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Chemistry,Biosynthesis,and Biological Activity of Halogenated Compounds Produced by Marine Microorganisms

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Chinese Journal of Chemistry 2022年第14期40卷 1729-1750,I0002页

作者： Jiamin Wang xiaoyan pang Chunmei Chen Chenghai Gao Xuefeng Zhou Yonghong Liu Xiaowei Luo CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of OceanologyChinese Academyof SciencesGuangzhouGuangdong 510301China Institute of Marine Drugs Guangxi University of Chinese MedicineNanningGuangxi 530200China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) GuangzhouGuangdong 511458China University of Chinese Academy of Sciences 19Yuquan RoadBejing 100049China

Natural products derived from marine microorganisms have been received great attention as a potential source of new compound entities for drug *** unique marine environment brings us a large group of halogen-containing natural products with abundant biological functionality and good ***,biosynthetically halogenated reactions are known as a significant strategy used to increase the pharmacological activities and pharmacokinetic properties of *** that a tremendous increase in the number of new halogenated compounds from marine microorganisms in the last five years,it is necessary to summarize these compounds with their diverse structures and promising *** this review,we have summarized the chemistry,biosynthesis(related halogenases),and biological activity of a total of 316 naturally halogenated compounds from marine microorganisms covering the period of 2015 to May *** reviewed chlorinated and brominated compounds with the ratio of 9:1 were predominantly originated from 36 genera of fungi(62%)and 9 bacterial strains(38%)with cytotoxic,antibacterial,and enzyme inhibitory activities,structural types of which are polyketides(38%),alkaloids(27%),phenols(11%),and *** review would provide a plenty variety of promising lead halogenated compounds for drug discovery and inspire the development of new pharmaceutical agents.

关键词： Marine microorganisms Natural products Halogenated compounds Biological activity Biosynthesis

New Neuraminidase Inhibitory Alkaloids from the Mangrove Soil-Derived Fungus Arthrinium *** 41305

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Journal of Ocean University of China 2023年第5期22卷 1446-1451页

作者： HU Yiwei ZHAO Kai ZHU Junheng QI Xin CHEN Weihao SONG Yingying pang xiaoyan LIU Yonghong WANG Junfeng CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaInnovation Academy of South China Sea Ecology and Environmental EngineeringSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China University of Chinese Academy of Sciences Beijing 100049China

New alkaloid,(E)-2-(hydroxyimino)-4-methylpentanamide(1)and a new cyclopentano[b]pyridine,4-hydroxy-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one(2),together with ten known compounds(3–12)were isolated from the mangrove soil-derived fungus Arthrinium *** *** spectroscopic analysis and X-Ray crystallographic analysis were used to elucidate the structure of(E)-2-(hydroxyimino)-4-methylpentanamide(1),including its absolute *** the isolated compounds(1–12)were evaluated for their antimicrobial and enzyme inhibitory activities against acetylcholinesterase(ACh E),neuraminidase(NAs),and phosphatidylinositol 3-kinase(PI3K).Among them,compounds 1 and 3 exhibited strong neuraminidase inhibitory activity with IC_(50)values of 12.04,1.92μmol L^(-1)(IC_(50)20μmol L^(-1)for oseltamivir acid),while compounds 5,6,8,and 10showed moderate neuraminidase inhibitory activity,and compounds 6–10 displayed weak enzyme inhibitory activities against PI3K.

关键词： Arthrinium alkaloid pyridine neuraminidase acetylcholinesterase

Evolution of spin density vectors in a strongly focused composite field

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Chinese Optics Letters 2021年第2期19卷 63-68页

作者： xiaoyan pang Chen Feng Xinying Zhao School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China School of Physics&Information Technology Shaanxi Normal UniversityXi’an 710061China

The evolution of the spin density vectors(SDVs) is studied in a strongly focused composite field. It is found that the SDVs can be spiral along the propagation axis, and they are perpendicular to the ysdirection on the ysaxis. This behavior is governed by the Gouy phase difference between the field polarization components. The 60° rotation of the spatial distribution of the transverse SDVs is also generated, which is found to be controlled by the Gouy phase difference between the field orbital angular momentum modes. Additionally, the spin density singularities are observed in the evolution of the SDVs.

关键词： spin density Gouy phase orbital angular momentum spin angular momentum polarization

Investigations on the general properties of biomass-based aldehyde tanned sheep fur for its selective post-tanning processing

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Journal of Leather Science and Engineering 2021年第1期3卷 54-66页

作者： Wei Ding Ya-nan Wang Jianfei Zhou Haiteng Liu xiaoyan pang Bi Shi China Leather and Footwear Research Institute Co.Ltd. Beijing 100015P.R.China College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China Key Laboratory of Leather Chemistry and Engineering of Ministry of Education Sichuan UniversityChengdu 610065P.R.China

Dialdehyde sodium alginate(DSA)is an alternative chrome-free tanning material for fur *** obtain satisfactory resultant fur and provide suggestions for the usage of DSA in fur making,the general properties of DSA tanned sheep fur were systematically *** tanning mechanism of DSA was analyzed and it was verified that DSA was mainly combined with collagen fiber by forming Schiff base covalent bonds while supplemented by a small number of hydrogen bonds and ionic *** to the acid sensitivity of Schiff base structure,DSA tanned fur had poor resistance to acid rinsing but had excellent resistance to washing and good fatliquoring ***,it had good resistances to yellowing and *** being retanned by chrome tanning agent,the fur was capable of enduring a high-temperature dyeing process(68°C for 8 h).Overall,DSA tanned sheep fur had favorable properties under appropriate post-tanning processing conditions to manufacture light-colored or dark-colored fur products with desirable physical properties.

