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Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi Chen Xinchen zhao xiaowei Liu Yujie Ouyang Chuan Xu Ying Shi Department of Oncology Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of MedicineUniversity of Electronic Science and Technology of China Institute for Breast Health Medicine State Key Laboratory of Biotherapy West China Hospital Sichuan University Acupuncture and Massage College Chengdu University of Traditional Chinese Medicine

Immune checkpoint inhibitors(ICIs) are used to relieve and refuel anti-tumor immunity by blocking the interaction, transcription, and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune checkpoints. Thousands of small molecule drugs or biological materials, especially antibody-based ICIs, are actively being studied and antibodies are currently widely used. Limitations, such as anti-tumor efficacy, poor membrane permeability, and unneglected tolerance issues of antibody-based ICIs, remain evident but are thought to be overcome by small molecule drugs. Recent structural studies have broadened the scope of candidate immune checkpoint molecules, as well as innovative chemical inhibitors. By way of comparison, small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic features. Several ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions, including immune regulation, anti-angiogenesis, and cell cycle regulation. In this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins, which will lay the foundation for further exploration.

关键词： CD47 Immune checkpoints programmed death protein 1 signal-regulatory protein α small molecule drugs

One-step hydrothermal synthesis of Cit-NaYbF_(4):Er^(3+)nanocrystals with enhanced red upconversion emission for in vivo fluorescence molecular tomography

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Journal of Rare Earths 2024年第1期42卷 36-45,I0002页

作者： Xiaoli Luo Qichen Chen Hongbo Guo Heng Zhang xiaowei He Wu zhao School of Mathematics and Computer Science Ningxia Normal UniversityGuyuan756099China School of Information Science and Technology Northwest UniversityXi'an710127China

Fluorescence imaging techniques represent essential tools in in vitro,preclinical,and clinical studies.In this study,an improved one-step hydrothermal method to synthesize citric acid(CA)modifiedα-NaYbF_(4):2%Er^(3+)nanocrystals was proposed.The introduction of various doping ions into NaYbF_(4):2%Er^(3+)and the different valence states of the same ions affect both the crystal size and upconversion luminesce nce.There fore,we investigated the upconversion luminesce nce enha ncement of NaYbF_(4):2%Er^(3+)by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles(UCNPs)co-doped with 5 mol%Fe^(2+)ions shows the greatest enhancement,especially for red emission at654 nm.Furthermore,HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detectio n.Confocal laser scanning microscope(CLSM)fluorescent images of HeLa cells indicate that NaYbF_(4):2%Er/5%Fe^(2+)leads to a clear outline and improves visualization of the cell morphology.In addition,the CA coated NaYbF_(4):2%Er^(3+)/5%Fe^(2+)nanoparticles and NaYbF_(4):2%Er^(3+)/5%Fe^(2+)show low cytotoxicity in HeLa cells.Organ imaging reveals the efficiency of these UCNPs to analyze the lungs,liver,and spleen.Together,these results indicate that the Cit-NaYbF_(4):2%Er^(3+)/5%Fe^(2+)UCNPs are efficient nanoprobes for fluorescence molecular to mography.

关键词： Hydrothermal method Fe^(2+)ion doping Tuning size Nanoprobes Fluorescence imaging Rare earths

Bilayer borophene:an efficient catalyst for hydrogen evolution reaction

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 13-23页

作者： Na Xing Nan Gao Panbin Ye xiaowei Yang Haifeng Wang Jijun zhao College of Sciences/Xinjiang Production&Construction Corps Key Laboratory of Advanced Energy Storage Materials and Technologies Shihezi UniversityShihezi832000China Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education)Dalian University of TechnologyDalian116024China School of Materials Science and Engineering Taizhou UniversityTaizhou318000China

The electrocatalytic hydrogen evolution reaction is a crucial technique for green hydrogen production.However,finding affordable,stable,and efficient catalyst materials to replace noble metal catalysts remains a significant challenge.Recent experimental breakthroughs in the synthesis of two-dimensional bilayer borophene provide a theoretical framework for exploring their physical and chemical properties.In this study,we systematically considered nine types of bilayer borophenes as potential electrocatalysts for the hydrogen evolution reaction.Our first-principles calculations revealed that bilayer borophenes exhibit high stability and excellent conductivity,possessing a relatively large specific surface area with abundant active sites.Both surface boron atoms and the bridge sites between two boron atoms can serve as active sites,displaying high activity for the hydrogen evolution reaction.Notably,the Gibbs free energy change associated with adsorption for these bilayer borophenes can reach as low as−0.002 eV,and the Tafel reaction energy barriers are lower(0.70 eV)than those on Pt.Moreover,the hydrogen evolution reaction activity of these two-dimensional bilayer borophenes can be described by engineering their work function.Additionally,we considered the effect of pH on hydrogen evolution reaction activity,with significant activity observed in an acidic environment.These theoretical results reveal the excellent catalytic performance of two-dimensional bilayer borophenes and provide crucial guidance for the experimental exploration of multilayer boron for various energy applications.

