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Right ventricular-arterial uncoupling as an independent prognostic factor in acute heart failure with preserved ejection fraction accompanied with coronary artery disease

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Chinese Medical Journal 2023年第10期136卷 1198-1206页

作者： Hongdan Jia Li Liu xile bi Ximing Li Hongliang Cong Department of Cardiology Clinical School of ThoracicTianjin Medical UniversityTianjin 300222China Department of Cardiology The First Hospital of QinhuangdaoQinhuangdaoHebei 066000China

Background:Right ventricular(RV)-arterial uncoupling is a powerful independent predictor of prognosis in heart failure with preserved ejection fraction(HFpEF).Coronary artery disease(CAD)can contribute to the pathophysiological characteristics of *** study aimed to evaluate the prognostic value of RV-arterial uncoupling in acute HFpEF patients with ***:This prospective study included 250 consecutive acute HFpEF patients with *** were divided into RV-arterial uncoupling and coupling groups by the optimal cutoff value,based on a receiver operating characteristic curve of tricuspid annular plane systolic excursion to pulmonary artery systolic pressure(TAPSE/PASP).The primary endpoint was a composite of all-cause death,recurrent ischemic events,and HF ***:TAPSE/PASP≤0.43 provided good accuracy in identifying patients with RV-arterial uncoupling(area under the curve,0.731;sensitivity,61.4%;and specificity,76.6%).Of the 250 patients,150 and 100 patients could be grouped into the RV-arterial coupling(TAPSE/PASP>0.43)and uncoupling(TAPSE/PASP≤0.43)groups,*** strategies were slightly different between groups;the RV-arterial uncoupling group had a lower rate of complete revascularization(37.0%[37/100]vs.52.7%[79/150],P*** Cox analysis showed TAPSE/PASP≤0.43 as an independent associated factor for the primary endpoint,all-cause death,and recurrent HF hospitalization(hazard ratios[HR]:2.21,95%confidence interval[CI]:1.44-3.39,P<0.001;HR:3.32,95%CI:1.30-8.47,P=0.012;and HR:1.93,95%CI:1.10-3.37,P=0.021,respectively),but not for recurrent ischemic events(HR:1.48,95%CI:0.75-2.90,P=0.257).Conclusion:RV-arterial uncoupling,based on TAPSE/PASP,is independently associated with

关键词： Heart failure with preserved ejection fraction Coronary artery disease Right ventricular-arterial coupling Prognosis Revascularization

Fern Diversity in the Mid-Cretaceous Amber Forests Revealed by Exceptionally Preserved Sporangium Types

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International Journal of Geosciences 2024年第5期15卷 351-365页

作者： Chunxiang Li xile Zhou Yiran Wang Department of Cenozoic biological Evolution and Environment Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing China Xiangxi Tujia and Miao Autonomous Prefecture Forest Resources Monitoring Center Jishou China School of Resources and Earth Sciences China University of Mining and Technology Xuzhou China

The amber deposits from the Albian-Cenomanian in Myanmar have emerged as a pivotal source for exceptionally abundant fossil insect fauna since their initial discovery. Recent studies have increasingly focused on elucidating the fern inventory and examining newly available fossils from Myanmar amber, suggesting a diverse fern flora that once thrived in Cretaceous forests. Through investigations of amber collections, with particular emphasis on sporangium structures—especially the annulus types preserved in amber inclusions—this study revealed additional novelties within the Cyatheales and Schizaeales in mid-Cretaceous Myanmar amber forests. The described specimens and newly discovered fossils provide compelling evidence that Polypodiales were not only diverse and abundant but also that other fern lineages, such as Cyatheales and Schizaeales, coexisted in these ancient forest ecosystems. This study reveals the high diversity of ferns in the mid-Cretaceous Myanmar area, while also implying the paleoecological and paleogeographical significance of the Mesozoic Burmese amber forests.

