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Inhibitory effect of Tong xie-Yao fang formula on colonic contraction in rats

World Journal of Gastroenterology 2015年第10期21卷 2912-2917页

作者： Cheng Yang Sheng-Sheng Zhang Xiao-Ling Li Zheng-fang Wang Lu-Qing Zhao Digestive Disease Diagnosis and Treatment Center Beijing Chinese Medicine HospitalCapital Medical University Basic Medicine College Beijing University of Chinese Medicine

AIM:To investigate the pharmacological effect ofTong xie-Yao fang(TXYF)formula and its underlying ***:A neonatal maternal separation plus restraint stress(NMS+RS)model of diarrheapredominant irritable bowel syndrome was developed by subjecting male Sprague-Dawley rats to daily maternal separation from postnatal days 2 to 21 plus restraint stress from days 50 to *** were randomly divided into two groups(NMS+RS and TXYF formula),and rats with no handling or separation were used as normal *** from postnatal day 60,rats were administered TXYF formula(9.84 g/100 g body weight)orally twice daily for 14 consecutive days,while the normal and NMS+RS groups were given distilled *** distinctions of movement index(MI,area under the curve of contraction intensity/min,mg/min)and contraction frequency(CF,number of contractions/min,times/min)of isolated colonic longitudinal smooth muscle strips(CLSMs)in the three groups before and after treatment were observed with a Power Lab *** inhibitors were applied,and then 10-4mol/L acetylcholine chloride(Ach)was added to CLSMs to induce muscle ***:Before treatment,the MI of CLSMs in the NMS+RS and TXYF formula groups was similar and both higher than that in the normal group(545.49±73.66 mg/min vs 245.76±34.44 mg/min and551.09±54.29 mg/min vs 245.76±34.44 mg/min,P<0.01,respectively).After treatment,the MI in the TXYF formula group was lower than that in the NMS+RS group(261.39±38.59 mg/min vs 533.9±61.63 mg/min,P<0.01).In the same way,the CF of CLSMs in the NMS+RS and TXYF formula groups was similar and both higher than that in the normal group(3.42±0.25 times/min and 3.31±0.21 vs1.1±0.17 times/min,P<0.01)before *** treatment,the CF in the TXYF formula group was lower than that in the NMS+RS group(1.42±0.87 times/min vs 3.11±0.82 times/min,P<0.01)and similar to that in the normal group(1.42±0.87 times/min vs 1.09±0.13 times/min).When8-(N,N-diethylamino)octyl 3,4,

关键词： Irritable bowel syndrome Neonatal maternal separat

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Regulating effect of Tong xie-Yao fang on colonic epithelial secretion via Cl- and HCO3- channel

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World Journal of Gastroenterology 2016年第48期22卷 10584-10591页

作者： Cheng Yang Ying Xiong Sheng-Sheng Zhang fang-Mei An Jing Sun Qing-Lin Zhang Qiang Zhan Department of Gastroenterology Wuxi People’s HospitalNanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Community Health Service Center of Jinkui Street Wuxi 214023Jiangsu ProvinceChina Digestive Disease Diagnosis and Treatment Center Beijing Chinese Medicine HospitalCapital Medical UniversityBeijing 100010China

