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Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： tao Lei DOU Renjie CHEN Xueming CAO Yu DAI Zhen HU Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

Chapter 28 The Loess Plateau of China:Aeolian Sedimentation and Fluvial Erosion,Both with Superlative Rates

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Chapter 28 The Loess Plateau of China:Aeolian Sedimentation ...

中国科学院地质与地球物理研究所第十届(2010年度)学术年会

作者： xiaoping Yang,tao Liu,and Baoyin Yuan

Loess,draped over various types of bedrock landforms,is found in about 10%of the land surface on *** various loess landscapes in the world,the Loess Plateau of China,located in the middle reaches of the Yellow River,is the largest terrain of continuous and thickest loess sedimentation,offering probably the best terrestrial record for research on Quaternary palaeoclimatic *** to loess deposition,karst landforms formed in Cambrian and Ordovician carbonates, sandstone hills and basins were common in the area of the present-day Loess *** major components of contemporary relief are tablelands(Yuan), long ridges(Liang) and round hills(Mao),all named after local folks’ *** erosion forms, such as gullies and dolines,have been impressively developed in the Loess Plateau,and their formation may have accompanied loess sedimentation for a long time,mostly in the Quaternary but occasionally much *** and collapse processes have been tremendously enhanced during historical times due to strong human impact.

关键词： China gully erosion human activity loess tableland

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民国时期广西瑶族的人权状况

黑龙江民族丛刊 2007年第1期 124-127页

作者：陶小平新疆喀什师范学院法政系新疆喀什844000

新桂系统治广西时期,当局提出“建设广西,复兴中国”的口号,并推行一系列有利于少数民族生存和发展的政策,初步改善了部分瑶族区域的生存状况;由于新桂系实行“三位一体”的集权体制,强制推行民族同化政策,简单粗暴地将少数民族的风俗... 详细信息

新桂系统治广西时期,当局提出“建设广西,复兴中国”的口号,并推行一系列有利于少数民族生存和发展的政策,初步改善了部分瑶族区域的生存状况;由于新桂系实行“三位一体”的集权体制,强制推行民族同化政策,简单粗暴地将少数民族的风俗一概斥之为“陋习”而强行取缔,并不断加重瑶族民众的捐税徭役负担,瑶族民众的生存状态和人权状况并无实质改善。

关键词：民国时期广西瑶族新桂系人权状况

一次大负荷跑台运动后大鼠心脏力-电变化和组织病理学观察

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中国运动医学杂志 2012年第4期31卷 325-330页

作者：陶小平宁波大学体育学院浙江宁波315211

目的:观察一次定量大负荷跑台运动后大鼠心脏心肌力-电变化和心肌组织病理学变化。方法:22只心电图正常SD大鼠随机分为对照组(n=8)和运动组(n=14)。采用BL-420E+型四道生理记录仪连续测定运动组一次定量大负荷跑台运动后0、5、10、20、3... 详细信息

目的:观察一次定量大负荷跑台运动后大鼠心脏心肌力-电变化和心肌组织病理学变化。方法:22只心电图正常SD大鼠随机分为对照组(n=8)和运动组(n=14)。采用BL-420E+型四道生理记录仪连续测定运动组一次定量大负荷跑台运动后0、5、10、20、30、50、70、90、110 min的心电图和左心室收缩功能,并于运动后110 min处死;对照组安静状态麻醉测定心电图和左心室收缩功能,麻醉后110 min处死。取材行心肌苏木精-伊红染色。根据运动后的心电变化,又将运动组分为心电异常组(ST段下压为异常,n=8)和心电无异常组(n=6)。结果:(1)大负荷运动后心电异常组大鼠左心室心肌收缩压和最大上升速率的时相变化不同步,运动后20和70 min心肌收缩力出现阶段性低值,而运动后15、90 min时+dp/dtmax出现阶段性低值,运动后110 min均恢复正常。(2)运动后心电异常组心电图出现T波倒置或低平、ST-T下移、J点下移等现象,T波和J点值均在运动后15、50min出现阶段性低值,T波运动后110 min恢复,接近正常,而J点值尚未完全恢复。(3)三组苏木精-伊红染色评分,两两组间比较均无显著性差异。结论:大负荷运动后大鼠心肌组织染色未见病理性改变,大鼠恢复期心脏力-电变化表现为短时可逆性心肌收缩功能障碍和心电异常变化。

