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新时代背景下劳模文化引导高校开展劳动教育的实践路径探析

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上海第二工业大学学报 2024年第2期41卷 218-222页

作者：聂晓瑜上海第二工业大学党委宣传部上海201209

劳模文化是以劳模为代表的先进劳动者的精神风貌和工作方式的集中体现,作为中华民族精神和时代精神的重要组成部分,体现了爱国主义和改革创新的核心价值。加强大学生的劳动教育是高校贯彻落实立德树人根本任务之所需,更是推动大学生全... 详细信息

劳模文化是以劳模为代表的先进劳动者的精神风貌和工作方式的集中体现,作为中华民族精神和时代精神的重要组成部分,体现了爱国主义和改革创新的核心价值。加强大学生的劳动教育是高校贯彻落实立德树人根本任务之所需,更是推动大学生全面发展之所应,而劳模文化为高校劳动教育的开展提供了鲜活案例和丰富教学资源。将探索新时代劳模文化引导高校开展劳动教育的实践路径,以此树立大学生正确的劳动观,助力培育具有高尚品德和职业素养的时代新人。

关键词：新时代劳模文化高校劳动教育育人机制路径

褪黑素通过调控Nrf2通路对甲醛暴露致大鼠急性肺损伤的保护作用

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安徽医科大学学报 2024年第1期59卷 23-28页

作者：王碧红聂潇雨丁威杰周佳婷徐贝琪张颖吕建国孙燕玲湖北科技学院医学部药学院咸宁437100 湖北科技学院基础医学院咸宁437100 湖北科技学院临床医学院咸宁437100

目的探讨褪黑素(MT)通过调控核因子E2相关因子2(Nrf2)信号通路对甲醛(FA)吸入致大鼠急性肺损伤(ALI)的保护作用及其机制。方法50只雌性Wistar大鼠随机分为Control组、FA组、FA+MT 5 mg/kg组、FA+MT 10 mg/kg组和FA+MT 20 mg/kg组,每组1... 详细信息

目的探讨褪黑素(MT)通过调控核因子E2相关因子2(Nrf2)信号通路对甲醛(FA)吸入致大鼠急性肺损伤(ALI)的保护作用及其机制。方法50只雌性Wistar大鼠随机分为Control组、FA组、FA+MT 5 mg/kg组、FA+MT 10 mg/kg组和FA+MT 20 mg/kg组,每组10只。除Control组外,其他各组连续21 d每天吸入3 mg/m 3 FA以构建染毒模型,然后用不同MT剂量治疗14 d,MT治疗期间继续染毒。苏木精-伊红(HE)染色观察肺组织病理学变化,称重测肺水含量和肺系数,吸光光度法测肺组织谷胱甘肽(GSH)、超氧化物歧化酶(SOD)和8-羟基脱氧鸟苷(8-OHdG)水平,酶联免疫吸附实验(ELISA)测肺泡灌洗液肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6和IL-1β的浓度,Western blot检测肺组织Nrf2、血红素氧合酶-1(HO-1)、核因子-κB(NF-κB)和磷酸化核因子-κB(p-NF-κB)的蛋白表达水平,定量聚合酶链反应(qPCR)检测肺组织Nrf2、HO-1及Kelch样ECH相关蛋白1(Keap1)的mRNA表达水平。结果与Control组相比,FA组大鼠出现明显肺损伤;肺组织GSH、SOD水平下降,8-OHdG水平升高(P<0.05);肺泡灌洗液TNF-α、IL-6和IL-1β水平升高(P<0.05);肺组织Nrf2、HO-1蛋白表达水平降低(P<0.05),p-NF-κB蛋白表达水平升高(P<0.05);肺组织Nrf2、HO-1的mRNA相对表达量降低,Keap1的mRNA相对表达量升高(P<0.05)。与FA组相比,MT组大鼠肺损伤有好转;肺组织GSH、SOD水平升高(P<0.05),8-OHdG水平下降(P<0.05);肺泡灌洗液TNF-α、IL-6和IL-1β水平下降(P<0.05);肺组织Nrf2、HO-1蛋白表达水平升高(P<0.05),p-NF-κB蛋白表达水平降低(P<0.05);肺组织Nrf2、HO-1的mRNA相对表达量升高(P<0.05),Keap1的mRNA相对表达量降低(P<0.05),且均呈剂量依赖性。结论MT可以通过调控Nrf2/Keap1/HO-1信号通路减轻氧化应激和炎症反应,缓解FA暴露诱导的急性肺损伤。

关键词：褪黑素核因子E2相关因子2 急性肺损伤甲醛

四川省某地区临床医生科研能力水平现状调查及影响因素分析

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西南医科大学学报 2024年第3期47卷 241-245页

