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人民币国际化背景下资本项目开放的法制构想

武汉理工大学学报（信息与管理工程版） 2022年第3期44卷 495-499页

作者：袁晓云汪慧颖李娇徐思向雅萍武汉理工大学财务处湖北武汉430070 湖北省交通运输厅湖北武汉430030 武汉理工大学法学与人文社会学院湖北武汉430070

为进一步研究人民币国际化背景下资本项目开放的法制路径,通过分析人民币资本项目开放的现状,指出人民币资本项目开放方面存在的法律和认知障碍。我国应发挥法律的引导和保障功能,适时以法律形式宣布人民币资本项目可兑换,并设计以人民... 详细信息

为进一步研究人民币国际化背景下资本项目开放的法制路径,通过分析人民币资本项目开放的现状,指出人民币资本项目开放方面存在的法律和认知障碍。我国应发挥法律的引导和保障功能,适时以法律形式宣布人民币资本项目可兑换,并设计以人民币国际化为目标的资本项目开放次序;在此基础上,出台《资本项目开放条例》,明确规定资本项目开放的目标、原则、模式、管理措施和预警体制,并设置回弹和例外条款,以保证资本项目开放制度更好地促进人民币国际化,为必要的资本项目管制留下制度空间。

关键词：人民币国际化资本项目可兑换资本项目开放法制构想资本项目开放次序

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骨肉瘤中铜死亡相关亚型鉴定、预后模型构建以及免疫细胞浸润分析

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中国免疫学杂志 2024年第1期40卷 58-66页

作者：邵子晨李华南章晓云孙伟康袁启鹏江西中医药大学临床医学院南昌330004 江西中医药大学附属医院南昌330004 广西中医药大学附属瑞康医院骨科南宁530011

目的:在铜死亡基因基础上分析骨肉瘤(OS)中铜死亡基因相关亚型鉴定、预后模型构建和免疫浸润的影响。方法:联合TARGET与GEO数据库对OS相关铜死亡基因进行生存分析及预后相关性分析。采用一致性聚类方法将OS分为铜死亡不同亚型。运用SSG... 详细信息

目的:在铜死亡基因基础上分析骨肉瘤(OS)中铜死亡基因相关亚型鉴定、预后模型构建和免疫浸润的影响。方法:联合TARGET与GEO数据库对OS相关铜死亡基因进行生存分析及预后相关性分析。采用一致性聚类方法将OS分为铜死亡不同亚型。运用SSGSEA对铜死亡分型进行免疫细胞差异分析。设置P value=0.05和q value=0.05,对铜死亡分型的差异基因进行GO及KEGG富集分析。依据Lasso回归分析及交叉验证结果构建预后模型,并进行风险评估分析和运用ROC曲线评估模型预测准确性。结合临床性状构建列线图预测患者生存期,同时进行风险差异分析。对OS样本进行免疫细胞浸润和肿瘤微环境分析。运用R软件“pRRophetic”包对OS样本进行药物敏感性分析。结果:确定FDX1、GLS、DLAT和PDHB为OS预后的高风险基因。对OS样本进行铜死亡分型,可将OS分为两型:CRGclusterA与CRGclusterB,其中CRGclusterA与Th2细胞相关,CRGclusterB与Th1细胞相关。大部分OS铜死亡基因在CRGclusterA中呈高表达。免疫细胞浸润分析结果表明γδT细胞、静息肥大细胞和静息树突状细胞与风险评分呈正相关,而CD8 T细胞与风险评分呈负相关。药物敏感性分析显示OS对Elesclomol与GW.441756更敏感。结论:本研究识别出CRGclusterA与CRGclusterB两种亚型。鉴定出4个预后高风险基因:FDX1、GLS、DLAT和PDHB,为OS预后评估和免疫治疗候选靶点提供了新见解。

关键词：铜诱导细胞死亡骨肉瘤一致性聚类免疫浸润预后模型

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Status Quo,Analysis and Suggestions for Public Awareness on Wetland Conservation in China

