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A High-Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy

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Chinese Journal of Chemistry 2024年第8期42卷 858-866页

作者： Weihua Wang Chu Han Shengjie xie Zisong cong Zixuan Yang Yuxin Feng Limin Xiang Heng Song College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,Autophagy is a multi-step cell metabolism process in which cells remove damaged and unwanted *** autophagy,autophagosomes fuse with lysosomes to form *** membrane components are recycled from autolysosomes through the autophagosomal components recycling(ACR),while lysosomal components circulate on the autolysosomal surface through the autophagic lysosome reformation(ALR)*** contain components from autophagosomes and ***,whether there is a fusion between autolysosome and autophagosome or lysosome at the organelle level remains *** this study,a pH and viscosity dual-controlled mitochondria-targeting fluorescent probe Mito-Q was designed based on an asymmetric norcyanine to achieve the high-contrast imaging of mitochondria-containing ***-Q not only effectively detected mitochondrial viscosity changes and mitophagy with high sensitivity,but more importantly,the fusion of mitochondria-containing autolysosomes and autophagosomes(FMAA)was observed during autophagy by the real-time confocal imaging of HeLa cells.

关键词： Mitophagy Autolysosomes Bioimaging Biosensors Fluorescence imaging

Application of modified discontinuous deformation analysis to dynamic modelling of the Baige landslide in the Jinsha River

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Journal of Mountain Science 2024年第7期21卷 2305-2319页

作者： xie Chenxi DENG Jianhui PENG Xinyan YANG Zhongkang ZHAO Siyuan LI hua State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610031China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610051China MOE Key Laboratory of Deep Earth Science and Engineering Institute for Disaster Management and ReconstructionSichuan UniversityChengdu 610031China Power China Chengdu Engineering Corporation Limited Chengdu 610031China

Accurate dynamic modeling of landslides could help understand the movement mechanisms and guide disaster mitigation and *** deformation analysis(DDA)is an effective approach for investigating ***,DDA fails to accurately capture the degradation in shear strength of rock joints commonly observed in high-speed *** this study,DDA is modified by incorporating simplified joint shear strength *** on the modified DDA,the kinematics of the Baige landslide that occurred along the Jinsha River in China on 10 October 2018 are *** violent starting velocity of the landslide is considered *** cases with different violent starting velocities are investigated to show their effect on the landslide movement ***,the landslide movement process and the final accumulation characteristics are analyzed from multiple *** results show that the violent starting velocity affects the landslide motion characteristics,which is found to be about 4 m/s in the Baige *** movement process of the Baige landslide involves four stages:initiation,high-speed sliding,impact-climbing,low-speed motion and *** accumulation states of sliding masses in different zones are different,which essentially corresponds to *** research results suggest that the modified DDA is applicable to similar high-level rock landslides.

关键词： Discontinuous deformation analysis(DDA) Baige landslide Violent starting velocity movement process Accumulation characteristics

Effectivity and safety of trifocal intraocular lenses and capsular tension rings implantation for cataract patients with axial high myopia

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 499-508页

作者： Shan hua Qiu-Xia xie Hu Wang Jing-Xiang Zhong Dongguan Aier Eye Hospital Jinan UniversityDongguan 523106Guangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Ophthalmology the Sixth Affiliated Hospital of Jinan UniversityDongguan 523576Guangdong ProvinceChina

●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was *** 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(260.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two *** postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular *** was no difference in the incidenc

关键词： trifocal intraocular lenses capsular tension ring axial high myopia cataract visual quality

Synergetic Control of Li^(+)Transport Ability and Solid Electrolyte Interphase by Boron-Rich Hexagonal Skeleton Structured All-Solid-State Polymer Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 154-163页

作者： Yanan Li Shunchao Ma Yuehua Zhao Silin Chen Tingting Xiao Hongxing Yin Huiyu Song Xiumei Pan Lina cong Haiming xie Department of Chemistry National&Local United Engineering Laboratory for Power BatteryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China

