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Building Simulation 2024年第4期17卷 607-624页

作者： Xiaotian Geng dong xie Zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

The morphology of urban areas plays a crucial role in determining solar potential,which directly affects photovoltaic capacity and the achievement of net-zero *** study focuses on the City of Melbourne to investigate the utilization of solar energy across different urban densities and proposes optimized *** analysis encompasses blocks with diverse population densities,examining medium and high-density *** utilizing a multi-objective genetic optimization approach,the urban morphology of these blocks is *** findings indicate that low-density blocks exhibit photovoltaic potential ranging from 1 to 6.6 times their total energy *** and high-density blocks achieve photovoltaic potential levels approximately equivalent to 40%-85%of their overall energy ***,significant variations in photovoltaic potential are observed among different urban forms within medium and high-density ***“elevated corners with central valley”prototype is proposed as an effective approach,enhancing the overall photovoltaic potential by approximately 14%.This study introduces novel analytical concepts,shedding light on the intricate relationship between urban morphologies and photovoltaic potential.

关键词： net-zero energy solar energy urban density urban morphology multi-objective optimization photovoltaic potential

Hydrodynamic Characteristics of Undular Tidal Bores in the Qiantang River Based on Field Observations

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China Ocean Engineering 2024年第3期38卷 505-518页

作者： ZHANG Shu-yu PAN Cun-hong ZHANG Shen-yang LI Ruo-hua CHENG Wenlong xie dong-feng Zhejiang Tongji Vocational College of Science and Technology Hangzhou 311231China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020China

Understanding the undular tidal bores in the Qiantang River is essential for effective river management and *** breaking tidal bores have been studied extensively, reports on undular tidal bores in the Qiantang Riverremain limited. Furthermore, observed data on undular tidal bores fulfilling the requirements of short measurementtime intervals, and spring, medium, and neap tide coverage, and providing detailed data for the global vertical stratificationof flow velocity are quite limited. Based on field observations at Qige in the Qiantang estuary, we analyzedthe characteristics of undular tidal bores. The results showed that the flooding amplitude (a) of the first wave isalways larger than its ebbing amplitude (b). Moreover, the vertical distribution of the maximum flood velocity exhibitesthree shapes, influenced by the tidal range, while that of the maximum ebb velocity exhibites a single shape. Duringthe initial phase of the flood tide in the spring and medium tides, the upper water body experiences multiple oscillatingchanges along the flow direction, corresponding to the alternating process of the crest and trough of the tide levelupon the arrival of the tidal bore. The tidal range is a crucial parameter in tidal bore hydrodynamics. By establishingthe relationship between hydrodynamic parameters and tidal range, other hydrodynamic parameters, such as the tidalbore height, maximum flood depth–averaged velocity, maximum flood stratified velocity at the measurement points,and duration of the flood tide current, can be effectively predicted, thereby providing an important reference for rivermanagement and maintenance.

关键词： tidal bores Qiantang Estuary tidal bore height tidal bore velocity propagation speed

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao Jiang Siyuan Zhao dong xie Qing Chen Qi Zhao Hao Wu Jian Luo Lili Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

Privacy-preserving pathological data sharing among multiple remote parties

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BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第3期5卷 67-77页

作者： Wu, Wei Chen, Fulong Wang, Taochun xie, dong Zhao, Chuanxin Wang, Chao Tang, Detao Li, Jingtao Zhang, Ji Anhui Normal Univ Anhui Prov Key Lab Network & Informat Secur Wuhu 241002 Peoples R China Univ Southern Queensland Toowoomba Qld 4350 Australia

The sharing of pathological data is highly important in various applications, such as remote diagnosis, graded diagnosis, illness treatment, and specialist system development. However, ensuring reliable, secure, privacy- preserving, and efficient sharing of pathological data poses significant challenges. This paper presents a novel solution that leverages blockchain technology to ensure reliability in pathological data sharing. Additionally, it employs conditional proxy re-encryption (C-PRE) and public key encryption with equality test technology to control the scope and preserve the privacy of shared data. To assess the practicality of our solution, we implemented a prototype system using Hyperledger Fabric and conducted evaluations with various metrics. We also compared the solution with relevant schemes. The results demonstrate that the proposed solution effectively meets the requirements for pathological data sharing and is practical in production scenarios.

