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Bioactive Materials 2022年第1期7卷 389-400页

作者： Jie Yu Sha Liu Yupeng Wang xidong he Qingfei Zhang Yanxin Qi Dongfang Zhou Zhigang Xie Xiaoyuan Li Yubin Huang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022PR China University of Science and Technology of China Hefei230026PR China Faculty of Chemistry Northeast Normal UniversityChangchun130024PR China

The combination of tumor ablation and immunotherapy is a promising strategy against tumor relapse and *** therapy(PTT)triggers the release of tumor-specific antigens and damage associated molecular patterns(DAMPs)***,the immunosuppressive tumor microenvironment restrains the activity of the effector immune ***,systematic immunomodulation is critical to stimulate the tumor microenvironment and augment the anti-tumor therapeutic *** this end,polyethylene glycol(PEG)-stabilized platinum(Pt)nanoparticles(Pt NPs)conjugated with a PD-L1 inhibitor(BMS-1)through a thermo-sensitive linkage were *** near-infrared(NIR)exposure,BMS-1 was released and maleimide(Mal)was exposed on the surface of Pt NPs,which captured the antigens released from the ablated tumor cells,resulting in the enhanced antigen internalization and *** addition,the Pt NPs acted as immune adjuvants by stimulating dendritic cells(DCs)***,BMS-1 relieved T cell exhaustion and induced the infiltration of effector T cells into the tumor ***,Pt NPs can ablate tumors through PTT,and augment the anti-tumor immune response through enhanced antigen presentation and T cells infiltration,thereby preventing tumor relapse and metastasis.

关键词： Pt nanoparticles PD-L1 small molecule inhibitors Antigen-capturing Anti-Tumor immunological effects Photothermal sensitive

Three-dimensional thermohaline structure estimation derived from HY-2 satellite data over the Maritime Silk Road and its applications

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Acta Oceanologica Sinica 2024年第5期43卷 41-53页

作者： Zhiqiang Chen xidong Wang Xiangyu Wu Yuan Cao Zikang he Dakui Wang Jian Chen Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210024China Laboratory for Regional Oceanography and Numercial Modeling Qingdao Marine Science and Technology CenterQingdao 266061China National Marine Environmental Forecasting Center Ministry of Natural ResourcesBeijing 100081China Beijing Institute of Applied Meteorology Beijing 100029China

Estimated ocean subsurface fields derived from satellite observations provide potential data sources for operational marine environmental monitoring and prediction *** study employs a statistic regression reconstruction method,in combination with domestic autonomous sea surface height and sea surface temperature observations from the Haiyang-2(HY-2)satellite fusion data,to establish an operational quasi-realtime three-dimensional(3D)temperature and salinity products over the Maritime Silk *** products feature a daily temporal resolution and a spatial resolution of 0.25°×0.25°and exhibit stability and *** have demonstrated the accuracy of the reconstructed thermohaline fields in capturing the 3D thermohaline variations through comprehensive statistical evaluations,after comparing them against Argo observations and ocean analysis data from *** results illustrate that the reconstructed fields effectively represent seasonal variations in oceanic subsurface structures,along with structural changes resulting from mesoscale processes,and the upper ocean’s responses to tropical ***,the incorporation of HY-2 satellite observations notably enhances the accuracy of temperature and salinity reconstructions in the Northwest Pacific Ocean and marginally improves salinity reconstruction accuracy in the North Indian Ocean when compared to the World Ocean Atlas 2018 monthly climatology thermohaline *** a result,the reconstructed product holds promise for providing quasi-real-time 3D temperature and salinity field information to facilitate fast decisionmaking during emergencies,and also offers foundational thermohaline fields for operational ocean reanalysis and forecasting *** contributions enhance the safety and stability of ocean subsurface activities and navigation.

