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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp(Ctenopharyngodon idella):in vitro and in vivo studies

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1638-1656页

作者： Piao Zhao Lin Feng Weidan Jiang Pei Wu Yang Liu Hongmei Ren xiaowan jin Lu Zhang Haifeng Mi Xiaoqiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Animal Disease‑Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130SichuanChina Tongwei Co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610041SichuanChina

Background Ochratoxin A(OTA),a globally abundant and extremely hazardous pollutant,is a significant source of contamination in aquafeeds and is responsible for severe food *** developmental toxicity of OTA and the potential relieving strategy of natural products remain *** study screened the substance curcumin(Cur),which had the best effect in alleviating OTA inhibition of myoblast proliferation,from 96 natural products and investigated its effect and mechanism in reducing OTA myotoxicity in vivo and in *** A total of 720 healthy juvenile grass carp,with an initial average body weight of 11.06±0.05 g,were randomly assigned into 4 groups:the control group(without OTA and Cur),1.2 mg/kg OTA group,400 mg/kg Cur group,and 1.2 mg/kg OTA+400 mg/kg Cur *** treatment consisted of 3 replicates(180 fish)for 60 *** Firstly,we cultured,purified,and identified myoblasts using the tissue block culture *** preliminary screening and re-screening of 96 substances,we examined cell proliferation-related indicators such as cell viability and ultimately found that Cur had the best ***,Cur could alleviate OTA-inhibited myoblast differentiation and myofibrillar development-related proteins(Myo G and MYHC)in vivo and in vitro and improve the growth performance of grass ***,Cur could also promote the expression of OTA-inhibited protein synthesis-related proteins(S6K1 and TOR),which was related to the activation of the AKT/TOR signaling ***,Cur could downregulate the expression of OTA-enhanced protein degradation-related genes(murf1,foxo3a,and ub),which was related to the inhibition of the Fox O3a signaling *** In summary,our data demonstrated the effectiveness of Cur in alleviating OTA myotoxicity in vivo and in *** study confirms the rapidity,feasibility,and effectiveness of establishing a natural product screening method targeting myoblasts to alleviate fungal toxin toxicity.

关键词： Curcumin Grass carp Myotoxic Ochratoxin A Protein deposition

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Establishing the link between D-mannose and juvenile grass carp(Ctenopharyngodon idella):Improved growth and intestinal structure associated with endoplasmic reticulum stress,mitophagy,and apical junctional complexes

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Animal Nutrition 2024年第3期18卷 450-463页

作者： Chong Zhang Lin Feng Pei Wu Yang Liu xiaowan jin Hongmei Ren Hua Li Fali Wu Xiaoqiu Zhou Weidan Jiang Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengdu 611130China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China

D-mannose,essential for protein glycosylation,has been reported to have immunomodulatory effects and to maintain intestinal flora *** addition to evaluating growth performance,we examined the impact of D-mannose on the structure of epithelial cells and apical junction complexes in the animal *** 1800 grass carp(16.20±0.01 g)were randomly divided into six treatments with six replicates of 50 fish each and fed with six different levels of D-mannose(0.52,1.75,3.02,4.28,5.50 and 6.78 g/kg diet)for 70 *** study revealed that D-mannose increased feed intake(P 0.05).D-mannose supplementation at 1.75 g/kg increased crude protein content in fish and lipid production value(P<0.05).D-mannose supplementation at 4.28 g/kg increased intestinal length,intestinal weight and fold height of grass carp compared to the control group(P<0.05).This improvement may be attributed to the phosphomannose isomerase(PMI)-mediated enhancement of *** study found that D-mannose supplementation at 4.28 or 3.02 g/kg reduced serum diamine oxidase activity or D-lactate content(P<0.05)and improved cellular and intercellular structures for the first *** improvement of cellular redox homeostasis involves alleviating endoplasmic reticulum(ER)stress through the inositol-requiring enzyme 1(IRE1),RNA-dependent protein kinase-like ER kinase(PERK),and activating transcription factor 6(ATF6)signaling *** alleviation of ER stress may be linked to the phosphomannomutase(PMM)-mediated enhancement of protein *** addition,ubiquitin-dependent[PTEN-induced putative kinase 1(PINK1)/Parkin]and ubiquitin-independent[BCL2-interacting protein 3-like(BNIP3L),BCL2-interacting protein 3(BNIP3),and FUN14 domain containing 1(FUNDC1)]mitophagy may play a role in maintaining cellular redox *** enhancement of intercellular structures includes enhancing tight junction and adherent junction structures,which may be closely associated with the small Rho GTPase pr

