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Mechatronic design of a novel linear compliant positioning stage with large travel range and high out-of-plane payload capacity

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Frontiers of Mechanical Engineering 2017年第2期12卷 265-278页

作者： Hua LIU xin xie Ruoyu TAN Lianchao ZHANG Dapeng FAN College of Mechatronic Engineering and Automation NationalUniversity of Defense Technology Changsha 410073 China

Most of the XY positioning stages proposed in previous studies are mainly designed by considering only a single performance indicator of the stage. As a result, the other performance indicators are relatively weak. In this study, a 2-degree-of-freedom linear compliant positioning stage （LCPS） is developed by mechatronic design to balance the interacting performance indicators and realize the desired positioning stage. The key parameters and the coupling of the structure and actuators are completely considered in the design. The LCPS consists of four voice coil motors （VCMs）, which are conformally designed for compactness, and six spatial leaf spring parallelograms. These parallelograms are serially connected for a large travel range and a high out-of-plane payload capacity. The mechatronic model is established by matrix structural analysis for structural modeling and by Kirchhof^s law for the VCMs. The sensitivities of the key parameters are analyzed, and the design parameters are subsequently determined. The analytical model of the stage is confirmed by experiments. The stage has a travel range of 4.4 mm 7.0 mm and a 0.16% area ratio of workspace to the outer dimension of the stage. The values of these performance indicators are greater than those of any existing stage reported in the literature. The closed-loop bandwidth is 9.5 Hz in both working directions. The stage can track a circular trajectory with a radius of 1.5 mm, with 40 Ixm error and a resolution of lower than 3 ~tm. The results of payload tests indicate that the stage has at least 20 kg out- of-plane payload capacity.

关键词： mechatronic design linear compliant posi-tioning stage large travel range high out-of-plane payload

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Design and testing of micro fluidic chemical analysis chip integrated with micro valveless pump

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Science China(Technological Sciences) 2005年第3期48卷 326-337页

作者： FU xin xie Haibo YANG Huayong JIA Zhijian FANG Qun State Key Laboratory of Fluid Power Transmission and Control Zhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power Transmission and ControlZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power Transmission and ControlZhejiang UniversityHangzhou 310027China Institute of Microanalytical SystemsZhejiang UniversityHangzhou 310028China Institute of Microanalytical SystemsZhejiang UniversityHangzhou 310028China

A new structure and working principle of the chip integrated with micro valveless pump for capillary electrophoresis was proposed in this paper. The micro valveless pump with plane structure has advantages of simple structure, and the process technology is compatible with existing micro chips for capillary electrophoresis. Based upon the mathematical model, simulation study of micro pump was carried out to investigate the influence of structural parameters on flow characteristics, and the performance of the integrated micro pump was also tested with different control parameters. The simulation results agree with the experimental results. Three samples, which are amino acid, fluorescein and buffer solution, have been examined with this chip. The results of the primary experiments showed that the micro valveless pump was promising in the integration and automatization of miniature integrated fluidic systems.

关键词： MEMS,micro valveless pump,micro fluidic chip,CFD,capillary electrophoresis.

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DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy

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Acta Pharmaceutica Sinica B 2015年第4期5卷 330-336页

作者： Yue Sheng Bo Sun xin xie Na Li Deli Dong The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Research Ministry of Education Department of PharmacologyHarbin Medical University

Our previous work found that DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl]quinoline) was a novel autophagy inhibitor. Here, we aimed to investigate the effects of DMH1 on chemotherapeutic drug-induced autophagy as well as the efficacy of chemotherapeutic drugs in different cancer cells. We found that DMH1 inhibited tamoxifen- and cispcis-diaminedichloroplatinum(II)(CDDP)-induced autophagy responses in MCF-7 and HeLa cells, and potentiated the anti-tumor activity of tamoxifen and CDDP for both cells. DMH1 inhibited 5-fluorouracil(5-FU)-induced autophagy responses in MCF-7 and HeLa cells, but did not affect the anti-tumor activity of 5-FU for these two cell lines. DMH1 itself did not induce cell death in MCF-7 and HeLa cells, but inhibited the proliferation of these cells. In conclusion, DMH1 inhibits chemotherapeutic drug-induced autophagy response and the enhancement of efficacy of chemotherapeutic drugs by DMH1 is dependent on the cell sensitivity to drugs.

