie cavities/inter-carriage gaps decreases by 38.2%and 30.3%,respectively,while it increases by 10.8%for the train with cavities but no ***,enclosing bogie cavities shows a good capability of aerodynamic drag reduction for a new generation of highspeed trains.

关键词： high-speed train aerodynamic drag RANS method bogie bogie cavity