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EXTENSION OF THE TOPSIS METHOD BASED ON PROSPECT THEORY AND TRAPEZOIDAL INTUITIONISTIC FUZZY NUMBERS FOR GROUP DECISION MAKING

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Journal of Systems Science and Systems Engineering 2014年第2期23卷 231-247页

作者： xihua li Xiaohong CHEN School of Business Central South University

Considering the decision maker＇s risk psychological factors and information ambiguity under uncertainty, a novel TOPSIS based on prospect theory （PT） and trapezoidal intuitionistic fuzzy numbers （YrIFNs） for group decision making is investigated, in which the criteria values and the criteria weights take the form of TrIFNs, and weights of decision makers are unknown. Firstly, distance measures for TrIFNs are used to induce value function under trapezoidal intuitionistic fuzzy environment. Secondly, the concepts of distance measures and trapezoidal intuitionistie fuzzy weighted averaging operator are employed to induce the weights of decision makers and thus the decision makers＇ options can be aggregated. Then the PT-based separation measures and relative closeness coefficient are defined and an algorithm for ranking alternatives under trapezoidal intuitionistic fuzzy environment is proposed. Finally, a numerical example further illustrates the practicality and effectiveness of the proposed TOPSIS method.

关键词： TOPSIS trapezoidal intuitionistic fuzzy numbers prospect theory group decision making distance measures

RNA结合基序蛋白家族在肿瘤发生发展中的作用及机制研究进展

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现代肿瘤医学 2024年第11期32卷 2115-2120页

作者：夏红李锡花戢福云湖北医药学院基础医学院细胞生物学与医学遗传学教研室湖北十堰442000 渝粤病理科学研究中心重庆400039

恶性肿瘤是世界上各个国家居民死亡的主要原因之一,也是延长人类预期寿命的重要障碍。RNA结合蛋白(RNA binding proteins,RBPs)作为一种重要的细胞内蛋白,在RNA转录、剪接、翻译、修饰、运输和稳定性等方面发挥着至关重要的作用。RNA结... 详细信息

恶性肿瘤是世界上各个国家居民死亡的主要原因之一,也是延长人类预期寿命的重要障碍。RNA结合蛋白(RNA binding proteins,RBPs)作为一种重要的细胞内蛋白,在RNA转录、剪接、翻译、修饰、运输和稳定性等方面发挥着至关重要的作用。RNA结合基序蛋白(RNA binding motif proteins,RBMs)是一个重要的RBPs家族亚群,具有与RBPs相同的结构域特征。已有的研究显示,RBMs蛋白家族成员与多种肿瘤的发生发展密切相关。该文就RBMs家族成员在肿瘤发生发展中的作用及机制进行综述。

关键词： RBPs RBMs 肿瘤 RNA 稳定性

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东江惠州-东莞段溶解氧偏低状态研究

环境科学与管理 2024年第3期49卷 106-111页

作者：苏淑珍黎细华广东省东莞生态环境监测站广东东莞523009

针对东江惠州-东莞段溶解氧偏低的问题,通过水质指标相关性分析、多元线性回归、主成分分析算法等3种方法,系统分析东江水质变化的时空特点,揭示东江惠州-东莞段范围内干流及其支流溶解氧的空间变化、季时节变化、垂直变化趋势。结果表... 详细信息

针对东江惠州-东莞段溶解氧偏低的问题,通过水质指标相关性分析、多元线性回归、主成分分析算法等3种方法,系统分析东江水质变化的时空特点,揭示东江惠州-东莞段范围内干流及其支流溶解氧的空间变化、季时节变化、垂直变化趋势。结果表明,剑潭电站过水运行方式对下游干流溶解氧造成重要影响;东江惠州-东莞段溶解氧主要与水温、高锰酸盐指数、氨氮、总磷负相关,有机物介导的生物耗氧和化学耗氧是东江溶解氧偏低的主要原因;与叶绿素呈显著正相关,藻类光合产氧是东江水体表层溶解氧的重要来源。

关键词：东江溶解氧偏低

Pillar[6]arene-based supramolecular self-assemblies for twopronged GSH-consumption-augmented chemo/photothermal therapy

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Nano Research 2023年第7期16卷 9921-9929页