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湿地科学 2011年第2期9卷 101-106页

作者： ZHANG xiaoyun XU Jiliang yuan Jun Academy of Forest Inventory and planning State Forestry Administration Beijing 100714 P. R. China College of Nature Conservation Beijing Forest University Beijing 100083 P. R. China

To understand the status of public awareness on wetland conservation in China,1237 people from 8 provinces or municipality were interviewed by *** analysis of the results,88.5%of the interviewees know the word 'wetland'.TV and radio is the main tool for them to get *** than two thirds of the respondents mainly learn the information on wetland conservation through TV and *** are still big gaps among different people in understanding *** 13.3%of the respondents give a completely right answer on question 'which areas are wetlands'.Most of the respondents cited lakes,marshes and rivers as wetlands,but more than half of them do not regard beaches,reservoirs,paddy fields and fish ponds as *** of the people cited wetlands can provide such functions as water conservation,climate regulation,protecting wildlife,removing pollution, but know little about other functions such as flood control,provisioning of aquatic products,and soil retention, and much less about the cultural functions such as recreation,and inherited folk *** for wastewater discharge, nearly half of the general public knows little about other threats of the wetland,while most of the people do not believe that artificial aquaculture will cause threats to the wetland *** awareness on wetland conservation in China needs to be *** of the respondents cited that TV,radio and internet are the most effective ways to publicize information on wetland *** than two thirds of the respondents mainly learn the information on wetland conservation through TV and radio,while 38.0%of the respondents mainly through internet. Specifically,for farmers/fishermen,posters/picture albums can benefit them more than the internet;the undergraduates also expect to learn wetland mainly through posters/picture albums;while for the primary and middle school students, the school education is another valuable source of publicity in addition to TV

关键词： wetland public awareness survey

A New Sequential Digital Multi-Signature Scheme

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China Communications 2007年第4期4卷 66-71页

作者： Jia xiaoyun Luo Shoushan Chen Ping yuan Chaowei Xidian Univ Inst Commun Networks Integrated Tech Xian 710071 Peoples R China Xidian Univ Natl Key Lab Integrated Serv Networks Xian 710071 Peoples R China Xidian Univ Sch Software Engn Xian 710071 Peoples R China Beijing Univ Posts & Telecommun Sch Telecommun Engn Beijing 10086 Peoples R China

The paper proposes a new sequential digital multi-signature scheme based on Knapsack public-key cryptosystem,which is different from the existing *** advantages of this scheme over the existing schemes are that it simplifies the signature generation process and speeds up the signature verification ***’s more,the scheme reduces the cost of communication and redundancy operation, and improves efficiency,and can avoid cheating by signer efficiently,so the scheme has very broad application prospects.

关键词： knapsack public-key cryptosystem digital signature sequential multi-signature

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国医大师班秀文治疗女性阴痿经验探析

世界科学技术-中医药现代化 2015年第8期17卷 1669-1672页

作者：彭红华员晓云戴铭刘玉筠张淑贤广西中医药大学基础医学院南宁530001

国医大师班秀文教授学验俱丰,善治妇科疾病,对经、带、胎、产及妇科杂病的诊治均有独到见解。女性阴痿隶属妇科杂病,《黄帝内经》中便有相关记载,但由于各种原因,中医对女性阴痿的研究远不及男性阳痿的多,班秀文教授的《妇科奇难病论治... 详细信息

国医大师班秀文教授学验俱丰,善治妇科疾病,对经、带、胎、产及妇科杂病的诊治均有独到见解。女性阴痿隶属妇科杂病,《黄帝内经》中便有相关记载,但由于各种原因,中医对女性阴痿的研究远不及男性阳痿的多,班秀文教授的《妇科奇难病论治》中对该病有专门论述,他认为引起女性阴痿的原因主要有禀赋不足,阳虚宫寒;七情所伤,肝失生发;脾胃虚弱,气血不足;痰湿郁滞,气机不畅四个方面。本文通过整理研究国医大师班秀文教授治疗女性阴痿的病案记录,从女性阴痿的病因病机分析、辨证施治以及治疗女性阴痿的经验进行简要阐述。并举2例女性阴痿的病案,详细分析其中的病因病机、辨证论治及治疗经验。两个病案的疗效显著,是中医临床医师学习治疗女性阴痿的重要资料。

