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Animal biodistribution, safety and validation study of dopamine transporter PET imaging agent ^(18)F-FECNT

Nuclear Science and Techniques 2009年第1期20卷 11-16页

作者： WANG Songpei CHEN Zhengping li xiaomin TANG Jie liU Chunyi ZOU Meifen PAN Donghui LU Chunxiong XU Yuping XU Xijie ZHOU Xingqin JIN Jian The Key Laboratory of Nuclear Medicine Ministry of Health PRC Jiangsu Institute of Nuclear Medicine Wuxi 214063 PR China School of Medicine and Pharmaceutics Jiangnan University Wuxi 214122 PR China

This work was to investigate the pharmacologic characteristics of 18F-FECNT (2β-carbomethoxy-3β- (4-chlorophenyl)-8-(2-[18F]fluoroethyl)nortropane) as a dopamine transporter (DAT) PET imaging agent. Its partition coefficients were determined in n-octanol and phosphate buffer (PB) (pH 7.0 and pH 7.4). 6-Hydroxydopamine (6-OHDA) left-sided lesioned Parkinsonian rats were established and validated by rotational behavior tests. Biodistribution in vivo in mice, autoradiography in normal and hemi-Parkinsonian rat brains, and toxicity test were performed. The results showed that partition coefficients were 34.14 (pH 7.0) and 56.41 (pH 7.4), respectively. Biodistribution exhibited rapid uptake and favorable retention in the mice brains. The major radioactivity was metabolized by the hepatic system. The autoradiography showed that 18F-FECNT was highly concentrated in striatum, and that the left and the right striatal uptake were symmetrical in normal SD rat brains. In left-sided lesioned PD rat brains, the striatal uptake of 18F-FECNT bilaterally decreased in comparison with normal rats. No significant uptake was visible in the 6-OHDA lesioned-sided striatal areas. The results demonstrated that 18F-FECNT binds to DAT was specific. Toxicity trial displayed that the acceptable dose per kilogram to mice was 625 times greater than that to human. These indicate that 18F-FECNT is a potentially safe and useful DAT PET imaging agent in the brain.

关键词： DAT PET ^18F-FECNT PD 原子核

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Electrically driven motion, destruction, and chirality change of polar vortices in oxide superlattices

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 77-84页

作者： Pan Chen Congbing Tan Zhexin Jiang Peng Gao Yuanwei Sun lifen Wang Xiaomei li Ruixue Zhu Lei liao Xu Hou Ke Qu Ning li xiaomin li Zhi Xu Kaihui liu Wenlong Wang Jinbin Wang Xiaoping Ouyang Xiangli Zhong Jie Wang Xuedong Bai Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China International Center for Quantum Materials Electron Microscopy LaboratorySchool of PhysicsPeking UniversityBeijing 100871China Hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and ElectronicsHunan University of Science and TechnologyXiangtan 411201China Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Collaborative Innovation Center of Quantum Matter Beijing 100871China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China State Key Laboratory for Artificial Microstructure&Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China

Topological polar vortices, which are electric analogs of magnetic objects, present great potential in applications of future nanoelectronics because of their nanometer size, anomalous dielectric response, and chirality. To enable the functionalities, it is prerequisite to manipulate the polar states and chirality by using external stimuli. Here, we probe the evolutions of polar state and chirality evolutions of topological polar vortices in Pb TiO;/Sr TiO;superlattices under an electric field by using atomically resolved in situ scanning transmission electron microscopy and phase-field simulations. We find that, under electric field, the chiral vortex cores can be moved laterally to form close-pair structures, transform into a/c domain stripes, and finally become a nonchiral c-domain. Such transition is reversible and spontaneous after bias removal. Interestingly, during switching and backswitching events, the vortex rotation can be changed, offering a potential strategy to manipulate vortex chirality. The revealed dynamic behavior of individual polar vortices at the atomic scale provides fundamentals for future device applications.