作者： Yang Bai xihua li Sijie Song Jing Yang Xia liu Zhaowei Chen Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an 710021China Institute of Food Safety and Environment Monitoring College of ChemistryFuzhou UniversityFuzhou 350108China

The abundant intracellular glutathione(GSH)in cancer cells severely undermines the therapeutic efficacy of different treatments due to their role in protecting cancer cells from the associated oxidative *** a highly integrated system to consume GSH would help to improve the therapeutic *** this study,supramolecular prodrug self-assemblies(SPSAs)with IR825 loaded inside were developed to consume GSH via two-pronged pathways while augmenting the therapeutic potency of chemo/photothermal *** were prepared using water-soluble pillar[6]arene(WP[6])as host units and H_(2)O_(2)-responsive nitrogen mustard prodrug,chlorambucil-(phenylboronic acid pinacol ester)conjugates(Cb-BE),as the *** SPSAs were internalized by cancer cells,the generation of quinone methide(QM)from Cb-BE and singlet oxygen(^(1)O_(2))from irradiation-activated IR825 could consume GSH in a concerted *** such,the therapeutic efficacies of the released chlorambucil and the accompanied hyperthermia were augmented toward synergistically inhibiting tumor growth.

关键词： supramolecular self-assemblies pillararene glutathione consumption chemo/photothermal therapy

国土空间治理视角下低效工业用地盘活研究——以成都市为例

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城乡规划 2024年第2期 47-55,65页

作者：胡双梅钟婷姚南彭耕李喜华成都市规划和自然资源局国土空间规划处成都市规划设计研究院规划二所成都市规划编制研究和应用技术中心

工业用地是承载制造业的关键载体,低效工业用地的盘活是在发展紧约束背景下保障产业空间的重要举措。文章在梳理现有研究实践的基础上,总结成都市低效工业用地的历史成因和盘活难点,阐述国土空间治理视角下盘活低效工业用地的总体思路,... 详细信息

工业用地是承载制造业的关键载体,低效工业用地的盘活是在发展紧约束背景下保障产业空间的重要举措。文章在梳理现有研究实践的基础上,总结成都市低效工业用地的历史成因和盘活难点,阐述国土空间治理视角下盘活低效工业用地的总体思路,从规划管控、技术标准、政策工具和实施监督四类治理工具角度提出具体举措,为类似地区提供借鉴。

关键词：国土空间治理低效工业用地盘活空间管控

Superatomic Aub clusters ligated by different N-heterocyclic carbenes and their ligand-dependent catalysis, photoluminescence, and proton sensitivity

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Nano Research 2020年第7期13卷 1908-1911页

作者： Hui Shen Sijin Xiang Zhen Xu Chen liu xihua li Cunfa Sun Shuichao lin Boon K.Teo Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsNational&Local Joint Engineering Research Center of Preparation Technology of NanomaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China School of Pharmaceutical Science Xiamen UniversityXiamen 361002China

We report herein a class of superatomic AU13 clusters stabilized by different N-heterocyclic carbenes(NHCs).The clusters show diverse metal surface structures,properties and functions as exemplified by:(1)the first anionic AU13 cluster[Au1g(NHC-1)sBr6],which has bulky NHC-1 ligands that lead to a rather open metal surface contributing to its high catalytic activity;(2)the tricationic cluster[Au13(NHC-2)sBr2]+which has bidentate,benzyl-rich NHC-2 ligands that make it ultra-stable and highly-luminescent,suitable for bio-imaging;and(3)by bearing two pyridyl groups on NHC-3,the dicationic cluster[Au:a(NHC-3)gClg]f+exhibits reversible and stable visible absorption and solubility responses to protonation/deprotonation cycles,making it a potential pH sensor(NHC-1=1,3-disopropylbenzimidazolin-ylidene;NHC-2=1,3-bis(1-benzyl-1H-benzimidazol-1-ium-yl)propane;NHC-3=1,3-bis(icolyI)benzimidazolin-ylidene).The study nicely demonstrates the importance of ligands in designing metal nanoclusters with desired functionalities.

