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卵巢上皮性癌、输卵管癌和原发性腹膜癌序贯化疗的疗效分析

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中华妇产科杂志 2024年第5期59卷 383-390页

作者：沈晓燕李小平王悦吴燕李艺杨莹超魏丽惠范源唐子倩北京大学人民医院妇产科北京100044 湖南省株洲市中心医院妇科株洲412001

目的探讨卵巢上皮性癌(卵巢癌)、输卵管癌和原发性腹膜癌序贯化疗的疗效。方法回顾性分析1992年1月—2019年1月北京大学人民医院收治的行分期手术或肿瘤细胞减灭术且术后给予辅助化疗的100例铂敏感型卵巢癌、输卵管癌和原发性腹膜癌患者... 详细信息

目的探讨卵巢上皮性癌(卵巢癌)、输卵管癌和原发性腹膜癌序贯化疗的疗效。方法回顾性分析1992年1月—2019年1月北京大学人民医院收治的行分期手术或肿瘤细胞减灭术且术后给予辅助化疗的100例铂敏感型卵巢癌、输卵管癌和原发性腹膜癌患者(分别为90、6、4例)的临床病理资料,根据术后辅助化疗模式不同分为序贯化疗组(70例)、常规化疗组(30例),比较两组患者的临床病理特征、化疗效果、化疗毒副反应及预后。结果(1)临床病理特征:序贯化疗组患者的年龄、肿瘤类型(包括卵巢癌、输卵管癌和原发性腹膜癌)、病理类型、国际妇产科联盟(FIGO)分期、术后残留灶大小、有无新辅助化疗、总化疗疗程数分别与常规化疗组比较,差异均无统计学意义(P均>0.05)。(2)化疗效果:序贯化疗组患者的中位完全缓解(CR)+部分缓解(PR)时间总和为80.0个月(范围:39~369个月),常规化疗组为28.0个月(范围:13~52个月),两组比较,差异有统计学意义(Z=-7.82,P0.05)。(4)预后:随访期内,序贯化疗组、常规化疗组患者的复发率分别为73%(51/70)、100%(30/30),中位复发间隔时间总和分别为70.5个月(范围:19~330个月)、15.0个月(范围:6~40个月),两组分别比较,差异均有统计学意义(P均<0.01)。序贯化疗组70例患者的中位无进展生存(PFS)时间为84.0个月(范围:34~373个月)、中位总生存(OS)时间为87.0个月(范围:45~377个月),常规化疗组分别为30.5个月(范围:14~60个月)、37.5个月(范围:18~67个月),两组分别比较,差异均有统计学意义(P均<0.001)。序贯化疗组患者的3年、5年、10年OS率分别为100%(70/70)、93%(65/70)、21%(15/70),常规化疗组分别为50%(15/30)、3%(1/30)和0,两组分别比较,差异均有统计学意义(P均<0.05)。结论采用序贯化疗可显著延长卵巢癌、输卵管癌和原发性腹膜癌患者的PFS和OS时间,疗效优于常规化疗患者,且毒副反应可控,建议用于卵巢癌、输卵管癌和原发性腹膜癌患者的一线化疗。

关键词：卵巢肿瘤输卵管肿瘤腹膜肿瘤序贯化疗治疗结果

发酵玉米芯多糖、还原糖含量近红外模型的建立

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中国饲料 2024年第7期 101-108页

作者：张燕王园杜涓李施垚郑越王春媛齐景伟安晓萍内蒙古农业大学动物科学学院内蒙古呼和浩特010018 内蒙古自治区草食家畜饲料工程技术研究中心内蒙古呼和浩特010018

本实验旨在应用近红外光谱技术(NIRS)结合化学计量学法快速预测发酵玉米芯中多糖、还原糖含量,为定量检测发酵玉米芯多糖、还原糖含量提供理论依据以及为玉米芯深加工利用提供技术支持。以105份微生物发酵的玉米芯为供试材料,采用苯酚-... 详细信息

