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Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response

National Science Review 2023年第10期10卷 32-43页

作者： Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng xiaoxi tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Fran?ois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue Institute of Preventive Veterinary Sciences and Department of Veterinary Medicine Zhejiang University College of Animal Sciences Ningbo Academy of Agricultural Sciences Hainan Institute of Zhejiang University Department of Microbiology Laboratory Shanghai Municipal Center for Disease Control and Prevention College of Veterinary Medicine Henan University of Animal Husbandry and Economy Key Laboratory of Prevention and Control Agents for Animal Bacteriosis Institute of Animal Husbandry and Veterinary Hubei Academy of Agricultural Sciences Division of Bacterial Diseases State Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences Poultry Institute Chinese Academy of Agricultural Sciences Department of Animal Public Health Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences Shandong Key Laboratory of Animal Disease Control and Breeding Institute of Animal Science and Veterinary MedicineShandong Academy of Agricultural Sciences College of Veterinary Medicine Yangzhou University Institute for Veterinary Food Science Faculty of Veterinary MedicineJustus-Liebig University Giessen Institut Pasteur Université Paris Cité Unité des bactéries pathogènes entériques School of Veterinary Medicine University of Surrey School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences CAS Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of Sciences Department of Microbiology and Microbial Engineering School of Life SciencesFudan University State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesThe First Affiliated Hospital College of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine

Understanding changes in pathogen behavior(*** virulence,a shift in transmission channel) is critical for the public health management of emerging infectious *** degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the ***,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be *** large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese *** phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection ***,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted ***-genome analysis pinpointed fimbrial degradation from a virulent *** later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in *** depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry ***,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission.

关键词： Salmonella host adaptation pathogenic evolution virulence evolution vertical transmission fimbrial adhesin

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Vibration Signal-Based Fault Diagnosis of Railway Point Machines via Double-Scale CNN

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Chinese Journal of Electronics 2023年第5期32卷 972-981页

作者： CHEN Xiaohan HU xiaoxi WEN tao CAO Yuan The School of Electronic and Information Engineering Beijing Jiaotong University The State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong University The National Engineering Research Center of Rail Transportation Operation Control System Beijing Jiaotong University

In the railway transportation industry,fault diagnosis of railway point machines(RPMs) is *** operational vibration signals can reflect the condition of various faults in mechanical devices, vibration sensing and monitoring and more importantly, vibration signal-based fault diagnosis for RPMs have attracted the attention of scholars and engineers. Most vibration signalbased fault-diagnosis methods for RPMs rely on data collected using high-sampling-rate sensors and manual feature extraction, hence are costly and insufficiently *** overcome these shortcomings, we propose a doublescale wide first-layer kernel convolutional neural network(DS-WCNN) for RPMs fault diagnosis using inexpensive and low-sampling-rate vibration sensors. The proposed wide first-layer kernels, which extract features from vibration observations, are particularly suitable for lowsampling-rate signals. Meanwhile, the proposed doublescale structure improves accuracy and noise suppression by combining two types of timescale features. Sufficient experiments, including noise addition and comparison,were conducted to demonstrate the robustness and accuracy of the proposed algorithm.

关键词： Vibrations Fault diagnosis Transportation industry Feature extraction Rail transportation Robustness Convolutional neural networks

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Data-driven technology of fault diagnosis in railway point machines:review and challenges

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Transportation Safety and Environment 2022年第4期4卷 19-32页

作者： xiaoxi Hu Yuan Cao tao Tang Yongkui Sun State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China National Engineering Research Center of Rail Transportation Operation Control System Beijing Jiaotong UniversityBeijing 100044China.

Safety and reliability are absolutely vital for sophisticated Railway Point Machines(RPMs).Hence,various kinds of sensors and transducers are deployed on RPMs as much as possible to monitor their behaviour for detection of incipient faults and anticipation using data-driven *** paper firstly analyses and summarizes six RPMs’characteristics and then reviews the data-driven algorithms applied to fault diagnosis in RPMs during the past *** provides not only the process and evaluation metrics but also the pros and cons of these different ***,regarding the characteristics of RPMs and the existing studies,eight challenging problems and promising research directions are pointed out.

