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超大尺寸高性能异材质多复合平板硫化机加热板的研究与开发

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锻压技术 2024年第5期49卷 102-108页

作者：邬早勤谢广明王磊骆宗安唐山文丰特钢有限公司河北唐山063200 东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110819 河北工业大学材料科学与工程学院天津300131

采用真空焊接复合制备了45钢+q.55B钢的AB型坯料,并通过调整该AB型复合坯料加热时在加热炉的上、下烧嘴的加热负荷,对AB型钢板进行了不对称复合坯轧制。通过二次真空焊接复合制备了45钢+q.55B钢+q.55B钢+45钢的ABBA型坯料,并对焊缝进行... 详细信息

采用真空焊接复合制备了45钢+q.55B钢的AB型坯料,并通过调整该AB型复合坯料加热时在加热炉的上、下烧嘴的加热负荷,对AB型钢板进行了不对称复合坯轧制。通过二次真空焊接复合制备了45钢+q.55B钢+q.55B钢+45钢的ABBA型坯料,并对焊缝进行焊后高温回火处理,得到了ABBA型轧制复合板。结果表明:ABBA型复合板的界面为良好的冶金结合,平均硬度值为(180±10)HBW,组织成分均匀,各位置的硬度无明显差异。基材45钢中主要由片状珠光体和块状铁素体组成,复材q.55B钢主要由大量铁素体和少量珠光体组成。复合板厚度方向的断面收缩率平均值为62.67%,性能优异。此外,还实际生产了170 mm×3420 mm×10620 mm的ABBA型复合板,单重超过48000 kg。

关键词： 45钢 q.55B钢复合板轧制高温塑性

EFFECTS OF MICROSTRVCTURE ON FATIGUE CRACK GROWTH BEHMIOR IN Ni-BASE SUPERALLOY GH586

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Acta Metallurgica Sinica(English Letters) 1999年第3期12卷 267-272页

作者： S.S. xie X.F. Pan T.L. Wang Z.X. Wang H.C. Yang and q. Wang ( School of Materials and Metallurgy, Northeastern Universityl Shenyang 110006, China)( School of Materials and Metallurgy, Northeastern Universityl Shenyang 110006, China)( School of Materia Northeastern Univ Shenyang China

Threshold stress values, muging from ～8 to 16MPa·m1/2 can be obtained in a Ni-base alloy GH586 by varying the microstructure through heat treatments. The threshold and low crack growth rate behaviors at room temperature, with varying groin size and γ'-distribution, have been investigated. The results indicate that grain size is an important microstructurol parameter that affects fatigue crack growth threshold and propagation behaviors, as the values of △Kth increase with increasing grain size, but the γ' -distribution also has important effect. Analyses show that the effects of groin size on threshold and low crack-growth rate behavior result from heterogeneous deformation and roughness-induced crack closure due to crystallographic slipping and cracking in coarse microstructure. The higher △Kth and lower fatigue crack growth rate with increasing amounts of fine γ' phases are closely related to less damage accumulation level in deformation zone of crack-tip resulted from heterogeneous deformation due to dislocations' shearing γ' precipitates.

关键词： superalloy GH586 fatigue crack growth threshold grain size γ'-distribution

鬼箭羽化学成分和药理作用的研究进展及其质量标志物预测

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天然产物研究与开发 2024年第6期36卷 1064-1081,1044页

作者：杜雨璇谢治深徐江雁王潘河南中医药大学中医药科学院河南中医药大学药学院郑州450046

鬼箭羽始载于《神农本草经》,列为中品,具有通经、破血、杀虫和散瘀止痛等功效。现代药理学研究表明其具有降血糖、抗肿瘤、抗炎镇痛、抗菌、抗氧化、抗病毒等药理作用,其活性成分以黄酮类和萜类成分为主。本文通过对鬼箭羽的化学成分... 详细信息

鬼箭羽始载于《神农本草经》,列为中品,具有通经、破血、杀虫和散瘀止痛等功效。现代药理学研究表明其具有降血糖、抗肿瘤、抗炎镇痛、抗菌、抗氧化、抗病毒等药理作用,其活性成分以黄酮类和萜类成分为主。本文通过对鬼箭羽的化学成分、药理作用、毒理等方面进行综述,并基于此,从植物亲缘关系、化学成分有效性、化学成分可测性等方面对鬼箭羽的质量标志物进行推测分析,初步预测芦丁、槲皮素、香橙素、儿茶素、β-谷甾醇、鬼箭羽二萜A和11-羰基-β-乳香酸等成分可作为鬼箭羽潜在的质量标志物,以期为鬼箭羽的质量控制和临床用药规范提供科学依据。

