检索结果-南通市图书馆

Effect and mechanism of Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia through connexin43(cx43)

引用

Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 985-990页

作者： Tao Wu Dan Wu Qinghua Wu Bing Zou Xiao Huang xiaoshu cheng Yanqing Wu Kui Hong Ping Li Department of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang University Jiangxi Health Vocational College

Objective: To explore the effect and mechanism of angiotensin II receptor blockers-Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. Methods: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group. ischemia group. Irbesartan group and Irbesartan+ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43 (Cx43) mRNA and western blot to detect the expression of Cx43 and phosphorylated Cx43. SD rats were randomly divided into the sham-operation group (SO). myocardial infarction group (MI). Irbesartan group and MI+ Irbesartan group, with 10 rats in each group. HE staining was employed to observe the change in the pathomorpholouy of left ventricular tissue and TUNEL method to analyze the cell apoptosis in the tissue. The immunofluorescence was adopted to observe the expression and distribution of Cx43 in the left ventricular myocardium and study the change in the expression of Cx43 in the cardiac muscular tissue at mRNA and protein level. Results: The intervention of lrbesartan in the condition of ischemia indicated the significant decrease in the number of necrotic cells. The expression of Cx43 was significantly decreased under the culture of ischemia (P<0.05), but in the presence of Irbesartan, the expression of Cx43 was increased compared with the ischemia group (p<0.01). The results of WB assay showed the similar trend of change at mRNA level. There was the significant difference in the score of ventricular arerythmia between MI group and SO group (P<0.01). The incidence of ventricular tachycardia or ventricular fibrillation was significantly increased compared with the one in SO group (P<0.05). There was the significant difference in the overall score between MI+Irbesartan group and MI group (P<0.05). The expression of Cx43 in the cardiac muscular tissue in MI group was significantly decreased (P<0.01(US) SO group). But

关键词： Irbesartan Myocardial lschemia Cx43 Connexin Arrhythmias

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathogenesis, diagnosis and treatment of cerebral fat embolism

引用

Chinese Journal of Traumatology 2015年第2期18卷 120-123页

作者： Yihua Zhou Ying Yuan Chahua Huang Lihua Hu xiaoshu cheng Department of ICU the Second Affiliated Hospital to Nanchang University Nanchang 330006 China Department of Cardiology the Second Affiliated Hospital to Nanchang University Nanchang 330006 China

In this study, we analyzed two cases of pure cerebral fat embolism and reviewed related literatures to explore the pathogenesis, clinical manifestations, diagnosis and treatment of cerebral fat embolism, improve the treatment efficiency and reduce the misdiagnosis rate. In our cases, patients fully returned to consciousness at the different times with good prognosis, normal vital signs and without obvious sequelae. For patients with the limb fractures, who developed coma without chest distress, dyspnea or other pulmonary symptoms 12 or 24 h post injury, cerebral fat embolism should be highly suspected, except for those with intracranial lesions, such as delayed traumatic intracerebral hemorrhage, etc. The early diagnosis and comprehensive treatment can improve prognosis.

关键词： Cerebral fat embolism Fractures Coma Nuclear magnetic resonance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stroke in young patients with paroxysmal supraventricular tachycardia: A report on two cases of thromboembolic stroke

Stroke in young patients with paroxysmal supraventricular ta...

引用

中华医学会第十五次全国心血管病学大会

作者： huihui Bao Juxiang Li Jianghua Yu kui Hong xiaoshu cheng the Second Affiliated Hospital of Nanchang University

It is widely acknowledged that atrial fibrillation is an independent predictor of thromboembolic stroke [1] , and that Paroxysmal supraventricular tachycardia (PSVT) is not associated with thromboembolic stroke. There...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A meta-analysis of percutaneous coronary intervention for chronic total coronary occlusions recanalization

A meta-analysis of percutaneous coronary intervention for ch...

