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中国农学通报 2006年第9期22卷 527-530页

作者：杜运科任亚琴王丽陈三乐刘鸿章樊晓中郑乃生陕西省宝鸡市农业科学研究所陕西岐山722400 陕西省农业信息站陕西西安710003

大力推进农业结构不断优化升级,实现产业化经营,是提高中国农业的整体素质、综合效益和国际竞争力的有效途径。在分析关中西部资源、产业现状、制约因素的同时,提出了促进关中西部农业产业化发展的对策和建议。

关键词：农业结构调整产业化现状建议

Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1170-1180页

作者： Qian He Qunying Mao xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu Division of Hepatitis and Enterovirus Vaccines Institute of Biological ProductsNational Institutes for Food and Drug ControlNHC Key Laboratory of Research on Quality and Standardization of Biotech ProductsNMPA Key Laboratory for Quality Research and Evaluation of Biological ProductsBeijing 102629People’s Republic of China Institute of Medical Biology Chinese Academy of Medicine Sciences&Peking Union Medical CollegeKunming 650118People’s Republic of China

Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the *** investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)*** neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque ***,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological *** correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism.

关键词： protective vaccine neutral

Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair

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Bioactive Materials 2021年第11期6卷 4014-4026页

作者： Qin fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma xiaozhong Zhou Chao Wang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu215123China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China Key Laboratory for Organic Electronics&Information Displays(KLOEID) Institute of Advanced Materials(IAM)and School of Materials Science and EngineeringNanjing University of Posts&TelecommunicationsNanjing210000China

The treatment of large-area bone defects still faces many difficulties and ***,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone *** clot gel platform as natural biomaterials can be engineered from autologous *** implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different ***,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and *** find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser *** further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease *** to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation.

关键词： Blood clot BMP-2 Osteoimmunology Photothermal therapy Bone repair

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GNSS伪距单点定位性能分析

测绘科学与工程 2020年第5期40卷 9-12页

作者：范孝忠孙长城王红伟 32033部队海南海口570100 32011部队北京100094 32023部队辽宁大连116023

标准定位服务(SPS)是卫星导航系统提供的基本服务,基于2019年全年国际GNSS监测评估系统(iGMAS)跟踪站数据,对比分析了***和Galileo单频单点定位(SPP)性能。实测数据分析表明:***,Galileo系统的水平定位精度、垂直定位精度分别为3.01m、2... 详细信息

标准定位服务(SPS)是卫星导航系统提供的基本服务,基于2019年全年国际GNSS监测评估系统(iGMAS)跟踪站数据,对比分析了***和Galileo单频单点定位(SPP)性能。实测数据分析表明:***,Galileo系统的水平定位精度、垂直定位精度分别为3.01m、2.29m、2.02m和5.94m、4.33m、3.45m;在中国大陆区域BDS定位精度最优,在高纬度区域BDS-2略差于GPS和Galileo,随着BDS全球系统建设完善,BDS性能必将进一步提升。

关键词： BDS GPS Galileo 单频单点定位精度分析

我国VGOS站0.3毫米参考点稳定度的可实现性分析

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测绘科学与工程 2020年第4期40卷 1-8页

作者：马小辉孙中苗张志斌范孝忠信息工程大学地理空间信息学院河南郑州450001 西安测绘研究所陕西西安710054 地理信息工程国家重点实验室陕西西安710054 中国科学院上海天文台上海200030 32033部队海南海口570100

针对VGOS站0.3mm的天线参考点稳定性指标需求,从归心测量计划及数据解算入手,利用敏感性分析法并结合实测25m天线靶标点位噪声,提出了VLBI天线参考点归心测量经验公式,用于参考点稳定度及其模型拟合形式误差的预估,所提公式计算结果与... 详细信息

针对VGOS站0.3mm的天线参考点稳定性指标需求,从归心测量计划及数据解算入手,利用敏感性分析法并结合实测25m天线靶标点位噪声,提出了VLBI天线参考点归心测量经验公式,用于参考点稳定度及其模型拟合形式误差的预估,所提公式计算结果与实测结果符合良好,可用于指导今后天线归心测量工作。基于高斯-赫尔默特平差模型的分析表明,靶标观测量测定精度应与其噪声保持一致,否则当靶标点位测定精度提高到一定水平时,靶点观测量将不再吸收天线本身及环境影响噪声,导致0.3mm归心稳定度难以实现。如采用25m天线靶标点位实测噪声,实现VGOS站0.3m m参考点稳定度可能需约600个分布均匀的靶点观测量。所给仿真算例指出,利用GNSS RTK,或需开展一周以上的长时段连续密集观测,方可实现0.3mm的参考点稳定度,且此长时段内的参考点变动趋势可由一定模型表示。

关键词： VGOS VLBI 参考点靶标点稳定度

In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model

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Bioactive Materials 2018年第1期3卷 102-109页

作者： Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao xiaozhong Qu Zhenzhong Yang Yining Huang Department of Neurology Peking University First HospitalBeijing 100034China State Key Laboratory of Polymer Physics and Chemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China College of Materials and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 ***,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the *** of free uPA no matter with or without US ***,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the *** work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke.