关键词： chirality polar vortex ferroelectrics in situ transmission electron microscopy phase-field simulations

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Interfacial Assembly Directed Unique Mesoporous Architectures:From Symmetric to Asymmetric

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Accounts of Materials Research 2020年第1期1卷 100-114页

作者： Tiancong Zhao liang Chen Runfeng lin Pengfei Zhang Kun Lan Wei Zhang xiaomin li Dongyuan Zhao Department of Chemistry Laboratory of Advanced Materials and Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of PolymersCollaborative Innovation Center of Chemistry for Energy Materials(2011-iChEM)Fudan UniversityShanghai 200433P.R.China

CONSPECTUS:Functional mesoporous materials have experienced flourishing developments over the past 30 years,and they are now a big family including large variety of compositions and *** to large surface area,high pore volume,tunable pore size,and unique mesostructures,mesoporous nanomaterials have been widely used in catalysis,energy conversion and storage,drug delivery,*** of the various methods of architecting mesoporous materials,the soft-templating method that allows regulating the architecture by tuning the assembly process,is used mostly for fabricating mesoporous *** soft templating methods,amphiphilic surfactants and precursors assemble into“soft”micelles,and micelles further assemble into mesoporous ***,micelles homogeneously nucleate and assemble into mesoporous *** a homogeneous assembly process naturally leads to“routine”structures such as nanospheres or other symmetric *** of nanoparticles during the micelle assembly process results in conventional core@shell structures,which though combining the mesoporous shell and functional core,is still ***,growing demands in diverse applications urgently require mesoporous nanomaterials with novelty in mesostructures,compositions,surface properties,morphologies,functionalities,***,researchers have been seeking to gain better control of the micelles’assembly process,pursuing the synthesis of mesoporous nanomaterials with unique architectures,especially morphology,mesostructure,surface chemistry,***,the effect of“interface”during micelles’assembly process has aroused great *** introduction of an interface into the reaction system turns the micelles’homogeneous assembly into a heterogeneous one,altering their assembly behavior and thus leading to mesoporous nanomaterials with unique *** manipulation of the interfacial-assembly behavior of micelles,a series of mesoporous nanomaterials wi

关键词： materials. interfacial symmetric

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玉米秆热解的最概然机理

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化工学报 2012年第8期63卷 2599-2605页

作者：李小民林其钊中国科学技术大学热科学与能源工程系安徽合肥230026

引言我国秸秆原料年产能约为7亿吨,约合3.5亿吨标准煤,包括玉米秆、麦秆和稻草等。秸秆的可再生性、零CO2排放和短生长周期等优势,使其成为生物质利用的重要对象之一。

关键词：玉米秆热解热重反应机理

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二元结构视野下对“增长极”理论的重新审视

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江海学刊 2008年第4期 64-69页

作者：李小敏南京大学社会学系

马克思主义经典作家和许多当代西方学者都从二元结构的视角出发,认真思考过"增长极"概念所概括的城市与工业在社会经济发展过程中的地位。"增长极"发展模式对发展中国家的经济起飞有着巨大的推动作用,但在实践中也产生了一些严重的负面... 详细信息

马克思主义经典作家和许多当代西方学者都从二元结构的视角出发,认真思考过"增长极"概念所概括的城市与工业在社会经济发展过程中的地位。"增长极"发展模式对发展中国家的经济起飞有着巨大的推动作用,但在实践中也产生了一些严重的负面效应。在我国经济快速发展的现实形势下,行政部门必须冷静客观地对待"增长极"的激发效应和负面效应,以积极主动的对策校正"增长极"的正负面效应,通过"以工促农、以城带乡"的长期战略,尽快促成"增长极"与"边缘区域"之间从"分化"到"融合"的转变。

关键词：增长极二元结构校正

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Image Registration Technique for Assessing the Accuracy of Intraoperative Osteotomy for Pelvic Tumors by 3D-Printed Patient-Specific Templates