关键词： Railway point machine(RPM) fault diagnosis data-driven technology condition monitoring

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A button switch inspired duplex hydrogel sensor based on both triboelectric and piezoresistive effects for detecting dynamic and static pressure

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Nanotechnology and Precision Engineering 2022年第2期5卷 12-20页

作者： Zhensheng Chen Jiahao Yu xiaoxi Zhang Haozhe Zeng Yunjia Li Jin Wu Kai tao Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical UniversityXi’an 710072China AVIC Xi’an Aircraft Industry Group Company Ltd. Xi’an 710089China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China

The capability to sense complex pressure variations comprehensively is vital for wearable electronics and flexible human–machine *** this paper,inspired by button switches,a duplex tactile sensor based on the combination of triboelectric and piezoresistive effects is designed and *** of its excellent mechanical strength and electrical stability,a double-networked ionic hydrogel is used as both the conductive electrode and elastic current *** addition,micro-pyramidal patterned polydimethylsiloxane(PDMS)acts as both the friction layer and the encapsulation elastomer,thereby boosting the triboelectric output performance *** duplex hydrogel sensor demonstrates comprehensive sensing ability in detecting the whole stimulation process including the dynamic and static *** dynamic stress intensity(10–300 Pa),the action time,and the static variations(increase and decrease)of the pressure can be identified precisely from the dual-channel *** with a signal processing module,an intelligent visible door lamp is achieved for monitoring the entire“contact–hold–release–separation”state of the external stimulation,which shows great application potential for future smart robot e-skin and flexible electronics.

关键词： Duplex hydrogel sensor Triboelectric nanogenerator Piezoresistive sensor Dynamic and static sensing

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Surface plasmon assisted high-performance photodetectors based on hybrid TiO_(2)@GaO_(x)N_(y)-Ag heterostructure

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Journal of Semiconductors 2023年第7期44卷 45-53页

作者： Jiajia tao Guang Zeng xiaoxi Li Yang Gu Wenjun Liu David Wei Zhang Hongliang Lu State Key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan Univer-sityShanghai 200433China Jiashan Fudan Institute Jiaxing 314100China

In this work,we reported a high-performance-based ultraviolet-visible(UV-VIS)photodetector based on a TiO_(2)@GaO_(x)N_(y)-Ag *** particles were introduced into TiO_(2)@GaO_(x)N_(y)to enhance the visible light detection perfor-mance of the heterojunction *** 380 nm,the responsivity and detectivity of TiO_(2)@GaO_(x)N_(y)-Ag were 0.94 A/W and 4.79×109 Jones,respectively,and they increased to 2.86 A/W and 7.96×1010 Jones at 580 *** rise and fall times of the response were 0.19/0.23 and 0.50/0.57 s,***,at 580 nm,the responsivity of fabricated devices is one to four orders of magnitude higher than that of the photodetectors based on TiO_(2),Ga_(2)O_(3),and other *** excellent optoelectronic characteristics of the TiO_(2)@GaO_(x)N_(y)-Ag heterojunction device could be mainly attributed to the synergistic effect of the type-Ⅱband structure of the metal-semiconductor-metal heterojunction and the plasmon resonance effect of Ag,which not only effectively promotes the separation of photogenerated carriers but also reduces the recombination *** is fur-ther illuminated by finite difference time domain method(FDTD)simulation and photoelectric *** TiO_(2)@GaO_(x)N_(y)-Ag arrays with high-efficiency detection are suitable candidates for applications in energy-saving communica-tion,imaging,and sensing networks.

关键词： TiO_(2)@GaO_(x)N_(y)-Ag ultraviolet-visible photodetector type-Ⅱband structure plasmon resonance effect

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Command Optimization for Missile Roll Autopilot

Command Optimization for Missile Roll Autopilot

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第25届中国控制与决策会议

作者： Cui xiaoxi Lou Yingming Wu tao Zhang Dongxiang Wang Linping Zhang Nan North China Institute of Navigation and Control Ordnance Science and Research Academy of China

ISBN: (纸本)9781467355339

As command optimization for missile roll autopilot has long been neglected by missile control engineers, this paper introduces two roll command optimization methods for missile 180° rotation. First, problems in roll autopilot design are stated and the importance of command optimization is illustrated. Second, linear and exponent command optimization methods are established with the quickly and efficient method of optimization time constant provided at the same time. Then compared with each other, the advantages and disadvantages are listed for the two optimization methods. At last, the conclusion about how to choose optimization method is deduced.

关键词： Linear Optimization Exponent Optimization Roll autopilot

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Research on Intangible Cultural Heritage Education and Inheritance in Universities

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Journal of Contemporary Educational Research 2020年第11期4卷 37-39页

作者： tao Ma xiaoxi Cao Tiangong University Tianjin 300384China

This paper first analyzes the advantages and problems of intangible cultural heritage education and inheritance in Chinese universities,and then points out the key points of local universities in constructing the education system of intangible cultural heritage in terms of curriculum setting,textbook preparation and pedagogical reform,and perfecting teacher deployment and teaching conditions.

