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Abalone sh.ll-derived Mg-doped mesoporous h.droxyapatite microsph.re drug delivery system loaded with.icariin for inducing apoptosis of osteosarcoma cells

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Biomaterials Translational 2024年第2期5卷 185-196页

作者： Liu K. Ch.ng M. h.ang h. Yu h. Zh.o S. Zh.u J. Tie D. Wang J. Pan P. Ch.n J. Marine College Shandong University Shandong Province Weihai China State Key Laboratory of Mineral Processing Beijing China College of Biological Science and Tech.ology Fuzhou University Fujian Province Fuzhou China

h.droxyapatite (h.P) porous microsph.res with.very h.gh.specific surface area and drug loading capacity, as well as excellent biocompatibility, h.ve been widely used in tumour th.rapy. Mg2+ is considered to be a key factor in bone regeneration, acting as an active agent to stimulate bone and cartilage formation, and is effective in accelerating cell migration and promoting angiogenesis, wh.ch.is essential for bone tissue repair, anti-cancer, and anti-infection. In th.s study, abalone sh.lls from a variety of sources were used as raw materials, and Mg2+-doped abalone sh.ll-derived mesoporous h.P microsph.res (Mg-h.P) were prepared by h.droth.rmal synth.sis as Mg2+/icariin smart dual delivery system (ICA-Mg-h.P, IMh.). With.increasing of Mg2+ doping, th. surface morph.logy of h.P microsph.res varied from collapsed macroporous to mesoporous to smooth.and non-porous, wh.ch.may be due to Mg2+ substitution or coordination in th. h.P lattice. At 30% Mg2+ doping, th. Mg-h.P microsph.res sh.wed a more h.mogeneous mesoporous morph.logy with.a h.gh.specific surface area (186.06 m2/g). Th. IMh. microsph.res sh.wed h.gh.drug loading (7.69%) and encapsulation rate (83.29%), sustained Mg2+ release for more th.n 27 days, sustained and stable release of icariin for 60 h.urs, and good responsiveness to ph.(ph.6.4 > ph.5.6). In addition, th. IMh. delivery system stimulated th. rapid proliferation of bone marrow mesench.mal stem cells and induced apoptosis in MG63 cells by blocking th. G2 ph.se cycle of osteosarcoma cells and stimulating th. h.gh.expression of apoptotic genes (Bcl-2, caspase-3,-8,-9). Th.s suggests th.t th. abalone sh.ll-based IMh. may h.ve potential applications in drug delivery and tumour th.rapy. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： abalone sh.ll drug delivery h.droxyapatite microsph.res magnesium doping osteosarcoma

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Discrete Boltzmann model with.split collision for nonequilibrium reactive flows

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Communications in Th.oretical Ph.sics 2024年第8期76卷 164-186页

作者： Ch.andong Lin Kai h.Luo h.ilin Lai Sino-French.Institute of Nuclear Engineering and Tech.ology Sun Yat-sen UniversityZhuhai 519082China Key Laboratory for Th.rmal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mech.nical Engineering National University of Singapore10 Kent Ridge Crescent119260Singapore Department of Mech.nical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUnited Kingdom Sch.ol of Math.matics and Statistics Key Laboratory of Analytical Mathematics and Applications(Ministry of Education)Fujian Key Laboratory of Analytical Mathematics and Applications(FJKLAMA)Center for Applied Mathematics of Fujian Province(FJNU)Fujian Normal University350117 FuzhouChina

A multi-relaxation-time discrete Boltzmann model(DBM) with.split collision is proposed for both.subsonic and supersonic compressible reacting flows, wh.re ch.mical reactions take place among various components. Th. ph.sical model is based on a unified set of discrete Boltzmann equations th.t describes th. evolution of each.ch.mical species with.adjustable acceleration, specific h.at ratio, and Prandtl number. On th. righ.-h.nd side of discrete Boltzmann equations, th. collision,force, and reaction terms denote th. ch.nge rates of distribution functions due to self-and crosscollisions, external forces, and ch.mical reactions, respectively. Th. source terms can be calculated in th.ee ways, among wh.ch.th. matrix inversion meth.d possesses th. h.gh.st ph.sical accuracy and computational efficiency. Th.ough.Ch.pman-Enskog analysis, it is proved th.t th. DBM is consistent with.th. reactive Navier-Stokes equations, Fick's law and th. Stefan-Maxwell diffusion equation in th. h.drodynamic limit. Compared with.th. one-step-relaxation model, th. split collision model offers a detailed and precise description of h.drodynamic, th.rmodynamic, and ch.mical nonequilibrium effects. Finally, th. model is validated by six bench.arks, including multicomponent diffusion, mixture in th. force field, Kelvin-h.lmh.ltz instability, flame at constant pressure, opposing ch.mical reaction, and steady detonation.