关键词： Mid-Cretaceous Myanmar Amber Polypodiales Cyatheales Schizaeales Sporangium

Coexisting fast–slow dendritic traveling waves in a 3D-array electric field coupled neuronal network

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Chinese Physics B 2024年第6期33卷 614-626页

作者：魏熙乐任泽宇卢梅丽樊亚琴常思远 The Tianjin Key Laboratory of Process Measurement and Control School of Electrical and Information EngineeringTianjin UniversityTianjin 300072China School of Information Technology Engineering Tianjin University of Technology and EducationTianjin 300074China

Coexistence of fast and slow traveling waves without synaptic transmission has been found in hhhippocampal tissues,which is closely related to both normal brain activity and abnormal neural activity such as epileptic discharge. However, the propagation mechanism behind this coexistence phenomenon remains unclear. In this paper, a three-dimensional electric field coupled hippocampal neural network is established to investigate generation of coexisting spontaneous fast and slow traveling waves. This model captures two types of dendritic traveling waves propagating in both transverse and longitude directions: the N-methyl-D-aspartate(NMDA)-dependent wave with a speed of about 0.1 m/s and the Ca-dependent wave with a speed of about 0.009 m/s. These traveling waves are synaptic-independent and could be conducted only by the electric fields generated by neighboring neurons, which are basically consistent with the in vitro data measured experiments. It is also found that the slow Ca wave could trigger generation of fast NMDA waves in the propagation path of slow waves whereas fast NMDA waves cannot affect the propagation of slow Ca waves. These results suggest that dendritic Ca waves could acted as the source of the coexistence fast and slow waves. Furthermore, we also confirm the impact of cellular spacing heterogeneity on the onset of coexisting fast and slow waves. The local region with decreasing distances among neighbor neurons is more liable to promote the onset of spontaneous slow waves which, as sources, excite propagation of fast waves. These modeling studies provide possible biophysical mechanisms underlying the neural dynamics of spontaneous traveling waves in brain tissues.

关键词： hippocampal network epileptiform dendritic oscillation traveling wave electric field coupling

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政府方视角下PPP项目管理有效性及其保障

建筑设计管理 2023年第6期40卷 13-18页

作者：宿辉毕喜乐田少卫吉林建筑大学长春春130118 上海建纬(成都)律师事务所成都610011

科学有效的项目管理是PPP项目成功的关键。从政府方角度出发分析PPP项目管理的复杂性及易出现的问题;基于政府方视角提出PPP项目管理专业保障机制,包括工程监理、项目管理(PM)以及全过程工程咨询模式;从合同、费用、绩效考核三方面保障... 详细信息

科学有效的项目管理是PPP项目成功的关键。从政府方角度出发分析PPP项目管理的复杂性及易出现的问题;基于政府方视角提出PPP项目管理专业保障机制,包括工程监理、项目管理(PM)以及全过程工程咨询模式;从合同、费用、绩效考核三方面保障PPP项目管理的有效性,从而加强政府方对PPP项目的有效监管,保障PPP项目的顺利实施。

关键词： PPP项目政府方项目管理

小鼠腹主动脉瘤模型中krüppel样因子5和组织蛋白酶Z的表达及其意义

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中华老年心脑血管病杂志 2018年第11期20卷 1195-1198页

作者：曲晓梦杨鑫陈琪毕喜乐李清钊孙健马冬华北理工大学公共卫生学院唐山063210 秦皇岛第一医院心血管内科

目的观察Krüppel样因子5(krüppel-like factor 5,KLF5)和组织蛋白酶Z(cathepsin Z,Cts Z)在CaPO4诱导的小鼠腹主动脉瘤模型中的表达情况及其意义。方法选择雄性C57BL/6小鼠16只,随机分为对照组和实验组,每组8只。CaPO4诱导腹主动脉瘤... 详细信息

