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重构本草——水蛭

长春中医药大学学报 2024年第2期40卷 135-139页

作者：沈梦菲黄晓巍张伟赵林华北京中医药大学北京100029 长春中医药大学药学院长春130117 西安市中医医院脑病医院西安710021 中国中医科学院广安门医院代谢病研究所北京100053

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出水蛭:功效主要为破血通经,逐瘀消癥。症靶为闭经或月经量少或月经血块多,心腹疼痛,肢体感觉异常,跌扑损伤之肿胀、... 详细信息

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出水蛭:功效主要为破血通经,逐瘀消癥。症靶为闭经或月经量少或月经血块多,心腹疼痛,肢体感觉异常,跌扑损伤之肿胀、疼痛、出血。标靶为腹内结块、肿瘤,恢复期脑卒中,肾纤维化,肝纤维化改变。现代药理研究发现,水蛭及其有效成分具有抗凝、抗血栓、抗肿瘤、抗炎、抗纤维化、降血脂、保护血管内皮细胞、抗神经损伤等作用。水蛭煎剂可引发胃肠道反应及过敏反应,孕妇及月经过多者禁用。高温破坏水蛭素,临床使用应注意冲服法或用量。临床使用水蛭煎服剂量多为1~9 g,打粉吞服剂量为0.3~10 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索水蛭用量与症靶、标靶的量效关系构建。

关键词：水蛭症靶标靶重构本草临床回归

油气储层用化学封堵材料性能室内评价方法发展方向

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石油钻采工艺 2024年第1期46卷 1-12页

作者：常启帆郑力会宇文昔涵黄小伟朱方辉李曜轩中国石油大学(北京)石油工程学院北京102249 川庆钻探长庆井下技术作业公司陕西西安710100 北京力会澜博能源技术有限公司北京102299

目前油气井储层封堵材料室内评价多以承压能力和储层保护能力为主,并以其作为入井依据。但随着技术进步和社会发展,只满足作业需求的某一项或几项指标,无法投入现场试用或应用,导致需要重复检测、评价,造成投入应用时间长,成功率低。从1... 详细信息

目前油气井储层封堵材料室内评价多以承压能力和储层保护能力为主,并以其作为入井依据。但随着技术进步和社会发展,只满足作业需求的某一项或几项指标,无法投入现场试用或应用,导致需要重复检测、评价,造成投入应用时间长,成功率低。从1000余篇国内外油气井安全性、储层保护和环境保护等相关主题词的文献中,发现封得住、稳得起、流得出、过得关和用得起等5项投入应用的性能指标需要检测,并以此为依据将检测方法分为5类。引入大数据思想分析应用成功率与测试指标数量的关系、投入应用时间与测试指标数量的关系发现,评价5类指标比评价单一指标的材料应用成功率最多高62%。5类评价方法项全部完成增加室内工作时间但投入应用的时间最多可节约77%。结果表明,封堵材料应用前评价5类指标,解决了封堵材料投入应用的时间长、效率低难题,不仅为储层封堵材料投入现场应用提供评价指标和检测方法,还为其他井筒作业材料提供了可借鉴的评价手段。

关键词：非常规油气工程技术封堵材料大数据储层伤害环保安全

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中国华南三水盆地发现氢气高异常渗出点

Science Bulletin 2024年第9期69卷 1217-1220页

作者：金之钧张盼盼刘润超黄晓伟王晓梅孟庆强刘金侠苏宇通张浩哲 Institute of Energy Peking UniversityBeijing 100871China Peking University Ordos Research Institute of Energy Ordos 017010China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing 100083China School of Energy and Resources China University of GeosciencesBeijing 100083China Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing 100083China Sinopec Star Company Limited Beijing 100083China

Natural hydrogen(H_(2))is also known as gold H_(2) and is a carbonfree energy resource with potential exploitation and utilization due to its renewable,environmentally friendly,and cost-effective characteristics[1].Natural H_(2) is distributed extensively worldwide,but varies in content in different regions and under varying geological conditions.At present,only the H_(2) wells in Mali are used for economic production[2,3].