关键词：大负荷运动心电图收缩功能 HE染色

我国优秀男子划艇运动员“能力主导型”高原训练期间机能指标变化

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天津体育学院学报 2010年第2期25卷 130-133页

作者：陶小平陶新连绍兴文理学院体育学院绍兴312000 上海思强体育场馆管理有限公司网球部上海200072

目的:探讨"能力主导型"高原训练期间运动员机能指标变化规律。方法:以12名国家男子划艇运动员为研究对象,在高原训练期间各阶段进行身体机能测试与分析。结果:(1)高原上各周WBC值都在正常范围内处在较低水平;(2)高原上训练Hb先呈显著性... 详细信息

目的:探讨"能力主导型"高原训练期间运动员机能指标变化规律。方法:以12名国家男子划艇运动员为研究对象,在高原训练期间各阶段进行身体机能测试与分析。结果:(1)高原上各周WBC值都在正常范围内处在较低水平;(2)高原上训练Hb先呈显著性升高后下降,Hct一直高于高原前;(3)高原第2周EPO显著性升高之后下降;(4)CK、BUN随力量课和跑步总量变化;高原第1周运动员的T/C值显著升高。结论:(1)"能力主导型"高原训练应密切监控WBC水平;(2)"能力主导型"高原训练没有提高运动员血液携氧能力;(3)BUN、CK值与陆上训练量的变化关系密切,可以用这两项指标反映运动员对陆上训练总量的适应情况。

关键词：高原训练男子划艇机能指标能力主导

Photo-induced self-formation of dual-cocatalysts on semiconductor surface

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Chinese Journal of Catalysis 2018年第11期39卷 1730-1735页

作者： Linchao Mu Qiao Zhang xiaoping tao Yue Zhao Shengyang Wang Junyan Cui Fengtao Fan Can Li State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energyand the Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Cocatalyst plays key roles in photogenerated charge separation and surface catalytic reactions in ***,it is not clear if the chemical states of cocatalysts changed or remains unchanged under photocatalytic reaction ***,taking Natao3 as an example,we systemically investigated the chemical states of nickel‐based cocatalysts during photocatalytic water splitting *** was found that photo‐induced self‐formation of Ni and NiO cocatalyst species take place on the surface of Natao3 *** self‐formation of dual‐cocatalysts not only occurs on 26‐facet Natao3,but also takes place on a more general 6‐facet *** work clarified that the chemical states of cocatalysts are changing and the redox dual‐cocatalysts are redistributed on the semiconductor surface owing to the reaction induced by photogenerated charges under the condition of photocatalytic reactions.

关键词： Photocatalysis Cocatalyst Chemical state Photogenerated charges Self‐formation

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美国7个图书馆员职业能力标准的比较分析

图书情报工作 2016年第24期60卷 14-19页

作者：盛小平陶倩华南师范大学经济与管理学院广州510006

[目的/意义]比较分析美国7个专门的图书馆职业能力标准,以发现其核心要素与主要条款。[方法/过程]在解析美国7个专门的图书馆职业能力标准内容基础上,比较分析各能力标准的适用对象、要素与条款的差异。[结果/结论]研究发现,7个能力标... 详细信息

[目的/意义]比较分析美国7个专门的图书馆职业能力标准,以发现其核心要素与主要条款。[方法/过程]在解析美国7个专门的图书馆职业能力标准内容基础上,比较分析各能力标准的适用对象、要素与条款的差异。[结果/结论]研究发现,7个能力标准各自定义了与众不同的用户;这些能力标准由组织管理、馆藏资源管理、营销与推广、交流技能、领导与规划、用户服务、职业素养、评估技能、信息技术、合作技能、教学技能、研究技能、客户知识、知识基础、职业发展、学科技能、课程知识、演讲技能18个能力要素组成;且同时出现在4个以上能力标准中的要素所定义的能力对于不同标准而言有明显的差异。