AIM To investigate the pharmacological effect of Tong xieYao fang(TXYF) formula, a Chinese herbal formula, on Diarrhea-predominant irritable bowel syndrome(D-IBS) *** In a neonatal maternal separation plus restraint stress(NMS + RS) model of D-IBS, male Sprague Dawley rats were randomly divided into two groups(NMS + RS group and TXYF-formula group) with no handlings were used as controls(NH group). Starting from postnatalday 60, rats in TXYF-formula group were administered TXYF-formula(4.92 g/100 g bodyweight) orally twice a day for 14 consecutive days while NH group and NMS + RS group were given distilled water. Using short-circuit current technology, we observed 5-HT-induced changes of current across ion channels, such as cystic fibrosis transmembrane conductance regulator(CFTR) Clchannel, epithelial Na+ channel(ENaC), Ca2+-dependent Cl- channel(CACC), Na+-K+-2Cl- co-transporter(NKCC), and Na+-HCO-3 co-transporter(NBC), in the colonic epithelium of three groups after exposure to drugs and specific blockers with a Power Lab System(AD Instruments International).RESULTS Under basal conditions, the changes of short-circuit current(?Isc, μA/cm2) induced by 5-HT were similar in NH group and TXYF-formula group, and both higher than NMS + RS group(70.86 μA/cm2 ± 12.32 μA/cm2, 67.67 μA/cm2 ± 11.68 μA/cm2 vs 38.8 μA/cm2 ± 7.25 μA/cm2, P < 0.01, respectively). When CACC was blocked by 4,4′-diisothiocyanato-stilbene-2,2′-disulfonic acid, 5-HT-induced ?Isc was smaller in NMS + RS group than in NH group and TXYF-formula group, respectively(48.41 μA/cm2 ± 13.15 μA/cm2 vs 74.62 μA/cm2 ± 10.73 μA/cm2, 69.22 μA/cm2 ± 11.7 μA/cm2, P < 0.05, respectively). The similar result could be obtained when ENaC was blocked by Amiloride(44.69 μA/cm2 ± 12.58 μA/cm2 vs 62.05 μA/cm2 ± 11.26 μA/cm2, 62.11 μA/cm2 ± 12.01 μA/cm2, P < 0.05, respectively). However, when CFTR Cl- channel was blocked by 1,1-dimethyl piperidinium chloride(DPC), 5-HT-induced ?Isc did not significantly differ in t

关键词： Ion channel Diarrhea-predominant irritable bowel syndrome Colonic mucosa Short-circuit current TongX ie-YaoF ang formula

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Charged-Exciton Complexes in Quantum Dots

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Communications in Theoretical Physics 2001年第7期36卷 95-100页

作者： xie Wen-fang Department of Physics Guangzhou University Guangzhou 510405 China

It is known experimentally that stable charged-exciton complexes can exist in low-dimensional semiconductor nanostructures. Much less is known about the properties of such charged-exciton complexes since three-body problems are very difficult to be solved, even numerically. Here we introduce the correlated hyperspherical harmonics as basis functions to solve the hyperangular equation for negatively and positively charged excitons (trions) in a harmonic quantum dot. By using this method, we have calculated the energy spectra of the low-lying states of a charged exciton as a function of the radius of quantum dot. Based on symmetry analysis, the level crossover as the dot radius increases can be fully explained as the results of symmetry constraint.

关键词： few-body system, charged-exciton complex, quantum dot, hyperspherical coordinate

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A Bound State of a Positively Charged Exciton in Quantum Dots

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Chinese Physics Letters 2001年第2期18卷 266-268页

作者： xie Wen-fang Department of Physics Guangzhou UniversityGuangzhou 510405

Using the method of few-body physics,we obtain the relation between the correlation energies of the low-lying states of the positively charged exciton X+and the radius of quantum *** also calculate the binding energies of the ground state of a positively charged exciton as a function of the electron-to-hole mass ratio for a few values of the strength of the *** find that there exists a critical mass ratioσ^(c),such that ifσ>σ^(c)(σ<σ^(c))the X^(+)configuration is stable(unstable),andσc increases as the strength of the confinement increases.

关键词： positively radius quantum

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Ground-State Transitions in Two Vertically Coupled Single Electron Quantum Dots

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Chinese Physics Letters 1999年第1期16卷 53-55页

作者： xie Wen-fang Department of Physics Guangzhou Normal UniversityGuangzhou 510400

Exact results for the two vertically coupled two-dimensional single electron quantum dots are obtained as a function of magnetic *** ground-state transition is investigated and the effect of the distance between a double-layer dot on the Coulomb interaction is *** results show that when the inter-dot distance increases,a higher magnetic field is needed to induce ground-state transitions and that for sufficiently large distance no transitions ***,the short-ranged component of Coulomb interaction is important whether the ground-state transition appears in double-layer quantum dots.