目的观察Krüppel样因子5(krüppel-like factor 5,KLF5)和组织蛋白酶Z(cathepsin Z,Cts Z)在CaPO4诱导的小鼠腹主动脉瘤模型中的表达情况及其意义。方法选择雄性C57BL/6小鼠16只,随机分为对照组和实验组,每组8只。CaPO4诱导腹主动脉瘤模型并测量腹主动脉直径;苏木精-伊红染色观察主动脉病理变化;血管弹力纤维染色分析弹性纤维断裂程度;免疫组织化学和实时定量PCR方法分别从蛋白和基因水平检测主动脉组织中KLF5和Cts Z相对表达量。结果实验组小鼠术后膨胀度明显大于对照组(2.573±0.790 vs 1.129±0.168,P<0.01)。与对照组比较,实验组小鼠血管弹性纤维断裂更为严重,且KLF5和Cts Z mRNA和蛋白在腹主动脉组织中表达明显升高,差异有统计学意义(P<0.05,P<0.01)。结论在CaPO4诱导损伤的小鼠腹主动脉组织中KLF5和Cts Z表达升高,并促进血管病理性重构。

关键词：主动脉瘤,腹组织蛋白酶类聚合酶链反应 RNA,信使基质金属蛋白酶类

Operando monitoring of dendrite formation in lithium metal batteries via ultrasensitive tilted fiber Bragg grating sensors

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Light(Science & Applications) 2024年第1期13卷 153-166页

作者： xile Han Hai Zhong Kaiwei Li Xiaobin Xue Wen Wu Nan Hu Xihong Lu Jiaqiang Huang Gaozhi Xiao Yaohua Mai Tuan Guo Institute of Photonics Technology Jinan UniversityGuangzhou 510632China Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510632China Key Laboratory of bionic Engineering(Ministry of Education) Jilin UniversityChangchun 130022China The Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong Province School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China Sustainable Energy and Environment Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhouGuangdong 511400China Advanced Electronics and Photonics Research Centre National Research Council of CanadaOttawa K1A OR6Canada

Lithium(Li)dendrite growth significantly deteriorates the performance and shortens the operation life of lithium metal *** the intricate dynamics of surface localized and rapid mass transport at the electrolyte–electrode interface of lithium metal is essential for the understanding of the dendrite growth process,and the evaluation of the solutions mitigating the dendrite growth *** we demonstrate an approach based on an ultrasensitive tilted fiber Bragg grating(TFBG)sensor which is inserted close to the electrode surface in a working lithium metal battery,without disturbing its *** to the superfine optical resonances of the TFBG,in situ and rapid monitoring of mass transport kinetics and lithium dendrite growth at the nanoscale interface of lithium anodes have been *** correlations between the performance of different natural/artificial solid electrolyte interphases(SEIs)and the time-resolved optical responses have been observed and quantified,enabling us to link the nanoscale ion and SEI behavior with the macroscopic battery *** new operando tool will provide additional capabilities for parametrization of the batteries’electrochemistry and help identify the optimal interphases of lithium metal batteries to enhance battery performance and its safety.

关键词： battery lithium electrolyte

bi_(2)O_(3)对K_(2)O–B_(2)O_(3)–SrO–Al_(2)O_(3)–Nb_(2)O_(5)–SiO_(2)玻璃陶瓷介电储能性能的影响

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硅酸盐学报 2024年第4期52卷 1229-1239页

作者：耿喜乐冯先杰尚飞陈国华桂林电子科技大学电子信息材料与器件教育部工程中心材料科学与工程学院广西桂林541004

随着电力电子系统的不断发展,高功率脉冲电容器的需求增多。电介质电容器因具有放电功率大、充放电速度快及性能稳定等优点,在电力系统、电子器件、脉冲电源等方面发挥着重要作用,广泛应用于民用领域及军事领域。通过熔融压延制备玻璃基... 详细信息

随着电力电子系统的不断发展,高功率脉冲电容器的需求增多。电介质电容器因具有放电功率大、充放电速度快及性能稳定等优点,在电力系统、电子器件、脉冲电源等方面发挥着重要作用,广泛应用于民用领域及军事领域。通过熔融压延制备玻璃基体,采用可控结晶工艺研究了不同含量的bi_(2)O_(3)(x=0.0%、1.0%、2.0%、4.0%,摩尔分数)对K_(2)O–B_(2)O_(3)–SrO–Al_(2)O_(3)–Nb_(2)O_(5)–SiO_(2)玻璃陶瓷物相演化、微观结构、介电和储能性能的影响。在该玻璃陶瓷中,KSr_(2)Nb_(5)O_(15)为主要析出晶相,当bi_(2)O_(3)的加入量为x=2.0%(摩尔分数)时,热处理温度为950℃时,玻璃陶瓷样品的储能密度最大可达到1.27 J/cm^(3),室温下介电常数可达342,是热处理温度为850℃时样品介电常数的1.9倍。在脉冲RLC电路测试中,当bi_(2)O_(3)的加入量为x=2.0%(摩尔分数)且施加电场强度为400 kV/cm时,实测储能密度随着热处理温度的升高从1.02 J/cm^(3)增加到1.33 J/cm^(3)。