关键词：班秀文女性阴痿中医治疗辨证论治

马来酸阿塞那平微乳凝胶剂的制备及经鼻入脑的靶向性研究

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中国药师 2024年第2期27卷 199-208页

作者：张水杰童晓云曾媛雷刚武汉科技大学附属天佑医院神经内科武汉430064 中部战区总医院药剂科武汉430019

目的制备马来酸阿塞那平微乳凝胶剂(ASPM-Emulgel),并通过鼻腔给药评价其脑靶向性。方法根据马来酸阿塞那平(ASPM)在不同种类油、乳化剂和助乳化剂中的平衡溶解度以及辅料相容性结果确定马来酸阿塞那平微乳(ASPMEmul)的处方组成及用量... 详细信息

目的制备马来酸阿塞那平微乳凝胶剂(ASPM-Emulgel),并通过鼻腔给药评价其脑靶向性。方法根据马来酸阿塞那平(ASPM)在不同种类油、乳化剂和助乳化剂中的平衡溶解度以及辅料相容性结果确定马来酸阿塞那平微乳(ASPMEmul)的处方组成及用量,并以卡波姆940作为凝胶基质将ASPM-Emul制备成凝胶剂;考察ASPM-Emul的粒径分布及微观形态,通过Franz扩散池法比较ASPM-Emul与ASPM-Emulgel的体外释放速率以及在羊鼻黏膜的渗透性;采用在体蟾蜍上颚模型法考察ASPM-Emulgel的鼻腔纤毛毒性;评价ASPM-Emulgel经大鼠鼻腔∶给∶药的脑靶向性。结果根据平衡溶解度和相容性结果,选择单亚油酸甘油酯、吐温80和二乙二醇单乙基醚分别作为ASPM-Emul的油相、乳化剂和助乳化剂,配比为4为淡蓝色半透明状微乳液,粒径为(73.6±7.4)nm,在透射电镜下可观察到微乳呈规则球形,均匀分散;体外释放及渗透结果显示,ASPM-Emul的释药速率较快,ASPMEmulgel释药速率持续平缓,但两者在羊鼻黏膜中的渗透率基本一致;ASPM-Emul和ASPM-Emulgel对蟾蜍鼻腔纤毛无明显毒性;与尾静脉ASPM组相比,ASPM-Emul和ASPM-Emulgel经鼻腔给药后在大脑中的药物含量显著增高,均表现出明显的脑靶向性,且ASPM-Emulgel的脑靶向效率更高。结论将ASPM制备成微乳凝胶剂,经鼻腔给药后可以显著提高药物的脑靶向性,有望提高马来酸阿塞那平的临床治疗效果。

关键词：马来酸阿塞那平微乳凝胶剂鼻腔给药脑靶向性 Franz扩散池法

水环境和水产品中β-N-甲氨基-L-丙氨酸(BMAA)检测方法和检出情况的研究进展

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环境化学 2024年第3期43卷 864-874页

作者：王琛刘桂华秦逍云刘红河姜杰杨胜园袁冠湘深圳市疾病预防控制中心深圳518055 南华大学公共卫生学院衡阳421001

本文对蓝藻毒素β-N-甲氨基-L-丙氨酸(β-N-methylamino-L-alanine,BMAA)的结构形态、检测方法、环境和食物中的检出情况等方面进行系统综述.研究结果表明,BMAA主要存在3种赋存形态(游离态、溶解结合态、沉淀结合态);环境和食物中的BMA... 详细信息