关键词： conditions friendly cost

板对板高速信号连接器对印制电路板及组装的挑战和解决方案

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印制电路信息 2024年第S1期32卷 50-58页

作者：胡高斌谢佳峰何波黄小伟蒲柯联想系统集成(深圳)有限公司广东深圳518057

板对板高速信号连接器实现GPU加速卡和GPU模块板之间连接,以及主板与GPU和CPU的模块板之间的连接。本论文旨在探讨板对板高速连接器应用在印制电路板(PCB)和印刷电路板组装(PCBA)中的挑战,并重点关注此类板对板连接器在PCB布线设计改善... 详细信息

板对板高速信号连接器实现GPU加速卡和GPU模块板之间连接,以及主板与GPU和CPU的模块板之间的连接。本论文旨在探讨板对板高速连接器应用在印制电路板(PCB)和印刷电路板组装(PCBA)中的挑战,并重点关注此类板对板连接器在PCB布线设计改善和PCBA焊接可靠性提升方面的实验测试验证,找到合适的解决方案。通过对连接器对应PCB的盘中孔(VIPPO)焊盘和非盘中孔焊盘混合设计,以及VIPPO加背钻设计对PCBA表面焊接的挑战,影响及其可靠性进行深入研究;并探讨了混合VIPPO焊盘的PCB设计生产优化思路,PCB质量检测方式和PCBA焊接可靠性提升方面的实验及其接受标准。本研究采用了一系列实验和测试方法,包括PCB设计参数优化、材料选配及其加工工艺改进以及可靠性测试等,以验证连接器焊接在PCB中的可靠性和稳定性。研究结果表明,通过PCB设计和加工优化来促进PCBA焊接可靠性提升,显著提高整体系统的可靠性和稳定性,从而满足服务器主板和GPU模块互连的可靠性。本研究为此连接器在电子设备中的应用提供了实验方法和参考数据,对于服务器的PCB的设计和制作提供指引,对提升PCBA可靠性具有重要的参考意义.

关键词：板对板连接器印制电路板设计优化盘中孔焊盘焊接可靠性

CPAFFC President Lin Songtian meets Ethiopian ambassador

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Voice of Friendship 2022年第2期 18-19页

作者： huang xiaowei 不详

On April 20,Lin Songtian,president of the Chinese People’s Association for Friendship with Foreign Countries,met with Teshome Toga Chanaka,Ethiopia’s ambassador to China.Sun Xueqing,director-general of the CPAFFC’s department of Asian and African affairs,also attended the meeting.Lin extended welcome to Teshome for visiting the association again.

关键词： Ethiopia bass Lin

Sri Lankan Prime Minister Gunawardena meets Lin Songtian and his party

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Voice of Friendship 2022年第4期 6-7页

作者： huang xiaowei 不详

On Nov 14,Sri Lankan Prime Minister Dinesh Gunawardena met with CPAFFC President Lin Songtian and his entourage at the prime minister’s office.They had constructive exchanges and reached broad consensus on deepening China-Sri Lanka friendly relations,building a high-quality model for intensive development under the Belt and Road Initiative and addressing the foreign exchange shortage and food security problems.

关键词： deepening Minister award

Masculinizer gene controls sexual differentiation in Hyphantria cunea

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Insect Science 2024年第2期31卷 405-416页

作者： xiaowei Li Huihui Liu Honglun Bi Yaohui Wang Jun Xu Sufang Zhang Zhen Zhang Ze Zhang Yongping huang Laboratory of Evolutionary and Functional Genomics School of Life SciencesChongqing UniversityChongqingChina CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Centerfor Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyShanghaiChina Key Laboratory of Forest Protection Research Institute of Forest EcologyEnvironment and ProtectionChinese Academy of ForestryState Forestry AdministrationBeijingChina

The Masculinizer gene,Masc,encodes a lepidopteran-specific novel CCCHtype zinc finger protein,which controls sex determination and dosage compensation in Bombyx mori.Considering the potential application of it in pest control,it is necessary to investigate the function of Masc gene in Hyphantria cunea,a globally invasive forest pest.In the present study,we identified and functionally characterized the Masc gene,HcMasc,in H.cunea.Sequence analysis revealed that HcMASC contained the conserved CCCH-type zinc finger domain,nuclear localization signal,and male determining domain,in which the last was confirmed to be required for its masculinization in BmN cell line.However,expression data showed that unlike male-biased expression in B.mori,Hc-Masc gene expresses in main all developmental stages or tissues in both sexes.Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-based disruption of the common exons 1 and 3 of the HcMasc gene resulted in imbalanced sex ratio and abnormal external genitalia of both sexes.Our results suggest that the HcMasc gene is required for both male and female sexual differentiation and dosage compensation in H.cunea and provide a foundation for developing better strategies to control this pest.