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 306-311页

作者： QU Yang YAN Mengning li xiaomin WU Bing liU Siyu WANG liao WU Wen AI Songtao Department of Radiology Shanghai Jiao Tong University School of MedicineShanghai200011China Shanghai Key Laboratory of Orthopaedic Implants Department of OrthopaedicsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

The study aimed to explore the feasibility of an image registration technique for assessing the accuracy of intraoperative osteotomy of pelvic tumors by 3-dimensional(3D)-printed patient-specific *** with malignant pelvic tumors who were admitted to our hospital between March 2014 and December 2020 were retrospectively *** underwent hemi-pelvic resection and reconstruction by 3D-printed individualized *** registration between the designed model and the postoperative segmented model of the prosthesis was used to obtain the intraoperative osteotomy plane and reduce metal artifacts in postoperative computed tomography(CT)*** distance and angle between the planned and actual osteotomy planes were then used to assess the accuracy of the intraoperative *** patients with 13 osteotomy planes were enrolled,including four males and four *** median age at the time of imaging examination was 44 years(range,33–54 years).All intraoperative osteotomy planes were assessed *** mean distance between the planned and true intraoperative osteotomy planes was−0.69 cm(−7.5–7.35 cm),and the mean angle was 6.57°±3.36°(1.05°–11.88°).This new assessment method of registering the designed model and the postoperative CT segmented model of the prosthesis may be used to assess the accuracy of intraoperative osteotomy for pelvic tumors,using 3D printed patient-specific templates.

关键词： pelvic tumor image registration 3D-printed patient-specific template intraoperative osteotomy

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Effects of Danggui Wuji granules on 16S rDNA, metagenome, and metabolome in BDS mice

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Science of Traditional Chinese Medicine 2024年第1期2卷 29-36页

作者： Hanhui Huang Yurong Deng Shisheng Chen Zongyuan li xiaomin li Jianhui Sun liyu Hao Zeyue Yu Aoao Wang Jianliang li Hairu Huo Guimin liu Hongmei li Institute of ChineseMateria Medica China Academy of Chinese Medical SciencesBeijingChina Tianjin University of Traditional Chinese Medicine TianjinChina PERFECT Daily Necessities Co LtdZhongshan GuangdongChina

Blood deficiency syndrome(BDS)refers to a pathological state with blood dysfunction and organ dystrophy in traditional Chinese *** Wuji granules(DWG)was developed from a formula containing Angelicae Sinensis Radix and Musculus et Os Galli ***,we investigated the mechanism of DWG in treating BDS by modulating gut *** found that DWG protected mice from BDS by elevating the levels of red blood cell count,hemoglobin,and hematocrit in peripheral blood and increasing the erythrocyte membrane Na+-K+-ATPase *** Wuji granules changed the composition and metabolites of colonic ***,Lactobacillus,Muribaculaceae,and Alistipes were the main genera showing changes after DWG *** findings revealed that DWG presented a positive therapeutic effect on BDS in mice by regulating the gut microbiota and *** protective mechanism of DWG was associated with pathways such as metabolic pathways,biosynthesis of secondary metabolites,ABC transporters,ribosome,thyroid hormone synthesis,lysine degradation,galactose metabolism,tyrosine metabolism,etc.

关键词： Blood deficiency syndrome Danggui Wuji granules 16S rDNA sequencing Metagenome Metabolomics Angelicae Sinensis Radix

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城市内部二元结构问题及多维度研究

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城市发展研究 2013年第9期20卷 141-144页

作者：李效民河海大学商学院济宁学院经济与管理系

在我国工业化和城市化快速发展过程中,传统体制下形成的以户籍制度为核心的城乡二元结构不仅没有消除,反而逐步向城市蔓延,城市二元结构中的高低收入差距逐步扩大,繁华的城市中心与棚户区并存,城市二元结构的日益强化,将导致严重的城市... 详细信息