关键词： Digital remote pathology Conditional proxy re-encryption Blockchain Data storage Data sharing PROXY RE-ENCRYPTION

Magnetic resonance imaging-based lymph node radiomics for predicting the metastasis of evaluable lymph nodes in rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1849-1860页

作者： Yong-Xia Ye Liu Yang Zheng Kang Mei-Qin Wang Xiao-dong xie Ke-Xin Lou Jun Bao Mei Du Zhe-Xuan Li Department of Radiology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina1 Department of Pathology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Colorectal Center The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina

BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient *** radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a *** To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable *** In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI *** MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were *** radiomics models used 3D features from T1WI and T2WI ***,a nomogram model combining conventional MRI and radiomics features was *** model used univariate analysis and multivariable logistic *** employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic *** performance was assessed using calibration and decision curve *** The nomogram model outperformed conventional MRI and single radiomics models in evaluating *** the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,*** the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),*** The nomogram model showed the best performance in predicting metastasis of evaluable LNs.

关键词： Radiomics Lymph node metastasis Rectal cancer Magnetic resonance imaging

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参数激励变势能函数压电俘能器的特性研究

机械设计与制造 2024年第8期402卷 375-380页

作者：解小东陈忠成谢进西南交通大学机械工程学院四川成都610031

提出了一种具有变势能函数的二自由度压电俘能器结构。利用拓展哈密顿原理推导了俘能器的机电耦合模型,并对系统进行了运动及动力学仿真分析。研究表明,在系统发生共振时,随着外部磁铁的运动,系统中的磁力和磁势能均发生变化,系统的磁... 详细信息

提出了一种具有变势能函数的二自由度压电俘能器结构。利用拓展哈密顿原理推导了俘能器的机电耦合模型,并对系统进行了运动及动力学仿真分析。研究表明,在系统发生共振时,随着外部磁铁的运动,系统中的磁力和磁势能均发生变化,系统的磁势能穿越了形状不同的磁势能曲线,产生了较大的磁势能变化,其中的大部分能量转化为梁的弹性势能,且通过对系统俘能特性的研究表明,俘能器的工作带宽与输出电压均方根峰值均得到较大提升,从而提高了俘能器的性能。

关键词：参数激励带宽变势能函数内共振

中药调控间充质干细胞外泌体治疗缺血性心脑血管疾病研究进展

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中国实验方剂学杂志 2024年第13期30卷 250-258页

作者：解冬张露张金生河南中医药大学郑州450046 河南中医药大学第三附属医院郑州450000

缺血性心脑血管疾病包括缺血性心脏病和缺血性脑血管病,具有高患病率、高致残率、高死亡率的特点,目前已成为全球死亡原因首位。缺血性心脏病和缺血性脑血管病的共同病因是血管狭窄、粥样硬化及梗死造成的局部供血减少,而其复杂的病理... 详细信息