关键词：图书馆员职业能力标准美国

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基于相位测量偏折术的反射镜三维面形测量

光学学报 2016年第2期36卷 101-107页

作者：袁婷张峰陶小平付锦江中国科学院长春光学精密机械与物理研究所中国科学院光学系统先进制造技术重点实验室吉林长春130033 中国科学院大学北京100049

基于相位测量偏折术(PMD)测量原理,提出了一种简单、可靠、精度高的三维面形检测新方法,可以运用于非球面反射镜精磨与粗抛光阶段的面形检测。所提检测方法通过利用入射光线、小孔坐标,以及虚拟的辅助表面来得到待测反射镜面的绝对高度... 详细信息

基于相位测量偏折术(PMD)测量原理,提出了一种简单、可靠、精度高的三维面形检测新方法,可以运用于非球面反射镜精磨与粗抛光阶段的面形检测。所提检测方法通过利用入射光线、小孔坐标,以及虚拟的辅助表面来得到待测反射镜面的绝对高度和梯度。测量时,在CCD相机前放置一个小孔光阑来实现小孔成像模型,并以该小孔的位置作为相机的位置,同时利用相移法并通过移动LCD显示屏一次,获得摄像机上每个像素点所对应的入射光线。该方法对实验设备的位置无特殊要求,不需要辅助器件,检测过程简单,检测结果可靠。而且,该检测方法采用虚拟的辅助表面对反射镜面进行检测而不是采用入射光线与反射光线的交点,不需要对相机光线进行标定,检测结果受标定误差的影响很小,所以该检测方法具有很高的检测精度。计算机仿真与初步实验验证了该方法的可行性。

关键词：测量光学检测高精度相位测量偏折术数字相移条纹反射

Surface assembly of cobalt species for simultaneous acceleration of interfacial charge separation and catalytic reactions on Cd_(0.9)Zn_(0.1)S photocatalyst

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Chinese Journal of Catalysis 2021年第6期42卷 1004-1012页

作者： Khakemin Khan Lifen Xu Ming Shi Jiangshan Qu xiaoping tao Zhaochi Feng Can Li Rengui Li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian National Laboratory for Clean EnergyDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Although photocatalytic water splitting has excellent potential for converting solar energy into chemical energy,the challenging charge separation process and sluggish surface catalytic reactions significantly limit progress in solar energy conversion using semiconductor ***,we demonstrate a feasible strategy involving the surface assembly of cobalt oxide species(CoO_(x))on a visible-light-responsive Cd_(0.9)Zn_(0.1)S(CZS)photocatalyst to fabricate a hierarchical CZS@CoO_(x) *** unique hierarchical structure effectively accelerates the directional transfer of photogenerated charges,reducing charge recombination through the smooth interfacial heterojunction between CZS and CoO_(x),as evidenced by photoluminescence(PL)spectroscopy and various electrochemical *** surface cobalt species on the CZS material also act as efficient cocatalysts for photocatalytic hydrogen production,with activity even higher than that of noble *** well-defined CZS@CoO_(x) heterostructure not only enhances the interfacial separation of photoinduced charges,but also improves surface catalytic *** leads to superior photocatalytic performances,with an apparent quantum efficiency of 20%at 420 nm for visible-light-driven hydrogen generation,which is one of the highest quantum efficiencies measured among noble-metal-free *** work presents a potential pathway for controlling complex charge separation and catalytic reaction processes in photocatalysis,guiding the practical development of artificial photocatalysts for successful transformation of solar to chemical energy.

关键词： Hierarchical heterostructure Interfacial charge separation Surface reaction Photocatalytic hydrogen evolution