本文对蓝藻毒素β-N-甲氨基-L-丙氨酸(β-N-methylamino-L-alanine,BMAA)的结构形态、检测方法、环境和食物中的检出情况等方面进行系统综述.研究结果表明,BMAA主要存在3种赋存形态(游离态、溶解结合态、沉淀结合态);环境和食物中的BMAA类目前主要采用经过AQC衍生的LCMS/MS法检测,样品需经形态分离后、采用MCX固相萃取小柱处理.水环境、水产品和藻类保健品中BMAA类的污染已被大量报道.亚洲、北美洲、欧洲的相关环境和食物中均有一定的检出(检出浓度:水样<0.01—25.3μg·L^(-1);藻类<0.01—300μg·g^(-1);非鲨鱼水产品中0.08—115.3μg·g^(-1);藻类保健品中0.04—0.73μg·g^(-1)).BMAA存在生物积累和生物放大的现象,水产品中营养级别越高的生物检出浓度就越高,如鲨鱼类产品中检出浓度高达34—2011μg·g^(-1),需要引起重视.我国目前对BMAA的相关研究还很有限,未来应加强检测方法、现场调查、风险评估等相关方面的研究,以全面了解我国人群对BMAA类物质的暴露风险.

关键词： β-N-甲氨基-L-丙氨酸(BMAA) LC-MS/MS 水环境水产品藻类产品

Systematic functional analysis and potential application of a serine protease from cold-adapted Planococcus bacterium

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Food Science and Human Wellness 2023年第5期12卷 1751-1761页

作者： Weijun Leng xiaoyun Wu Xianghui Qi Hongying Liu Li yuan Ruichang Gao School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Ocean College of Hebei Agriculture University Qinhuangdao 066000China

In this study, a gene encoding serine protease(PmSpr288)from cold-adapted bacterium, namely Planococcus maritimus XJ11, was cloned and overexpressed in Escherichia coli BL21(DE3). Bioinformatics analysis revealed that PmSpr288 belongs to serine protease S8 superfamily with a classical catalytic triad comprised by the Asp49, His86 and Ser251. Moreover, PmSpr288 was found to be active over broad alkaline pH and low-moderate temperature, and exhibited wide range of protein substrate specificity. In addition, PmSpr288 was able to hydrolyze the meat proteins actin and myosin, and molecular docking results suggested that the crucial interaction between PmSpr288 and actin/myosin complexes was mainly occupied by hydrogen bonds. The muscle protein hydrolysates of silver carp prepared by PmSpr288 was shown to have antioxidant activity via DPPH radical scavenging assay, which presented an IC_(50) valve of 1.309 mg/mL. In conclusion, these characteristics imply that PmSpr288 has potential biotechnological application prospect for the production of bioactive peptides.

关键词： Protease Silver carp Protein hydrolysates Molecular docking Bioactive peptides

Polybenzoxazine/organosilicon composites with low dielectric constant and dielectric loss

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Chinese Journal of Chemical Engineering 2023年第12期64卷 241-249页

作者： Manlin yuan Xin Lu xiaoyun Ma Hao Lin Angui Lu Liyan Shao Zhong Xin State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

The evolution of electronic communication technology raises higher requirements for low dielectric constant(low-k)*** this,a benzoxazine functional organosilicon(HP-aptes)with dense Si—O—Si crosslinking networks and large sterically hindered tert-butyl groups was prepared by the sol–gel ***,a series of polybenzoxazine composites(PPHP)were prepared from intrinsically low dielectric constant bis-functional benzoxazine monomer(P-aptmds)and *** double crosslinking networks of polybenzoxazine and organosilicon further increased the crosslinking density and decreased the dipole density of composites,which endowed the composites with enhanced low-k *** the content of HP-aptes is 30%(mass),the crosslinking density was 2.05×10^(-3)mol·cm^(-3),while that of PP-aptmds was 3.31×10^(-3)mol·cm^(-3).In addition,the dielectric constant and dielectric loss of PPHP composite at 1 MHz could reach 2.61 and 0.0056,respectively.

关键词： Polybenzoxazine Organosilicon Composite Dielectric constant