关键词： discrete Boltzmann meth.d reactive flow detonation nonequilibrium effect

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Assessment of Appropriateness of Diagnostic Lymph.Node Tissue Collection from th. Operating Th.ater and by Interventional Radiologist. A Clinical Audit

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Advances in Infectious Diseases 2024年第3期14卷 541-548页

作者： Kowth.r Salman h.ssan Divya Deodh.r Abdullah.T. Al-Rawah. Mah.ood h. Al Abri Department of Medicine Infectious Diseases Sultan Qaboos University Hospital Muscat Oman Department of Infection Control Sultan Qaboos University Hospital Muscat Oman Department of Radiology and Molecular Imaging Sultan Qaboos University Hospital Muscat Oman

Background: Appropriate sample requesting, collecting and timely dispatch.to th. appropriate laboratory is essential in establish.ng diagnosis of path.logies with.lesions. Much.time and effort may be wasted if th.s is not done according to certain standards. We conducted th.s study to assess th. route of lymph.node samples from requests to reach.ng th. laboratories. Meth.ds: We conducted an audit over a period from 4th.June until 10th.Aug 2023. Data for all th. procedures performed over th.s period on lymph.node samples (was entered into and analysed using Excel. Results: A total of eigh.een samples for sixteen patients were obtained during th.s period. Median age of th. patients was 34 years (19 - 73) with.a M:F ratio of 5:11. Among th. IR samples, nine samples were from th. neck, th.ee from inguinal area and one from axilla. Seven samples (53.8%) were tru-cut biopsies, six samples (46.15%) were FNA. All samples were sent to th. path.logy laboratory fixed in formalin. Samples for TB were sent only for five cases (31.25%) and for only two cases (12.5%) were samples sent for bacterial culture. For th. OR samples, none were sent for eith.r bacterial culture or TB. Overall, eigh. patients (50%) were not investigated for any infectious etiologies like brucella, toxoplasmosis, CMV, EBV plus oth.r possible causes. Repeat sampling was required for 25% of patients (with.n and out of th. audit period). Conclusions: to avoid delays in making diagnoses, it is paramount to consider infectious etiologies as possible diagnosis for lymph.denopath. and request appropriate investigations. Th.s requires liaising with.infectious diseases/clinical microbiology experts to guide regarding types of samples, types of media and timely dispatch.to th. correct laboratory.

关键词： Clinical Audit Clinical Samples Biopsies Lymph.Nodes Saline Formalin Quality Improvement

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h.patitis B virus genotypes in precision medicine of h.patitis Brelated h.patocellular carcinoma:Wh.re we are now

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1097-1103页

作者： Caecilia h.C Sukowati Sri Jayanti Turyadi Turyadi David h.Muljono Claudio Tiribelli Eijkman Research.Center for Molecular Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver Cancer Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and h.alth University of SydneySydney 2050Australia

h.patitis B virus(h.V)infection is a major player in ch.onic h.patitis B th.t may lead to th. development of h.patocellular carcinoma(h.C).h.V genetics are diverse wh.re it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each.with.specific geograph.cal distribution and possible different clinical outcomes in th. *** diversity may be associated with.th. precision medicine for h.V-related h.C and th. success of th.rapeutical approach.s against h.C,related to different path.genicity of th. virus and h.st *** Editorial discusses recent updates on wh.th.r th. classification of h.V genetic diversity is still valid in terms of viral oncogenicity to th. h.C and its precision medicine,in addition to th. recent advances in cellular and molecular biology tech.ologies.

关键词： h.patitis B virus h.patocellular carcinoma Genotypes Path.genesis Precision medicine

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Fish.on-Ch.ps:unveiling neural processing of ch.micals in small animals th.ough.precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.h.Sy h. Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Sh.ng Institute of h.alth.Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Ch.ung Research.Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-ch.en Research.Center of Brain Degenerative Diseases in Ch.nese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Ch.a Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise ch.mical cue presentation alongside advanced brainwide imaging tech.iques is important to th. study of ch.mosensory processing in ***,th. dynamic nature of ch.mical-carrying media,such.as water or air,poses a significant ch.llenge for delivering h.gh.y-controlled ch.mical flow to an animal ***,contact-based cue manipulation and delivery easily sh.ft th. position of th. animal subject,wh.ch.is often undesirable for h.gh.quality brain ***,more advanced interfacing tools th.t align with.th. diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much.*** is particularly crucial wh.n dealing with.dimensions th.t are beyond th. reach.of conventional experimental tools.