关键词： Sheep fur Dialdehyde sodium alginate Stability Post-tanning Chrome retanning

Preparation of aerogel and its application progress in coatings: a mini overview

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Journal of Leather Science and Engineering 2021年第1期3卷 269-284页

作者： Berhanu Telay Mekonnen Wei Ding Haiteng Liu Song Guo xiaoyan pang Zhiwen Ding Mohammed Hussein Seid China Leather and Footwear Research Institute Co.Ltd Beijing 100015Peo-ple’s Republic of China Leather Industry Development Institute 24692 Addis AbabaEthiopia

Aerogels are predominantly mesoporous,extremely lightweight,low density(∼0.003 g/cm 3)and thermally insulat-ing *** the years,aerogels have gained increasing attention due to their extraordinary properties(light,heat,sound,electricity and force)and application potentials in varieties of *** studies have been carried out regarding aerogel preparation and its applications in coatings on different *** this review,an overview of aerogels preparation and their application progress in coatings of most common substrates is *** is paid to aerogel coatings of textiles,leather,and substrates other than leather and textiles for special functionali-ties that could address the application progress in *** review will help to inspire scientists and engineers towards novel aerogel materials and technologies to boost the industrial fabrication of flexible advanced materials.

关键词： Aerogel Hydrogel Sol-gel technique Aerogel coatings Silica aerogel

Stability Test of Naomai Xingshen Capsules

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Medicinal Plant 2022年第4期13卷 19-21,33页

作者： Congyan ZENG xiaoyan pang Yuliang HU Xiaofang XIN Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine Zhongshan 528400China

[Objectives]To explore the stability of Naomai Xingshen Capsules.[Methods]Accelerated test and long-term test were carried out to investigate the changes in properties,identification,moisture,disintegration time and microbial limit of Naomai Xingshen Capsules.[Results]There were basically no changes in all indicators for the three batches of samples(after 6-month accelerated test and 24-month long-term test),and they all met the requirements of quality standards.[Conclusions]The preparation of Naomai Xingshen Capsules is stable and reliable,and the stability test provides a reliable basis for its expiration date.

关键词： Naomai Xingshen Capsules Accelerated test Long-term test Stability

Adenoid cystic carcinoma of the Bartholin’s gland:A report of two new cases

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Adenoid cystic carcinoma of the Bartholin’s gland:A report ...

Development of Medical Informatization in the Era of Big Data

中华医学会第十次全国妇产科学术会议妇科肿瘤会场（妇科肿瘤学组、妇科病理学组）

作者： xiaoyan pang Fang Wen Yi Zhang Department of Gynecology The First Affiliated Hospital of China Medical University

Background Adenoid cystic carcinoma(ACC) of the Bartholin's gland is a rare malignancy of the female genital tract and there have been about 70 reported cases in the world literature. Cases Two new cases of ACC of the... 详细信息

关键词： ACC Adenoid cystic carcinoma of the Bartholin s gland:A report of two new cases

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Journal of Electronic Research and Application 2023年第5期7卷 14-23页

作者： Yong Ding Xiujun Cai xiaoyan pang Jinming Ye Xiaohong Ding Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China

The purpose of this paper is to discuss the development of medical informatization in the era of big *** literature review and theoretical analysis,the development of medical informatization in the era of big data is deeply *** results show that medical informatization has developed rapidly in the era of big data,and its role in clinical decision-making,scientific research,teaching,and management has become increasingly *** development of medical informatization in the era of big data has important purposes and methods,which can produce important results and conclusions and provide strong support for the development of the medical field.

关键词： Electronic medical record system Digitization of medical images Clinical decision support system

非经典涡旋光束在高数值孔径系统中的传播特性

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西安电子科技大学学报 2020年第4期47卷 102-108页

作者：李锦虹庞晓炎冯晨西北工业大学电子信息学院陕西西安710072

非经典涡旋是一种与经典涡旋具有相同拓扑荷数但是不同相位分布的光相位螺旋结构。基于理查德和沃尔夫矢量衍射理论,推导了在高数值孔径系统中线偏振非经典涡旋在焦点区域的表达式,并通过数值模拟研究了此光束在聚焦场的传播特性。研究... 详细信息

非经典涡旋是一种与经典涡旋具有相同拓扑荷数但是不同相位分布的光相位螺旋结构。基于理查德和沃尔夫矢量衍射理论,推导了在高数值孔径系统中线偏振非经典涡旋在焦点区域的表达式,并通过数值模拟研究了此光束在聚焦场的传播特性。研究中发现,横向焦移现象不仅存在于离轴(或轴上)涡旋的紧聚焦光场中,也存在于非经典涡旋的紧聚焦光场中,并且此两种横向焦移虽然表现形式一样,但是影响因素却截然不同。结果表明,由于横向焦移的存在,在非经典涡旋的相位分布因子和聚焦系统半孔径角满足一定的条件时,总场强分布图形可沿光轴方向顺时针旋转前进,同时场强最大值点也将从传播轴负半空间到正半空间旋转180°。研究结果为结构光场的调控提供新的方法,将在光镊等领域有潜在的应用。

关键词：非经典涡旋横向焦移紧聚焦