作者：陈鹏甘雪辉赵月霞聂潇雨杨欣雨汤艳西南医科大学儿科学系泸州646000 西南医科大学公共卫生学院实验教学中心泸州646000 西南医科大学临床医学院泸州646000 西南医科大学基础医学院泸州646000 西南医科大学麻醉学系泸州646000 西南医科大学立普社团泸州646000

目的了解四川省某地区临床医生科研能力水平现状,分析可能影响临床医生科研水平的因素。方法采用“问卷星”平台向四川省某地区各级各类医院的临床医生进行问卷调查,收集临床医生的基本信息和科研情况相关资料。结果超过半数的临床医生... 详细信息

目的了解四川省某地区临床医生科研能力水平现状,分析可能影响临床医生科研水平的因素。方法采用“问卷星”平台向四川省某地区各级各类医院的临床医生进行问卷调查,收集临床医生的基本信息和科研情况相关资料。结果超过半数的临床医生近5年内未参与过任何课题(50.2%)和未发表过任何论文(56.7%),其中科研知晓率40.3%,科研实践率33.8%。不同学历、不同级别医疗机构、不同科室和不同专业技术职称的临床医生对科研的知晓情况差异均具有统计学意义(P<0.05)。多因素分析结果:硕士及以上学历与大专及以下学历对比(OR=14.658,95%CI:3.351~64.117)和三级医院与一级医院对比(OR=3.662,95%CI:1.315~10.197)均与临床医生知晓科研有关。不同学历、不同级别医疗机构和科研知晓情况的临床医生在科研实践上的差异有统计学意义(P<0.05)。多因素分析结果:知晓科研(OR=2.529,95%CI:1.163~5.500)与临床医生科研实践有关。结论受调查的四川省某地区临床医生科研水平欠佳,与学历、医院条件等因素有一定影响。

关键词：科研能力临床医生科研成果影响因素现状调查

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Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2161-2175页

作者： Chunling Wang Junchao Xu xiaoyu Cheng Ge Sun Fenfen Li Guangjun nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Sino-Danish Center for Education and Research Beijing 100190China Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for *** strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies,with a primary focus on vascular regulation and stromal ***,these methods may trigger or facilitate tumor metastasis as a ***,there is an urgent need for innovative strategies that boost intratumoral drug accumulation without compromising treatment *** another important factor affecting drug tumor accumulation besides vasculature and stroma,the impact of tumor-associated lymphatic vessels(LVs)has not been widely *** the current research,we verified that anlotinib,a tyrosine kinase inhibitor with anti-lymphangiogenesis activity,and SAR131675,a selective VEGFR-3 inhibitor,effectively decreased the density of tumor lymphatic vessels in mouse cancer models,further enhancing drug accumulation in tumor *** combining anlotinib with therapeutic drugs,including doxorubicin(Dox),liposomal doxorubicin(Lip-Dox),and anti-PD-L1 antibody,we observed improved anti-tumor efficacy in comparison with monotherapy ***,this strategy significantly reduced tumor metastasis and elicited stronger anti-tumor immune *** work describes a new,clinically transferrable approach to augmenting intratumoral drug accumulation,which shows great potential to address the current,unsatisfactory efficacies of therapeutic drugs without introducing metastatic risk.

关键词： drugs angiogenesis metastasis

Imaging through scattering media via spatial-temporal encoded pattern illumination

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Photonics Research 2022年第7期10卷 1689-1694页

作者： XINGCHEN ZHAO xiaoyu nie ZHENHUAN YI TAO PENG MARLAN O.SCULLY Institute for Quantum Science and Engineering Texas A&M UniversityCollege StationTexas 77843USA School of Physics Xi’an Jiaotong UniversityXi’an 710049China Baylor University WacoTexas 76706USA Princeton University PrincetonNew Jersey 08544USA

Optical imaging through scattering media has long been a *** approaches have been developed for focusing light or imaging objects through scattering media,but usually,they are either invasive,limited to stationary or slow-moving media,or require high-resolution cameras and complex algorithms to retrieve the *** utilizing spatial-temporal encoded patterns(STEPs),we introduce a technique for the computation of imaging that overcomes these *** a single-pixel photodetector,we demonstrate non-invasive imaging through scattering *** technique is insensitive to the motion of the ***,we demonstrate that our image reconstruction algorithm is much more efficient than correlation-based algorithms for single-pixel imaging,which may allow fast imaging for applications with limited computing resources.