关键词： bilayer borophene hydrogen evolution reaction work function pH effect

Transmit Power Minimization for IRS-Assisted NOMA-UAV Networks

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China Communications 2024年第5期21卷 137-152页

作者： zhao Chen Pang xiaowei Tang Jie Liu Mingqian zhao Nan Zhang Xiuyin Wang Xianbin School of Information and Communication Engineering Dalian University of TechnologyDalian 116024China School of Electronic and Information Engineering South China University of TechnologyGuangzhou 510641China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Department of Electrical and Computer Engineering Western UniversityLondonON N6A 5B9Canada

The flexibility of unmanned aerial vehicles(UAVs)allows them to be quickly deployed to support ground users.Intelligent reflecting surface(IRS)can reflect the incident signal and form passive beamforming to enhance the signal in the specific direction.Motivated by the promising benefits of both technologies,we consider a new scenario in this paper where a UAV uses non-orthogonal multiple access to serve multiple users with IRS.According to their distance to the UAV,the users are divided into the close users and remote users.The UAV hovers above the close users due to their higher rate requirement,while the IRS is deployed near the remote users to enhance their received power.We aim at minimizing the transmit power of UAV by jointly optimizing the beamforming of UAV and the phase shift of IRS while ensuring the decoding requirement.However,the problem is non-convex.Therefore,we decompose it into two sub-problems,including the transmit beamforming optimization and phase shift optimization,which are transformed into second-order cone programming and semidefinite programming,respectively.We propose an iterative algorithm to solve the two sub-problems alternatively.Simulation results prove the effectiveness of the proposed scheme in minimizing the transmit power of UAV.

关键词： intelligent reflecting surface nonorthogonal multiple access phase shift optimization transmit beamforming optimization unmanned aerial vehicle

Occurrence and vertical distribution of aluminum and rare earths in weathered crust elution-deposited rare earth ore:Effect of soil solution pH and clay minerals

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Journal of Rare Earths 2024年第7期42卷 1394-1402页

作者： Jiaxin Pan Longsheng zhao Zheng Li xiaowei Huang Zongyu Feng Jun Chen National Engineering Research Center for Rare Earth China GRINM Group Co.Ltd. School of Metallurgical and Ecological Engineering University of Science and Technology Beijing (USTB) GRIREM Advanced Materials Co. Ltd. GRIREM Hi-Tech Co. Ltd. GRIMAT Engineering Institute Co. Ltd.

Weathered crust elution-deposited rare earth ore is crucial source of medium and heavy rare earths,with in-situ leaching being the most common mining method.The high contents of impurity of aluminum in the leach solution are a significant challenge for the subsequent enrichment process of rare earths.A comprehensive understanding of the occurrences and vertical distribution of aluminum and rare earths within typical vertical profiles can provide valuable insights into entire design of the in-situ leaching.This paper improves a five-step sequential extraction method to analyze the occurrence and vertical distribution of rare earths and aluminum in vertical profiles from Chongzuo and Longyan.Experimental results demonstrate that soil solution pH is the main factor affecting the vertical distribution of ionexchangeable rare earths.Both samples have distinct areas of enrichment for ion-exchangeable rare earths or aluminum.Ion-exchangeable rare earths are primary concentrated in the middle and lower parts of the ore layer(4-13 m in Chongzuo,14-22 m in Longyan),while the ion-exchangeable aluminum is mainly enriched in the upper part of the ore layer(1-5 m in Chongzuo,and 2-14 m in Longyan).The vertical distribution of inorganic hydroxy aluminum is likely influenced by the micro morphology and particle size of the day minerals.The inorganic hydroxy aluminum concentration in Chongzuo samples decreases continuously from 415.65 to 120.95 mg/kg with increasing sampling depth,whereas the concentration in Longyan samples(110.55-171.27 mg/kg) is almost independence with sampling depth.These results provide direct guidance for the entire design of the injection well depth and the leaching parameters,thereby inhibiting the leaching of impurity of aluminum and lower the consumption of leaching agent.

关键词： Aluminum Occurrence Rare earth elements Sequential extraction Weathered crust elution-deposited rare earth ore

Anti-N-methyl-D-aspartate receptor type autoimmune encephalitis with severe pneumonia:a case report

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World Journal of Emergency Medicine 2024年第2期15卷 142-146页

作者： Yi Gu Xiandong Liu Tiancao Dong Qian Yang xiaowei Bao Dongyang zhao Lunxian Tang Department of Internal Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200120China

Autoimmune encephalitis(AE)is a type of encephalitis caused by autoimmune disease.AE was included on a list of the first batch of 121 rare diseases published by the Chinese National Health Commission on 11^(th)May 2018.Currently,patients with AE account for 10%-20% of encephalitis cases,with 54%-80% of those cases classified as the anti-N-methyl-D-aspartate receptor(NMDAR)type,which is the most common type.[1]In 2010,China reported the first case of a patient withanti-NMDARtype AE.