本实验旨在应用近红外光谱技术(NIRS)结合化学计量学法快速预测发酵玉米芯中多糖、还原糖含量,为定量检测发酵玉米芯多糖、还原糖含量提供理论依据以及为玉米芯深加工利用提供技术支持。以105份微生物发酵的玉米芯为供试材料,采用苯酚-硫酸法和DNS法分别测定多糖和还原糖含量。利用偏最小二乘法(PLS),通过不同预处方式和不同波长建立发酵玉米芯多糖、还原糖含量的近红外分析模型。结果表明:多糖模型采用标准正态变量变换(SNV)+1阶导数的方法对全谱图进行预处理的效果较好,优化后的模型决定系数(R2)、校正均方根误差(RMSEC)、校准标准差(SEC)分别为0.82、9.28、9.34,其相对分析误差(PRD)为2.37;还原糖模型采用1阶导数+标准正态变量变换(SNV)+去趋势化(Detrend)的方法对全谱图进行预处理的效果较好,优化后的模型决定系数(R2)、校正均方根误差(RMSEC)、校准标准差(SEC)分别为0.84、4.03、4.04,其相对分析误差(PRD)为2.48;预测集决定系数分别为0.85、0.88。本研究构建的NIRS模型校正和交互验证决定系数均较大,相对分析误差均大于2,说明模型预测性能较好,建立的模型有助于发酵玉米芯多糖、还原糖含量活性成分的筛选。

关键词：玉米芯多糖还原糖近红外模型偏最小二乘法

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基于冲击强度的聚丙烯紫外老化构效分析

常州工学院学报 2024年第1期37卷 40-43页

作者：岳桂杰陈奎郑小平张天云兰州城市学院培黎机械工程学院甘肃兰州730070 兰州城市学院信息工程学院甘肃兰州730070

结合FTIR、DSC表征和冲击强度测试,研究紫外老化过程中聚丙烯(PP)结晶度和羰基指数的变化及其对冲击强度的影响,并构建方程进一步分析上述构效关系。结果表明:随着老化时间的延长,PP的冲击强度先因羰基指数和结晶度的增加而快速下降,后... 详细信息

结合FTIR、DSC表征和冲击强度测试,研究紫外老化过程中聚丙烯(PP)结晶度和羰基指数的变化及其对冲击强度的影响,并构建方程进一步分析上述构效关系。结果表明:随着老化时间的延长,PP的冲击强度先因羰基指数和结晶度的增加而快速下降,后因结晶度的减少而减缓进一步下降的速度;PP的结晶度对冲击强度的影响随着老化时间的延长而下降,羰基指数则相反;直到老化325 h左右,PP的结晶度对拉伸强度的影响仍不容忽视。

关键词：聚丙烯紫外老化冲击强度结晶度羰基指数

Cs_(2)TiI_(6):A potential lead-free all-inorganic perovskite material for ultrahigh-performance photovoltaic cells and alpha-particle detection

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Nano Research 2022年第3期15卷 2697-2705页

作者： Peng Zhao Jie Su Yujia Guo Lu Wang Zhenhua Lin yue Hao xiaoping Ouyang Jingjing Chang State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology Shaanxi Joint Key Laboratory of GrapheneSchool of MicroelectronicsXidian University2 South Taibai RoadXi’an 710071China Shaanxi Engineering Research Center of Controllable Neutron Source School of ScienceXijing UniversityXi’an 710123China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China

The lead contamination and long-term stability are the two important problems limiting the commercialization of organic–inorganic lead halide *** this study,through an innovative multi-scale simulation strategy based on the first-principle calculations coupling with drift-diffusion model and Monte Carlo method,a new discovery is shed on the vacancy-ordered double perovskite Cs_(2)TiI_(6),a potential nontoxic and stable perovskite material for high-performance solar cell andα-particle *** excellent photon absorption character and ultrahigh carrier mobility(μn=2.26×10^(4)cm^(2)/Vs,μp=7.38×10^(3)cm^(2)/Vs)of Cs_(2)TiI_(6)induce ultrahigh power conversion efficiency(PCE)for both single-junction solar cell(22.70%)and monolithic all-perovskite tandem solar cell(26.87%).Moreover,the outstanding device performance can be remained even in high energy charge particle detection(α-particle)with excellent charge collection efficiency(CCE=99.2%)and mobility-lifetime product(μτh=1×10^(–3)cm^(2)/V).Furthermore,to our surprise,the solar cell andα-particle detector based on Cs_(2)TiI_(6)material are able to withstand ultrahigh fluence proton beam up to 1013 and 1015 p/cm2 respectively,which strongly suggests that semiconductor devices based on Cs_(2)TiI_(6)material are able to apply in the *** multi-scale simulation connecting from material to device reveals that Cs_(2)TiI_(6)perovskite has the great potential for photovoltaic cells,α-particle detection and even their space application.