关键词： carbene ligands gold nanocluster catalysis luminescenee Au13

miR-130b inhibits proliferation and promotes differentiation in myocytes via targeting Sp1

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Journal of Molecular Cell Biology 2021年第6期13卷 422-432页

作者： Yu-Cheng Wang Xiaohan Yao Mei Ma Huihui Zhang Hui Wang Lei Zhao Shengnan liu Chao Sun Peng li Yuting Wu xihua li Jingjing Jiang Yuying li Yan li Hao Ying Shanghai Xuhui District Central Hospital Zhongshan-Xuhui HospitalFudan UniversityShanghai 200001China CAS Key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China Department of Neuromuscular Disease Children’s Hospital of Fudan UniversityShanghai 201102China Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghai 200031China State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi 214122China Key Laboratory of Food Safety Risk Assessment Ministry of HealthBeijing 100021China

Muscle regeneration after damage or during myopathies requires a fine cooperation between myoblast proliferation and myogenic differentiation.A growing body of evidence suggests that microRNAs play critical roles in myocyte proliferation and differentiation ***,the molecular mechanisms underlying the orchestration are not fully ***,we showed that miR-130b is able to repress myoblast proliferation and promote myogenic differentiation via targeting Sp1 transcription ***,overexpression of miR-130b is capable of improving the recovery of damaged muscle in a freeze injury ***,miR-130b expression is declined in the muscle of muscular dystrophy ***,these results indicated that miR-130b may play a role in skeletal muscle regeneration and myopathy ***,our findings suggest that the miR-130b/Sp1 axis may serve as a potential therapeutic target for the treatment of patients with muscle damage or severe myopathies.

关键词： miR-130b muscle regeneration proliferation differentiation Sp1

A comparative analysis of small RNAs between two Upland cotton backcross inbred lines with different fiber length: Expression and distribution

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The Crop Journal 2019年第2期7卷 198-208页

作者： Guoyuan liu Man Wu Wenfeng Pei xihua li Nuohan Wang Jianjiang Ma Xinshan Zang Shuxun Yu Jinfa Zhang Jiwen Yu State Key Laboratory of Cotton Biology Cotton Institute of the Chinese Academy of Agricultural Sciences Key Laboratory of Cotton Genetic Improvement Ministry of Agriculture Department of Plant and Environmental Sciences New Mexico State University

The cotton fiber is the most important raw material for the textile industry and an ideal model system for studying cell elongation. However, the genetic variation of fiber elongation in relation to miRNA is poorly understood. A high-throughput comparative RNA-seq of two lines differing in fiber length(FL) from a backcross inbred line(BIL)population of G. hirsutum × G. barbadense revealed differentially expressed(DE) miRNAs and their targets in rapidly elongating fibers. A real-time quantitative PCR analysis was further performed to validate the results. A total of 463(including 47 DE) miRNAs were identified,and seven DE miRNAs were co-localized with seven FL quantitative trait loci(QTL)identified in the G. hirsutum × G. barbadense population. Of 82(including 21 DE) targets identified, nine(including one DE) were also co-localized with the seven FL QTL. The relationship between the allopolyploid and its diploid ancestral species with respect to miRNAs and their targets was also characterized. These results will facilitate the understanding of the molecular genetic mechanism of fiber elongation with regards to miRNAs in cotton.

关键词： Allopolyploid Gossypium Fiber elongation miRNA QTL hotspots

基于PIC12F675设计的漏血监测智能传感器

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仪器仪表学报 2005年第Z2期26卷 284-286页

作者：李昔华重庆工商大学计算机技术与信息工程学院重庆400067

介绍了一种应用于医用血液净化设备安全监控环节,对滤器破膜导致的血液渗漏进行实时监测的传感器设计方法与工作原理,并结合MICROCHIP新型嵌入式芯片PIC12F675,设计了具有模糊识别、灵敏度任意调节和串行接口的智能传感器,给出了器件污... 详细信息

介绍了一种应用于医用血液净化设备安全监控环节,对滤器破膜导致的血液渗漏进行实时监测的传感器设计方法与工作原理,并结合MICROCHIP新型嵌入式芯片PIC12F675,设计了具有模糊识别、灵敏度任意调节和串行接口的智能传感器,给出了器件污损自适应处理方法和器件失效报警措施。

关键词：血液透析血液净化智能传感器红外发光二极管灵敏度调节