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Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification

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Journal of Materials Science & Technology 2024年第1期168卷 250-264页

作者： xiaotong zhao Jiali Hu Jingjun Nie Dafu Chen Gaowu Qin Erlin Zhang Key Lab.for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing 100035China

Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical *** the antibacterial and cardiovas-cular biological benefits of Cu^(2+)and titanium-nitride-oxide(TiN x O y)coatings,a Cu_(2)O/CuO-TiN x O y coating with upregulated Cu^(2+)release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface *** superhydrophilic and nanostructured Cu_(2)O/CuO-TiN x O y coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu_(2)O in the coating released Cu^(2+)faster than Ti_(2)Cu phase in the *** gratifying,the coating demonstrated perfect antibacterial properties(R>99.9%against ***),owing primarily to direct contact sterilization of Cu_(2)O/*** most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106%-116%),and particularly migration(RMR:158%-247%)compared with the control *** coating extract also signifi-cantly stimulated in vitro angiogenesis *** rapid endothelialization for Cu_(2)O/CuO-TiN x O y coating was attributed to the surface nanostructure and Cu^(2+)/NO_(2)−release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO *** of the findings indicated that the Cu_(2)O/CuO-TiN x O y coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.

关键词： Titanium-copper alloy Titanium-nitride-oxide(TiNxOy) Cu^(2+)release Antibacterial property Cell compatibility

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Dual Attention Based Feature Pyramid Network

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China Communications 2020年第8期17卷 242-252页

作者： Huijun Xing Shuai Wang Dezhi Zheng xiaotong zhao College of Software Beihang UniversityBeijing 100191China Research Institute for Frontier Science Beihang UniversityBeijing 100191China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Object detection could be recognized as an essential part of the research to scenarios such as automatic driving and pedestrian detection, etc. Among multiple types of target objects, the identification of small-scale objects faces significant challenges. We would introduce a new feature pyramid framework called Dual Attention based Feature Pyramid Network(DAFPN), which is designed to avoid predicament about multi-scale object recognition. In DAFPN, the attention mechanism is introduced by calculating the topdown pathway and lateral pathway, where the spatial attention, as well as channel attention, would participate, respectively, such that the pyramidal feature maps can be generated with enhanced spatial and channel interdependencies, which bring more semantical information for the feature pyramid. Using the COCO data set, which consists of a considerable quantity of small-scale objects, the experiments are implemented. The analysis results verify the optimized performance of DAFPN compared with the original Feature Pyramid Network(FPN) specifically for the identification on a small scale. The proposed DAFPN is promising for object detection in an era full of intelligent machines that need to detect multi-scale objects.

关键词： object detection convolutional neural networks feature pyramid

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Robust trajectory planning for UAV communication systems in the presence of jammers

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Chinese Journal of Aeronautics 2022年第10期35卷 265-274页

作者： Lingyun ZHOU xiaotong zhao Xin GUAN Enbin SONG XIN ZENG Qingjiang SHI School of Software Engineering Tongji UniversityShanghai 200092China College of Mathematics and School of Aeronautics and Astronautics Sichuan UniversityChengdu 610064China Department of Information and Communication Engineering Tongji UniversityShanghai 200092China

Unmanned Aerial Vehicle(UAV)has emerged as a promising novel application for the Sixth-Generation(6G)wireless communication by leveraging more favorable Line-of-Sight(Lo S)***,the jamming resistance by exploiting UAV’s mobility is a new challenge in the UAV-ground *** paper investigates the trajectory planning problem in an UAV communication system,where the UAV is operated by a Ground Control Unit(GCU)to perform certain tasks in the presence of multiple jammers with imperfect power and location *** ensure the reliability of the GCU-to-UAV link,we formulate the problem as a non-convex semi-infinite optimization,aiming to maximize the average worst-case Signal-toInterference-plus-Noise Ratio(SINR)over a given flight duration by designing the robust trajectory of the UAV under stringent energy availability *** handle this problem efficiently,we develop an iterative algorithm for the solution with the aid of S-procedure and Successive Convex Approximation(SCA)*** results demonstrate the efficacy of our proposed algorithm and offer some useful design insights to practical system.

关键词： 6G UAV communications Jamming resistance Trajectory optimization Robust design Non-convex optimization

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一种大视场红外相机的畸变校正方法

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红外技术 2024年第5期46卷 584-591页

作者：田三虎赵劲松何红星陈树刚康丽珠唐鑫刘咏梅赵小童昆明物理研究所云南昆明650223

本文针对大视场红外相机的畸变校正过程复杂的问题,提出了一种新的畸变校正方法。首先,选择单参数除法模型(division model,DM)作为相机畸变模型,使用改进的加速特征稳健算法(speed-up robust features,SURF)自动获取两幅有相同场景的... 详细信息