关键词： encephalitis autoimmune aspartate

Wetting sub-nanochannels via ionic hydration effect for improving charging dynamics

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Green Energy & Environment 2024年第3期9卷 473-480页

作者： Yayun Shi Xiaoli zhao Qihang Liu Zhenghui Pan Congcong Liu Shanyi Zhu Zhijun Zuo xiaowei Yang State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan030024China School of Materials Science and Engineering Tongji UniversityShanghai201804China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China

The ionic transport in sub-nanochannels plays a key role in energy storage,yet suffers from a high energy barrier.Wetting sub-nanochannels is crucial to accelerate ionic transport,but the introduction of water is challenging because of the hydrophobic extreme confinement.We propose wetting the channels by the exothermic hydration process of pre-intercalated ions,the effect of which varies distinctly with different ionic hydration structures and energies.Compared to the failed pre-intercalation of SO_(4)^(2-),HSO_(4)^(-) with weak hydration energy results in a marginal effect on the HOMO(Highest Occupied Molecular Orbital)level of water to avoid water splitting during the electrochemical intercalation.Meanwhile,the ability of water introduction is reserved by the initial incomplete dissociation state of HSO_(4)^(-),so the consequent exothermic reionization and hydration processes of the intercalated HSO_(4)^(-) promote the water introduction into sub-nanochannels,finally forming the stable confined water through hydrogen bonding with functional groups.The wetted channels exhibit a significantly enhanced ionic diffusion coef-ficient by~9.4 times.

关键词： Sub-nanochannels Ionic hydration Ionic transport Supercapacitors Confined water

Degradation analysis and doping modification optimization for high-voltage P-type layered cathode in sodium-ion batteries

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Journal of Energy Chemistry 2024年第2期89卷 1-9,I0002页

作者： Bao Zhang Yi zhao Minghuang Li Qi Wang Lei Cheng Lei Ming Xing Ou xiaowei Wang National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina Zhejiang Power New Energy Co. LTDZhuji 311800ZhejiangChina

Advancing high-voltage stability of layered sodium-ion oxides represents a pivotal avenue for their progress in energy storage applications.Despite this,a comprehensive understanding of the mechanisms underpinning their structural deterioration at elevated voltages remains insufficiently explored.In this study,we unveil a layer delamination phenomenon of Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2)(NNM)within the 2.0-4.3 V voltage,attributed to considerable volumetric fluctuations along the c-axis and lattice oxygen reactions induced by the simultaneous Ni^(3+)/Ni^(4+)and anion redox reactions.By introducing Mg doping to diminished Ni-O antibonding,the anion oxidation-reduction reactions are effectively mitigated,and the structural integrity of the P2 phase remains firmly intact,safeguarding active sites and precluding the formation of novel interfaces.The Na_(0.67)Mg_(0.05)Ni_(0.25)Mn_(0.7)O_(2)(NMNM-5)exhibits a specific capacity of100.7 mA h g^(-1),signifying an 83%improvement compared to the NNM material within the voltage of2.0-4.3 V.This investigation underscores the intricate interplay between high-voltage stability and structural degradation mechanisms in layered sodium-ion oxides.

关键词： Soidum ion batteries Layer cathode materials P-type High-voltage performance Degradation analysis

Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H:quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase

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Chinese Journal of Natural Medicines 2024年第1期22卷 75-88页

作者： SONG Jiangzhou ZOU Guiqing zhao Zhou ZHU Ya XUE Jiayu AO Lanjia SUN Huiyong HAO Haiping ZHANG Bo XU xiaowei State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavin protease highly expressed in various cancer cells.NQO1 catalyzes a futile redox cycle in substrates,leading to substantial reactive oxygen species(ROS)production.This ROS generation results in extensive DNA damage and elevated poly(ADP-ribose)polymerase 1(PARP1)-mediated consumption of nicotinamide adenine dinucleotide(NAD^(+)),ultimately causing cell death.Nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD^(+)salvage synthesis pathway,emerges as a critical target in cancer therapy.The concurrent inhibition of NQO1 and NAMPT triggers hyperactivation of PARP1 and intensive NAD+depletion.In this study,we designed,synthesized,and assessed a novel series of proqodine A derivatives targeting both NQO1 and NAMPT.Among these,compound T8 demonstrated potent antitumor properties.Specifically,T8 selectively inhibited the proliferation of MCF-7 cells and induced apoptosis through mechanisms dependent on both NQO1 and NAMPT.This discovery offers a promising new molecular entity for advancing anticancer research.

关键词： NQO1 ROS NAMPT NAD^(+) T8