关键词： Grass carp(Ctenopharyngodon idella) D-mannose Intestine structure Endoplasmic reticulum stress Mitophagy Apical junctional complex

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硒对叶绿体及光合作用的影响

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分子植物育种 2019年第1期17卷 288-294页

作者：金小琬朱茜黄进杜丽峨王丽陈稷四川农业大学农学院成都611130 成都理工大学环境学院成都610059

硒不但是人类和动物必需的微量元素,其在植物的生长发育过程中也起着重要作用。已有研究表明,适当的硒处理可以提高植物的产量和品质,增强植物的抗逆性,但是过高的硒会损害植物的结构,抑制生长,降低叶绿素含量。但对于硒对植物叶绿体及... 详细信息

硒不但是人类和动物必需的微量元素,其在植物的生长发育过程中也起着重要作用。已有研究表明,适当的硒处理可以提高植物的产量和品质,增强植物的抗逆性,但是过高的硒会损害植物的结构,抑制生长,降低叶绿素含量。但对于硒对植物叶绿体及光合作用的影响尚未进行过系统的总结。本研究通过分析和总结硒是如何通过对叶绿体及光合作用实施调控,进而改变作物品质及植物的抗逆性,为合理、安全的施用硒肥提供理论依据,使之可以更好地发挥有益于农业生产和人类健康的生物学效应。

关键词：硒植物叶绿体光合作用抗逆性

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水稻OsRSH基因家族的生物信息学分析

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分子植物育种 2019年第22期17卷 7277-7285页

作者：杜丽峨黄进王丽梁欢金小琬陈稷四川农业大学农学院成都611130 成都理工大学环境学院成都610059

鸟苷(五)四磷酸,即(p)ppGpp(Guanosine tetraphosphate and pentaphosphate),是两类相关核苷酸ppGpp和pppGpp的总称,普遍存在于植物中。环境中光照、盐、PH、UV、植物激素等条件的变化会引起植物中(p)ppGpp水平的改变。植物中(p)ppGpp... 详细信息

鸟苷(五)四磷酸,即(p)ppGpp(Guanosine tetraphosphate and pentaphosphate),是两类相关核苷酸ppGpp和pppGpp的总称,普遍存在于植物中。环境中光照、盐、PH、UV、植物激素等条件的变化会引起植物中(p)ppGpp水平的改变。植物中(p)ppGpp的合成和水解是由一类叫RSH(RelA/SpoT homolog)的蛋白来完成。有研究发现RSH与植物生长、基因表达及胁迫应答等密切相关,且不同植物中RSH蛋白的种类、结构和表达方式各有不同。本研究利用Interpro、Clustal Omega、splitstree、Plant CARE、Rice xpro等生物工具,分别对水稻RSH家族各成员的蛋白结构进行比较,对它们在光照应答、组织特性表达和激素应答过程中存在的特异性和差异性进行系统的分析,对它们在植物体内的生物功能进行了初步的解析和预测。我们发现水稻Os RSH和拟南芥AtRSH在结构、功能和表达上具有高度相似性,在组织呈现特异性表达,参与激素应答过程,为今后深入开展水稻RSH基因家族的功能研究提供了一定的依据。

关键词：水稻(Oryza sativa) RSH 组织特性表达激素应答生物信息学分析

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日本小学“综合学习时间”实施之启示——以绪川小学“大家一起守卫的一个地球”为例

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教育与教学研究 2016年第8期30卷 119-123页

作者：金晓婉杨培禾首都师范大学初等教育学院北京100037

日本小学的"综合学习时间"是典型的实践性课程,重视体验和过程,与中国小学的综合实践活动课程在培养目标、课程设置、学习内容和学习方式等方面有共同之处。日本爱知县绪川小学开展的"大家一起守卫的一个地球"是综合实践活动课程的典型... 详细信息

日本小学的"综合学习时间"是典型的实践性课程,重视体验和过程,与中国小学的综合实践活动课程在培养目标、课程设置、学习内容和学习方式等方面有共同之处。日本爱知县绪川小学开展的"大家一起守卫的一个地球"是综合实践活动课程的典型代表,环境教育主题与综合实践课程的"实地考察、发现思考、担当行动"三环节有机结合,实现了使课程关乎儿童幸福生活的教育理念。其对中国小学综合实践活动课程的启示为:因地制宜,多元化整合课程资源;合理指导,助力活动顺利进行;秉承理念,灌注课程人文内涵。