关键词：玻璃陶瓷相结构介电性能储能性能

沙库巴曲缬沙坦对慢性心力衰竭合并肾功能不全患者容量管理的优化作用

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中华老年多器官疾病杂志 2023年第5期22卷 339-344页

作者：贾红丹毕希乐赵云凤宋婷婷刘丽秦皇岛市第一医院心血管内科河北秦皇岛066000

目的观察慢性心力衰竭(简称心衰)合并肾功能不全患者应用沙库巴曲缬沙坦后容量状态变化及其对心脏结构和功能的影响。方法连续纳入2020年12月至2022年3月秦皇岛市第一医院收治的慢性心衰合并肾功能不全患者84例,分为沙库巴曲缬沙坦组(... 详细信息

目的观察慢性心力衰竭(简称心衰)合并肾功能不全患者应用沙库巴曲缬沙坦后容量状态变化及其对心脏结构和功能的影响。方法连续纳入2020年12月至2022年3月秦皇岛市第一医院收治的慢性心衰合并肾功能不全患者84例,分为沙库巴曲缬沙坦组(n=48)和对照组(n=36)。沙库巴曲缬沙坦组给予沙库巴曲缬沙坦,对照组接受单一的缬沙坦治疗。测量2组患者服药6个月后24 h尿量、利尿剂用量,检测血浆B型脑钠肽(BNP)水平,随访纽约心脏病协会(NYHA)分级变化,并以超声心动图评估心脏结构及功能变化情况。结果与对照组比较,服药后沙库巴曲缬沙坦组患者24 h尿量明显增多[(1 514.38±694.73)和(1 003.33±178.92)ml;P<0.01];NYHA分级明显改善(P=0.032)。与服药前比较,服药后沙库巴曲缬沙坦组患者服用利尿剂剂量[(19.38±7.55)和(23.75±7.89)mg]、BNP水平[811(250,1 481)和1 980(727,5 014)pg/ml]明显降低(均P<0.01);24 h尿量[(1 514.38±694.73)和(890.63±121.45)ml]明显增加(P<0.01)。与对照组比较,服药后沙库巴曲缬沙坦组患者左室射血分数(LVEF)[(36.87±6.16)%和(33.08±7.59)%]、二尖瓣环E峰与A峰比值(E/A)[1.30(1.25,1.82)和1.04(0.59,2.53)]、每搏输出量(SV)[(102.39±20.85)和(77.98±18.51)ml]、心输出量(CO)[(7.39±2.18)和(5.84±1.72)L/min]均明显升高(均P<0.05),左房内径(LA)[(42.97±6.01)和(48.17±5.17)mm]缩小(P<0.05);与服药前比较,服药后沙库巴曲缬沙坦组患者左室收缩末内径[50.5(50.0,56.1)和54.0(48.3,61.9)mm]、左室舒张末内径[(64.9±10.3)和(69.0±12.1)mm]、LA[(42.97±6.01)和(47.61±8.06)mm]均明显缩小(均P<0.01);SV[(102.39±20.85)和(68.13±29.96)ml]、CO[(7.39±2.18)和(5.66±2.49)L/min]、E/A[1.30(1.25,1.82)和0.93(0.88,1.10)]、LVEF[(36.87±6.16)%和(27.26±6.24)%]均明显升高(均P<0.01)。结论与单一使用缬沙坦比较,沙库巴曲缬沙坦可明显改善合并肾功能不全的慢性心衰患者的容量超负荷,优化容量管理措施,改善心脏收缩及舒张功能。