关键词： Autophagy Tamoxifen 5-Fluorouracil Cancer cells

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Influence of yttrium on the structure and magnetostriction of Fe_(83)Ga_(17) alloy

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International Journal of Minerals,Metallurgy and Materials 2012年第9期19卷 849-855页

作者： Xi-ming Xiao Xue-xu Gao Ji-heng Li Jian-xin xie State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Polycrystalline Fe83Ga17 alloy rods with various amounts of yttrium were prepared by high vacuum induction melting. It is found that yttrium addition has a significant effect on the structure and magnetostriction of Fes3Ga17 alloy. The small addition of yttrium alters the solidification character and the grain shape of Fe83Ga17 alloy, and as a result, columnar grains with the 〈100〉 preferential direction are pro- duced. Yttrium addition improves the magnetostrictive performance of the as-cast Fes3Ga17 alloy. The magnetostriction values of the as-cast alloy with 0.32at% and 0.64at% yttrium addition go up to 119×10^-6 and 137×10^-6 under 15 MPa compressive stress, respectively. The energy dispersive spectroscopy （EDS） result shows that almost all of the yttrium atoms exist in the Y2Fe17-xGax phase. A small amount of this kind of secondary phase cannot obviously increase the saturate magnetic field.

关键词： gallium alloys iron alloys yttrium magnetostfiction supercooling polycrystallirte materials

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FEM analysis of metal flowing behaviors in porthole die extrusion based on the mesh reconstruction technology of the welding process

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International Journal of Minerals,Metallurgy and Materials 2010年第6期17卷 763-769页

作者： Dong-nan Huang Zhi-hao Zhang Jing-yuan Li Jian-xin xie Advanced Materials and Technologies Institute University of Science and Technology Beijing Beijing 100083 China School of Materials Science and Engineering Inner Mongolia University of Technology Huhhot 010051 China

A reconstruction technology of finite element meshes based on reversal engineering was applied to solve mesh penetration and separation in the finite element simulation for the divergent extrusion. The 3D numerical simulation of the divergent extrusion process in- cluding the welding stage for complicated hollow sections was conducted. Based on the analysis of flowing behaviors, the flowing velocities of the alloy in portholes and near the welding planes were properly controlled through optimizing the expansion angle as well as porthole ar- eas and positions. After the die structure optimization, defects such as warp, wrist, and the wavelike are eliminated, which improves the sec- tion-forming quality. Meanwhile, the temperature distribution in the cross section is uniform. Especially, the temperature of the C-shape notch with a larger thickness is lower than that of other regions in the cross section, which is beneficial for balancing the alloy flowing velocity.

关键词： numerical simulation extrusion metal forming metal flow reconstruction

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Pseudo-Random Sequences Generated by a Class of One-Dimensional Smooth Map

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Chinese Physics Letters 2011年第8期28卷 20-23页

作者： WANG xing-Yuan QIN Xue xie Yi-xin Faculty of Electronic Information and Electrical Engineering Dalian University of TechnologyDalian 116024

We extend a class of a one-dimensional smooth *** make sure that for each desired interval of the parameter the map’s Lyapunov exponent is *** we propose a novel parameter perturbation method based on the good property of the extended one-dimensional smooth *** perturb the parameter𝑟in each iteration by the real number xi generated by the *** auto-correlation function and NIST statistical test suite are taken to illustrate the method’s randomness *** provide an application of this method in image *** show that the pseudo-random sequences are suitable for this application.

关键词： parameter iteration method

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Severe lumbar spinal stenosis combined with Guillain-Barrésyndrome:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1096-1102页

作者： Dan-Feng Xu Bing Wu Jin-xin Wang Jian Yu Jian-xin xie Department of Orthopedic Surgery Shaoxing Central HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Guillain-Barrésyndrome(GBS)is a rare disorder that typically presents with ascending weakness,pain,paraesthesias,and numbness,which mimic the findings in lumbar spinal ***,we report a case of severe lumbar spinal stenosis combined with *** SUMMARY A 70-year-old man with a history of lumbar spinal stenosis presented to our emergency department with severe lower back pain and lower extremity *** resonance imaging confirmed the diagnosis of severe lumbar spinal ***,his symptoms did not improve postoperatively and he developed dysphagia and upper extremity *** electromyogram was *** on his symptoms,physical examination,and electromyogram,he was diagnosed with *** 5 d of intravenous immunoglobulin(0.4 g/kg/d for 5 d)therapy,he gained 4/5 of strength in his upper and lower extremities and denied *** had regained 5/5 of strength in his extremities when he was discharged and had no symptoms during *** GBS should be considered in the differential diagnosis of spinal disorder,even though magnetic resonance imaging shows severe lumbar spinal *** case highlights the importance of a careful diagnosis when a patient has a history of a disease and comes to the hospital with the same or similar symptoms.