关键词： HY-2 satellite observations subsurface structures reconstruction Maritime Silk Road operational thermohaline product

Two-dimensional ballistic transistors for advanced-node integrated circuits

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National Science Review 2024年第3期11卷 9-10页

作者： Jia Li xidong Duan Hunan Provincial Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University

As the feature size of metal-oxide-semiconductor-field-effect-transistors(MOSFETs) in integrated circuits(ICs)is reduced to sub-10-nm, the traditional channel materials are plagued by enhanced scattering and short-cha... 详细信息

关键词： CONTACT

Responses of the Southern Ocean mixed layer depth to the eastern and central Pacific El Niño events during austral winter

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Acta Oceanologica Sinica 2024年第7期43卷 1-14页

作者： Yuxin Shi Hailong Liu xidong Wang Quanan Zheng School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Greater Mekong Subregion Yunnan UniversityKunming 600650China College of Oceanography Hohai UniversityNanjing 210098China Department of Atmospheric and Oceanic Science University of Maryland at College ParkCollege Park 20742USA

Based on the Ocean Reanalysis System version 5(ORAS5)and the fifth-generation reanalysis datasets derived from European Centre for Medium-Range Weather Forecasts(ERA5),we investigate the different impacts of the central Pacific(CP)El Niño and the eastern Pacific(EP)El Niño on the Southern Ocean(SO)mixed layer depth(MLD)during austral *** MLD response to the EP El Niño shows a dipole pattern in the South Pacific,namely the MLD dipole,which is the leading El Niño-induced MLD variability in the *** tropical Pacific warm sea surface temperature anomaly(SSTA)signal associated with the EP El Niño excites a Rossby wave train propagating southeastward and then enhances the Amundsen Sea low(ASL).This results in an anomalous cyclone over the Amundsen *** a result,the anomalous southerly wind to the west of this anomalous cyclone advects colder and drier air into the southeast of New Zealand,leading to surface cooling through less total surface heat flux,especially surface sensible heat(SH)flux and latent heat(LH)flux,and thus contributing to the mix layer(ML)*** east of the anomalous cyclone brings warmer and wetter air to the southwest of Chile,but the total heat flux anomaly shows no significant *** warm air promotes the sea ice melting and maintains fresh water,which strengthens *** results in a shallower *** the CP El Niño,the response of MLD shows a separate negative MLD anomaly center in the central South *** Rossby wave train triggered by the warm SSTA in the central Pacific Ocean spreads to the Amundsen Sea,which weakens the ***,the anomalous anticyclone dominates the Amundsen ***,the anomalous northerly wind to the west of anomalous anticyclone advects warmer and wetter air into the central and southern Pacific,causing surface warming through increased SH,LH,and longwave radiation flux,and thus contributing to the ML ***,to the east of the anomalous anticyclone,there is n

关键词： Southern Ocean mixed layer depth Central Pacific El Niño Eastern Pacific El Niño Rossby wave train

Reply to Comment on“Chemical vapor deposition synthesis and Raman scattering investigation of quasi-one-dimensional ZrS_(3) nanoflakes”

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Nano Research 2024年第9期17卷 8649-8650页

作者： Yang Chen Yuanyuan Jin Junqiang Yang Yizhang Ren Zhuojun Duan Xiao Liu Jian Sun Song Liu Xukun Zhu xidong Duan Institute of Chemical Biology and Nanomedicine(ICBN) College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Hunan Key Laboratory of Two-Dimensional Materials and State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China School of Physics and Electronics Central South UniversityChangsha 410083China

1 Introduction Thanks very much for *** taking time to comment on our recent paper regarding“Chemical vapor deposition synthesis and Raman scattering investigation of quasi-one-dimensional ZrS_(3) nanoflakes”.We summarize the suggestions of *** as made in the comment[1].First,*** suggested that there are just three peaks of two S 2p doublets in Fig.2(b)in the original paper[1],which is inconsistent to the four peaks of previous reports[2-4].Second,*** mentioned that the ratio of two S 2p doublets is helpful to identify the sulfur vacancies,which have a great impact on the n-type semiconducting nature of ZrS_(3).Third,*** mentioned that Zr 3d peak appearing at 184.7 eV is wider than previous reports[2,4],which may be accounted by the appearance of ZrS_(2)O,and Zr remains in the tetravalent state.