关键词：慢性心力衰竭肾功能不全沙库巴曲缬沙坦容量管理超声心动图

沙库巴曲缬沙坦对慢性射血分数降低心力衰竭合并肾功能不全患者的肾脏保护作用

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中华老年多器官疾病杂志 2023年第7期22卷 492-496页

作者：贾红丹毕希乐赵云凤宋婷婷刘丽秦皇岛市第一医院心血管内科河北秦皇岛066000

目的观察沙库巴曲缬沙坦对合并肾功能不全的慢性心力衰竭(简称心衰)患者肾功能的影响。方法连续纳入2020年12月至2022年3月秦皇岛市第一医院慢性心衰合并肾功能不全患者84例,分为沙库巴曲缬沙坦组(n=48)和对照组(n=36)。沙库巴曲缬沙坦... 详细信息

目的观察沙库巴曲缬沙坦对合并肾功能不全的慢性心力衰竭(简称心衰)患者肾功能的影响。方法连续纳入2020年12月至2022年3月秦皇岛市第一医院慢性心衰合并肾功能不全患者84例,分为沙库巴曲缬沙坦组(n=48)和对照组(n=36)。沙库巴曲缬沙坦组接受沙库巴曲缬沙坦治疗,对照组接受单一的缬沙坦治疗。观察2组患者服药后6个月和12个月肌酐、估算的肾小球滤过率(eGFR)、尿素氮、尿酸、肾功能恶化(WRF)指标的变化情况。采用SPSS 22.0软件进行数据分析。根据数据类型,组间比较分别采用t检验、非参数秩和检验、非参数检验、Mann-Whitney U检验及χ2检验。结果服药后6个月,对比基线水平,沙库巴曲缬沙坦组肌酐、eGFR的变化值与对照组比较无明显差异;尿素氮及尿酸下降值显著高于对照组[-2.62(1.83,3.90)和0.45(0.29,0.70)mmol/L,P<0.01;-137.00(-92.30,-201.13)和-9.65(49.00,-79.80)μmol/L,P=0.000];与对照组比较,沙库巴曲缬沙坦降低了患者的收缩压及舒张压[(132±17)和(133±24)mmHg(1 mmHg=0.133 kPa),P=0.824;(81±14)和(82±12)mmHg,P=0.732],但尚无统计学差异,NYHA分级明显改善(Z=-2.150,P=0.032)。服药后12个月,对比基线水平,沙库巴曲缬沙坦组eGFR下降值明显低于对照组[-2.21(1.33,3.49)和-22.11(12.32,29.67)ml/(min·1.73m 2),P=0.023];肌酐升高值明显低于对照组[1.50(0.98,2.07)和31.65(22.77,42.53)μmol/L,P=0.043];尿素氮及尿酸下降值也显著高于对照组[-2.80(2.01,4.23)和0.80(0.58,1.14)mmol/L,P<0.01;-141.00(-96.40,-200.25)和-8.45(45.00,-77.70)μmol/L,P=0.000];沙库巴曲缬沙坦组收缩压及舒张压降幅、NYHA分级均显著优于对照组[(123±14)和(130±17)mmHg,P=0.042;(76±11)和(81±11)mmHg,P=0.042;Z=-2.200,P=0.028]。服药后6个月,沙库巴曲缬沙坦组WRF发生率与对照组相比无明显统计学差异[3(6.25%)和7(19.44%),P=0.132];服药后12个月,沙库巴曲缬沙坦组WRF发生率显著低于对照组[4(8.33%)和9(25.00%),P=0.037]。结论沙库巴曲缬沙坦组心功能改善先于肾脏保护出现,血压降低和肾脏保护同步。与单一的缬沙坦比较,沙库巴曲缬沙坦可以延缓、控制合并肾功能不全的慢性心衰患者肾功能的恶化,减少WRF的发生。随服药时间的延长,对肾功能的保护作用更显著。

关键词：慢性心力衰竭肾功能不全沙库巴曲缬沙坦肾功能恶化