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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang Hua Yue Shuang Wang Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

On-surface synthesis and characterization of polyynic carbon chains

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National Science Review 2024年第3期11卷 192-199页

作者： Wenze Gao wei Zheng Luye Sun Faming Kang Zheng Zhou wei Xu Interdisciplinary Materials Research Center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne

Steady-state Voltage Security-constrained Optimal Frequency Control for Weak HVDC Sending-end AC Power Systems

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 658-669页

作者： Qiangqiang Wang Liangzhong Yao Jian Xu Yuping Zheng wei Li wei Wang School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network(Wuhan University) Wuhan 430072China State Key Laboratory of Smart Grid Protection and Control NARI Group Corporation(State Grid Electric Power Research Institute)Nanjing 211106China

Due to the fact that a high share of renewable energy sources(RESs)are connected to high-voltage direct current(HVDC)sending-end AC power systems,the voltage and frequency regulation capabilities of HVDC sending-end AC power systems have *** has resulted in potential system operating problems such as overvoltage and overfrequency,which occur simultaneously when block faults exist in the HVDC *** this study,a steady-state voltage security-constrained optimal frequency control method for weak HVDC sending-end AC power systems is *** integrated virtual inertia control of RESs is employed for system frequency *** dynamic reactive power compensation devices are utilized to control the voltage of all nodes meet voltage security ***,an optimization model that simultaneously considers the frequency and steady-state voltage security constraints for weak HVDC sending-end AC power systems is *** optimal control scheme with the minimum total cost of generation tripping and additional dynamic reactive power compensation required is obtained through the optimization *** are conducted on a modified IEEE 9-bus test system and practical Qing-Yu line commutated converter based HVDC(LCC-HVDC)sending-end AC power system to verify the effectiveness of the proposed method.

关键词： Renewable energy source(RES) high-voltage direct current(HVDC) AC power system optimal frequency control steady-state voltage security dynamic reactive power compensation

Lift-Off Effect of Koch and Circular Differential Pickup Eddy Current Probes

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 283-293页

作者： Guolong Chen Zheng Cao Shuaishuai Zhang Ji wei wei Gao Wuyin Jin School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050China

A flexible or planar eddy current probe with a differential structure can suppress the lift-off noise during the inspection of ***,the extent of the lift-off effect on differential probes,including different coil structures,*** this study,two planar eddy current probes with differential pickup structures and the same size,Koch and circular probes,were used to compare lift-off *** eddy current distributions of the probes perturbed by 0°and 90°cracks were obtained by finite element *** analysis results show that the 90°crack can impede the eddy current induced by the Koch probe even further at relatively low lift-off *** peak-to-peak values of the signal output from the two probes were compared at different lift-off distances using finite element analysis and experimental *** addition,the effects of different frequencies on the lift-off were studied *** results show that the signal peak-to-peak value of the Koch probe for the inspection of cracks in 90°orientation is larger than that of the circular probe when the lift-off distance is smaller than 1.2 *** addition,the influence of the lift-off distance on the peak-to-peak signal value of the two probes was studied via *** indicates that the influence becomes more evident with an increase in excitation *** research discloses the lift-off effect of differential planar eddy current probes with different coil shapes and proves the detection merit of the Koch probe for 90°cracks at low lift-off distances.

关键词： Eddy current testing Differential pickup probe Fractal Koch curve Flexible eddy current probe

Highly homogeneous zero-index metamaterials make devices more compact and perform better

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Light(Science & Applications) 2024年第5期13卷 806-807页

作者： wei-Xiang Jiang State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast University210096 NanjingChina

A highly homogeneous microwave zero-index metamaterial based on high-permittivity SrTiO3 ceramics is demonstrated to realize the small-aperture high-directivity *** a novel technique is a remarkable step forward to de... 详细信息

关键词： ceramics SrTiO3 Highly

Improved Approximation Schemes for Early Work Scheduling on Identical Parallel Machines with a Common Due Date

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Journal of the Operations Research Society of China 2024年第2期12卷 341-350页

作者： wei-Dong Li School of Mathematics and Statistics Yunnan UniversityKunming650504YunnanChina

We study the early work scheduling problem on identical parallel machines in order to maximize the total early work,i.e.,the parts of non-preemptive jobs that are executed before a common due *** preprocessing and constructing an auxiliary instance which has several good properties,for any desired accuracy,we propose an efficient polynomial time approximation scheme with running time O(f(1/ε)n),where n is the number of jobs and f(1/ε)is exponential in 1/ε,and a fully polynomial time approximation scheme with running time O(1/ε^(2m+1)+n)when the number of machines is fixed.

关键词： Scheduling Early work Polynomial time approximation scheme Effcient polynomial time approximation scheme Fully polynomial time approximation scheme

PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan Wang Feng Li Shuang Wang Jiaqi Meng Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

Fixed-Time Antidisturbance Consensus Tracking for Nonlinear Multiagent Systems With Matching and Mismatching Disturbances

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1410-1423页

作者： Xiangmin Tan Chunyan Hu Guanzhen Cao Qinglai wei wei Li Bo Han Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190 School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China IEEE

In this paper,fixed-time consensus tracking for mul-tiagent systems(MASs)with dynamics in the form of strict feed-back affine nonlinearity is addressed.A fixed-time antidistur-bance consensus tracking protocol is proposed,which consists of a distributed fixed-time observer,a fixed-time disturbance observer,a nonsmooth antidisturbance backstepping controller,and the fixed-time stability analysis is conducted by using the Lyapunov theory *** paper includes three main ***,a distributed fixed-time observer is developed for each follower to obtain an estimate of the leader’s output by utilizing the topology of the communication ***,a fixed-time disturbance observer is given to estimate the lumped disturbances for feedforward ***,a nonsmooth antidisturbance backstepping tracking controller with feedforward compensation for lumped disturbances is *** order to mitigate the“explosion of complexity”in the tradi-tional backstepping approach,we have implemented a modified nonsmooth command filter to enhance the performance of the closed-loop *** simulation results show that the pro-posed method is effective.

关键词： Antidisturbance backstepping consensus tracking fixed-time stability multiagent system(MASs) strict feedback affine nonlinear systems.

CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells

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Neural Regeneration Research 2024年第6期19卷 1169-1170页

作者： Li-Na wei Department of Pharmacology University of Minnesota Medical SchoolMinneapolisMNUSA

Retinoic acid(RA),the active metabolite of vitamin A(the retinoids),elicits a wide spectrum of biological activities critical to the development and health of most of the organ systems including the nervous systems(Corcoran et al.,2002).The effects of RA are mediated by two very distinct pathways;the first is manifested in the nucleus by binding to a large family of nuclear RA receptors(RARs)to regulate proper expression of RAtargeted genes.

关键词： canonical spectrum critical

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基于问卷调查的物流实验课教学改革研究

科教文汇 2012年第32期 46-47页

作者：魏晓倩张昕天津师范大学管理学院天津300387

本文首先简述了物流实验课改革的社会背景及调研目的,进而指出了现有物流实验课存在的不足和改进方向,并且通过问卷调查、访谈、上网搜查资料等方法研究,得出物流实验课在内容和形式上存在的不足点,最后提出应以社会企业需求以及学生的... 详细信息

本文首先简述了物流实验课改革的社会背景及调研目的,进而指出了现有物流实验课存在的不足和改进方向,并且通过问卷调查、访谈、上网搜查资料等方法研究,得出物流实验课在内容和形式上存在的不足点,最后提出应以社会企业需求以及学生的兴趣为导向进行改进,综合运用各种课堂形式和教学模式,并改革考试模式。

关键词：物流实验课教学模式改革