关键词： Hollow nanogel Ultrasound responsive Urokinase delivery Thrombolysis In vivo evaluation

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基于LSTM神经网络的地震事件分类

计算机应用与软件 2023年第4期40卷 75-79页

作者：张帆杨晓忠王树波华北电力大学控制与计算机工程学院北京102206 华北电力大学数理学院北京102206 内蒙古自治区地震局内蒙古呼和浩特010051

地震信号可视为时间序列,采用在时间序列数据处理中有较好表现的LSTM神经网络实现天然地震和爆破的分类。对原始信号进行短时傅里叶变换,得到时频谱,拆分为多通道时间序列,作为LSTM神经网络的输入,实现时间序列到标签的分类。通过反复... 详细信息

地震信号可视为时间序列,采用在时间序列数据处理中有较好表现的LSTM神经网络实现天然地震和爆破的分类。对原始信号进行短时傅里叶变换,得到时频谱,拆分为多通道时间序列,作为LSTM神经网络的输入,实现时间序列到标签的分类。通过反复的实验选取了最优的输入数据尺度和模型超参数,选取的模型包含两个堆叠的双向LSTM层的神经网络。训练集上的5折交叉验证结果显示验证集平均准确率达到98.36%,测试集准确率为97.5%。测试结果表明,采用的模型在地震事件分类中有较好的效果。

关键词：天然地震爆破分类机器学习 LSTM

A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome

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Signal Transduction and Targeted Therapy 2021年第2期6卷 223-225页

作者： Weiqi Hong Jingyun Yang Zhenfei Bi Cai He Hong Lei Wenhai Yu Yun Yang Changfa fan Shuaiyao Lu xiaozhong Peng Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest Chino HospitalSichuan UniversityNo.17Block 3Southern Ren min Rood610041 ChengduSichuanPeople's Republic of China National Kunming High-level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeYun nonChina Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control102629 BeijingChina State Key Laboratory of Medical Molecular Biology Deportment of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina

Dear Editor,The COVID-19 pandemic has covered more than 200 countries and regions around the world since its outbreak in January *** date,the SARS-CoV-2 virus has caused>1.2 million *** mortality rate of COVID-19 is closely concerned with the clinical symptoms of the patients from mild-to-severe ***,in its most severe form,COVID-19 leads to life-threatening pneumonia and acute respiratory distress syndrome(ARDS),which is mostly accom-panied by a hyperactive immune response called"cytokine storm"and has high death rates from 40 to 50%.

关键词： distress acute respiratory

可持续生计框架下农户闲置宅基地处置意愿的影响因素研究

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山西农业大学学报:社会科学版 2023年第5期22卷 25-33页

作者：范胜龙郭楠江晓忠福建农林大学公共管理与法学院福建福州350002

基于福建省460份农户调研数据,通过可持续生计框架,运用无序多分类Logit模型对农户的闲置宅基地的处置意愿进行实证研究。研究发现:总体上,农户对闲置宅基地的处置存在多种意愿,但当前处置意愿仍然较低;从具体的生计资本指标影响分析看... 详细信息

基于福建省460份农户调研数据,通过可持续生计框架,运用无序多分类Logit模型对农户的闲置宅基地的处置意愿进行实证研究。研究发现:总体上,农户对闲置宅基地的处置存在多种意愿,但当前处置意愿仍然较低;从具体的生计资本指标影响分析看,宅基地宗数、户均劳动力水平和宅基地政策认知情况等因素对农户宅基地的处置意愿均产生显著正向影响;农户的出租意愿受到是否有城镇住房因素的影响,农户宅基地转让意愿受到家庭现有耕地面积的影响,农户宅基地置换意愿还受到宅基地建筑面积与留村的直系亲属数量、家庭年均收入的影响,农户宅基地退出意愿则受到家庭现有耕地面积、是否担任村干部及家庭保障情况等因子的影响。据此提出:尊重农户多元意愿,采取差异性盘活政策;持续推进宅改政策宣传,促进农户转变私权意识;普及农村职业教育,完善农户社保机制。

关键词：可持续生计框架处置意愿无序多分类Logit模型

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摆线轮孔型结构对摆线轮振动特性影响分析

机械强度 2023年第4期45卷 999-1004页

作者：杨帆杨建军邓效忠李天兴徐家科河南科技大学机电工程学院洛阳471003 洛阳科大格尔传动研究院有限公司洛阳471003 宁波中大力德智能传动股份有限公司宁波315300

摆线轮是RV减速器中的核心部件,摆线轮的孔型结构对RV减速器的传动平稳度有较大影响。针对摆线针轮传动系统进行啮合接触分析,得到摆线轮在实际啮合过程的实际啮合齿对数,计算出各齿对啮合转角及综合啮合刚度。在有限元软件中,以摆线针... 详细信息

摆线轮是RV减速器中的核心部件,摆线轮的孔型结构对RV减速器的传动平稳度有较大影响。针对摆线针轮传动系统进行啮合接触分析,得到摆线轮在实际啮合过程的实际啮合齿对数,计算出各齿对啮合转角及综合啮合刚度。在有限元软件中,以摆线针轮综合啮合刚度为弹性约束,对摆线轮进行了动态响应分析,摆线轮在扇形减重孔处振动最大,易发生变形。针对摆线轮不同扇形孔结构,采用三因素四水平的正交试验进行了动力学仿真,结果表明,随着摆线轮转速提升,扇形孔的上底圆半径始终是影响摆线轮振动的最主要因素,而倒圆半径的影响力逐渐增强,两腰夹角的影响力逐渐减弱,为摆线轮的结构设计提供了依据。

关键词：摆线轮综合啮合刚度正交试验结构优化