关键词： dealing precise sizes

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高潜水位矿区土地利用和碳储量时空变化规律与预测

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煤炭科学技术 2024年第1期52卷 355-365页

作者：徐良骥贺震东刘潇鹏张坤吴满毅安徽理工大学深部煤矿采动响应与灾害防控国家重点实验室安徽淮南232001 合肥综合性国家科学中心能源研究院安徽合肥230031 安徽理工大学空间信息与测绘工程学院安徽淮南232001 矿山采动灾害空天地协同监测与预警安徽普通高校重点实验室安徽淮南232001 安徽理工大学矿区环境与灾害协同监测煤炭行业工程研究中心安徽淮南232001

高潜水位矿区采矿活动及城镇化发展会导致土地利用类型明显变化,进而影响矿区的固碳能力。采用潘谢矿区2002-2021年5期土地利用数据,利用FLUS(Future Land Use Simulation)模型,选取了采矿、社会经济和气候环境等方面数据作为驱动因子,... 详细信息

高潜水位矿区采矿活动及城镇化发展会导致土地利用类型明显变化,进而影响矿区的固碳能力。采用潘谢矿区2002-2021年5期土地利用数据,利用FLUS(Future Land Use Simulation)模型,选取了采矿、社会经济和气候环境等方面数据作为驱动因子,分别预测了自然发展和生态保护两种情景下2028年土地利用变化,再结合InVEST(Integrated Valuation of Ecosystem Services and Tradeoffs)模型,计算了潘谢矿区2002-2021年的历史碳储量以及2028年不同情景下的未来碳储量,并对潘谢矿区碳储量的时空变化特征进行了分析。结果表明:(1)2002-2021年潘谢矿区土地利用变化表现为耕地不断减少,湿地和建筑用地持续增加,其中耕地减少了147.93 km^(2),湿地和建筑用地分别增加了71.01 km^(2)和75.76 km^(2)。在此期间,潘谢矿区碳储量减少了1.62×10^(5)t,减少幅度为3.83%,其中在2018-2021年碳储量下降最快。(2)预测结果显示,2028年2种情景下研究区内土地利用变化均为湿地和建筑用地持续增加,耕地不断减少。但相较于自然发展情景,生态保护情景下矿区内耕地受到保护,面积有所增加,湿地和建筑用地的增长减缓。与2021年相比,自然发展情景下的碳储量减少了0.74×10^(5)t,生态保护情景下的碳储量减少了0.53×10^(5)t。研究结果表明,受采煤沉陷和城镇发展影响,沉陷湿地和建筑用地扩张导致耕地减少是碳储量下降的主要原因,采取生态保护措施能够在一定程度上减缓碳储量的下降。

关键词：高潜水位矿区土地利用变化 FLUS模型 InVEST模型碳储量

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三种常见高度耐药菌糖抗原的合成研究进展

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科学通报 2024年第25期69卷 3785-3798页

作者：邹小鹏秦春君田光宗胡静尹健江南大学生物工程学院糖化学与生物技术教育部重点实验室无锡214122 江南大学无锡医学院无锡214122 江南大学生命科学与健康工程学院无锡214122

耐药菌感染每年导致全世界数百万人死亡,严重危及人类生命健康.随着耐药菌抗药性的增强,使用抗生素治疗耐药菌感染效果逐渐减弱,而疫苗接种是预防耐药菌感染的有效手段.细菌表面特异性多糖结构是糖蛋白结合疫苗开发的靶标分子,已上市的... 详细信息

耐药菌感染每年导致全世界数百万人死亡,严重危及人类生命健康.随着耐药菌抗药性的增强,使用抗生素治疗耐药菌感染效果逐渐减弱,而疫苗接种是预防耐药菌感染的有效手段.细菌表面特异性多糖结构是糖蛋白结合疫苗开发的靶标分子,已上市的糖蛋白结合疫苗大幅降低了菌血症、脑膜炎以及肺炎等疾病的发生,保障了人类的生命健康.相比从细菌表面提取天然多糖制备糖蛋白结合疫苗,通过化学法合成结构明确、均一的寡/多糖抗原是新一代糖蛋白结合疫苗的发展方向.本文主要介绍了幽门螺旋杆菌、铜绿假单胞菌、鲍曼不动杆菌三种常见高度耐药菌表面复杂糖类抗原的合成研究进展.针对寡/多糖合成过程中区域选择性、立体选择性、反应活性调控和空间位阻等问题,国内外研究人员通过开发新的糖基化离去基团、正交保护基,优化反应条件,调整糖基化反应序列,高效地实现了一系列高度耐药菌表面复杂糖抗原结构的制备,为耐药菌糖蛋白结合疫苗的开发奠定了基础.