关键词： state. synthesis quasi

Recent Advances in Spin-coating Precursor Mediated Chemical Vapor Deposition of Two-Dimensional Transition Metal Dichalcogenides

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Precision Chemistry 2024年第7期2卷 282-299页

作者： Dingyi Shen Yejun Jin Zucheng Zhang Rong Song Miaomiao Liu Wei Li Xin Li Ruixia Wu Bo Li Jia Li Bei Zhao xidong Duan Hunan Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan University410082 ChangshaChina Key Laboratory of Quantum Materials and Devices of Ministry of Education School of PhysicsSoutheast UniversityNanjing 211189China Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan University410082 ChangshaChina

Two-dimensional(2D)transition metal dichalcogenides(TMDs)have garnered widespread interest in the scientific community and industry for their exceptional physical and chemistry properties,and great potential for applications in diverse fields including(opto)electronics,electrocatalysis,and energy *** vapor deposition(CVD)is one of the most compelling growth methods for the scalable growth of high-quality 2D ***,the conventional CVD process for synthesis of 2D TMDs still encounters significant challenges,primarily attributed to the high melting point of precursor powders,and achieving a uniform distribution of precursor atmosphere on the substrate to obtain controllable smaple domains is *** spin-coating precursor mediated chemical vapor deposition(SCVD)strategy provides refinement over traditional methods by eliminating the use of solid precursors and ensuring a more clean and uniform distribution of the growth material on the ***,the SCVD process allows fine-tuning of material thickness and purity by manipulating solution composition,concentration,and the spin coating *** Review presents a comprehensive summary of recent advances in controllable growth of 2D TMDs with a SCVD ***,a series of various liquid precursors,additives,source supply methods,and substrate engineering strategies for preparing atomically thin TMDs by SCVD are ***,2D TMDs heterostructures and novel doped TMDs fabricated through the SCVD method are ***,the current challenges and perspectives to synthesize 2D TMDs using SCVD are discussed.

关键词： Spin-coating Chemical vapor deposition Liquid precursor Substrate Two-dimensional materials heterostructure Doping Film

南蛇藤醇对小鼠非酒精性脂肪性肝炎的抑制作用

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医药导报 2022年第7期41卷 947-953页

作者：李登科宋铃榆何锡东胡越杨红刘琦贵州医科大学临床医学院贵阳550004 贵州医科大学附属医院消化内科贵阳550004

目的观察南蛇藤醇对蛋氨酸-胆碱缺乏(MCD)饮食诱导的小鼠非酒精性脂肪性肝炎(NASH)的改善作用。方法将小鼠随机分为正常对照组、模型对照组及南蛇藤醇组,每组6只。正常对照组喂养蛋氨酸-胆碱充足(MCS)饮食;模型对照组喂养MCD饮食;南蛇... 详细信息

目的观察南蛇藤醇对蛋氨酸-胆碱缺乏(MCD)饮食诱导的小鼠非酒精性脂肪性肝炎(NASH)的改善作用。方法将小鼠随机分为正常对照组、模型对照组及南蛇藤醇组,每组6只。正常对照组喂养蛋氨酸-胆碱充足(MCS)饮食;模型对照组喂养MCD饮食;南蛇藤醇组给予MCD饮食喂养+南蛇藤醇腹腔注射(1 mg·kg^(-1),隔天1次)。均持续喂养5周。称量并记录小鼠体质量及肝质量;苏木精-伊红(he)染色观察肝组织脂肪变性程度;非酒精性脂肪性肝病活动度(NAS)评分评估小鼠肝病活动度;油红染色法观察小鼠肝组织脂质沉积程度;生化试剂盒检测小鼠肝脏三酰甘油(TG)、血清丙氨酸氨基转移酶(ALT)及天冬氨酸氨基转移酶(AST)水平;实时荧光定量聚合酶链反应(qPCR)检测巨噬细胞特异性表面抗原F4/80、白细胞介素-1β(IL-1β)表达;Masson's染色法观察小鼠肝脏纤维化程度;免疫组化观察小鼠肝脏Ⅰ型胶原蛋白α1(COL1A1)阳性细胞。结果与正常对照组比较,模型对照组小鼠体质量与肝质量均明显减轻(P<0.01);肝组织脂肪变性,NAS评分显著升高(P<0.01);肝组织出现明显脂质沉积,TG含量显著升高(P<0.01);血清ALT及AST明显升高(P<0.01);F4/80、IL-1β显著升高(P<0.01);肝组织出现较多纤维增生,COL1A1阳性细胞明显增加(P<0.01)。与模型对照组比较,南蛇藤醇组小鼠肝组织脂肪变性明显减轻,NAS评分显著降低(P<0.01);肝组织脂质沉积明显减轻,TG含量显著降低(P<0.05);血清ALT、AST水平明显降低(P<0.05);F4/80、IL-1β水平显著降低(P<0.05);肝组织纤维增生减轻,COL1A1阳性细胞减少(P<0.01)。结论南蛇藤醇对MCD饮食诱导的小鼠NASH具有抑制作用。