关键词： Universities Intangible cultural heritage Education and heritage

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基于岩石圈厚度和地幔横向黏度变化的地幔对流模型重估云南地区剪切波各向异性源的深度

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地学前缘 2021年第2期28卷 284-295页

作者：朱涛马小溪中国地震局地球物理研究所北京100081 中国地震局地质研究所地震动力学国家重点实验室北京100029 吉林省地震局吉林长春130117

在已有模型的基础上,考虑岩石圈厚度和软流层横向黏度的变化,本文建立了更接近地球实际情形的地幔对流模型,然后重新推测了导致云南地区剪切波各向异性的软流层源的深度。结果表明:岩石圈厚度和软流层横向黏度变化对云南地区的软流层各... 详细信息

在已有模型的基础上,考虑岩石圈厚度和软流层横向黏度的变化,本文建立了更接近地球实际情形的地幔对流模型,然后重新推测了导致云南地区剪切波各向异性的软流层源的深度。结果表明:岩石圈厚度和软流层横向黏度变化对云南地区的软流层各向异性源的深度及软流层的变形程度和机制具有重要影响;软流层各向异性对云南西南部区域、东部区域北纬26°N以南和四川盆地及其西缘的剪切波分裂具有明显的贡献,它们分别位于90~180、170~330和200~320 km深度;在云南西南部区域和东部区域北纬26°N以南,导致剪切波分裂的软流层可能处于大剪切变形状态,主要受地幔流动方向/流动平面模式控制,而四川盆地及其西缘的则处于小剪切变形状态,主要受应变模式的控制。

关键词：软流层各向异性地震各向异性地幔对流软流层变形地幔动力学

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基于深度特征匹配的转辙机自动开闭器静接点尺寸测量方法研究

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铁道学报 2023年第5期45卷 57-64页

作者：胡小溪曹源唐涛北京交通大学轨道交通控制与安全国家重点实验室北京100044 北京交通大学轨道交通运行控制系统国家工程研究中心北京100044

自动开闭器是转辙机上负责动作控制与状态表示的频繁动作关键部件,使用过程中的接点磨损会影响控制与反馈电路的导通。然而,由于其安全关键、磨损样本稀少、工作环境恶劣,使得自动开闭器的在线监测成为转辙机维护维修的难题。针对上述问... 详细信息

自动开闭器是转辙机上负责动作控制与状态表示的频繁动作关键部件,使用过程中的接点磨损会影响控制与反馈电路的导通。然而,由于其安全关键、磨损样本稀少、工作环境恶劣,使得自动开闭器的在线监测成为转辙机维护维修的难题。针对上述问题,基于机器视觉提出一种深度特征匹配的目标检测方法。首先利用VGGNet自适应地提取接点模板和待搜索样本的深度特征,采取归一化互相关算法和反向映射算法完成目标定位,利用权重优化和非极大值抑制优化边界框,实现小样本数据集情况下兼顾精度与鲁棒性的目标定位;然后使用大津法二值化、中值滤波、水平差分算子等完成静接点图像处理;最后使用标定板换算获得静接点的几何尺寸数据。实验结果表明:本方法在实际应用中的定位检测精度达到85.93%,召回率达到90.63%,F 1达到88.22%;在尺寸测量误差方面,RMSE、MAE、MAPE分别为2.56 mm、1.55 mm、12.94%。

关键词：尺寸测量目标检测小样本自动开闭器深度特征匹配

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基于词项和语义融合的地铁信号设备故障文本预处理

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铁道学报 2021年第2期43卷 78-85页

作者：胡小溪牛儒唐涛北京交通大学轨道交通控制与安全国家重点实验室北京100044

数据预处理是数据驱动故障诊断的前提,为了更好地提取数据特征,针对地铁信号设备的故障记录提出一种基于词项和语义融合的文本自动预处理方法。采用隐式马尔可夫链识别特定线路的信号专有词汇,结合既有词库形成特定线路信号专用词库,解... 详细信息

数据预处理是数据驱动故障诊断的前提,为了更好地提取数据特征,针对地铁信号设备的故障记录提出一种基于词项和语义融合的文本自动预处理方法。采用隐式马尔可夫链识别特定线路的信号专有词汇,结合既有词库形成特定线路信号专用词库,解决线路专用信号设备故障词库的生成问题;分别在词项空间和语义空间进行故障记录的聚类、特征词提取与融合,形成故障记录的词袋表示,并在专家模板的基础上应用KNN算法统一故障记录描述,解决故障记录的模糊性问题。以某地铁线2015-2017年的故障记录为数据源进行试验,结果表明该方法有效,宏平均F1测试值达到95.56%。

关键词：文本预处理地铁信号 HMM K-means LDA

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