缺血性心脑血管疾病包括缺血性心脏病和缺血性脑血管病,具有高患病率、高致残率、高死亡率的特点,目前已成为全球死亡原因首位。缺血性心脏病和缺血性脑血管病的共同病因是血管狭窄、粥样硬化及梗死造成的局部供血减少,而其复杂的病理过程涉及炎症、焦亡、凋亡、自噬等多种机制,干预单一的病理环节治疗作用有限,亟需寻找可同时干预多个病理环节的新的治疗策略或药物。间充质干细胞通过其旁分泌效应起到组织修复的作用,外泌体在其中扮演重要角色,间充质干细胞外泌体具有与母细胞相似的免疫调节和修复特性,同时可减少干细胞直接应用后的不良反应及输注毒性,其在治疗缺血性心脑血管疾病中具有广泛应用前景。中药及组方具有多成分、多靶标、多层次系统调节的作用特点,中药可通过对间充质干细胞源性外泌体的调控改善细胞微环境从而对缺血性心脑血管疾病发挥治疗作用,体现现代中医微观辨证的观点,是中医药现代化的又一重要领域。该文对间充质干细胞外泌体对缺血性心脑血管疾病的治疗作用及机制进行了综述,同时讨论了中药调控间充质外泌体在缺血性心脑血管疾病中的应用作用,为中医药防治缺血性心脑血管病提供新思路。

关键词：中医药间充质干细胞外泌体缺血性心脏病缺血性脑血管疾病

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领域自适应方法用于医学影像研究进展

中国医学影像技术 2024年第6期40卷 936-939页

作者：岳珂娟伍炯星谢东湖南第一师范学院计算机学院湖南长沙410205 中南大学湘雅三医院急诊科湖南长沙410013 湖南人文科技学院信息学院湖南娄底417000

人工智能有助于提高医学影像学诊断准确率、提高工作效率,但训练模型的过程中需要对大量图像数据进行标注,且需面临域偏移等问题;利用领域自适应方法可基于少量标注数据训练高效模型。本文就领域自适应方法用于医学影像研究进展进行综述。

关键词：机器学习诊断显像领域自适应域偏移

基于响应面法设计与制备磷石膏矿渣基复合胶凝材料

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混凝土 2024年第7期 149-152,159页

作者：李悦谢东林辉北京工业大学城市与工程安全减灾教育部重点实验室北京100124

为了促进磷石膏等固废材料的资源化利用,优化设计和制备了力学强度满足P·O 42.5级水泥规范要求的胶凝材料,基于响应面法对磷石膏-矿渣-石灰-锂渣-钢渣五元体系进行试验设计,分别以3 d、7 d和28 d抗压强度为响应值,探究磷石膏矿渣基复... 详细信息

为了促进磷石膏等固废材料的资源化利用,优化设计和制备了力学强度满足P·O 42.5级水泥规范要求的胶凝材料,基于响应面法对磷石膏-矿渣-石灰-锂渣-钢渣五元体系进行试验设计,分别以3 d、7 d和28 d抗压强度为响应值,探究磷石膏矿渣基复合胶凝材料力学性能的变化规律,建立了磷石膏矿渣基复合胶凝材料力学性能预测模型。结果表明最优配合比为磷石膏33.86%,矿渣39.13%,石灰2.28%,锂渣20.1%,钢渣4.65%,胶凝材料的3 d、7 d和28 d抗压强度分别达到18.8 MPa、32.3 MPa、50.3 MPa,满足P·O 42.5级水泥规范要求,并且实测值与预测值的相对误差绝对值均小于5%,说明基于响应面法优化设计磷石膏矿渣基复合胶凝材料具有可行性。

关键词：磷石膏复合胶凝材料响应面法力学强度

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浅析电气自动化技术在电气工程中的作用

模具制造 2024年第2期24卷 205-207页

作者：解东安徽亳州新能源学校安徽利辛236700

对电气自动化技术在电气工程中的应用价值进行分析,并从实现电气设备自动优化配置、总线控制系统自动化监控以及变电站自动化管理等方面阐述电气自动化技术在电气工程中的作用,以期将电气自动化技术优势作用充分发挥,解决传统电气工程... 详细信息

对电气自动化技术在电气工程中的应用价值进行分析,并从实现电气设备自动优化配置、总线控制系统自动化监控以及变电站自动化管理等方面阐述电气自动化技术在电气工程中的作用,以期将电气自动化技术优势作用充分发挥,解决传统电气工程生产与运行所面临的问题,从而为我国电力事业高质量发展提供助力。

关键词：电气工程电气自动化技术运行效率

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