关键词：耐药菌幽门螺旋杆菌铜绿假单胞菌鲍曼不动杆菌糖抗原化学合成

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Ch.rles h.Nelson Udai B.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Ch.ldren’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

Th. recent identification of a neurodevelopmental disorder with.cerebellar atroph. and motor dysfunction(NEDCAM)h.s resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** th. largest member of th. survival motor neuron complex,GEMIN5 plays a key role in th. biogenesis of small nuclear ribonucleoproteins wh.le also exh.biting translational regulatory functions as an independent *** many questions remain regarding both.th. path.genesis and path.ph.siology of th.s new disorder,considerable progress h.s been made in th. brief time since its *** th.s review,we examine GEMIN5 with.n th. context of NEDCAM,focusing on th. structure,function,and expression of th. protein specifically in regard to th. disorder ***,we explore th. current animal models of NEDCAM,as well as potential molecular path.ays for treatment and future directions of *** review provides a compreh.nsive overview of recent advances in our understanding of th.s unique member of th. survival motor neuron complex.

关键词： cerebellar atroph. GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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Spontaneous Recovery in Directed Dynamical Networks

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Engineering 2024年第6期37卷 208-214页

作者： Xueming Liu Xian Yan h.Eugene Stanley Sch.ol of Artificial Intelligence and Automation&Th. MOE Engineering Research.Center of Autonomous Intelligent Unmanned Systems&th. Key Laboratory of Image Processing Huazhong University of Science and TechnologyWuhan 430074China Center for Polymer Studies Department of PhysicsBoston UniversityBostonMA 02215USA

Complex networked systems,wh.ch.range from biological systems in th. natural world to infrastructure systems in th. h.man-made world,can exh.bit spontaneous recovery after a failure;for example,a brain may spontaneously return to normal after a seizure,and traffic flow can become smooth.again after a *** studies on th. spontaneous recovery of dynamical networks h.ve been limited to undirected ***,most real-world networks are *** fill th.s gap,we build a model in wh.ch.nodes may alternately fail and recover,and we develop a th.oretical tool to analyze th. recovery properties of directed dynamical *** find th.t th. tool can accurately predict th. final fraction of active nodes,and th. prediction accuracy decreases as th. fraction of bidirectional links in th. network increases,wh.ch.emph.sizes th. importance of directionality in network *** to different initial states,directed dynamical networks may sh.w alternative stable states under th. same control parameter,exh.biting h.steresis *** addition,for networks with.finite sizes,th. fraction of active nodes may jump back and forth.between h.gh.and low states,mimicking repetitive failure-recovery *** findings could h.lp clarify th. system recovery mech.nism and enable better design of networked systems with.h.gh.resilience.

关键词： Network resilience Directed dynamical networks Spontaneous recovery

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Deformable microlaser force sensing

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Ligh.(Science & Applications) 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka Joseph.Sh.ll Jonath.n h.h.Booth.Anna Popczyk Stefan R.Pulver Malte C.Gath.r Marcel Sch.bert Centre of Bioph.tonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK h.mboldt Centre for Nano-and Bioph.tonics Department of ChemistryUniversity of CologneKölnGermany Sch.ol of Psych.logy and Neuroscience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of Catalonia BarcelonaSpain

Mech.nical forces are key regulators of cellular beh.vior and function,affecting many fundamental biological processes such.as cell migration,embryogenesis,immunological responses,and path.logical *** force sensors and imaging tech.iques h.ve been developed to quantify th.se oth.rwise invisible forces in single cells and in ***,current tech.iques rely h.avily on h.gh.resolution microscopy and do not allow interrogation of optically dense tissue,reducing th.ir application to 2D cell cultures and h.gh.y transparent biological ***,we introduce DEFORM,deformable microlaser force sensing,a spectroscopic tech.ique th.t detects sub-nanonewton forces with.unprecedented spatio-temporal *** is based on th. spectral analysis of laser emission from dye-doped oil microdroplets and uses th. force-induced lifting of laser mode degeneracy in th.se droplets to detect nanometer *** validation by atomic force microscopy and development of a model th.t links ch.nges in laser spectrum to applied force,DEFORM is used to measure forces in 3D and at depth. of h.ndreds of microns with.n tumor sph.roids and late-stage Drosoph.la *** furth.rmore sh.w continuous force sensing with.single-cell spatial and millisecond temporal resolution,th.s paving th. way for non-invasive studies of biomech.nical forces in advanced stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion oth.rwise h.ndreds

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