本文针对大视场红外相机的畸变校正过程复杂的问题,提出了一种新的畸变校正方法。首先,选择单参数除法模型(division model,DM)作为相机畸变模型,使用改进的加速特征稳健算法(speed-up robust features,SURF)自动获取两幅有相同场景的畸变红外图像的特征点对,然后利用九点非迭代算法和核密度估计方法获取图像的畸变参数,最后根据求得的畸变参数使用基于边缘保持的灰度插值方法对图像进行畸变校正。在整个过程中,不需要预先知道相机的参数和场景信息,通过输入两幅具有相同场景的图像,完成畸变校正,为大视场红外相机的畸变校正提供了一种新的解决方法。实验结果表明,使用该方法对大视场红外相机进行畸变校正具有可行性和鲁棒性。

关键词：大视场红外相机畸变校正自标定除法模型

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资金约束下建筑低碳供应链减碳决策研究

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项目管理技术 2024年第1期22卷 104-109页

作者：赵孝通刘兴民杨鹏飞山东建筑大学管理工程学院山东济南250101

资金约束是影响建筑供应链低碳化发展的关键因素。运用演化博弈理论,构建消费者、建设单位、建材生产单位三方演化博弈模型,分析资金约束下建筑供应链各方策略对低碳化发展的影响,并使用MATLAB进行数值仿真。结果表明:资金约束下过高的... 详细信息

资金约束是影响建筑供应链低碳化发展的关键因素。运用演化博弈理论,构建消费者、建设单位、建材生产单位三方演化博弈模型,分析资金约束下建筑供应链各方策略对低碳化发展的影响,并使用MATLAB进行数值仿真。结果表明:资金约束下过高的低碳水平会影响建筑供应链低碳化发展;低碳附加值收益提高会使各方更倾向于选择低碳策略;政府的补贴政策对各方策略选择有较大影响。根据研究结果提出促进建筑供应链低碳化发展和缓解资金约束压力的具体建议。

关键词：建筑低碳供应链资金约束演化博弈仿真分析

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A novel biomedical titanium alloy with high antibacterial property and low elastic modulus

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Journal of Materials Science & Technology 2021年第22期81卷 13-25页

作者： Diangeng Cai xiaotong zhao Lei Yang Renxian Wang Gaowu Qin Da-fu Chen Erlin Zhang Key Laboratory for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China

β-type titanium alloys have attracted much attention as implant materials because of their low elastic modulus and high strength,which is closer to human bones and can avoid the problem of stress fielding and extend the lifetime of ***,other issues,such as the infection or inflammation postimplantation,still trouble the titanium alloy's clinical *** this paper,we developed a novel nearβ-titanium alloy(Ti-13Nb-13Zr-13Ag,TNZA)with low elastic modulus and strong antibacterial ability by the addition of Ag element followed by proper microstructure controlling,which could reduce the stress shielding and bacterial infections *** microstructure,mechanical properties,corrosion resistance,antibacterial properties and cell toxicity were studied using SEM,electrochemical testing,mechanical test and cell *** results have demonstrated that TNZA alloy exhibited an elastic modulus of 75-87 GPa and a strong antibacterial ability(up to 98%reduction)and good ***,it was also shown that this alloy's corrosion resistance was better than that of *** the results suggested that Ti-13Nb-13Zr-13Ag might be a competitive biomedical titanium alloy.

关键词： Low Young’s modulus Antibacterial property Titanium alloy Compatibility Antibacterial titanium alloy

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Antibacterial metals and alloys for potential biomedical implants

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Bioactive Materials 2021年第8期6卷 2569-2612页

作者： Erlin Zhang xiaotong zhao Jiali Hu Ruoxian Wang Shan Fu Gaowu Qin Key Lab.for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityShenyang150819China Research Center for Metallic Wires Northeastern UniversityShenyang110819China

Metals and alloys,including stainless steel,titanium and its alloys,cobalt alloys,and other metals and alloys have been widely used clinically as implant materials,but implant-related infection or inflammation is still one of the main causes of implantation *** bacterial infection or inflammation that seriously threatens human health has already become a worldwide *** metals and alloys recently have attracted wide attention for their long-term stable antibacterial ability,good mechanical properties and good biocompatibility in vitro and in *** this review,common antibacterial alloying elements,antibacterial standards and testing methods were *** developments in the design and manufacturing of antibacterial metal alloys containing various antibacterial agents were described in detail,including antibacterial stainless steel,antibacterial titanium alloy,antibacterial zinc and alloy,antibacterial magnesium and alloy,antibacterial cobalt alloy,and other antibacterial metals and *** on the antibacterial properties,mechanical properties,corrosion resistance and biocompatibility of antibacterial metals and alloys have been summarized in detail for the first *** is hoped that this review could help researchers understand the development of antibacterial alloys in a timely manner,thereby could promote the development of antibacterial metal alloys and the clinical application.