关键词： media scattering illumination

Entangled photons enabled time-frequency-resolved coherent Raman spectroscopy and applications to electronic coherences at femtosecond scale

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Light(Science & Applications) 2022年第10期11卷 2415-2423页

作者： Zhedong Zhang Tao Peng xiaoyu nie Girish S.Agarwal Marian O.Scully Department of Physics City University of Hong KongKowloonHong Kong SARChina City University of Hong Kong Shenzhen Research InstituteShenzhenGuangdong 518057China Institute for Quantum Science and Engineering Texas A&M UniversityCollege StationTX 77843USA School of Physics Xi'an Jiaotong UniversityXi'anShaanxi 710049China Department of Biological and Agricultural Engineering Texas A&M UniversityCollege StationTX 77843USA Baylor University WacoTX 76704USA

Quantum entanglement has emerged as a great resource for spectroscopy and its importance in two-photon spectrum and microscopy has been *** studies focus on the two-photon absorption,whereas the Raman spectroscopy with quantum entanglement still remains elusive,with outstanding issues of temporal and spectral *** we study the new capabilities provided by entangled photons in coherent Raman *** ultrafast frequency-resolved Raman spectroscopy with entangled photons is developed for condensed-phase molecules,to probe the electronic and vibrational *** quantum correlation between the photons,the signal shows the capability of both temporal and spectral resolutions not accessible by either classical pulses or the fields without *** develop a microscopic theory for this Raman spectroscopy,revealing the electronic coherence dynamics even at timescale of *** suggests new paradigms of optical signals and spectroscopy,with potential to push detection below standard quantum limit.

关键词： spectroscopy. coherent spectroscopy

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基于北斗的电子界碑态势情报信息系统研究

情报理论与实践 2019年第8期42卷 121-123,167页

作者：聂晓愚北京理工大学管理与经济学院中共辽宁省委党校

针对我国边防界碑数量庞大、布局分散、环境复杂、易被毁移的管理特点,为实现界碑位置及态势情报的及时管控,提出了构建基于北斗的电子界碑态势情报信息系统方案,开展了电子界碑管控软件、定位感知终端、巡检移动终端等技术产品研究,为... 详细信息

针对我国边防界碑数量庞大、布局分散、环境复杂、易被毁移的管理特点,为实现界碑位置及态势情报的及时管控,提出了构建基于北斗的电子界碑态势情报信息系统方案,开展了电子界碑管控软件、定位感知终端、巡检移动终端等技术产品研究,为国家边防界碑态势情报管控提供支撑,为国家信息化情报应用提供典型案例。

关键词：情报系统电子界碑北斗导航系统

Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer

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Nano Research 2024年第10期17卷 9044-9051页

作者： Mengdie Chen Anying Zhu Furong Zhu Ziwen Lei Tao Huang Shengnan Du Dongdong Wang xiaoyu Zhang Huan Min Yingqiu Qi Guangjun nie Department of Pharmacology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450008China Department of General Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Breast Disease The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450003China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China

Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic ***-rich-alpha-2-glycoprotein 1(LRG1)has emerged as a notable target due to its markedly elevated expression in breast tumors,suggesting the viability of LRG1 as a theranostic *** our study,we employed phage display technology to identify a peptide,termed ET,that binds to LRG1 with a dissociation constant of 48.4μ*** modified with fluorescent cyanine dye,the ET peptide showcased effective tumor-targeting imaging across three different primary breast tumor models and a metastatic breast tumor *** also undertook a comprehensive safety evaluation,which verified the good biosafety credentials of ET *** summary,the ET peptide identified in this study shows effective LRG1-targeting ability both in vitro and in vivo,thus exhibiting immense potential for clinical translation.

关键词： breast cancer leucine-rich-alpha-2-glycoprotein 1(LRG1) phage display peptide tumor targeting

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略论军队管理工作的科学决策

军事历史研究 2007年第1期21卷 164-168页

作者：聂筱谕上海理工大学

军事决策是军队管理者最基本的职能。现代军事发展对军队管理和军事决策提出了更高的要求,军队决策的正确、科学与否,不仅直接关系到“打得赢”、“不变质”两大历史性课题的根本解决,更关系到我军革命化、现代化、正规化目标的最终实... 详细信息

军事决策是军队管理者最基本的职能。现代军事发展对军队管理和军事决策提出了更高的要求,军队决策的正确、科学与否,不仅直接关系到“打得赢”、“不变质”两大历史性课题的根本解决,更关系到我军革命化、现代化、正规化目标的最终实现。这要求军队管理者必须着眼于军队管理工作发展的全局,确立科学、合理、规范的决策程序;树立依法治军的观念,实出军事决策法制化;建立健全军队管理的决策责任追究制度;掌握决策的科学方法,努力提高决策素质。

关键词：军队管理科学决策现代军事