关键词：日本小学综合学习时间综合实践活动环境教育

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搅拌模型下矿物的微波加热温升特性研究

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中国矿业大学学报 2024年第2期53卷 318-333页

作者：龙盛壹洪溢都孙晓婉阳富强郭进聂闻福州大学环境与安全工程学院福建福州350108 中国科学院海西研究院泉州装备制造研究中心福建泉州362000

为探讨复合矿物的微波加热机制,使用COMSOL Multiphyics软件,基于任意拉格朗日-欧拉(ALE)方法建立起环绕式微波加热模型来开展对不同组分结构和占比的复合矿物模型的温升特性研究.研究结果表明:相比于无搅拌加热模型,在铜片长度为5 cm,... 详细信息

为探讨复合矿物的微波加热机制,使用COMSOL Multiphyics软件,基于任意拉格朗日-欧拉(ALE)方法建立起环绕式微波加热模型来开展对不同组分结构和占比的复合矿物模型的温升特性研究.研究结果表明:相比于无搅拌加热模型,在铜片长度为5 cm,转速为(π/3)rad/s的环绕式模型中,矿物加热的效率更高,温度分布更均匀;复合矿物组分结构的变化会改变电磁波的分布,黄铁矿包裹方解石模型的微波加热效率低于方解石包裹黄铁矿模型;在黄铁矿包裹方解石模型中,黄铁矿厚度变化会引起电磁波相位变化,使得矿内电场热点和冷点偏移,并且其厚度大小在穿透深度前后对比,射入的电磁波强度差距较大,电场强度有显著差异;相同组分占比下,非均质矿物整体的电场模比复合均质矿物更低更稳定,组分间的电场强度更为接近;随着黄铁矿占比的增加,非均质矿物整体在微波加热30 s后的温度变化可分为小波峰区(0~10%)、大波峰区(10%~50%)、平稳区(50%~75%),组分间的温差逐渐变小.

关键词：微波破岩数值模拟复合矿物加热机制

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裂殖壶菌合成二十二碳六烯酸机理研究进展

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中国油脂 2019年第8期44卷 109-115页

作者：杨浩金小琬唐嘉淇黄健庭陈天晓杨雪薇黎双飞深圳大学生命与海洋科学学院广东省植物表观遗传学重点实验室广东深圳518055

二十二碳六烯酸(DHA)属于ω-3不饱和脂肪酸,是保持人体健康的重要营养成分之一,具有重要的医药应用和营养价值。与植物和动物来源相比,裂殖壶菌合成DHA的工业应用前景广阔。研究表明,过表达聚酮合成酶(Polyketide synthase,PKS)和脂肪... 详细信息

二十二碳六烯酸(DHA)属于ω-3不饱和脂肪酸,是保持人体健康的重要营养成分之一,具有重要的医药应用和营养价值。与植物和动物来源相比,裂殖壶菌合成DHA的工业应用前景广阔。研究表明,过表达聚酮合成酶(Polyketide synthase,PKS)和脂肪酸合成酶(Fatty acid synthase,FAS)途径中的关键作用酶基因与改变培养条件(如碳源、氮源、温度、无机盐、微量元素、前体物质及生物促进剂等),均可显著提高DHA产量。此外,不同限制条件下的裂殖壶菌基因组及转录组的测序分析,揭示了DHA合成过程种不饱和双键形成、信号传导、脂质转运及代谢的分子机制。

关键词：裂殖壶菌二十二碳六烯酸合成培养条件基因组测序转录组测序

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Design and Tests of Biomimetic Blades for Soil-rototilling and Stubble-breaking

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Journal of Bionic Engineering 2015年第3期12卷 495-503页

作者： jin Tong Wenfeng Ji Honglei Jia Donghui Chen xiaowan Yang The Key Laboratory of Bionic Engineering (Ministry of Education China) and the College of Biological and Agricultural Engineering Jilin University (Nanling Campus) Changchun 130022 China The College of Engineering Huazhong Agricultural University Wuhan 430070 China