引用

中华医学会第十五次全国心血管病学大会

作者： Long Jiang xiaoshu cheng Renqiang Yang Yingli Fan Rui Zhan Lijuan Hu the Second Affiliated Hospital of Nanchang University the First Affiliated Hospital of Nanchang University

Objective To perform an evaluation (meta-analysis) on short-term and long-term prognosis of percutaneous coronary intervention (PCI) for patients with chronic total occlusions (CTO) recanalization. Background Despite advances in procedural techniques and expertise, PCI for CTO recanalization in sele ct patients remains a challenge.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Case Fatality Rate of Patients with Acute Myocardial Infarction in 253 Chest Pain Centers--China,2019-2020

引用

China CDC weekly 2022年第24期4卷 518-521页

作者： Zheng Long Wei Liu Zhenping Zhao Suijun Tong Lijun Wang Maigeng Zhou Dingcheng Xiang Yundai Chen Jianan Wang xiaoshu cheng Bao Li Lang Li Wei Li Bei Shi Hong Shi Peng Yin Kai Huang Yong Huo National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Cardiology General Hospital of the PLA Southern Theater CommandGuangzhou CityGuangdong ProvinceChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchang CityJiangxi ProvinceChina Department of Cardiology the Second Hospital of Shanxi Medical UniversityTaiyuan CityShanxi ProvinceChina Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanning CityGuangxi Zhuang Autonomous RegionChina Department of Cardiology the Affiliated Hospital of Guizhou Medical UniversityGuiyang CityGuizhou ProvinceChina Department of Cardiology Affiliated Hospital of Zunyi Medical UniversityZunyi CityGuizhou ProvinceChina Chinese Medical Association BeijingChina Department of Cardiology Union Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan CityHubei ProvinceChina Department of Cardiology Peking University First HospitalBeijingChina

Summary What is already known about this topic?Acute myocardial infarction(AMI)is the most serious form of cardiovascular *** case fatality rate(CFR)of AMI patients is an important index to reflect the prognosis of *** is added by this report?During the study period,the overall 30-day,60-day,and 90-day CFR of AMI was 5.9%,6.9%,and 7.6%,*** CFRs in gradeⅢhospitals were lower than in gradeⅡhospitals,and the in-hospital CFR was significantly lower than that in post-discharge out-of-hospital.

关键词： cardiovascular Patients prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and Safety of Bivalirudin versus Heparin plus Glycoprotein Ⅱb/Ⅲa inhibitors in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized trials

Efficacy and Safety of Bivalirudin versus Heparin plus Glyco...

引用

中华医学会第十五次全国心血管病学大会

作者： Long jiang xiaoshu cheng Renqiang Yang Yingli Fan Rui Zhan Lijuan Hu The Second Affiliated Hospital of Nanchang University The First Affiliated Hospital of Nanchang University

Background Recently, several randomized trials which compared bivalirudin with heparin plus glycoprote in Ⅱb/Ⅲa inhibitors (GPIs) in patients undergoing percutaneous coronary intervention (PCI) had been publi shed. The purpose of this study was to perform an up-to-date meta-analysis of randomized trials on the effe ctiveness and safety of bivalirudin versus heparin plus GPIs in patients undergoing PCI.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Analysis of SCN5A Mutation in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Analysis of SCN5A Mutation in Patients with Arrhythmogenic R...

引用

中华医学会第十五次全国心血管病学大会

作者： Jinzhu Hu Jianhua Yu Xiyan Dai Hui Zhou Juxiang Li xiaoshu cheng Kui Hong Cardiology Department the Second Affiliated Hospital of Nanchang University

Aim Arrhythmogenic right ventricular cardiomyopathy/Dysplasia (ARVC/D) is a genetically determined disorder, characterized by the two component: cardiomyopathy and arrhythmia. To date, the molecular pathogenesis underly this phenomenon is poorly understood. Whether the ion channel defect involved in the ARVC/D is unknown. The aim of this study was systematically evaluate the sodium channel variants in ARVC/D.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国急性ST段抬高型心肌梗死患者院前应用硝酸甘油或中成药对症状改善及梗死相关动脉血流影响的比较研究

引用

中国循环杂志 2024年第1期39卷 41-47页

作者：赵广玉王朵儿杨进刚鲁晔陶水英程晓曙叶君明贺春晖吴超许海燕乔树宾赵延延王杨李卫高晓津杨跃进中国急性心肌梗死注册研究组中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心北京100037 中国医学科学院北京协和医学院国家心血管病中心阜外医院医学统计部北京102308 南昌大学第二附属医院心血管内科南昌330006 萍乡市人民医院心血管内科萍乡337055 不详

目的:比较中国急性ST段抬高型心肌梗死(STEMI)患者院前应用硝酸甘油或中成药对症状改善及对梗死相关动脉(IRA)血流的影响。方法:依托中国急性心肌梗死注册研究于2013年1月1日至2014年3月31日期间,纳入全国108家医院7 d内发病且明确报告... 详细信息