关键词：鬼箭羽质量标志物黄酮类三萜类糖尿病肾病抗肿瘤

Different fundus imaging modalities and technical factors in AI screening for diabetic retinopathy:a review

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Eye and Vision 2020年第1期7卷 201-213页

作者： Gilbert Lim Valentina Bellemo Yuchen xie Xin q.Lee Michelle Y.T.Yip Daniel S.W.Ting School of Computing National University of SingaporeSingaporeSingapore Singapore Eye Research Institute Singapore National Eye CentreSingaporeSingapore Duke-NUS Medical School National University of Singapore11 Third Hospital Road AvenueSingapore 168751Singapore Vitreo-Retinal Service Singapore National Eye Center11 Third Hospital Road AvenueSingapore 168751Singapore Artificial Intelligence in Ophthalmology Singapore Eye Research Institute11 Third Hospital Road AvenueSingapore 168751Singapore

Background:Effective screening is a desirable method for the early detection and successful treatment for diabetic retinopathy,and fundus photography is currently the dominant medium for retinal imaging due to its convenience and *** screening using fundus photographs has however involved considerable costs for patients,clinicians and national health systems,which has limited its application particularly in less-developed *** advent of artificial intelligence,and in particular deep learning techniq.es,has however raised the possibility of widespread automated *** text:In this review,we first briefly survey major published advances in retinal analysis using artificial *** take care to separately describe standard multiple-field fundus photography,and the newer modalities of ultrawide field photography and smartphone-based ***,we consider several machine learning concepts that have been particularly relevant to the domain and illustrate their usage with extant ***:In the ophthalmology field,it was demonstrated that deep learning tools for diabetic retinopathy show clinically acceptable diagnostic performance when using colour retinal fundus *** intelligence models are among the most promising solutions to tackle the burden of diabetic retinopathy management in a comprehensive ***,future research is crucial to assess the potential clinical deployment,evaluate the cost-effectiveness of different DL systems in clinical practice and improve clinical acceptance.

关键词： Artificial intelligence Deep learning Diabetic retinopathy Fundus photographs Retinal imaging modalities Survey

苍附导痰汤治疗多囊卵巢综合征大鼠的血清代谢组学和网络药理学研究

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山西医科大学学报 2024年第7期55卷 895-907页

作者：谢军解达帅杨伟马乐姚宏军石萍山西医科大学附属运城市中心医院中医科运城044000 山西医科大学附属运城市中心医院药学部

目的基于超高效液相色谱-四极杆-静电场轨道阱串联质谱(UHPLC-q.-MS)分析苍附导痰汤对多囊卵巢综合征大鼠血清中内源性标志物的影响,并结合网络药理学研究其发挥药效的作用通路。方法将40只大鼠随机分为正常组、模型组、达英-35组和苍... 详细信息

目的基于超高效液相色谱-四极杆-静电场轨道阱串联质谱(UHPLC-q.-MS)分析苍附导痰汤对多囊卵巢综合征大鼠血清中内源性标志物的影响,并结合网络药理学研究其发挥药效的作用通路。方法将40只大鼠随机分为正常组、模型组、达英-35组和苍附导痰组,每组10只。采用来曲唑法诱导多囊卵巢综合征(PCOS)大鼠模型,造模成功后,达英-35组给予达英-35灌胃,苍附导痰组给予苍附导痰汤灌胃,每天1次,连续28 d。ELISA法检测大鼠血清促卵泡生长激素(FSH)、促黄体生成素(LH)、睾酮(T)、雌二醇(E2)含量差异水平;苏木精-伊红(HE)染色法观察大鼠卵巢组织病理形态学变化;采用UHPLC-q.-MS分析各组大鼠血清样品,基于主成分分析法(PCA)及正交偏最小二乘判别分析法(OPLS-DA)筛选出相关差异代谢物,并依据MetaboAnalyst数据库查询相关代谢通路。采用网络药理学探究苍附导痰汤治疗多囊卵巢综合征的关键靶点,使用KEGG数据库富集分析作用通路,并借助MetScape插件构建“代谢物-反应-酶-基因”网络。结果与正常组相比,模型组大鼠血清中FSH含量明显上升(P<0.05),LH、T、E2含量显著上升(P<0.01);与模型组相比,达英-35组大鼠血清中LH、T、E2含量显著降低(P<0.01),苍附导痰组大鼠血清中T明显降低(P<0.05),LH、E2含量显著降低(P<0.01)。与模型组比较,达英-35组和苍附导痰组大鼠卵巢组织形态明显改善;代谢组学筛选15个苍附导痰汤治疗多囊卵巢综合征的差异代谢物,涉及类固醇激素生物合成、甘油磷脂代谢、精氨酸和脯氨酸代谢等途径。网络药理学分析显示苍附导痰汤治疗多囊卵巢综合征的核心靶点为AKT1、ESR1、EGFR等,KEGG富集显示涉及内分泌抵抗、类固醇合成、雌激素信号通路等;采用MetScape插件构建“代谢物-反应-酶-基因”网络,发现6个关键靶点CYP1B1、CYP19A1、AKR1C1、AKR1C3、HSD17B1、HSD17B2,以及涉及类固醇激素生物合成通路。结论苍附导痰汤对多囊卵巢综合征大鼠显示出潜在的治疗作用,这可能与其对类固醇激素合成代谢路径的调节作用有关,治疗的内源性标志物包括17a-羟基孕烯醇酮、孕酮、皮质酮,这些指标有助于监测治疗效果。