关键词： CRISPR/Cas9 dosage compensation Hyphantria cunea Masc sexual differentiation

Carbon uptake by cement in China:Estimation and contribution to carbon neutrality goals

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Science China Earth Sciences 2024年第6期67卷 2056-2067页

作者： Mingjing MA Zi huang Jiaoyue WANG Le NIU Wenfeng ZHANG xiaowei XU Fengming XI Zhu LIU Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Department of Earth System Science Tsinghua UniversityBeijing 100084China Department of Engineering Science University of OxfordOxfordOX13UK

Cement is a widely used construction material globally.Its manufacturing contributes to anthropogenic CO_(2)emissions significantly.However,its alkaline compounds can absorb CO_(2)from the surrounding environment and engage in a carbonation reaction,thereby functioning as a carbon sink.As a major cement producer and consumer,China has an important responsibility to rigorously investigate and accurately account for cement carbon uptake.This study presents a comprehensive analytical model of cement carbon uptake from China,revealing a substantial increase in carbon uptake from 1930 to 2021,peaking at 426.77 Mt CO_(2)(95% Confidence Interval:317.67-874.33 Mt CO_(2))in 2021.The uptake accounts for 8.10% to 45.40% of China’s annual land sink and 2.51% to 4.54% of the global land sink.The cumulative carbon uptake by cement is approximately 7.06 Gt CO_(2)(95%CI:5.22–9.44 Gt CO_(2))during this period,offsetting 50.7% of the total emissions(13.91 Gt CO_(2),95%CI:12.44–17.00 Gt CO_(2))from the cement industry.Notably,cement mortar contributed to most absorption(65.64%).From a life cycle perspective,the service stage of cement materials is the period where the largest CO_(2)sink is formed,accounting for 90.03% of the total.Therefore,the potential for carbon sequestration in cement materials and their waste is enormous.Additionally,the model improves the accuracy of cement carbon accounting,supporting both China and global carbon neutrality assessments.Thus,it is crucial for China to achieve its carbon neutrality goals sooner by prioritizing the environmental benefits of cement materials and wastes,and accelerating the development and commercialization of CO_(2)sequestration technologies for cement and its by-products.

关键词： Cement Carbon uptake Life cycle assessment Carbon emission reduction Carbon neutrality

Forms of nitrogen uptake,translocation,and transfer via arbuscular mycorrhizal fungi:A review

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Science China(Life Sciences) 2012年第6期55卷 474-482页

作者： JIN HaiRu LIU Jie LIU Jing huang xiaowei College of Chemistry and Life Science Zhejiang Normal UniversityJinhua 321004China

Arbuscular mycorrhizal(AM) fungi are obligate symbionts that colonize the roots of more than 80% of land plants.Experiments on the relationship between the host plant and AM in soil or in sterile root-organ culture have provided clear evidence that the extraradical mycelia of AM fungi uptake various forms of nitrogen(N) and transport the assimilated N to the roots of the host plant.However,the uptake mechanisms of various forms of N and its translocation and transfer from the fungus to the host are virtually unknown.Therefore,there is a dearth of integrated models describing the movement of N through the AM fungal hyphae.Recent studies examined Ri T-DNA-transformed carrot roots colonized with AM fungi in 15 N tracer experiments.In these experiments,the activities of key enzymes were determined,and expressions of genes related to N assimilation and translocation pathways were quantified.This review summarizes and discusses the results of recent research on the forms of N uptake,transport,degradation,and transfer to the roots of the host plant and the underlying mechanisms,as well as research on the forms of N and carbon used by germinating spores and their effects on amino acid metabolism.Finally,a pathway model summarizing the entire mechanism of N metabolism in AM fungi is outlined.

关键词：丛枝菌根真菌吸收机制氮代谢转运 AM真菌寄主植物示踪实验根外菌丝