在我国工业化和城市化快速发展过程中,传统体制下形成的以户籍制度为核心的城乡二元结构不仅没有消除,反而逐步向城市蔓延,城市二元结构中的高低收入差距逐步扩大,繁华的城市中心与棚户区并存,城市二元结构的日益强化,将导致严重的城市贫困问题,加大城市管理的难度,并造成城市化进程的不稳定。城市内部的二元结构还存在于社会、政治、文化生活等多个方面,可以称之为多维度的二元结构。为此,应从社会保障、职业培训等多个维度加以考虑,逐步消除"城市二元结构"。

关键词：城市多维度二元结构突破

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Research on the evolutionary dynamics of interdisciplinary collaboration from the perspective of co-authorship

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Data Science and Informetrics 2022年第3期2卷 134-152页

作者： xiaomin li Jinjin Chen Wenge Zuo liying Zhou library of China Agricultural University BeijingChina library of XiHua University YibinChina

Despite the growing interest in exploring the interdisciplinary collaboration patterns and the factors in relation to team assembly in the first place, the dynamics of interdisciplinary collaboration with time varying is hardly known. Based on the longitudinally co-authorship network perspective, the paper investigates the evolutionary dynamics of interdisciplinary collaboration using separable temporal exponential-family random graph model(STERGM). The results from STERGM show that structural properties, properties of researcher and link properties affect the evolution of interdisciplinary co-authorship network to varying degrees. Network transitivity and preferential attachment play a decisive role in formation of links and hamper dissolution of ties in the network. The number of collaborators of interdisciplinary researchers plays an active role in the formation of partnerships and hamper dissolution of partnerships in the initial stage;specialization of team members inhibits the establishment of collaborative relationship in the initial stage and promotes the dissolution of connections in the later stage of project;the large difference in specialization value between members is not conducive to the formation of relations in the initial stage, but conducive to the maintenance of collaborative relations after links establishment. The same discipline background is conducive to the formation of relations but not conducive to the maintenance of collaborative relationships in interdisciplinary co-author network.

关键词： Interdisciplinary collaboration Co-authorship network Separable temporal exponential random graph model(STERGM)

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浅海竖L型悬空管道三维动力响应分析

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振动与冲击 2020年第20期39卷 47-54,66页

作者：李效民郝兴龙李朋中国海洋大学工程学院山东青岛266100 山东科技大学土木工程与建筑学院山东青岛266590

海底管道不仅会在平直段出现悬空,膨胀弯管处也会出现悬空,此时水平悬空段与垂直立管段整体呈L型并长期处于波浪海流激励下,波流作用引起的动力响应及疲劳损伤不容忽视。基于向量式有限元(VFIFE)法,考虑三向管土接触作用,建立了考虑往... 详细信息

海底管道不仅会在平直段出现悬空,膨胀弯管处也会出现悬空,此时水平悬空段与垂直立管段整体呈L型并长期处于波浪海流激励下,波流作用引起的动力响应及疲劳损伤不容忽视。基于向量式有限元(VFIFE)法,考虑三向管土接触作用,建立了考虑往复运动时侧向土抗力位移模型,采用非线性STOKES五阶波模拟了波流联合作用下埕岛水域某竖L型海底悬空管道的动力响应,并对考虑波流联合作用以及底端管卡松动的特殊情况下的动力响应进行了分析,评价其对疲劳寿命的影响。结果表明:对于两端固定的竖L型海底悬空管道,最不利点为管卡处,其次为管土分离点、弯头处以及跨中,共四个潜在危险点,其中,跨中的应力峰值较小;考虑波流联合作用与不考虑波流联合作用差别显著;只有横向约束的管卡在管道最小疲劳寿命方面优于固定管卡;考虑侧向往复运动土体作用理论对管道整体的应力以及疲劳影响较小,但对跨中及管土分离点处的位移影响较大。

关键词：向量式有限元悬空管道波流联合动力响应管土相互作用

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