关键词：南蛇藤醇非酒精性脂肪性肝炎胆碱-蛋氨酸缺乏炎症

CPK激酶调控植物生长发育的分子机理及其研究进展

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科学通报 2024年第8期69卷 1082-1095页

作者：刘欣李炜佳李希东陈艳梅中国农业大学生物学院北京100193 北京农学院生物与资源环境学院北京102206

钙离子依赖性蛋白激酶(calcium-dependent protein kinase,CDPK或CPK)是细胞信号转导中发挥重要调控功能的一类丝氨酸/苏氨酸蛋白激酶.植物基因组编码大量的CPK激酶.当外界钙离子浓度发生变化时,CPK激酶能感知这些变化并与钙离子结合,... 详细信息

钙离子依赖性蛋白激酶(calcium-dependent protein kinase,CDPK或CPK)是细胞信号转导中发挥重要调控功能的一类丝氨酸/苏氨酸蛋白激酶.植物基因组编码大量的CPK激酶.当外界钙离子浓度发生变化时,CPK激酶能感知这些变化并与钙离子结合,导致蛋白构象改变以及释放自抑制结构域对激酶活性的抑制,从而激活CPK激酶.激活的CPK激酶通过磷酸化底物蛋白把钙信号向下游传递并引发胞内信号通路的级联反应,最终调控植物生长发育或对外界环境信号的响应.本文概述了CPK激酶的基本结构和分子特征,以及CPK激酶在调控植物生长发育、激素信号机理、生物和非生物胁迫应答过程中的最新研究进展,并对当前研究中存在的问题和未来的研究方向进行探讨与展望.

关键词： ABA CPK激酶钙信号钙指纹钙调蛋白磷酸化

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伸缩臂履带起重机转台的有限元分析

机械管理开发 2021年第4期36卷 53-55,273页

作者：权哲奎何喜东蒋佩赵瑞恒李兵浙江三一装备有限公司浙江湖州313000 湖州师范学院工学院浙江湖州313000

对SCC250TB型伸缩臂履带起重机的转台进行了受力分析,利用Hypermesh分析软件建立其有限元分析模型,并在ANSYS软件中分析了转台整体多工况下的强度,得到转台在各个工况下的应力分布云图,为转台的设计优化提供数据支撑。

关键词：履带起重机转台有限元

冬春季父母代种鸡偏肺病毒与鸡毒支原体混合感染防治措施

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中国禽业导刊 2022年第12期39卷 47-49页

作者：朱丙亮何锡栋贺增杰朱耀强樊朝磊福建圣农发展股份有限公司福建光泽354100

禽偏肺病毒(Avian metapneumovirus,aMPV),国内称肿头综合征,该病毒最早在火鸡上发现,可引起严重的呼吸道症状。4~6周龄易感,带毒不显示临床症状,但抗体水平急剧升高;接触传播,传播迅速,发病率和死亡率较高。患禽出现打喷嚏、啰音、鼻... 详细信息

禽偏肺病毒(Avian metapneumovirus,aMPV),国内称肿头综合征,该病毒最早在火鸡上发现,可引起严重的呼吸道症状。4~6周龄易感,带毒不显示临床症状,但抗体水平急剧升高;接触传播,传播迅速,发病率和死亡率较高。患禽出现打喷嚏、啰音、鼻窦炎、结膜炎、眼部有分泌物、头部肿胀、蛋壳质量差、产蛋下降的临床症状,给生产造成严重的损失。

关键词：父母代种鸡鸡毒支原体产蛋下降头部肿胀蛋壳质量禽偏肺病毒混合感染呼吸道症状