关键词： Antibacterial metals and alloys Antibacterial alloying elements Antibacterial stainless steel Antibacterial titanium alloy Antibacterial magnesium alloy

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基于社会网络分析法的既有社区绿色改造驱动路径研究

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项目管理技术 2024年第5期22卷 87-92页

作者：刘兴民杨鹏飞孔得平赵孝通山东建筑大学管理工程学院山东济南250101 济南远茂置业有限责任公司山东济南250013

为提高既有社区绿色改造水平,探索既有社区绿色改造的驱动路径,基于利益相关方视角,采用社会网络分析法,以利益相关方的绿色行为为网络节点、以各行为之间的关联关系为网络连线,构建利益相关方在既有社区绿色改造中的绿色行为关系网络... 详细信息

为提高既有社区绿色改造水平,探索既有社区绿色改造的驱动路径,基于利益相关方视角,采用社会网络分析法,以利益相关方的绿色行为为网络节点、以各行为之间的关联关系为网络连线,构建利益相关方在既有社区绿色改造中的绿色行为关系网络。使用Ucinet 6软件进行网络中心性分析,识别各利益相关方在既有社区绿色改造中的关键绿色行为和驱动路径,为推动既有社区绿色改造的进一步发展提供参考。

关键词：社会网络分析法利益相关方既有社区绿色改造驱动路径

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Solution-processed top-contact electrodes strategy for organic crystalline field-effect transistor arrays

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Nano Research 2022年第2期15卷 858-863页

作者： Xi Zhang xiaotong zhao Limei Rao Jing Zhang Mingchao Xiao Danlei Zhu Chunlei Li Xiaosong Shi Jie Liu Jie Liu Lang Jiang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of the Chinese Academy of Sciences Beijing 100049China

Organic crystals,especially ultra-thin two-dimensional(2D)ones such as monolayer molecular crystals,are fragile and vulnerable to traditional vacuum *** to now,most of the methods reported for fabricating organic field-effect transistors(OFETs)with top-electrodes on the 2D molecular crystals are based on mechanical-transfer *** method for large scale in-situ electrode deposition is *** this work,the silver mirror reaction(SMR)is introduced to construct top-contact electrodes on 2D organic crystalline thin *** based on bilayer crystalline films with solution-processed silver electrodes show comparable performance to devices with transferred gold *** addition to that,OFETs with SMR fabricated silver electrodes show lower contact resistance than the ones with evaporated silver ***,the temperature under which SMR electrodes annealed is relatively low(60℃),making this approach applicable to varies of organic semiconductors,such as spin-coated polymer films,vacuum evaporated films,2D and even monolayer crystalline ***,OFETs with sub-micrometer channel width and 25μm channel length are realized which might find practical application in the ultra-small pixel mini/micro-LEDs.

关键词： solution processed electrodes top contact organic crystalline thin films organic field-effect transistors

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迟发型多种酰基辅酶A脱氢酶缺乏症3例患儿的临床及遗传学分析

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中华医学遗传学杂志 2024年第7期41卷 790-796页

作者：王梦琴王曦马昂谷裕赵小桐张耀东李东晓陈永兴卫海燕郑州大学附属儿童医院河南省遗传代谢性疾病重点实验室河南省儿童神经发育工程研究中心郑州450018 郑州大学附属儿童医院河南省儿童医院郑州儿童医院东区内分泌遗传代谢科郑州450018

目的探讨3例迟发型(Ⅲ型)多种酰基辅酶A脱氢酶缺乏症(MADD)患儿的临床特征和基因变异特点。方法回顾分析2020年3月至2022年3月就诊于郑州大学附属儿童医院的3例迟发型MADD患儿的临床资料。患儿进行全外显子组测序,针对候选变异进行Sange... 详细信息

目的探讨3例迟发型(Ⅲ型)多种酰基辅酶A脱氢酶缺乏症(MADD)患儿的临床特征和基因变异特点。方法回顾分析2020年3月至2022年3月就诊于郑州大学附属儿童医院的3例迟发型MADD患儿的临床资料。患儿进行全外显子组测序,针对候选变异进行Sanger测序家系验证。对3例患儿进行改善代谢治疗并追踪随访1~3年。结果3例患儿中男2例、女1例,就诊年龄为出生2个月~11岁7个月,例1及例2分别表现为间断呕吐、下肢肌无力,例3为新生儿筛查异常但未发病。3例患儿血串联质谱结果均提示短中长链多种酰基肉碱升高,例1及例2尿气相色谱质谱分析示戊二酸及多种双羧酸升高。3例患儿均检出ETFDH基因复合杂合变异。其中例1携带父源c.1211T>C(p.M404T)变异及母源c.488-22T>G变异,例2携带父源c.1717C>T(p.Q573X)变异及母源c.250G>A(p.A84T)变异,例3携带父源c.1285+1G>A变异及母源c.629A>G(p.S210N)变异。3例患儿均被给予大剂量维生素B2、左卡尼汀及辅酶Q10等改善代谢,辅以低脂、低蛋白及高碳水化合物饮食。随访患儿均病情稳定,生长发育正常。结论ETFDH基因的复合杂合变异可能是Ⅲ型MADD患儿存在反复肌无力、呕吐,短中长链多种酰基肉碱升高,戊二酸及多种双羧酸升高的遗传学病因。

关键词：遗传性疾病迟发型多种酰基辅酶A脱氢酶缺乏症 ETFDH基因血串联质谱尿气相色谱质谱基因变异

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