目的:比较中国急性ST段抬高型心肌梗死(STEMI)患者院前应用硝酸甘油或中成药对症状改善及对梗死相关动脉(IRA)血流的影响。方法:依托中国急性心肌梗死注册研究于2013年1月1日至2014年3月31日期间,纳入全国108家医院7 d内发病且明确报告院前使用或不使用硝酸甘油或中成药的13064例STEMI患者(已排除共用两类药物患者),其中5280例患者接受了急诊冠状动脉造影。对比使用两类药物对患者症状缓解及IRA的TIMI血流分级水平的影响,其中症状缓解包括完全缓解(症状消失)和部分缓解(不同程度缓解)。结果:13064例患者中,2892例(22.1%)院前应用了硝酸甘油或中成药,其中1149例(8.8%)使用了硝酸甘油,1743例(13.3%)使用了中成药,10172例院前未用药。应用硝酸甘油或中成药的患者,6 h内到达医院的比例(57.4%vs.60.8%vs.50.3%,P<0.0010),与使用院前急救系统的比例(11.8%vs.12.2%vs.9.5%,P=0.0004)均高于未用药的患者。使用硝酸甘油的患者部分缓解比例高于使用中成药的患者(33.8%vs.25.1%,P<0.0010)。多因素Logistic分析显示,使用硝酸甘油较使用中成药完全和部分缓解的可能性较高(OR=1.331,95%CI:1.129~1.569,P=0.0007)。使用硝酸甘油或中成药的患者与未用药患者的院内死亡率相似。在接受急诊冠状动脉造影的患者中,使用中成药或硝酸甘油及未用药患者IRA的TIMI血流达到2~3级的比例分别为21.6%、15.8%和19.3%(P=0.0405)。多因素Logistic回归分析显示,与未用药患者相比,使用中成药患者的TIMI血流达到2~3级水平无明显优势(OR=0.856,95%CI:0.705~1.040,P=0.1171),使用硝酸甘油的患者TIMI血流达到2~3级水平可能性降低(OR=0.666,95%CI:0.495~0.895,P=0.0071)。结论:中国约有22.1%的STEMI患者院前单用硝酸甘油或中成药,含服硝酸甘油对症状改善作用优于中成药,与未用药患者相比,应用这两类药物的患者的TIMI血流未见明显改善。

关键词：急性ST段抬高型心肌梗死硝酸甘油中成药症状改善 TIMI血流

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Omega-3 fatty acids for the prevention of atrial fibrillation:a meta-analysis

Omega-3 fatty acids for the prevention of atrial fibrillatio...

引用

中华医学会心电生理和起搏分会第十次全国学术年会

作者： Min Huang,Renqiang Yang,Kui Hong,xiaoshu cheng Department of Cardiology,Second Affiliated Hospital of Nanchang University 330000

Objectives Experimental animal studies suggest that omega-3 fatty acids(n-3 PUFAs) may reduce the risk of atrial fibrillation(AF).However,randomized controlled trials(RCTs) have yielded conflicting *** performed a meta-analysis of all RCTs to assess the role of n-3 PUFA in AF prevention. Methods We systematically searched electronic databases including PubMed MEDLINE, EMBASE,CBM and Cochrane Library for RCTs that reported the effects of n-3 PUFAs on the prevention of AF. Results Seven studies for primary prevention and 6 studies for secondary prevention were included in our *** primary prevention of postoperative AF after cardiac surgery,there was significant heterogeneity among the studies(p=0.07,I

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

心脏植入式电子装置感染预防的研究进展

引用

临床心血管病杂志 2020年第8期36卷 765-767页

作者：王涛鲍慧慧程晓曙南昌大学第二附属医院心内科南昌大学第二附属医院心血管病防治中心江西省心血管疾病临床医学研究中心南昌330006

心脏植入式电子装置应用越来越广泛,但感染率居高不下。感染后不仅影响植入式电子装置的正常工作,而且严重危害患者的生命健康。预防感染发生,降低感染率,一直以来备受重视。本文对目前各种预防感染措施的有效性和不足等进行阐述,旨在... 详细信息

心脏植入式电子装置应用越来越广泛,但感染率居高不下。感染后不仅影响植入式电子装置的正常工作,而且严重危害患者的生命健康。预防感染发生,降低感染率,一直以来备受重视。本文对目前各种预防感染措施的有效性和不足等进行阐述,旨在为预防心脏植入式电子装置感染提供参考。

关键词：心脏植入式电子装置感染预防

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：