关键词： Cs_(2)TiI_(6) first-principle theory drift-diffusion model Monte Carlo method alpha-particle detection

Recent advances in gel polymer electrolyte for high-performance lithium batteries

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Journal of Energy Chemistry 2019年第10期28卷 126-142页

作者： Ming Zhu Jiaxin Wu yue Wang Mingming Song Lei Long Sajid Hussain Siyal xiaoping Yang Gang Sui State Key Laboratory of Organic-Inorganic Composites College of Materials Science and Engineering Beijing University of Chemical Technology

Lithium batteries (LBs) have become increasingly important energy storage systems in our daily life. However, their practical applications are still severely plagued by the safety issues from liquid electrolyte, especially when the batteries are exposed to mechanical, thermal, or electrical abuse conditions. Gel polymer electrolytes (GPEs) are being considered as an effective solution to replace currently available organic liquid electrolyte for building safer LBs. This review provides recent advancements in GPEs applied for high-performance LBs. On the one hand, from the environmental and economic point of view, the skeletons of GPEs changed from traditional polymer to renewable and degradable polymer. On the other hand, in addition to being as a component with good electrochemical and physical characterizations, the GPEs also need to provide some functions for addressing the concerns of lithium (Li) dendrites, unstable cathode electrolyte interface, dissolution and migration of transition metal ions,"shuttle effect" of polysulfides, and so on. Finally, to synchronously meet the challenges from the advanced cathode and Li metal anode, the bio-based GPEs with multi-functionality are proposed to develop high-energy/powerdensity batteries in the future.

关键词： Lithium ion batteries Gel polymer electrolyte Skeleton Functionality

Target-directed isolation and identification of a serum lectin from lamprey (Lampetra japonica) by chromatographys and MALDI-TOF/TOF

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Acta Oceanologica Sinica 2018年第5期37卷 113-116页

作者： HAN Yinglun GOU Meng SONG xiaoping SONG Tao SHI Biyue PANG yue LI Qingwei College of Life Science Liaoning Normal University Dalian 116029 China Lamprey Research Center Liaoning Normal University Dalian 116029 China Affiliated Zhongshan Hospital of Dalian University Dalian 116001 China

A 105-k Da polymer lectin was purified from lamprey（Lampetra japonica） serum by chromatography methods including cation ion-exchange chromatography with a SP-Sepharose TM XL column and size exclusion chromatography with a Superdex 200 column. The target fractions were collected according to the direction of hemagglutinating activity. The results revealed that the active fractions could adsorb on SP-Sepharose column and showed a 280 nm UV absorbance peak corresponding to molecular weights of 105 k Da in the following size exclusion chromatography. The target fractions with hemagglutinating activity were further checked by NativePAGE and SDS-PAGE. Two single bands at around 105 k Da and 35 k Da were displayed by two electrophoresis methods respectively, indicating that the protein exists as a trimer in solution. After Native-PAGE and SDS-PAGE,two bands were excised from the gels respectively and further identified by MALDI-TOF/TOF as serum lectin（gi：13094239）. The lectin was able to agglutinate rabbit red blood cells（RRBCs） and sheep red blood cells（SRBCs） in vitro. The lectin isolated from lamprey serum in the current study might be helpful for deeply understanding the innate immune molecules dependent immune defence in jawless vertebrates which have been proved recently that they possess a lymphocyte-based system of anticipatory immunity with variable lymphocyte receptors as mediators.

关键词： Lampetra japonica lectin purification identification MALDI-TOF/TOF

Adenosine cyclic phosphate with ultrasonic-assisted pectinase extraction alleviated allergic reactions in RBL-2H3 through inhibiting the influx of intracellular Ca^(2+)

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Food Science and Human Wellness 2023年第3期12卷 832-841页

作者： Qiao Bai xiaoping Feng Yu Wang Chunyu Wu Ye Liu Jiao Sun Tianli yue Fangyu Long College of Food Science and Engineering Northwest A&F UniversityYangling 712100China Beijing Key Laboratory of Plant Resource Research and Development Beijing Technology and Business UniversityBeijing 100048China Department of Breast Surgery The Affi liated Hospital of Qingdao UniversityQingdao 266000China