High Li^(+)transference number electrolytes have long been understood to provide attractive candidates for realizing uniform deposition of Li^(+).However,such electrolytes with immobilized anions would result in incomplete solid electrolyte interphase(SEI)formation on the Li anode because it suffers from the absence of appropriate inorganic components entirely derived from anions ***,a boron-rich hexagonal polymer structured all-solid-state polymer electrolyte(BSPE+10%LiBOB)with regulated intermolecular interaction is proposed to trade off a high Li^(+)transference number against stable SEI *** Li^(+)transference number of the as-prepared electrolyte is increased from 0.23 to 0.83 owing to the boron-rich cross-linker(BC)*** intriguingly,for the first time,the experiments combined with theoretical calculation results reveal that BOB^(-)anions have stronger interaction with B atoms in polymer chain than TFSI^(-),which significantly induce the TFSI^(-)decomposition and consequently increase the amount of LiF and Li3N in the SEI ***,a LiFePO_(4)|BSPE+10%LiBOBlLi cell retains 96.7%after 400 cycles while the cell without BC-resisted electrolyte only retains 40.8%.BSPE+10%LiBOB also facilitates stable electrochemical cycling of solid-state Li-S *** study blazes a new trail in controlling the Li^(+)transport ability and SEI properties,synergistically.

关键词： all-solid-state electrolyte boron-rich polymer lithium metal batteries lithium-ion transference number solid electrolyte interphase layer

马铃薯class Ⅰ patatin基因在试管块茎形成中的功能

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作物学报 2006年第9期32卷 1406-1409页

作者：司怀军柳俊谢从华国家蔬菜改良中心华中分中心/园艺植物生物学教育部重点实验室/华中农业大学

将正反义classⅠpatatin基因导入马铃薯品种甘农薯2号中,有2个转正义基因株系试管块茎的可溶性蛋白含量和LAH活性与对照相比有不同程度的增加,有3个转反义基因株系的可溶性蛋白质含量下降,并且所有转反义基因植株的LAH活性都不同程度地... 详细信息

将正反义classⅠpatatin基因导入马铃薯品种甘农薯2号中,有2个转正义基因株系试管块茎的可溶性蛋白含量和LAH活性与对照相比有不同程度的增加,有3个转反义基因株系的可溶性蛋白质含量下降,并且所有转反义基因植株的LAH活性都不同程度地降低。试管块茎的诱导结果表明,有1个转正义基因株系的结薯株率和单株结薯数比其对照明显增加,有2个转反义基因株系的结薯株率和单株结薯数比对照明显减少,说明该classⅠpatatin基因参与了马铃薯试管块茎的形成及其调控。

关键词：马铃薯 class Ⅰ patatin基因转化块茎形成

基于FLS的多级队列CPU调度系统仿真研究

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计算机仿真 2015年第7期32卷 335-339页

作者：周思林谢从华常熟理工学院计算机科学与工程学院江苏常熟215500

传统的多级队列调度方法为每个队列分配一个优先等级,并根据队列的等级将过程分配到不同的子队列中。高优先级队列中的过程通常会抢占低优先级队列过程的资源,使低优先级队列中的过程一直得不到服务。针对上述问题,利用模糊符号逻辑,提... 详细信息

传统的多级队列调度方法为每个队列分配一个优先等级,并根据队列的等级将过程分配到不同的子队列中。高优先级队列中的过程通常会抢占低优先级队列过程的资源,使低优先级队列中的过程一直得不到服务。针对上述问题,利用模糊符号逻辑,提出了一种多级队列CPU调度算法。上述算法将就绪队列分为两个子队列,每个子队列包含I/O极限处理和CPU极限处理,且CPU时间动态地分配到每个队列中。设计了两种模糊干扰系统,一种系统动态地为两个子队列分配CPU处理时间,另一种系统计算时间量子来调度I/O极限过程。仿真结果表明,所提算法改善了过程饥饿问题,以及平均响应时间性能。

关键词：模糊干扰系统调度极限模糊逻辑符号

Electrochemically recycling degraded superalloy and valorizing CO_(2)in the aff ordable borate-modified molten electrolyte

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Tungsten 2024年第2期6卷 382-393页

作者： Xiang Chen Yuan Sun Long Wang Xin Qu Yan Zhao Hong-Wei xie Di-hua Wang hua-Yi Yin Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang 110819China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China School of Resource and Environmental Science Wuhan UniversityWuhan 430072China