关键词： Lumbar spinal stenosis Guillain-Barrésyndrome Lower back pain Paraesthesias Diagnose Case report

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Correlation of basic indicators with stages of keratoconus assessed by Pentacam tomography

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1136-1140页

作者： Xian-Li Du Min Chen Li-xin xie Qingdao University Qingdao Eye Hospital Shandong Eye Institute Shandong Academy of Medical Sciences

AIM: To evaluate the diagnostic efficiency of basic indicators and find characteristic indicators for keratoconus (KC) at adjacent stages, and to assess the progression pattern of KC. METHODS: One hundred and eight (41 subclinical, 40 moderate, and 27 severe) keratoconic patients (108 eyes) and 105 myopic patients (105 eyes) as controls were recruited in this prospective, comparative case series study. Pentacam topography was performed. Receiver operating -characteristic curves were used to get the characteristic indicators. RESULTS: The most efficient distinguishing index between the subclinical KC and the controls was posterior elevation value (PEV, AUC =0.882), with the highest specificity being 93.8%. Corneal thickness (AUC=0.852) and posterior inferior-superior value (I-S) ranked second and third (AUC=0.776). When KC became moderate, PEV remained to be of the highest diagnostic efficiency (AUC=0.988), followed by the anterior elevation value (AUC=0.986) and other parameters of anterior surface. The diagnostic value increased significantly in the anterior curvature indices (all AUC >0.900) and appeared in the anterior best fitting sphere radius (AUC= 0.919) when KC developed into the severe stage. CONCLUSION: In the subclinical stage of KC, PEV, thickness, and posterior I-S had important diagnostic values, and elevation values remained most efficient when KC developed to the moderate stage. The anterior curvature indices were most characteristic when KC became severe. KC first appeared in the inferior cornea of posterior surface, but the feature of protrusion formed at the moderate stage.

关键词： keratoconus progression pattern Pentacam topography diagnostic efficiency

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Fusarium solani Activates Dectin-1 in Experimentally Induced Keratomycosis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 153-159页

作者： Ling-juan XU Li-xin xie Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye instituteQingdao 266071China

In this study,the response of Dectin-1 on macrophages to Fusarium solani(***)and the expression patterns of Dectin-1 in experimentally ***-induced keratomycosis were *** macrophages isolated after intraperitoneal injection of sodium thioglycollate were co-cultured with laminarin and spores of *** for 12 *** expression levels of Dectin-1 and CARD9 were detected by immunofluorescence and real-time quantitative polymerase chain reaction.A mouse model of fungal keratitis was established by substromal inoculation with spores of *** lesions and inflammatory responses were observed by slit-lamp and histopathology at 1,2,3,5,and 7 day(s)after ***-1 expression was significantly upregulated on macrophages stimulated by spores of ***-1 was not detected in normal corneas of C57 BL/6 mice,but detected in infected corneas from the first day after inoculation,with high m RNA levels observed on days 2 and ***9,a key transducer of Dectin-1 signaling,was also upregulated in infected *** conclusion,Dectin-1 is an important recognition receptor in ***-induced keratitis,but the molecular mechanisms warrant further investigation.

关键词： Dectin-1 Fusarium solani keratitis

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Effective incineration technology with a new-type rotary waste incinerator

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Journal of Environmental Sciences 2003年第6期15卷 768-772页

作者： CHEN Lie-qiang ZHU Jian-zhong CAI Ming-zhao xie xin-yuan Research Institute of Chemical Engineering South China University of TechnologyGuangzhou 510641China.

The technology of steady combustion in a new type of rotary incinerator is firstly discussed. The formation and control of HCl,NOx and SO_(2) during the incineration of sampled municipal organic solid waste are studied with the incinerator. Results showed that the new model of rotary incinerator can effectively control and reduce the pollutant formations by post combustion.

关键词： rotary incinerator municipal organic solid waste HCl NOx SO _(2) control

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