关键词： field. transitions quantum

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A Study of a Confined Hydrogen Negative Ion

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Communications in Theoretical Physics 2007年第6期47卷 1111-1113页

作者： xie Wen-fang Department of Physics Guangzhou University Guangzhou 510006 China

The ground and three low-excited states of the hydrogen negative ion confined by a spherical harmonic oscillator potential are studied employing the adiabatic hyperspherical approach method. Total energies are obtained as a function of the confined potential radii. We find that the confinement may cause accidental degeneracies between levels with different low-excited states and the inversion of the energy values.

关键词： hydrogen negative ion energy spectrum

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Three Charged Bosons Confined in a Harmonic Trap

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Communications in Theoretical Physics 2005年第3X期44卷 529-531页

作者： xie Wen-fang Department of Physics Guangzhou University Guangzhou 510405 China

A system of three charged bosons confined in a harmonic trap has been investigated by an exact diagonalization. We report a calculation for the energy spectrum of the low-lying states of a system of three charged *** important feature of the low-lying states of three charged bosons in a harmonic trap is obtained via an analysis of the energy spectrum.

关键词： boson energy spectrum

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Ground State Transitions of Four-Electron Quantum Dots in Zero Magnetic Field

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Communications in Theoretical Physics 2008年第3期49卷 763-766页

作者： xie Wen-fang Department of Physics Guangzhou University Guangzhou 510006 China

In this paper, we study four electrons confined in a parabolic quantum dot in the absence of magnetic field, by the exact diagonalization method. The ground-state electronic structures and orbital and spin angular momenta transitions as a function of the confined strength are investigated. We find that the confinement may cause accidental degeneracies between levels with different low-lying states and the inversion of the energy values. The present results are useful to understand the optical properties and internal electron-electron correlations of quantum dot materials.

关键词： electron-electron interaction quantum dot semiconductor

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Singlet-Triplet Transitions of a Poeschl-Teller Quantum Dot

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Communications in Theoretical Physics 2006年第6X期46卷 1101-1104页

作者： xie Wen-fang Department of Physics Guangzhou University Guangzhou 510006 China

We study the energy spectra of a two-dimensional two-electron quantum dot （QD） with P6schl-Tefler confining potential under the influence of perpendicular homogeneous magnetic field. Calculations are made by using the method of numerical diagonalization of Hamiltonian matrix within the effectlve-mass approximation. A ground-state behavior （spin singlet-triplet transitions） as a function of the strength of a magnetic field is found. We find that the dot radius R of a Poeschl-Teller potential is important for the ground-state transition and the feature of ground-state for a Poeschl Teller QD and a parabolic QD is similar when R is larger. The larger the well depth, the higher the magnetic field for the singlet-triplet transition of the ground-state of two interacting electrons in a Poesehl-Teller QD.

关键词： electron-electron interaction quantum dot semiconductor

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Donor Centers in a Gaussian Potential

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Communications in Theoretical Physics 2007年第1期47卷 167-170页

作者： xie Wen-fang Department of Physics Guangzhou University Guangzhou 510006 China

We study a neutral donor center （D^0） and a negatively charged donor center （D^-） trapped by a quantum dot, which is subjected to a Gaussian potential confinement. Calculations are made by using the method of numerical diagonalization of Hamiltonian within the effective-mass approximation. The dependence of the ground state of the neutral shallow donor and the negatively charged donor on the dot size and the potential depth is investigated. The same calculations performed with the parabolic approximation of the Gaussian potential lead to the results that are qualitatively and quantitatively different from each other.

关键词： donor quantum dots

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