Integrating electrochemical reduction of CO_(2)and electrochemical oxidation to recycle degraded superalloys is a promising solution to ease resource scarcity and safeguard environmental ***,we propose an electrochemical technique for the conversion of bulk superalloy scraps and CO_(2)into oxide powder at the anode and solid carbon at the cathode,*** particular,a borax-modifi ed CaCl_(2)-based molten salt electrolyte is used for enhancing the electrochemical oxidation of superalloy *** a temperature of 700℃and a voltage of 2.8 V,90.55 wt.%of alloy scraps were oxidized in a molten CaCl_(2)–NaCl–CaCO_(3)–Na_(2)B_(4)O_(7)with an acid–base ratio(K_(a/b))of *** synergy of Cl−and B_(4)O_(7)2−of electrolyte prevents the passivation of the alloy anode and enables continuous ***,the Ni and Co in the anode products are recovered by sulfation roasting with recovery efficiencies of 85.58%and 95.27%for Ni and Co,***,modulating the alkalinity of the electrolyte for enhancing oxidation/pulverization of alloy scrap anode provides new insight into electrochemically recovering superalloy scraps.

关键词： Superalloy scraps Recycling Molten salt Alkalinity Electrochemical oxidation Cobalt

基于多分辨率的非参数正交多项式医学图像融合方法

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模式识别与人工智能 2012年第2期25卷 300-304页

作者：刘哲宋余庆陈健美晏燕华谢从华江苏大学计算机科学与通信工程学院镇江212013 吉林师范大学计算机学院四平136000

基于估计理论的图像融合方法都是假设图像偏移或噪声服从高斯混合分布,容易造成模型不匹配和丢失局部细节等问题.文中提出一种基于小波的多分辨率的非参数正交多项式医学图像融合方法.首先,对图像进行多分辨率分解.对低频部分,根据图像... 详细信息

基于估计理论的图像融合方法都是假设图像偏移或噪声服从高斯混合分布,容易造成模型不匹配和丢失局部细节等问题.文中提出一种基于小波的多分辨率的非参数正交多项式医学图像融合方法.首先,对图像进行多分辨率分解.对低频部分,根据图像信息模型和非参数正交多项式混合模型,采用非参数期望最大法估计模型参数,获得低频融合结果.对高频部分,采用系数绝对值选大法进行融合.然后,将高频和低频部分结果进行反变换,得到最终融合图像.实验结果表明,该方法融合质量优于其它方法,融合时间大为缩短.

关键词：估计理论正交多项式多分辨率非参数期望最大法(NEM) 图像融合

Improving flight performance of UAVs by ice shape modulation

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Chinese Journal of Aeronautics 2024年第8期37卷 49-62页

作者： Jiajun ZHANG Xuecheng LIU hua LIANG Like xie Biao WEI Haohua ZONG Yun WU Yinghong Li National Key Lab of Aerospace Power System and Plasma Technology Air Force Engineering UniversityXi’an 710038China Institute of Aero-Engine School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

Aircraft icing poses a great threat to flight *** response to the characteristics of high-power consumption,large volume,and heavy weight of traditional anti-/de-icing technologies,the concept of ice shape modulation is proposed,which is called ice tolerant ***,the flight performance of Unmanned Aerial Vehicle(UAV)was compared in three states:no ice,full ice,and modulated ice through flight *** was found that ice shape modulation has a significant improvement effect on the aerodynamic performance of aircraft under icing *** the three modulated ice shape conditions in this experiment,the lift coefficient of the UAV under different ice shape modulation conditions increased by 18%–33%,and the stalling angle was delayed by 3°-5°.Subsequently,the pressure distribution,streamlines in the flow field,and detached vortex distribution of the UAV model in these three states were obtained through numerical simulation,to study the mechanism of ice shape modulation on the aerodynamic performance of *** simulation found that the reason for the improvement of the wings effect after ice shape modulation is that the modulated area forms a leading-edge protrusion structure similar to a vortex *** structure prolongs the mixed flow region on the wings surface and reduces the trend of flow separation,which plays a role in increasing lift and reducing drag for UAVs under icing ***,a reverse reachable set that can be used for unexpected state recovery is used as the definition of flight safety boundaries,and an aircraft dynamics model is established to obtain flight safety boundaries for different *** has found that the flight safety boundary of the UAV in a no ice state is greater than that in a modulated ice state,and the safety boundary in a modulated ice state is greater than that in a full ice *** with the full ice state,the flight safety boundary after modulation has expanded by 27.0%.The sch

关键词： Ice shape modulation Aerodynamic performance Reachable set Flight safety UAV