关键词：苍附导痰汤多囊卵巢综合征代谢组学网络药理学类固醇激素生物合成

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A reversible microarray immobilization strategy based on thiol-q.inone reaction

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Chinese Chemical Letters 2022年第1期33卷 213-216页

作者： Ling Feng Ping Wang Yi Feng Jie Zhang q.ngxin Chen Yusheng xie Jingdong Luo Jiang Xia Shao q.Yao Hongyan Sun Cancer and Aging Research Institution School of Life ScienceShandong University of TechnologyZibo 255000China Department of Chemistry and COSDAF(Centre of Super-Diamond and Advanced Films) City University of Hong KongHong KongChina Key Laboratory of Biochip Technology Biotech and Health CentreShenzhen Research Institute of City University of Hong KongShenzhen 518057China College of Food Engineering Qingdao Institute of TechnologyQingdao 266300China Department of Chemistry The Chinese University of Hong KongHong KongChina Department of Chemistry National University of SingaporeSingapore 117543Singapore

Microarray technology has been widely applied in biomedical *** key to microarray study is to develop efficient immobilization *** this study,we designed a new reversible microarray immobilization method based on thiol-q.inone reaction.A q.inone-functionalized slide was fabricated through H_(2)O_(2)treatment of dopamine-coated *** thiol-containing molecules can be anchored onto the q.inone-functionalized slides via thioether linker,which could be cleaved under H_(2)O_(2) treatment to regenerate q.inone groups on the *** highly versatile approach can be widely used for immobilization of various thiol-containing molecules.

关键词： Reversible Microarray Biochip Thiol-q.inone reaction Peptides Thiol-proteins

构建基于ResNet-18的1型发作性睡病猝倒面容预测模型

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中华医学杂志 2024年第27期104卷 2549-2555页

作者：袁于青朱银陈邦占尹天天柯青谢亮南昌大学江西医学院第二附属医院神经内科南昌南昌大学数学与计算机学院南昌南昌大学玛丽女王学院南昌浙江大学医学院第一附属医院神经内科杭州

目的应用深度学习图像识别网络ResNet-18, 基于临床拍摄视频, 建立猝倒面容预测模型。方法本研究为横断面研究, 收集2020至2023年在南昌大学第二附属医院首诊未经治疗的1型发作性睡病患者25例及健康对照25名, 采集的图像预处理后, 共获... 详细信息

目的应用深度学习图像识别网络ResNet-18, 基于临床拍摄视频, 建立猝倒面容预测模型。方法本研究为横断面研究, 收集2020至2023年在南昌大学第二附属医院首诊未经治疗的1型发作性睡病患者25例及健康对照25名, 采集的图像预处理后, 共获得1 180张图片, 其中583张猝倒面容, 597张正常面容。从中抽取90%作为训练集与验证集, 随后数据扩增5倍, 扩充后的数据集抽取80%作为训练集, 20%作为验证集, 即训练集数量为(583+597)×0.9×0.8×5=4 248, 验证集数量为(583+597)×0.9×0.2×5=1 062, 训练集与验证集用于训练参数建立模型, 并通过五折交叉验证法进行训练, 构建采用迁移学习方式的ResNet-18猝倒面容识别模型。原未扩增前图像抽取10%(118张)作为测试集, 测试集数据不参与数据增强和模型训练, 仅用于测试模型最终效果。最后将ResNet-18与VGG-16、ResNet-34和Inception V3深度学习模型进行比较, 用受试者工作特征曲线评估ResNet-18图像识别网络在猝倒面容识别中的价值。结果 25例1型发作性睡病患者中, 男15例, 女10例, 年龄[M(q., q.)]为14.0(11.0, 20.5)岁;25名健康对照者中, 男14名, 女11名, 年龄16.0(14.4, 23.0)岁。ResNet-18图像识别网络在测试集中的总体准确率为90.9%, 灵敏度为96.4%, 特异度为85.2%, 受试者工作特征曲线下面积为0.99(95%CI:0.96～1.00)。ResNet-18模型参数量为11.69 M, 浮点运算量为1 824.03 M, 单张图片识别时间为5.9 ms。结论基于深度学习图像识别网络ResNet-18构建的猝倒面容预测模型在猝倒面容的识别上有较高的准确率。