Jujube contains abundant cyclic adenosine monophosphate(cAMP)and the ultrasonic-assisted pectinase extraction(UAPE)conditions for obtaining the maximum cAMP yield from jujube were *** array design was applied to evaluate the effects of 4 variables by UAPE on cAMP *** results showed that the optimal cAMP yield(783.0μg/g)was derived at ratio of liquid to solid 5 mL/g,ratio of pectinase to raw material 1.5%,time 60 min and temperature 40℃.Moreover,the effect of cAMP on the anti-allergic function of action induced by immunoglobulin E(IgE)and its meschanism was investigated through establishing the sensitized cell model in rat basophilic leukemia(RBL-2 H3)cells using dinitrophenylated(DNP)-bovine serum albumin(BSA)-*** results showed that cAMP interfered with sensitized cells,effectively inhibited the occurrence of basophil degranulation in dose dependence,and significantly reduced the activity ofβ-hexosamindase(β-hex),at the optimal concentration of 50μg/*** level of anti-inflammatory factor interleukin-10(IL-10)was promoted and the content of pro-inflammatory factor tumor necrosis factor-α(TNF-α)was suppressed by *** addition,influx of intracellular Ca^(2+) was repressed *** results demonstrate that jujube cAMP regulated the cytokine balance in the allergy pathway through blocking the influx of extracellular Ca^(2+),with the prevention of allergy symptoms.

关键词： Ultrasonic-assisted pectinase extraction Cyclic adenosine monophosphate Rat basophilic leukemia cells Ca^(2+)influx Allergy

Crystal Facet-Dependent Intrinsic Charge Separation on Well-Defined Bi_(4)TaO_(8)Cl Nanoplate for Efficient Photocatalytic Water Oxidation

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Energy Material Advances 2022年第1期2022卷 214-222页

作者： Abraham Adenle Ming Shi xiaoping Tao yue Zhao Bin Zeng Na Ta Rengui Li State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

The development of photocatalysts with wide spectral absorption and high charge separation efficiency has always been a pursued objective for photocatalytic solar energy ***,we reported a wide-range visible-light-active Bi_(4)TaO_(8)Cl(BTOC)single crystal nanoplate with dominating{110}and{001}facets for enhancing the intrinsic charge separation *** selective photodeposition of metals and metal oxides provides evidences of photogenerated electrons and holes spatially separated on{110}and{001}coexposed facets of BTOC,*** intrinsic charge separation efficiency was demonstrated to be closely dependent on the crystal facets,which can be modulated by tuning the coexposed crystal facet *** surface modification of BTOC with suitable dual cocatalyst Ag and RuOx enables remarkable improvement of charge separation efficiency and photocatalytic water oxidation *** by comparison between well-defined BTOC nanoplate and BTOC nanoparticles confirmed the significance of coexposed crystal facets for efficient spatial charge separation and the blocking of reverse reaction from Fe^(2+)to Fe^(3+)ions during water oxidation reaction,indicating that rational modulation of exposed crystal facets is significant for controlling the intrinsic charge separation efficiency on Bi_(4)TaO_(8)Cl photocatalyst for efficient photocatalytic water splitting.

关键词： separation plate spatially

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新入职护士心理护理临床实践体验的质性研究

上海护理 2024年第7期24卷 21-25页

作者：崇月朱晓萍李玉梅王艳波同济大学附属精神卫生中心上海200124 同济大学医学院上海200433 同济大学附属第十人民医院上海200070 同济大学附属肺科医院上海200092

目的通过质性研究的方法探讨新入职护士心理护理临床实践体验,为构建新入职护士心理护理临床培训方案提供实证参考。方法2022年9-12月,采用目的抽样法,选取来自上海市3所三级甲等医院的14名新入职护士进行半结构式深入访谈,采用主题分... 详细信息

目的通过质性研究的方法探讨新入职护士心理护理临床实践体验,为构建新入职护士心理护理临床培训方案提供实证参考。方法2022年9-12月,采用目的抽样法,选取来自上海市3所三级甲等医院的14名新入职护士进行半结构式深入访谈,采用主题分析法对访谈资料进行整理分析。结果围绕新入职护士心理护理实践体验,提炼出3个主题:基于自身需求体会到心理护理的重要性、在患者照护过程中有意识地观察和实践心理护理、对于规范化培训阶段心理护理能力提升存在多方面的培训需求。结论新入职护士能较好意识到临床心理护理的重要性,能够逐渐将心理护理理念融入临床实践,但其自助能力与助人能力均有待提升。护理管理者可结合临床情境案例等,针对新入职护士开展相关培训,促进其心理护理实践技能的临床转化与迁移。

关键词：新入职护士规范化培训心理护理临床实践质性研究