Biomimetic blades for soil-rototilling and stubble-breaking were designed learning from the geometrical structure of the tips of toes of mole rat （Scaptochirus moschatus）. The orientation, the number and the central angle of the biomimetic structure were taken as the testing factors. The optimal structure of the biomimetic blade was determined through the tests of soil-rototilling and stubble-breaking operation in an indoor soil bin. The optimal combination of the biomimetic structure pa- rameters is that three arc concave teeth are equally arranged on the front cutting edge with a central angle of 60°. The results of comparative tests between the optimal biomimetic blade and a conventional universal blade show the torque acting on the biomimetic blade is lower during soil-rototilling and stubble-breaking operations. The results of field tests show that the working quality of the biomimetic blades meets the requirements of the national standard of China. Tests of soil-rototilling show that, when the orientation of the biomimetic structure was at low and middle levels, the torque ofbiomimetic blades decreased from 34.17 N·m to 31.03 N·m. The torque also decreased with the increase of the number of biomimetic structure. The average torques were 34.57 N·m, 33.44 N·m and 31.37 N·m, respectively. The maximum different value between two levels of central angle was 0.41 N·m. Tests in field indicate that for soil-rototilling operation, the tillage depth is deeper than 80 mm, the soil-crushing rate （length of soil block less than 40 mm） is over 50 %, and the vegetation coverage rate is over 55 %. For stubble-breaking operation, the stubble-breaking depth is deeper than 70 ram, the stubble-breaking rate （length of stubble less than 40 mm） is over 60%, and the stubble coverage rate is over 80%, which can meet the stubble-breaking requirement of corn.

关键词： biomimetics mole rat (Scaptochirus moschatus) soil-rototilling stubble-breaking torque working quality

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Influence of using amorphous silicon stack as front heterojunction structure on performance of interdigitated back contact-heterojunction solar cell （IBC-HJ）

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Frontiers in Energy 2017年第1期11卷 96-104页

作者： Rui JIA Ke TAO Qiang LI xiaowan DAI Hengchao SUN Yun SUN Zhi jin Xinyu LIU Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China

Interdigitated back contact-heterojunction （IBC-HJ） solar cells can have a conversion efficiency of over 25%. However, the front surface passivation and structure have a great influence on the properties of the IBC-HJ solar cell. In this paper, detailed numerical simulations have been performed to investigate the potential of front surface field （FSF） offered by stack of n-type doped and intrinsic amorphous silicon （a-Si） layers on the front surface of IBC-HJ solar cells. Simulations results clearly indicate that the electric field of FSF should be strong enough to repel minority carries and cumulate major carriers near the front surface. However, the overstrong electric field tends to drive electrons into a-Si layer, leading to severe recombination loss. The n-type doped amorphous silicon （n-a-Si） layer has been optimized in terms of doping level and thickness. The optimized intrinsic amorphous silicon （i-a-Si） layer should be as thin as possible with an energy band gap （Es） larger than 1.4 eV. In addition, the simulations concerning interface defects strongly suggest that FSF is essential when the front surface is not passivated perfectly. Without FSF, the IBC-HJ solar cells may become more sensitive to interface defect density.

关键词： amorphous silicon front surface field simulations interdigitated back contact-heterojunction solar cells

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The effect of nitrogen on the compressibility and conductivity of iron at high pressure

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Geoscience Frontiers 2021年第2期12卷 983-989页

作者： Yukai Zhuang xiaowan Su Nilesh P.Salke Zhongxun Cui Qingyang Hu Dongzhou Zhang jin Liu Center for High Pressure Science and Technology Advanced Research(HPSTAR) Beijing 100094China School of Earth and Space Sciences Peking UniversityBeijing 100871China Hawai’i Institute of Geophysics and Planetology School of Ocean and Earth Science and TechnologyUniversity of Hawai’i at ManoaHonoluluHI96822USA

Although nitrogen in the Earth’s interior has attracted significant attention recently,it remains the most enigmatic of the light elements in the Earth’s *** this work,synchrotron X-ray diffraction(XRD)and electrical conductivity experiments were conducted on iron nitrides(Fe_(2)N and Fe_(4)N)in diamond anvil cells(DACs)up to about 70 GPa at ambient *** results show that iron nitrides are stable up to at least 70 *** the equation of state(EOS)parameters,iron nitrides are more compressible than iron ***,using the van der Pauw method and Wiedemann-Franz law,the electrical and thermal conductivity of samples were determined to be much lower than that of iron *** conductivities of Fe_(2)N and Fe_(4)N were similar at 20–70 GPa,suggesting no evident effects by varying the N stoichiometries in iron *** nitrides are less dense and conductive but more compressible than carbides at 0–70 *** study indicates that less nitrogen than carbon can explain geophysical phenomena in the deep Earth,such as the density deficit.

关键词： High pressure Iron nitrides Synchrotron X-ray diffraction Electrical conductivity

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