关键词：发作性睡病猝倒人工智能图像处理横断面研究

超高海拔地区1000kV变电站导线连接金具防晕型结构设计与优化

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电网技术 2024年第4期48卷 1787-1798,I0102,I0103页

作者：张军刘鹏滕文涛李瑶琴谢梁彭宗仁刘闯电力设备电气绝缘国家重点实验室(西安交通大学) 陕西省西安市710049 中国电力科学研究院有限公司北京市海淀区100192 电网环境保护国家重点实验室(中国电力科学研究院有限公司) 湖北省武汉市430074

防晕型金具设计是特高压变电站电晕防治和电磁环境治理的关键,特别是在高海拔地区,电晕防治尤为重要。采用有限元仿真和试验相结合的研究方法,提出了满足工程需求的海拔校正指数公式、线性公式和金具表面场强控制值,计算获得了高海拔特... 详细信息

防晕型金具设计是特高压变电站电晕防治和电磁环境治理的关键,特别是在高海拔地区,电晕防治尤为重要。采用有限元仿真和试验相结合的研究方法,提出了满足工程需求的海拔校正指数公式、线性公式和金具表面场强控制值,计算获得了高海拔特高压变电站导线连接金具表面的电场分布,给出了各导线连接金具的结构优化方案并通过了高海拔电晕试验验证。结果表明:按文中推荐方法计算得到的4000m海拔校正系数为1.51,与标准q.GDW 551—2010推荐值相差1.9%。高海拔特高压变电站中导线连接金具表面场强应进行差异化控制:上层金具不超过1.32kV/mm,局部不超过1.52kV/mm;下层金具不超过0.99kV/mm,局部不超过1.14kV/mm。采用所提推荐方案时,各导线连接金具电晕熄灭电压均高于698.5kV且保有一定安全裕度,可满足4000m高海拔特高压变电站使用要求。研究成果可为我国超高海拔地区特高压变电站的防晕型金具设计提供依据,助力我国构建绿色环保的新型能源体系。

关键词： 4000m 超高海拔 1000kV变电站电晕防治导线连接金具结构优化

Characterization for elastic constants of fused deposition modelling-fabricated materials based on the virtual fields method and digital image correlation

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Acta Mechanica Sinica 2017年第6期33卷 1075-1083页

作者： q.ankun Cao Huimin xie AML Department of Engineering Mechanics Tsinghua University Beijing 100084 China

Fused deposition modelling(FDM), a widely used rapid prototyping process, is a promising techniq.e in manufacturing engineering. In this work, a method for characterizing elastic constants of FDM-fabricated materials is proposed. First of all, according to the manufacturing process of FDM, orthotropic constitutive model is used to describe the mechanical behavior. Then the virtual fields method(VFM) is applied to characterize all the mechanical parameters(q. q. q. q. using the full-field strain,which is measured by digital image correlation(DIC). Since the principal axis of the FDM-fabricated structure is sometimes unknown due to the complexity of the manufacturing process, a disk in diametrical compression is used as the load configuration so that the loading angle can be changed conveniently. To verify the feasibility of the proposed method, finite element method(FEM) simulation is conducted to obtain the strain field of the disk. The simulation results show that higher accuracy can be achieved when the loading angle is close to 30?. Finally, a disk fabricated by FDM was used for the experiment. By rotating the disk, several tests with different loading angles were conducted. To determine the position of the principal axis in each test, two groups of parameters(q. q. q. q. are calculated by two different groups of virtual fields. Then the corresponding loading angle can be determined by minimizing the deviation between two groups of the parameters. After that, the four constants(q. q. q. q. were determined from the test with an angle of 27?.

关键词： Fused deposition modelling Virtual fields method Digital image correlation Orthotropic constitutive model Disk compression